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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metolazone
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Accession:CHEBI:64354 term browser browse the term
Definition:A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Synonyms:exact_synonym: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
 related_synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;   Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23);   InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N;   SMILES=CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O;   Zaroxolyn;   metolazona;   metolazonum
 alt_id: CHEBI:6903
 xref: CAS:17560-51-9;   DrugBank:DB00524;   Drug_Central:1783;   KEGG:D00431;   LINCS:LSM-1680
 xref_mesh: MESH:D008788
 xref: PMID:12671341;   PMID:15095363;   PMID:1593359;   PMID:16189620;   PMID:16538931;   PMID:16717105;   PMID:16908225;   PMID:1886511;   PMID:1928234;   PMID:1946137;   PMID:2071258;   PMID:21387350;   PMID:21886902;   PMID:8199745;   PMID:8205244;   PMID:8870895;   PMID:9089428;   Patent:US2008139593;   Patent:US3360518;   Reaxys:965506;   Wikipedia:Metolazone


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metolazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Metolazone results in increased activity of NR1I2 protein
[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            diuretic 1121
              metolazone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              oxoacid 18193
                                chalcogen oxoacid 11482
                                  sulfur oxoacid 11085
                                    sulfonic acid 7333
                                      sulfonic acid derivative 7333
                                        sulfonamide 3168
                                          metolazone 1
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