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G |
Ace |
angiotensin I converting enzyme |
multiple interactions increases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein] |
CTD |
PMID:31629013 |
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NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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G |
Ace2 |
angiotensin I converting enzyme 2 |
multiple interactions decreases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] |
CTD |
PMID:31629013 |
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NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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G |
Adra2a |
adrenoceptor alpha 2A |
decreases expression |
ISO |
Pregabalin results in decreased expression of ADRA2A mRNA |
CTD |
PMID:22489711 |
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NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
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G |
Agt |
angiotensinogen |
decreases expression multiple interactions |
EXP |
Pregabalin results in decreased expression of AGT protein Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein] |
CTD |
PMID:31629013 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression multiple interactions |
EXP |
Pregabalin results in increased expression of AGTR1 protein Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein] |
CTD |
PMID:31629013 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
affects localization |
EXP |
Pregabalin affects the localization of CACNA1C protein |
CTD |
PMID:22949532 |
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NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
decreases response to substance affects response to substance multiple interactions affects binding decreases expression affects localization |
ISO EXP |
CACNA2D1 gene mutant form results in decreased susceptibility to Pregabalin CACNA2D1 affects the susceptibility to Pregabalin CACNA2D1 protein affects the susceptibility to and affects the activity of Pregabalin; Pregabalin binds to and affects the activity of CACNA2D1 protein Pregabalin binds to and affects the activity of CACNA2D1 protein; Pregabalin results in decreased expression of and affects the localization of CACNA2D1 protein Pregabalin binds to CACNA2D1 protein Pregabalin results in decreased expression of CACNA2D1 mRNA Pregabalin affects the localization of CACNA2D1 protein |
CTD |
PMID:16460711 PMID:17088553 PMID:19339603 PMID:22949532 PMID:24133248 PMID:24269977 |
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NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
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G |
Casp3 |
caspase 3 |
affects expression |
EXP |
Pregabalin affects the expression of CASP3 protein |
CTD |
PMID:21394310 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cnr1 |
cannabinoid receptor 1 |
affects expression |
ISO |
Pregabalin affects the expression of CNR1 mRNA |
CTD |
PMID:22017514 |
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NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
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G |
Drd2 |
dopamine receptor D2 |
decreases expression |
ISO |
Pregabalin results in decreased expression of DRD2 mRNA |
CTD |
PMID:22489711 |
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NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] |
CTD |
PMID:25290014 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression multiple interactions |
EXP |
Pregabalin results in decreased expression of MAS1 protein Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein] |
CTD |
PMID:31629013 |
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NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
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G |
Nppb |
natriuretic peptide B |
increases expression multiple interactions |
EXP |
Pregabalin results in increased expression of NPPB protein Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein] |
CTD |
PMID:31629013 |
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NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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G |
P2rx3 |
purinergic receptor P2X 3 |
affects expression |
EXP |
Pregabalin affects the expression of P2RX3 mRNA; Pregabalin affects the expression of P2RX3 protein |
CTD |
PMID:24136739 |
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NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions decreases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] |
CTD |
PMID:31629013 |
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NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
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G |
Slc1a1 |
solute carrier family 1 member 1 |
multiple interactions increases activity |
EXP |
chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein] |
CTD |
PMID:22511482 |
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NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
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G |
Stx1a |
syntaxin 1A |
affects response to substance |
ISO |
STX1A affects the susceptibility to Pregabalin |
CTD |
PMID:24269977 |
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NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; Pregabalin inhibits the reaction [Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] |
CTD |
PMID:14499429 |
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NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
EXP |
Pregabalin results in increased expression of TGFB1 protein |
CTD |
PMID:25340254 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Th |
tyrosine hydroxylase |
increases expression affects expression |
ISO |
Pregabalin results in increased expression of TH mRNA Pregabalin affects the expression of TH mRNA |
CTD |
PMID:22017514 PMID:22489711 |
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NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Vincristine results in increased expression of TNF protein] |
CTD |
PMID:26102012 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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