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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quercetin O-glucoside
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Accession:CHEBI:64621 term browser browse the term
Definition:A quercetin O-glycoside that is an O-glucosylated derivative of quercetin.
Synonyms:related_synonym: quercetin O-glucosides


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quercetin 3-O-beta-D-glucofuranoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA CTD PMID:18032389 NCBI chr 1:47,695,833...47,713,879 JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA CTD PMID:20033131 NCBI chr 5:151,590,968...151,601,394 JBrowse link
G Apoa1 apolipoprotein A1 increases secretion ISO isoquercitrin results in increased secretion of APOA1 protein CTD PMID:24963805 NCBI chr 8:46,527,251...46,529,035 JBrowse link
G Atf6 activating transcription factor 6 increases expression EXP isoquercitrin results in increased expression of ATF6 mRNA CTD PMID:30365939 NCBI chr13:82,927,579...83,106,381 JBrowse link
G Atxn2 ataxin 2 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:34,754,132...34,851,175 JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:121,072,228...121,107,902 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO isoquercitrin results in decreased expression of BCL2 mRNA CTD PMID:30597948 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 affects expression ISO isoquercitrin affects the expression of CASP3 mRNA CTD PMID:30597948 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 decreases expression ISO isoquercitrin results in decreased expression of CASP8 mRNA CTD PMID:30597948 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Cat catalase multiple interactions EXP [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30298849 PMID:30817903 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA] CTD PMID:21295105 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein] CTD PMID:14654164 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA] CTD PMID:21295105 NCBI chr 5:104,009,839...104,019,082 JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO isoquercitrin affects the expression of CTNNB1 mRNA CTD PMID:30597948 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein] CTD PMID:14654164 NCBI chr14:17,181,030...17,183,075 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
EXP
ISO
[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA
isoquercitrin results in decreased activity of CYP1A1 protein
CTD PMID:16271822 PMID:20033131 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA CTD PMID:20033131 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO isoquercitrin results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:81,594,534...81,608,567 JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA CTD PMID:18032389 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA CTD PMID:18032389 NCBI chr 1:199,015,081...199,031,055 JBrowse link
G Egf epidermal growth factor multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:26109002 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:26109002 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA CTD PMID:18032389 NCBI chr15:37,412,143...37,440,198 JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA CTD PMID:18032389 NCBI chr 2:174,497,402...174,507,031 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr 6:95,493,589...95,496,877 JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA] CTD PMID:31068541 NCBI chr  X:120,238,515...120,504,106 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA] CTD PMID:20033131 PMID:20045035 NCBI chr 8:79,105,561...79,117,472 JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA] CTD PMID:20033131 PMID:20045035 NCBI chr 2:195,649,845...195,655,402 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA CTD PMID:18032389 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA CTD PMID:18032389 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:21295105 PMID:30817903 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Ibsp integrin-binding sialoprotein increases expression EXP isoquercitrin results in increased expression of IBSP mRNA CTD PMID:30365939 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA CTD PMID:21295105 PMID:31068541 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA] CTD PMID:30817903 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA] CTD PMID:30817903 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Insig1 insulin induced gene 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA CTD PMID:18032389 NCBI chr 4:7,315,494...7,323,972 JBrowse link
G Jak1 Janus kinase 1 increases expression ISO isoquercitrin results in increased expression of JAK1 mRNA CTD PMID:30597948 NCBI chr 5:115,780,248...115,888,841 JBrowse link
G Jak2 Janus kinase 2 increases expression ISO isoquercitrin results in increased expression of JAK2 mRNA CTD PMID:30597948 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Lct lactase multiple interactions EXP [migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin CTD PMID:12663055 NCBI chr13:39,781,929...39,824,456 JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA CTD PMID:18032389 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:26109002 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:26109002 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO isoquercitrin affects the expression of MCL1 mRNA CTD PMID:30597948 NCBI chr 2:183,219,137...183,235,676 JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 8:87,549,043...87,660,251 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:18715546 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:18715546 