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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fumigaclavine C
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Accession:CHEBI:64673 term browser browse the term
Definition:An ergot alkaloid produced by the fungus Aspergillus fumigatus that is ergoline which is substituted by a 2-methylbut-3-en-2-yl group at position 2, methyl groups at the 6 and 8beta positions, and by an acetoxy group at the 9beta position.
Synonyms:exact_synonym: (8beta,9beta)-6,8-dimethyl-2-(2-methylbut-3-en-2-yl)ergolin-9-yl acetate
 related_synonym: Formula=C23H30N2O2;   InChI=1S/C23H30N2O2/c1-7-23(4,5)22-16-11-18-20(15-9-8-10-17(24-22)19(15)16)21(27-14(3)26)13(2)12-25(18)6/h7-10,13,18,20-21,24H,1,11-12H2,2-6H3/t13-,18+,20+,21-/m0/s1;   InChIKey=OSICWVVWEXKSBD-LFAYTRTRSA-N;   SMILES=[H][C@@]12Cc3c([nH]c4cccc(c34)[C@@]1([H])[C@@H](OC(C)=O)[C@@H](C)CN2C)C(C)(C)C=C
 xref: CAS:62867-47-4
 xref_mesh: MESH:C492995
 xref: MetaCyc:CPD-12338;   PMID:15231043;   PMID:16023606;   PMID:16397874;   PMID:16557450;   PMID:16902860;   PMID:18678866;   PMID:19256529;   PMID:21762706;   PMID:22344643;   PMID:350117;   Reaxys:19760287
 cyclic_relationship: is_conjugate_base_of CHEBI:67147


show annotations for term's descendants           Sort by:
fumigaclavine C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO fumigaclavine C results in decreased expression of IFNG mRNA; fumigaclavine C results in decreased expression of IFNG protein CTD PMID:16023606 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12a interleukin 12A decreases expression ISO fumigaclavine C results in decreased expression of IL12A mRNA CTD PMID:16023606 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO fumigaclavine C results in decreased expression of IL1B mRNA CTD PMID:16023606 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression ISO fumigaclavine C results in decreased expression of IL2 mRNA; fumigaclavine C results in decreased expression of IL2 protein CTD PMID:16023606 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 ISO fumigaclavine C results in decreased activity of MMP9 protein
fumigaclavine C results in decreased expression of MMP9 mRNA		 CTD PMID:16023606 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO fumigaclavine C results in decreased expression of TNF mRNA CTD PMID:16023606 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            fumigaclavine C 6
              9-deacetoxyfumigaclavine C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    main group molecular entity 19761
                      s-block molecular entity 19612
                        hydrogen molecular entity 19601
                          hydrides 19077
                            inorganic hydride 17986
                              pnictogen hydride 17973
                                nitrogen hydride 17870
                                  azane 17655
                                    ammonia 17654
                                      organic amino compound 17654
                                        polyamine 8342
                                          diamine 8271
                                            ergoline 19
                                              fumigaclavine C 6
                                                9-deacetoxyfumigaclavine C 0
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