CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: divalent inorganic cation
Accession: CHEBI:64641
browse the term
Definition: An inorganic cation with a valency of two.
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CD14
CD14 molecule
affects expression
EXP
cadmium nitrate affects the expression of CD14 mRNA
CTD
PMID:29421334
NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581
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CXCL8
C-X-C motif chemokine ligand 8
affects expression affects secretion
EXP
cadmium nitrate affects the expression of CXCL8 mRNA cadmium nitrate affects the secretion of CXCL8 protein
CTD
PMID:29421334
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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DEFB1
defensin beta 1
increases expression
EXP
cadmium nitrate results in increased expression of DEFB1 mRNA
CTD
PMID:29421334
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IFNB1
interferon beta 1
increases expression
EXP
cadmium nitrate results in increased expression of IFNB1 mRNA
CTD
PMID:29421334
NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
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IL18
interleukin 18
increases expression
EXP
cadmium nitrate results in increased expression of IL18 mRNA
CTD
PMID:29421334
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
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IL6
interleukin 6
increases expression
EXP
cadmium nitrate results in increased expression of IL6 mRNA
CTD
PMID:29421334
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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LOC110258578
interleukin-1 beta-like
increases expression
EXP
cadmium nitrate results in increased expression of IL1B mRNA
CTD
PMID:29421334
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MAPK14
mitogen-activated protein kinase 14
affects expression
EXP
cadmium nitrate affects the expression of MAPK14 mRNA
CTD
PMID:29421334
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
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MAPK8
mitogen-activated protein kinase 8
increases expression
EXP
cadmium nitrate results in increased expression of MAPK8 mRNA
CTD
PMID:29421334
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
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MYD88
MYD88 innate immune signal transduction adaptor
affects expression
EXP
cadmium nitrate affects the expression of MYD88 mRNA
CTD
PMID:29421334
NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109
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NFKB1
nuclear factor kappa B subunit 1
affects expression
EXP
cadmium nitrate affects the expression of NFKB1 mRNA
CTD
PMID:29421334
NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
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RELA
RELA proto-oncogene, NF-kB subunit
increases expression
EXP
cadmium nitrate results in increased expression of RELA mRNA
CTD
PMID:29421334
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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SOCS1
suppressor of cytokine signaling 1
decreases expression
EXP
cadmium nitrate results in decreased expression of SOCS1 mRNA
CTD
PMID:29421334
NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967
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STAT3
signal transducer and activator of transcription 3
decreases expression
EXP
cadmium nitrate results in decreased expression of STAT3 mRNA
CTD
PMID:29421334
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
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TLR4
toll like receptor 4
affects expression
EXP
cadmium nitrate affects the expression of TLR4 mRNA
CTD
PMID:29421334
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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TLR5
toll like receptor 5
increases expression
EXP
cadmium nitrate results in increased expression of TLR5 mRNA
CTD
PMID:29421334
NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024
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TNF
tumor necrosis factor
increases expression
EXP
cadmium nitrate results in increased expression of TNF mRNA
CTD
PMID:29421334
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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ENPEP
glutamyl aminopeptidase
multiple interactions
EXP
Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame]
CTD
PMID:8141778
NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
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GAPDH
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
EXP
[Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein
CTD
PMID:26582256
NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
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AOC1
amine oxidase copper containing 1
affects binding
EXP
cobaltous chloride binds to AOC1 protein
CTD
PMID:16842785
NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
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HSP90B1
heat shock protein 90 beta family member 1
increases expression
EXP
cobaltous chloride results in increased expression of HSP90B1 mRNA
CTD
PMID:17464326
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
cobaltous chloride results in increased expression of HSPA5 mRNA
CTD
PMID:17464326
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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AOC1
amine oxidase copper containing 1
increases activity
EXP
cupric chloride results in increased activity of AOC1 protein
CTD
PMID:16842785
NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
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ATOX1
antioxidant 1 copper chaperone
increases expression
EXP
Copper Sulfate results in increased expression of ATOX1 mRNA
CTD
PMID:22585802
NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597
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CCNB1
cyclin B1
increases secretion
EXP
Copper Sulfate results in increased secretion of CCNB1 protein
CTD
PMID:24521407
NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
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COX17
cytochrome c oxidase copper chaperone COX17
decreases expression
EXP
Copper Sulfate results in decreased expression of COX17 mRNA
CTD
PMID:22585802
NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,587,621
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GHRH
growth hormone releasing hormone
increases expression
EXP
Copper Sulfate results in increased expression of GHRH mRNA
CTD
PMID:21110139
NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
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HSP90B1
heat shock protein 90 beta family member 1
increases expression
EXP
Copper Sulfate results in increased expression of HSP90B1 mRNA
CTD
PMID:17464326