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA CTD PMID:31068541 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA] CTD PMID:20045035 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA] CTD PMID:21295105 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA] CTD PMID:20033131 PMID:31068541 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA CTD PMID:30298849 NCBI chr19:30,715,648...31,059,885 JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA] CTD PMID:25129099 NCBI chr10:88,727,912...88,857,375 JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA] CTD PMID:25129099 NCBI chr14:72,648,771...72,670,521 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 NCBI chr11:71,108,100...71,185,170 JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:21,942,233...21,953,034 JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA] CTD PMID:25129099 NCBI chr 5:161,353,718...161,376,993 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression ISO isoquercitrin affects the expression of PIK3CA mRNA CTD PMID:30597948 NCBI chr 2:115,175,275...115,249,034 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO isoquercitrin results in increased expression of PIK3R1 mRNA CTD PMID:30597948 NCBI chr 2:32,878,942...32,963,611 JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:164,727,803...164,740,168 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:14654164 PMID:20045035 PMID:30817903 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:26109002 NCBI chr 7:105,126,725...105,331,848 JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO isoquercitrin results in increased expression of RELB mRNA CTD PMID:30597948 NCBI chr 1:79,257,738...79,285,490 JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP isoquercitrin results in increased expression of RUNX2 mRNA CTD PMID:30365939 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Sc5d sterol-C5-desaturase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA CTD PMID:18032389 NCBI chr 8:42,629,649...42,641,257 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA] CTD PMID:20045035 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr14:77,553,990...77,618,589 JBrowse link
G Sqle squalene epoxidase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA CTD PMID:18032389 NCBI chr 7:90,867,973...90,883,623 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide] CTD PMID:18032389 NCBI chr 7:113,663,202...113,720,850 JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO isoquercitrin results in increased expression of STAT3 mRNA CTD PMID:30597948 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO isoquercitrin results in increased expression of STAT6 mRNA CTD PMID:30597948 NCBI chr 7:63,480,229...63,497,551 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA] CTD PMID:25129099 NCBI chr10:14,850,765...14,853,046 JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO isoquercitrin results in increased expression of TIMP1 protein CTD PMID:18715546 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] CTD PMID:14654164 PMID:21295105 PMID:30817903 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein] CTD PMID:21295105 NCBI chr 4:158,150,815...158,163,592 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA] CTD PMID:30817903 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein] CTD PMID:21295105 NCBI chr19:33,136,148...33,142,714 JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:31068541 NCBI chr 5:72,712,334...72,724,564 JBrowse link
G Tyk2 tyrosine kinase 2 affects expression ISO isoquercitrin affects the expression of TYK2 mRNA CTD PMID:30597948 NCBI chr 8:19,641,881...19,667,157 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:41,485,033...41,495,590 JBrowse link
quercetin 3-O-beta-D-glucopyranoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA CTD PMID:18032389 NCBI chr 1:47,695,833...47,713,879 JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA CTD PMID:20033131 NCBI chr 5:151,590,968...151,601,394 JBrowse link
G Apoa1 apolipoprotein A1 increases secretion ISO isoquercitrin results in increased secretion of APOA1 protein CTD PMID:24963805 NCBI chr 8:46,527,251...46,529,035 JBrowse link
G Atf6 activating transcription factor 6 increases expression EXP isoquercitrin results in increased expression of ATF6 mRNA CTD PMID:30365939 NCBI chr13:82,927,579...83,106,381 JBrowse link
G Atxn2 ataxin 2 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:34,754,132...34,851,175 JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:121,072,228...121,107,902 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO isoquercitrin results in decreased expression of BCL2 mRNA CTD PMID:30597948 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 affects expression ISO isoquercitrin affects the expression of CASP3 mRNA CTD PMID:30597948 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 decreases expression ISO isoquercitrin results in decreased expression of CASP8 mRNA CTD PMID:30597948 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Cat catalase multiple interactions EXP [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30298849 PMID:30817903 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA] CTD PMID:21295105 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein] CTD PMID:14654164 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA] CTD PMID:21295105 NCBI chr 5:104,009,839...104,019,082 JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO isoquercitrin affects the expression of CTNNB1 mRNA CTD PMID:30597948 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein] CTD PMID:14654164 NCBI chr14:17,181,030...17,183,075 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
