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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lidocaine
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Accession:CHEBI:6456 term browser browse the term
Definition:The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Synonyms:exact_synonym: N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
 related_synonym: 2-(Diethylamino)-2',6'-acetoxylidide;   2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;   Formula=C14H22N2O;   InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17);   InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N;   Lidoderm;   SMILES=CCN(CC)CC(=O)Nc1c(C)cccc1C;   alpha-diethylamino-2,6-dimethylacetanilide
 xref: Beilstein:2215784;   CAS:137-58-6;   DrugBank:DB00281;   Drug_Central:1579;   HMDB:HMDB0014426;   KEGG:C07073;   KEGG:D00358;   LINCS:LSM-3165
 xref_mesh: MESH:D008012
 xref: PMID:11106996;   PMID:11120381;   PMID:11431418;   PMID:11692349;   PMID:15056998;   PMID:16668583;   PMID:17214917;   PMID:18940244;   Patent:GB706409;   Patent:GB758224;   Patent:US2441498;   Reaxys:2215784;   VSDB:1903;   Wikipedia:Lidocaine


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lidocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa6 annexin A6 increases expression EXP Lidocaine results in increased expression of ANXA6 mRNA; Lidocaine results in increased expression of ANXA6 protein CTD PMID:27018092 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433 		JBrowse link
G Blvrb biliverdin reductase B decreases expression EXP Lidocaine results in decreased expression of BLVRB protein CTD PMID:27018092 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion
multiple interactions		 ISO
EXP		 Lidocaine results in increased secretion of CALCA protein
capsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]
Lidocaine inhibits the reaction [Potassium results in increased secretion of CALCA protein]		 CTD PMID:18172555 PMID:18178321 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 decreases expression
decreases activity
increases activity		 ISO
EXP		 Lidocaine results in decreased expression of CASP3 protein
Lidocaine results in decreased activity of CASP3 protein
Lidocaine results in increased activity of CASP3 protein		 CTD PMID:15099683 PMID:17585225 PMID:20194319 PMID:21047305 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Lidocaine results in decreased expression of CASP9 protein CTD PMID:20194319 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:14570645 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna1 cyclin A1 affects expression ISO Lidocaine affects the expression of CCNA1 mRNA CTD PMID:18931217 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO Lidocaine affects the expression of CCNA2 mRNA CTD PMID:18931217 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Lidocaine affects the expression of CCNB1 mRNA CTD PMID:18931217 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO Lidocaine affects the expression of CCNB2 mRNA CTD PMID:18931217 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnc cyclin C affects expression ISO Lidocaine affects the expression of CCNC mRNA CTD PMID:18931217 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Ccnd1 cyclin D1 affects expression ISO Lidocaine affects the expression of CCND1 mRNA CTD PMID:18931217 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Lidocaine affects the expression of CCNE1 mRNA CTD PMID:18931217 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccnf cyclin F affects expression ISO Lidocaine affects the expression of CCNF mRNA CTD PMID:18931217 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Lidocaine affects the expression of CDK2 mRNA CTD PMID:18931217 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO Lidocaine affects the expression of CDK4 mRNA CTD PMID:18931217 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO Lidocaine affects the expression of CDKN1A mRNA CTD PMID:18931217 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Lidocaine affects the expression of CDKN1B mRNA CTD PMID:18931217 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Lidocaine affects the expression of CDKN2A mRNA CTD PMID:18931217 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis EXP CES1D protein results in increased hydrolysis of Lidocaine CTD PMID:12019189 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Lidocaine CTD PMID:15447735 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
decreases methylation
affects metabolic processing
decreases ethylation		 ISO Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]
CYP3A4 protein results in decreased methylation of Lidocaine
CYP3A4 protein affects the metabolism of Lidocaine
CYP3A4 protein results in decreased ethylation of Lidocaine		 CTD PMID:9298257 PMID:15383492 PMID:15447735 PMID:15887009 PMID:18846481 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Lidocaine CTD PMID:15383492 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 decreases expression
increases expression		 EXP Lidocaine results in decreased expression of DDAH2 protein
Lidocaine results in increased expression of DDAH2 mRNA		 CTD PMID:27018092 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Lidocaine affects the expression of E2F1 mRNA CTD PMID:18931217 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Lidocaine affects the expression of E2F2 mRNA CTD PMID:18931217 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f3 E2F transcription factor 3 affects expression ISO Lidocaine affects the expression of E2F3 mRNA CTD PMID:18931217 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G E2f4 E2F transcription factor 4 affects expression ISO Lidocaine affects the expression of E2F4 mRNA CTD PMID:18931217 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Lidocaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression		 ISO
EXP		 Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]
Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Lidocaine affects the expression of FOS protein		 CTD PMID:7887109 PMID:17136530 PMID:20950675 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gnb2 G protein subunit beta 2 increases expression EXP Lidocaine results in increased expression of GNB2 mRNA; Lidocaine results in increased expression of GNB2 protein CTD PMID:27018092 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA] CTD PMID:21288974 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO HRH1 protein binds to Lidocaine
[HRH1 protein binds to Lidocaine] which results in increased import of Calcium		 CTD PMID:32061592 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Lidocaine results in decreased expression of IL13 protein CTD PMID:18382663 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Lidocaine results in decreased expression of IL4 protein CTD PMID:18382663 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Lidocaine results in decreased expression of IL6 protein CTD PMID:16378115 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Lidocaine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Lidocaine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Lidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 7:104,429,186...104,473,924
