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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lidocaine
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Accession:CHEBI:6456 term browser browse the term
Definition:The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Synonyms:exact_synonym: N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
 related_synonym: 2-(Diethylamino)-2',6'-acetoxylidide;   2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;   Formula=C14H22N2O;   InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17);   InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N;   Lidoderm;   SMILES=CCN(CC)CC(=O)Nc1c(C)cccc1C;   alpha-diethylamino-2,6-dimethylacetanilide
 xref: Beilstein:2215784;   CAS:137-58-6;   DrugBank:DB00281;   Drug_Central:1579;   HMDB:HMDB0014426;   KEGG:C07073;   KEGG:D00358;   LINCS:LSM-3165
 xref_mesh: MESH:D008012
 xref: PMID:11106996;   PMID:11120381;   PMID:11431418;   PMID:11692349;   PMID:15056998;   PMID:16668583;   PMID:17214917;   PMID:18940244;   Patent:GB706409;   Patent:GB758224;   Patent:US2441498;   Reaxys:2215784;   VSDB:1903;   Wikipedia:Lidocaine

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lidocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa6 annexin A6 increases expression EXP Lidocaine results in increased expression of ANXA6 mRNA; Lidocaine results in increased expression of ANXA6 protein CTD PMID:27018092 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605 		JBrowse link
G Blvrb biliverdin reductase B decreases expression EXP Lidocaine results in decreased expression of BLVRB protein CTD PMID:27018092 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion
multiple interactions		 ISO
EXP		 Lidocaine results in increased secretion of CALCA protein
capsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]
Lidocaine inhibits the reaction [Potassium results in increased secretion of CALCA protein]		 CTD PMID:18172555, PMID:18178321 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Casp3 caspase 3 decreases expression
decreases activity
increases activity		 ISO
EXP		 Lidocaine results in decreased expression of CASP3 protein
Lidocaine results in decreased activity of CASP3 protein
Lidocaine results in increased activity of CASP3 protein		 CTD PMID:15099683, PMID:17585225, PMID:20194319, PMID:21047305 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Lidocaine results in decreased expression of CASP9 protein CTD PMID:20194319 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:14570645 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccna1 cyclin A1 affects expression ISO Lidocaine affects the expression of CCNA1 mRNA CTD PMID:18931217 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO Lidocaine affects the expression of CCNA2 mRNA CTD PMID:18931217 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Lidocaine affects the expression of CCNB1 mRNA CTD PMID:18931217 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO Lidocaine affects the expression of CCNB2 mRNA CTD PMID:18931217 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnc cyclin C affects expression ISO Lidocaine affects the expression of CCNC mRNA CTD PMID:18931217 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706 		JBrowse link
G Ccnd1 cyclin D1 affects expression ISO Lidocaine affects the expression of CCND1 mRNA CTD PMID:18931217 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Lidocaine affects the expression of CCNE1 mRNA CTD PMID:18931217 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccnf cyclin F affects expression ISO Lidocaine affects the expression of CCNF mRNA CTD PMID:18931217 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Lidocaine affects the expression of CDK2 mRNA CTD PMID:18931217 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO Lidocaine affects the expression of CDK4 mRNA CTD PMID:18931217 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO Lidocaine affects the expression of CDKN1A mRNA CTD PMID:18931217 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Lidocaine affects the expression of CDKN1B mRNA CTD PMID:18931217 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Lidocaine affects the expression of CDKN2A mRNA CTD PMID:18931217 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis EXP CES1D protein results in increased hydrolysis of Lidocaine CTD PMID:12019189 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Lidocaine CTD PMID:15447735 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Lidocaine CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 decreases expression
increases expression		 EXP Lidocaine results in decreased expression of DDAH2 protein
Lidocaine results in increased expression of DDAH2 mRNA		 CTD PMID:27018092 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Lidocaine affects the expression of E2F1 mRNA CTD PMID:18931217 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Lidocaine affects the expression of E2F2 mRNA CTD PMID:18931217 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G E2f3 E2F transcription factor 3 affects expression ISO Lidocaine affects the expression of E2F3 mRNA CTD PMID:18931217 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831 		JBrowse link
G E2f4 E2F transcription factor 4 affects expression ISO Lidocaine affects the expression of E2F4 mRNA CTD PMID:18931217 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Lidocaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression		 ISO
EXP		 Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]
Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Lidocaine affects the expression of FOS protein		 CTD PMID:7887109, PMID:17136530, PMID:20950675 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gnb2 G protein subunit beta 2 increases expression EXP Lidocaine results in increased expression of GNB2 mRNA; Lidocaine results in increased expression of GNB2 protein CTD PMID:27018092 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA] CTD PMID:21288974 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO HRH1 protein binds to Lidocaine
[HRH1 protein binds to Lidocaine] which results in increased import of Calcium		 CTD PMID:32061592 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Lidocaine results in decreased expression of IL13 protein CTD PMID:18382663 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Lidocaine results in decreased expression of IL4 protein CTD PMID:18382663 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Lidocaine results in decreased expression of IL6 protein CTD PMID:16378115 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Lidocaine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Lidocaine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:280,383,579...280,397,784
Ensembl chr 1:280,383,579...280,397,784 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Lidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 7:113,894,918...113,938,397
Ensembl chr 7:113,903,557...113,937,941 		JBrowse link
G Kng2 kininogen 2 multiple interactions
decreases activity		 ISO Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]
Lidocaine results in decreased activity of KNG1 protein		 CTD PMID:1371395, PMID:10655909 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lgals1 galectin 1 decreases expression ISO Lidocaine results in decreased expression of LGALS1 protein CTD PMID:18382663 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:12196597 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:12196597 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Lidocaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Orm1 orosomucoid 1 affects binding
multiple interactions		 ISO Lidocaine binds to ORM1 protein alternative form
Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]		 CTD PMID:8946472 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Prkcb protein kinase C, beta increases expression
multiple interactions		 EXP Lidocaine results in increased expression of PRKCB protein
Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein]		 CTD PMID:30240660 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 affects expression ISO Lidocaine affects the expression of RBL1 mRNA CTD PMID:18931217 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression ISO Lidocaine affects the expression of RBL2 mRNA CTD PMID:18931217 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Lidocaine results in increased expression of S100A8 protein CTD PMID:18382663 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Lidocaine results in increased expression of S100A9 protein CTD PMID:18382663 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 multiple interactions ISO Lidocaine binds to and results in decreased activity of SCN4A protein CTD PMID:14662728 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A protein mutant form affects the susceptibility to Lidocaine CTD PMID:18599870 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Sell selectin L multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein] CTD PMID:9336308 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine] CTD PMID:16725121 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP Lidocaine results in increased expression of STMN1 mRNA; Lidocaine results in increased expression of STMN1 protein CTD PMID:27018092 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of Lidocaine metabolite CTD PMID:10460806 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases sulfation ISO SULT1B1 protein results in increased sulfation of Lidocaine metabolite CTD PMID:10460806 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231 		JBrowse link
G Tgfa transforming growth factor alpha decreases expression ISO Lidocaine results in decreased expression of TGFA protein CTD PMID:18382663 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]; Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 affects expression ISO Lidocaine affects the expression of TRP53 mRNA CTD PMID:18931217 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO
EXP		 Lidocaine results in increased activity of TRPA1 protein CTD PMID:18172555 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions		 ISO
EXP		 Lidocaine results in increased activity of TRPV1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [TRPV1 protein results in increased abundance of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lidocaine results in increased activity of TRPV1 protein]
TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]		 CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Ubl7 ubiquitin-like 7 decreases expression EXP Lidocaine results in decreased expression of UBL7 protein CTD PMID:27018092 NCBI chr 8:62,696,557...62,715,694
Ensembl chr 8:62,696,720...62,714,017 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          lidocaine 72
            lidocaine hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              serine family amino acid 1851
                                                glycine 928
                                                  glycine derivative 916
                                                    glycinamide 74
                                                      lidocaine 72
                                                        lidocaine hydrochloride + 0
paths to the root

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