isoquercitrin results in decreased activity of CYP1A1 protein
[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA
CTD PMID:16271822 PMID:20033131 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA CTD PMID:20033131 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO isoquercitrin results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:81,594,534...81,608,567 JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA CTD PMID:18032389 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA CTD PMID:18032389 NCBI chr 1:199,015,081...199,031,055 JBrowse link
G Egf epidermal growth factor multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:26109002 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:26109002 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA CTD PMID:18032389 NCBI chr15:37,412,143...37,440,198 JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA CTD PMID:18032389 NCBI chr 2:174,497,402...174,507,031 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr 6:95,493,589...95,496,877 JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA] CTD PMID:31068541 NCBI chr  X:120,238,515...120,504,106 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA] CTD PMID:20033131 PMID:20045035 NCBI chr 8:79,105,561...79,117,472 JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA] CTD PMID:20033131 PMID:20045035 NCBI chr 2:195,649,845...195,655,402 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA CTD PMID:18032389 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA CTD PMID:18032389 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:21295105 PMID:30817903 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Ibsp integrin-binding sialoprotein increases expression EXP isoquercitrin results in increased expression of IBSP mRNA CTD PMID:30365939 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA CTD PMID:21295105 PMID:31068541 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA] CTD PMID:30817903 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA] CTD PMID:30817903 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Insig1 insulin induced gene 1 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA CTD PMID:18032389 NCBI chr 4:7,315,494...7,323,972 JBrowse link
G Jak1 Janus kinase 1 increases expression ISO isoquercitrin results in increased expression of JAK1 mRNA CTD PMID:30597948 NCBI chr 5:115,780,248...115,888,841 JBrowse link
G Jak2 Janus kinase 2 increases expression ISO isoquercitrin results in increased expression of JAK2 mRNA CTD PMID:30597948 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Lct lactase multiple interactions EXP [migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin CTD PMID:12663055 NCBI chr13:39,781,929...39,824,456 JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA CTD PMID:18032389 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:26109002 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:26109002 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO isoquercitrin affects the expression of MCL1 mRNA CTD PMID:30597948 NCBI chr 2:183,219,137...183,235,676 JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 8:87,549,043...87,660,251 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:18715546 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:18715546 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA CTD PMID:31068541 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA] CTD PMID:20045035 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA] CTD PMID:21295105 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA] CTD PMID:20033131 PMID:31068541 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA CTD PMID:30298849 NCBI chr19:30,715,648...31,059,885 JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA] CTD PMID:25129099 NCBI chr10:88,727,912...88,857,375 JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA] CTD PMID:25129099 NCBI chr14:72,648,771...72,670,521 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 NCBI chr11:71,108,100...71,185,170 JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:21,942,233...21,953,034 JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA] CTD PMID:25129099 NCBI chr 5:161,353,718...161,376,993 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression ISO isoquercitrin affects the expression of PIK3CA mRNA CTD PMID:30597948 NCBI chr 2:115,175,275...115,249,034 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO isoquercitrin results in increased expression of PIK3R1 mRNA CTD PMID:30597948 NCBI chr 2:32,878,942...32,963,611 JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:164,727,803...164,740,168 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:14654164 PMID:20045035 PMID:30817903 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] CTD PMID:26109002 NCBI chr 7:105,126,725...105,331,848 JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO isoquercitrin results in increased expression of RELB mRNA CTD PMID:30597948 NCBI chr 1:79,257,738...79,285,490 JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP isoquercitrin results in increased expression of RUNX2 mRNA CTD PMID:30365939 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Sc5d sterol-C5-desaturase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA CTD PMID:18032389 NCBI chr 8:42,629,649...42,641,257 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA] CTD PMID:20045035 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr14:77,553,990...77,618,589 JBrowse link