Ensembl chr 7:104,437,934...104,473,175 		JBrowse link
G Kng2 kininogen 2 multiple interactions
decreases activity		 ISO Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]
Lidocaine results in decreased activity of KNG1 protein		 CTD PMID:1371395 PMID:10655909 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lgals1 galectin 1 decreases expression ISO Lidocaine results in decreased expression of LGALS1 protein CTD PMID:18382663 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:12196597 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:12196597 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions		 EXP Lidocaine results in decreased expression of MBP mRNA; Lidocaine results in decreased expression of MBP protein
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein]		 CTD PMID:33166664 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mir199a2 microRNA 199a-2 increases expression
multiple interactions		 EXP Lidocaine results in increased expression of MIR199A mRNA
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in increased expression of MIR199A mRNA]		 CTD PMID:33166664 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063 		JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions
decreases expression		 EXP [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA] CTD PMID:33166664 NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474 		JBrowse link
G Myrf myelin regulatory factor multiple interactions
decreases expression		 EXP [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]
Lidocaine results in decreased expression of MYRF mRNA; Lidocaine results in decreased expression of MYRF protein		 CTD PMID:33166664 NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157 		JBrowse link
G Nefm neurofilament medium chain multiple interactions
decreases expression		 ISO NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein] CTD PMID:34193770 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Ngf nerve growth factor decreases expression
multiple interactions		 ISO Lidocaine results in decreased expression of NGF protein
NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]
NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]		 CTD PMID:34193770 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nnat neuronatin multiple interactions
decreases expression		 ISO NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein] CTD PMID:34193770 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Lidocaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Orm1 orosomucoid 1 affects binding
multiple interactions		 ISO Lidocaine binds to ORM1 protein alternative form
Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]		 CTD PMID:8946472 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression
multiple interactions		 EXP Lidocaine results in decreased expression of PLP1 mRNA
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA]		 CTD PMID:33166664 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Lidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkcb protein kinase C, beta increases expression
multiple interactions		 EXP Lidocaine results in increased expression of PRKCB protein
Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein]		 CTD PMID:30240660 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 affects expression ISO Lidocaine affects the expression of RBL1 mRNA CTD PMID:18931217 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression ISO Lidocaine affects the expression of RBL2 mRNA CTD PMID:18931217 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Lidocaine results in increased expression of S100A8 protein CTD PMID:18382663 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Lidocaine results in increased expression of S100A9 protein CTD PMID:18382663 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 multiple interactions ISO Lidocaine binds to and results in decreased activity of SCN4A protein CTD PMID:14662728 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A protein mutant form affects the susceptibility to Lidocaine CTD PMID:18599870 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sell selectin L multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein] CTD PMID:9336308 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine] CTD PMID:16725121 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP Lidocaine results in increased expression of STMN1 mRNA; Lidocaine results in increased expression of STMN1 protein CTD PMID:27018092 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of Lidocaine metabolite CTD PMID:10460806 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases sulfation ISO SULT1B1 protein results in increased sulfation of Lidocaine metabolite CTD PMID:10460806 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Tgfa transforming growth factor alpha decreases expression ISO Lidocaine results in decreased expression of TGFA protein CTD PMID:18382663 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]; Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]
Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]		 CTD PMID:9336308 PMID:32471037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects expression ISO Lidocaine affects the expression of TRP53 mRNA CTD PMID:18931217 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO
EXP		 Lidocaine results in increased activity of TRPA1 protein CTD PMID:18172555 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions		 ISO
EXP		 Lidocaine results in increased activity of TRPV1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [TRPV1 protein results in increased abundance of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lidocaine results in increased activity of TRPV1 protein]
TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]		 CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Ubl7 ubiquitin-like 7 decreases expression EXP Lidocaine results in decreased expression of UBL7 protein CTD PMID:27018092 NCBI chr 8:58,321,157...58,340,353
Ensembl chr 8:58,320,866...58,340,344 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
decreases expression		 ISO NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein] CTD PMID:34193770 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          lidocaine 82
            lidocaine hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        amino acid 14919
                                          alpha-amino acid 12937
                                            L-alpha-amino acid 11598
                                              serine family amino acid 2575
                                                glycine 1617
                                                  glycine derivative 1604
                                                    glycinamide 84
                                                      lidocaine 82
                                                        lidocaine hydrochloride + 0
paths to the root