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ONTOLOGY REPORT - ANNOTATIONS


Term:levobunolol
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Accession:CHEBI:6438 term browser browse the term
Definition:A cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma.
Synonyms:exact_synonym: 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one
 related_synonym: (-)-Bunolol;   (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone;   Formula=C17H25NO3;   InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1;   InChIKey=IXHBTMCLRNMKHZ-LBPRGKRZSA-N;   SMILES=CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12;   levobunololum
 xref: Beilstein:6484587;   CAS:47141-42-4;   DrugBank:DB01210;   Drug_Central:431;   HMDB:HMDB0015341;   KEGG:C07914;   KEGG:D08115;   LINCS:LSM-6578
 xref_mesh: MESH:D002040
 xref: PMID:19626454;   PMID:20960417;   PMID:21368570;   PMID:23390358;   PMID:2873545;   PMID:2881799;   PMID:3019819;   PMID:3050679;   PMID:3058836;   PMID:3062528;   PMID:3067745;   PMID:3513594;   PMID:3881032;   PMID:3912600;   Patent:US2011263638;   Patent:US2011275617;   Patent:WO2008002929;   Patent:WO2011140194;   Reaxys:6484587;   Wikipedia:Levobunolol
 cyclic_relationship: is_conjugate_acid_of CHEBI:72567


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levobunolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-DMb RT1 class II, locus DMb JBrowse link 20 3,945,383 3,952,838 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      chemical role 19224
        environmental contaminant 18541
          naphthalene 2335
            tetralin 145
              levobunolol 1
                dihydrolevobunolol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    main group molecular entity 19641
                      s-block molecular entity 19403
                        hydrogen molecular entity 19392
                          hydrides 18362
                            organic hydride 17701
                              organic fundamental parent 17701
                                hydrocarbon 17176
                                  cyclic hydrocarbon 15118
                                    arene 15105
                                      polycyclic arene 14529
                                        ortho-fused polycyclic arene 9550
                                          ortho-fused bicyclic arene 2387
                                            naphthalene 2335
                                              tetralin 145
                                                levobunolol 1
                                                  dihydrolevobunolol 0
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