G Sqle squalene epoxidase multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA CTD PMID:18032389 NCBI chr 7:90,867,973...90,883,623 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide] CTD PMID:18032389 NCBI chr 7:113,663,202...113,720,850 JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO isoquercitrin results in increased expression of STAT3 mRNA CTD PMID:30597948 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO isoquercitrin results in increased expression of STAT6 mRNA CTD PMID:30597948 NCBI chr 7:63,480,229...63,497,551 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA] CTD PMID:25129099 NCBI chr10:14,850,765...14,853,046 JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO isoquercitrin results in increased expression of TIMP1 protein CTD PMID:18715546 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] CTD PMID:14654164 PMID:21295105 PMID:30817903 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein] CTD PMID:21295105 NCBI chr 4:158,150,815...158,163,592 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA] CTD PMID:30817903 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions EXP isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein] CTD PMID:21295105 NCBI chr19:33,136,148...33,142,714 JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:31068541 NCBI chr 5:72,712,334...72,724,564 JBrowse link
G Tyk2 tyrosine kinase 2 affects expression ISO isoquercitrin affects the expression of TYK2 mRNA CTD PMID:30597948 NCBI chr 8:19,641,881...19,667,157 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:41,485,033...41,495,590 JBrowse link
quercetin 4'-O-beta-D-glucopyranoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein] CTD PMID:32602595 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:32602595 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:32602595 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]]; spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein] CTD PMID:32602595 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cryz crystallin zeta increases activity ISO spiraeoside results in increased activity of CRYZ protein CTD PMID:8968052 NCBI chr 2:243,552,037...243,580,369 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein] CTD PMID:32602595 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Lct lactase multiple interactions EXP [migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside CTD PMID:12663055 NCBI chr13:39,781,929...39,824,456 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein] CTD PMID:32602595 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Plcg2 phospholipase C, gamma 2 decreases phosphorylation ISO spiraeoside results in decreased phosphorylation of PLCG2 protein CTD PMID:15613018 NCBI chr19:45,547,416...45,683,930 JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions EXP
ISO
[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
spiraeoside inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]
CTD PMID:12663055 PMID:17495124 NCBI chr14:77,553,990...77,618,589 JBrowse link
G Syk spleen associated tyrosine kinase decreases phosphorylation ISO spiraeoside results in decreased phosphorylation of SYK protein CTD PMID:15613018 NCBI chr17:12,604,615...12,678,437 JBrowse link
rutin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein] CTD PMID:25478064 NCBI chr 5:67,678,267...67,801,162 JBrowse link
G Acly ATP citrate lyase decreases activity ISO Rutin results in decreased activity of ACLY protein CTD PMID:17032037 NCBI chr10:85,412,045...85,464,253 JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr20:4,148,150...4,151,361 JBrowse link
G Agt angiotensinogen multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein] CTD PMID:24117263 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Ahr aryl hydrocarbon receptor decreases localization
multiple interactions
ISO Rutin results in decreased localization of AHR protein
Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
CTD PMID:21756928 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein] CTD PMID:22426011 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO Rutin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:182,997,731...183,056,584 JBrowse link
G Atxn2 ataxin 2 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:34,754,132...34,851,175 JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:121,072,228...121,107,902 JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression
ISO Rutin affects the expression of BAX protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
Rutin results in increased expression of BAX protein
CTD PMID:15975156 PMID:28811126 PMID:29522708 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of BBC3 mRNA] CTD PMID:27239252 NCBI chr 1:77,013,281...77,022,509 JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
decreases expression
ISO
EXP
Rutin affects the expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]
Rutin results in decreased expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]
Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]
CTD PMID:15975156 PMID:19557821 PMID:26062544 PMID:28811126 PMID:29522708 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA] CTD PMID:26062544 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of BRAF protein] CTD PMID:32864822 NCBI chr 4:68,375,484...68,510,652 JBrowse link
G Casp1 caspase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein] CTD PMID:22426011 NCBI chr 8:2,587,812...2,597,403 JBrowse link
G Casp3 caspase 3 affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity
ISO
EXP
Rutin affects the cleavage of CASP3 protein
Rutin results in increased cleavage of CASP3 protein
Rutin inhibits the reaction [Cholesterol, Dietary results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]
Rutin results in increased expression of CASP3 mRNA
Rutin results in increased activity of CASP3 protein
