Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pregabalin
go back to main search page
Accession:CHEBI:64356 term browser browse the term
Definition:A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.
Synonyms:exact_synonym: (3S)-3-(aminomethyl)-5-methylhexanoic acid
 related_synonym: (S)-3-Isobutyl GABA;   3-Isobutyl GABA;   Formula=C8H17NO2;   InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1;   InChIKey=AYXYPKUFHZROOJ-ZETCQYMHSA-N;   Lyrica;   SMILES=CC(C)C[C@H](CN)CC(O)=O
 alt_id: MESH:D000069583
 xref: CAS:148553-50-8;   DrugBank:DB00230;   Drug_Central:2255;   KEGG:D02716
 xref_mesh: MESH:D000069583
 xref: PMID:22339078;   PMID:22345870;   PMID:22362672;   PMID:22366121;   PMID:22404404;   PMID:22413436;   PMID:22415534;   PMID:22415535;   PMID:22424859;   PMID:22431439;   PMID:22448469;   PMID:22449111;   PMID:22459341;   PMID:22468635;   PMID:22470326;   PMID:22473300;   PMID:22473872;   PMID:22476240;   PMID:22480279;   Patent:EP1178034;   Patent:EP2418194;   Patent:US2008311635;   Patent:US6359169;   Reaxys:8404778;   Wikipedia:Pregabalin


show annotations for term's descendants           Sort by:
 
pregabalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
increases expression		 EXP Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein] CTD PMID:31629013 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
decreases expression		 EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] CTD PMID:31629013 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adra2a adrenoceptor alpha 2A decreases expression ISO Pregabalin results in decreased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions		 EXP Pregabalin results in decreased expression of AGT protein
Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]		 CTD PMID:31629013 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions		 EXP Pregabalin results in increased expression of AGTR1 protein
Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]		 CTD PMID:31629013 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects localization EXP Pregabalin affects the localization of CACNA1C protein CTD PMID:22949532 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 decreases response to substance
affects response to substance
multiple interactions
affects binding
decreases expression
affects localization		 ISO
EXP		 CACNA2D1 gene mutant form results in decreased susceptibility to Pregabalin
CACNA2D1 affects the susceptibility to Pregabalin
CACNA2D1 protein affects the susceptibility to and affects the activity of Pregabalin; Pregabalin binds to and affects the activity of CACNA2D1 protein
Pregabalin binds to and affects the activity of CACNA2D1 protein; Pregabalin results in decreased expression of and affects the localization of CACNA2D1 protein
Pregabalin binds to CACNA2D1 protein
Pregabalin results in decreased expression of CACNA2D1 mRNA
Pregabalin affects the localization of CACNA2D1 protein		 CTD PMID:16460711 PMID:17088553 PMID:19339603 PMID:22949532 PMID:24133248 More... NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Casp3 caspase 3 affects expression EXP Pregabalin affects the expression of CASP3 protein CTD PMID:21394310 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO Pregabalin affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Pregabalin results in decreased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:25290014 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression
multiple interactions		 EXP Pregabalin results in decreased expression of MAS1 protein
Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]		 CTD PMID:31629013 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 EXP Pregabalin results in increased expression of NPPB protein
Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]		 CTD PMID:31629013 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G P2rx3 purinergic receptor P2X 3 affects expression EXP Pregabalin affects the expression of P2RX3 mRNA; Pregabalin affects the expression of P2RX3 protein CTD PMID:24136739 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions
decreases expression		 EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
increases activity		 EXP chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein] CTD PMID:22511482 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Stx1a syntaxin 1A affects response to substance ISO STX1A affects the susceptibility to Pregabalin CTD PMID:24269977 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Pregabalin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; Pregabalin inhibits the reaction [Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Pregabalin results in increased expression of TGFB1 protein CTD PMID:25340254 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase increases expression
affects expression		 ISO Pregabalin results in increased expression of TH mRNA
Pregabalin affects the expression of TH mRNA		 CTD PMID:22017514 PMID:22489711 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Pregabalin inhibits the reaction [Vincristine results in increased expression of TNF protein] CTD PMID:26102012 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        molecular messenger 18298
          neurotransmitter 10941
            gamma-aminobutyric acid 153
              pregabalin 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        monocarboxylic acid 17618
                                          fatty acid 16009
                                            short-chain fatty acid 15698
                                              fatty acid 4:0 7902
                                                butyric acid 6273
                                                  gamma-aminobutyric acid 153
                                                    pregabalin 21
paths to the root