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
Copper Sulfate results in increased expression of HSPA5 mRNA
CTD
PMID:17464326
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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IGF1
insulin like growth factor 1
increases secretion
EXP
Copper Sulfate results in increased secretion of IGF1 protein
CTD
PMID:24521407
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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SST
somatostatin
decreases expression
EXP
Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein
CTD
PMID:21110139
NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850
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AKT1
AKT serine/threonine kinase 1
increases expression
EXP
lead acetate results in increased expression of AKT1 mRNA
CTD
PMID:29273543
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AMH
anti-Mullerian hormone
decreases expression multiple interactions
EXP
lead acetate results in decreased expression of AMH mRNA lead acetate results in decreased expression of and results in decreased secretion of AMH protein
CTD
PMID:29273543
NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312
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FSHB
follicle stimulating hormone subunit beta
multiple interactions
EXP
lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol]
CTD
PMID:29273543
NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
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FSHR
follicle stimulating hormone receptor
decreases expression
EXP
lead acetate results in decreased expression of FSHR mRNA
CTD
PMID:29273543
NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
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HSP90B1
heat shock protein 90 beta family member 1
increases expression
EXP
lead acetate results in increased expression of HSP90B1 mRNA
CTD
PMID:17464326
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
lead acetate results in increased expression of HSPA5 mRNA
CTD
PMID:17464326
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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INHA
inhibin subunit alpha
multiple interactions
EXP
lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]
CTD
PMID:29273543
NCBI chr15:121,581,847...121,586,020
Ensembl chr15:121,580,803...121,586,006
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INHBB
inhibin subunit beta B
decreases expression multiple interactions
EXP
lead acetate results in decreased expression of INHBB mRNA lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]; lead acetate results in decreased expression of and results in decreased secretion of INHBB protein
CTD
PMID:29273543
NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
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MTOR
mechanistic target of rapamycin kinase
increases expression
EXP
lead acetate results in increased expression of MTOR mRNA
CTD
PMID:29273543
NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
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BAX
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of BAX mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]
CTD
PMID:28803810
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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BECN1
beclin 1
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of BECN1 protein 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]
CTD
PMID:28803810
NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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CASP3
caspase 3
multiple interactions increases expression increases cleavage
EXP
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein] Zinc Sulfate results in increased expression of CASP3 mRNA
CTD
PMID:28803810
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP6
caspase 6
increases expression
EXP
Zinc Sulfate results in increased expression of CASP6 mRNA
CTD
PMID:28803810
NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045
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CASP8
caspase 8
multiple interactions increases cleavage
EXP
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]
CTD
PMID:28803810
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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CYCS
cytochrome c, somatic
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of CYCS mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]
CTD
PMID:28803810
NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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GPX1
glutathione peroxidase 1
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]
CTD
PMID:32280687
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]
CTD
PMID:32280687
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MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
increases expression
EXP
Zinc Sulfate results in increased expression of MAP1LC3A mRNA
CTD
PMID:28803810
NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
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MT1A
metallothionein 1A
increases expression
EXP
Zinc Sulfate results in increased expression of MT1A mRNA
CTD
PMID:25895165
NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672
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NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]
CTD
PMID:32280687
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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SLC30A1
solute carrier family 30 member 1
increases expression
EXP
Zinc Sulfate results in increased expression of SLC30A1 mRNA
CTD
PMID:25895165
NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672
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SLC39A10
solute carrier family 39 member 10
decreases expression increases expression
EXP
Zinc Sulfate results in decreased expression of SLC39A10 mRNA Zinc Sulfate results in increased expression of SLC39A10 mRNA
CTD
PMID:16804107
NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611
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SOD1
superoxide dismutase 1
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]
CTD
PMID:32280687
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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SQSTM1
sequestosome 1
increases expression multiple interactions decreases expression
EXP
Zinc Sulfate results in increased expression of SQSTM1 mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]
CTD
PMID:28803810
NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
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TNF
tumor necrosis factor
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]
CTD
PMID:32280687
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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