CTD PMID:15975156 PMID:24726691 PMID:24908156 PMID:25129099 PMID:26091902 PMID:27239252 PMID:28811126 PMID:29315975 PMID:29522708 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO
EXP
Rutin results in increased activity of CASP7 protein
Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]
CTD PMID:24726691 PMID:25129099 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA
Rutin results in increased expression of CASP8 mRNA
CTD PMID:26091902 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Cat catalase multiple interactions ISO
EXP
Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
Rutin inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]
CTD PMID:19833193 PMID:21605616 PMID:25478064 PMID:25753322 PMID:29743444 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Rutin binds to and results in decreased activity of CBR1 protein; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:11306090 PMID:18579125 NCBI chr11:32,860,618...32,862,981 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion
decreases expression
ISO
EXP
Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
Rutin results in decreased secretion of CCL2 protein
Rutin results in decreased expression of CCL2 mRNA
CTD PMID:21756928 PMID:21967610 PMID:25478064 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
EXP Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CCL5 mRNA] CTD PMID:28693884 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein] CTD PMID:24117263 NCBI chr 1:20,802,199...20,805,315 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA
Rutin results in decreased expression of CCND1 mRNA
CTD PMID:26091902 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cd68 Cd68 molecule decreases expression EXP Rutin results in decreased expression of CD68 protein CTD PMID:28693884 NCBI chr10:54,381,814...54,383,693 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Rutin inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 mRNA] CTD PMID:15652231 NCBI chr10:38,386,945...38,388,926 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 decreases expression EXP Rutin results in decreased expression of CX3CL1 mRNA CTD PMID:28693884 NCBI chr19:10,227,337...10,237,826 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases secretion
decreases expression
ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]
Rutin results in decreased secretion of CXCL10 protein
Rutin results in decreased expression of CXCL10 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression
multiple interactions
EXP Rutin results in decreased expression of CXCL12 mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CXCL12 mRNA]
CTD PMID:28693884 NCBI chr 4:150,388,326...150,401,173 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Rutin results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Rutin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Rutin results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Egf epidermal growth factor multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA] CTD PMID:26062544 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Rutin results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:94,858,438...94,909,630 JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA] CTD PMID:26062544 NCBI chr 1:199,743,200...199,745,746 JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions
ISO
EXP
Rutin results in increased expression of FN1 protein
Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]
CTD PMID:24117263 PMID:26408079 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein] CTD PMID:24908156 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Rutin results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:5,198,825...5,406,785 JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Rutin results in increased expression of GDNF mRNA CTD PMID:28693884 NCBI chr 2:56,893,992...56,919,935 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein] CTD PMID:25478064 PMID:25753322 PMID:26062544 PMID:27239252 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein] CTD PMID:25478064 NCBI chr 8:109,026,905...109,028,031 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO
EXP
Rutin results in decreased activity of GSR protein
Rutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
CTD PMID:15782287 PMID:21605616 PMID:25753322 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein CTD PMID:22902988 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Ifng interferon gamma multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA CTD PMID:28693884 NCBI chr 7:22,282,895...22,361,972 JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein] CTD PMID:20015448 NCBI chr 1:121,549,839...121,838,545 JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP Lipopolysaccharides promotes the reaction [Rutin results in increased expression of IL10 mRNA]
Rutin results in increased expression of IL10 mRNA; Rutin results in increased expression of IL10 protein
CTD PMID:28693884 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il18 interleukin 18 multiple interactions
decreases expression
EXP Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Rutin results in decreased expression of IL18 mRNA
CTD PMID:22426011 PMID:28693884 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]
Rutin results in decreased expression of IL1B mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL1B mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]
CTD PMID:15652231 PMID:18958421 PMID:19557821 PMID:22426011 PMID:28693884 PMID:29315975 PMID:29522708 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
Rutin results in decreased expression of IL6 mRNA; Rutin results in decreased expression of IL6 protein
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL6 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]
Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:15652231 PMID:18958421 PMID:21756928 PMID:22426011 PMID:25753322 PMID:26062544 PMID:27239252 PMID:28693884 PMID:29743444 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Insr insulin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 NCBI chr12:1,193,193...1,330,976 JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
multiple interactions
ISO
EXP
Rutin results in decreased expression of IRS1 protein
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]
CTD PMID:20015448 PMID:22426011 NCBI chr 9:83,552,964...83,605,797 JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
EXP Rutin results in increased expression of ITGAM protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of ITGAM protein]
CTD PMID:28693884 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA] CTD PMID:26062544 NCBI chr 5:115,780,248...115,888,841 JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein] CTD PMID:22426011 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Rutin results in decreased expression of JUN protein
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]
CTD PMID:20015448 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO Rutin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552 JBrowse link
G Lep leptin multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Lepr leptin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:116,294,409...116,477,904 JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224 JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K5 mRNA] CTD PMID:26062544 NCBI chr 8:63,625,220...63,852,090 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK1 protein]
Rutin results in decreased phosphorylation of MAPK1 protein
CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK3 protein]
Rutin results in decreased phosphorylation of MAPK3 protein
CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mir100 microRNA 100 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR100 mRNA] CTD PMID:32864822 NCBI chr 8:41,901,225...41,901,304 JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR125B1 mRNA] CTD PMID:32864822 NCBI chr 8:41,952,966...41,953,052 JBrowse link
G Mir1306 microRNA 1306 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR1306 mRNA] CTD PMID:32864822 NCBI chr11:82,709,651...82,709,723 JBrowse link
G Mir152 microRNA 152 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR152 mRNA] CTD PMID:32864822 NCBI chr10:81,832,936...81,833,020 JBrowse link
G Mir181c microRNA 181c multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR181C mRNA] CTD PMID:32864822 NCBI chr19:23,983,523...23,983,628 JBrowse link
G Mir185 microRNA 185 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR185 mRNA] CTD PMID:32864822 NCBI chr11:82,664,716...82,664,795 JBrowse link
G Mir195 microRNA 195 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR195 mRNA] CTD PMID:32864822 NCBI chr10:54,951,838...54,951,924 JBrowse link
G Mir196c microRNA 196c multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR196C mRNA] CTD PMID:32864822 NCBI chr10:81,231,006...81,231,085 JBrowse link
G Mir199a2 microRNA 199a-2 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR199A2 mRNA] CTD PMID:32864822 NCBI chr13:74,582,954...74,583,063 JBrowse link
G Mir204 microRNA 204 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR204 mRNA] CTD PMID:32864822 NCBI chr 1:220,316,931...220,317,040 JBrowse link
G Mir208b microRNA 208b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR208B mRNA] CTD PMID:32864822 NCBI chr15:28,451,638...28,451,749 JBrowse link
G Mir211 microRNA 211 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR211 mRNA] CTD PMID:32864822 NCBI chr 1:117,777,539...117,777,644 JBrowse link
G Mir22 microRNA 22 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR22 mRNA] CTD PMID:32864822 NCBI chr10:60,307,039...60,307,133 JBrowse link
G Mir26b microRNA 26b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR26B mRNA] CTD PMID:32864822 NCBI chr 9:75,976,596...75,976,680 JBrowse link
G Mir296 microRNA 296 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR296 mRNA] CTD PMID:32864822 NCBI chr 3:163,051,838...163,051,915 JBrowse link
G Mir30c1 microRNA 30c-1 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR30C1 mRNA] CTD PMID:32864822 NCBI chr 5:134,349,237...134,349,325 JBrowse link
G Mir3558 microRNA 3558 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3558 mRNA] CTD PMID:32864822 NCBI chr 6:7,181,751...7,181,864 JBrowse link
G Mir3584 microRNA 3584 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3584 mRNA] CTD PMID:32864822 NCBI chr 1:246,786,249...246,786,329 JBrowse link
G Mir3588 microRNA 3588 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3588 mRNA] CTD PMID:32864822 NCBI chr11:16,245,611...16,245,716 JBrowse link
G Mir365b microRNA 365b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR365B mRNA] CTD PMID:32864822 NCBI chr10:64,686,255...64,686,340 JBrowse link
G Mir494 microRNA 494 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR494 mRNA] CTD PMID:32864822 NCBI chr 6:128,728,710...128,728,792 JBrowse link
G Mir6216 microRNA 6216 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR6216 mRNA] CTD PMID:32864822 NCBI chr 3:44,756,861...44,756,938 JBrowse link
G Mir664-2 microRNA 664-2 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR664-2 mRNA] CTD PMID:32864822 NCBI chr13:96,793,099...96,793,157 JBrowse link
G Mir760 microRNA 760 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR760 mRNA] CTD PMID:32864822 NCBI chr 2:210,392,616...210,392,695 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Rutin results in decreased expression of and results in decreased activity of MMP2 protein
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]
CTD PMID:26408079 PMID:29743444 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Rutin results in decreased expression of MMP9 mRNA
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]
CTD PMID:16304905 PMID:29743444 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions
EXP Rutin results in increased expression of MRC1 protein
[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein
CTD PMID:28693884 NCBI chr17:77,249,187...77,330,857 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]
[Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein
CTD PMID:22902988 PMID:31412289 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:19557821 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] CTD PMID:22426011 NCBI chr10:44,326,770...44,353,814 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP
ISO
Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Rutin results in decreased expression of NOS2 mRNA; Rutin results in decreased expression of NOS2 protein
Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:11500931 PMID:12512693 PMID:22902988 PMID:25080890 PMID:25753322 PMID:28693884 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA] CTD PMID:25129099 NCBI chr10:88,727,912...88,857,375 JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA] CTD PMID:25129099 NCBI chr14:72,648,771...72,670,521 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 NCBI chr11:71,108,100...71,185,170 JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA] CTD PMID:25129099 NCBI chr 5:161,353,718...161,376,993 JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression ISO Rutin results in decreased expression of PNPLA3 mRNA CTD PMID:17032037 NCBI chr 7:115,293,538...115,314,077 JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression
EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein]
Rutin results in increased expression of PON1 mRNA
CTD PMID:25478064 NCBI chr 4:33,294,737...33,325,759 JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein] CTD PMID:25478064 NCBI chr 4:33,356,983...33,383,681 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein] CTD PMID:22426011 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein] CTD PMID:25478064 NCBI chr20:6,298,785...6,363,970 JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:164,727,803...164,740,168 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
[Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
Rutin results in decreased expression of PTGS2 mRNA
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
CTD PMID:11500931 PMID:15652231 PMID:19557821 PMID:21756928 PMID:22902988 PMID:25080890 PMID:25753322 PMID:28693884 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 1:182,601,657...182,603,013 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A mRNA]; Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A protein] CTD PMID:32864822 NCBI chr 2:193,208,631...193,286,513 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [Glucose affects the localization of RELA protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Rutin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]
CTD PMID:19557821 PMID:21756928 PMID:29522708 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Rutin results in increased expression of SIRT1 mRNA; Rutin results in increased expression of SIRT1 protein CTD PMID:30365940 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 increases expression
multiple interactions
EXP Rutin results in increased expression of SLAMF1 protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of SLAMF1 protein]
CTD PMID:28693884 NCBI chr13:84,270,316...84,305,497 JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 NCBI chr 1:48,076,657...48,103,679 JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 NCBI chr 1:203,845,039...203,852,496 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein] CTD PMID:19605544 NCBI chr 1:48,121,061...48,163,268 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein] CTD PMID:19605544 NCBI chr 1:205,522,579...205,531,179 JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:72,328,334...72,461,981 JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:174,551,463...174,619,988 JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects localization
multiple interactions
ISO Rutin affects the localization of SLCO2B1 protein
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Cholic Acid]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Taurocholic Acid]
CTD PMID:24285294 NCBI chr 1:153,959,288...154,007,294 JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA] CTD PMID:27239252 NCBI chr18:69,849,884...69,918,926 JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA] CTD PMID:27239252 NCBI chr18:67,243,742...67,274,438 JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein] CTD PMID:22426011 NCBI chr10:103,193,909...103,197,322 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein] CTD PMID:22902988 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Rutin inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:109,184,697...109,216,133 JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Rutin results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:66,267,094...66,274,368 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of STAT3 mRNA]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein] CTD PMID:22426011 PMID:26062544 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr 4:118,618,043...118,700,897 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
CTD PMID:22902988 PMID:24117263 PMID:27239252 PMID:28693884 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]
Rutin results in decreased expression of TNF mRNA; Rutin results in decreased expression of TNF protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]
CTD PMID:14654164 PMID:18958421 PMID:19557821 PMID:21605616 PMID:21756928 PMID:22426011 PMID:22902988 PMID:25753322 PMID:28693884 PMID:29743444 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TP53 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TRP53 protein]
CTD PMID:27239252 PMID:29522708 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:41,485,033...41,495,590 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25080890 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO Rutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein] CTD PMID:20015448 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Rutin inhibits the reaction [Cyclophosphamide results in increased activity of XDH protein] CTD PMID:25753322 NCBI chr 6:21,530,463...21,592,172 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      chemical role 19254
        antioxidant 14376
          quercetin 4026
            quercetin O-glycoside 448
              quercetin O-glucoside 187
                2''-acetylpetiolaroside 0
                3-O-methylquercetin-7-O-beta-D-glucopyranoside 0
                calabricoside A 0
                calabricoside B 0
                camellianoside 0
                petiolaroside + 0
                petiolaroside decaacetate 0
                quercetin 3,4'-di-O-beta-D-glucoside 0
                quercetin 3,7-di-O-beta-D-glucoside 0
                quercetin 3-O-(6''-malonyl-glucoside) 7-O-glucoside 0
                quercetin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                quercetin 3-O-[beta-D-xylosyl-(1->2)-beta-D-glucoside] 0
                quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside] 0
                quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]-7-O-beta-D-glucopyranoside 0
                quercetin 3-O-beta-D-glucofuranoside 86
                quercetin 3-O-beta-D-glucopyranoside 86
                quercetin 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside 0
                quercetin 3-O-gentiotetroside 0
                quercetin 3-O-rhamnoside-7-O-glucoside 0
                quercetin 4'-O-beta-D-glucopyranoside 11
                quercetin 7,4'-di-O-beta-D-glucoside 0
                quercetin 7-O-beta-D-glucoside 0
                quercetin-3-O-(6''-O-caffeoyl)-galactoside 0
                rutin 136
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  oxacycle 17539
                                    benzopyran 10268
                                      1-benzopyran 9991
                                        flavonoid 6513
                                          flavones 4201
                                            hydroxyflavone 4189
                                              flavonols 4099
                                                7-hydroxyflavonol 4078
                                                  quercetin 4026
                                                    quercetin O-glycoside 448
                                                      quercetin O-glucoside 187
                                                        2''-acetylpetiolaroside 0
                                                        3-O-methylquercetin-7-O-beta-D-glucopyranoside 0
                                                        calabricoside A 0
                                                        calabricoside B 0
                                                        camellianoside 0
                                                        petiolaroside + 0
                                                        petiolaroside decaacetate 0
                                                        quercetin 3,4'-di-O-beta-D-glucoside 0
                                                        quercetin 3,7-di-O-beta-D-glucoside 0
                                                        quercetin 3-O-(6''-malonyl-glucoside) 7-O-glucoside 0
                                                        quercetin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                                                        quercetin 3-O-[beta-D-xylosyl-(1->2)-beta-D-glucoside] 0
                                                        quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside] 0
                                                        quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]-7-O-beta-D-glucopyranoside 0
                                                        quercetin 3-O-beta-D-glucofuranoside 86
                                                        quercetin 3-O-beta-D-glucopyranoside 86
                                                        quercetin 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                        quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside 0
                                                        quercetin 3-O-gentiotetroside 0
                                                        quercetin 3-O-rhamnoside-7-O-glucoside 0
                                                        quercetin 4'-O-beta-D-glucopyranoside 11
                                                        quercetin 7,4'-di-O-beta-D-glucoside 0
                                                        quercetin 7-O-beta-D-glucoside 0
                                                        quercetin-3-O-(6''-O-caffeoyl)-galactoside 0
                                                        rutin 136
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