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ONTOLOGY REPORT - ANNOTATIONS


Term:metolazone
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Accession:CHEBI:64354 term browser browse the term
Definition:A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Synonyms:exact_synonym: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
 related_synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;   Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23);   InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N;   SMILES=CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O;   Zaroxolyn;   metolazona;   metolazonum
 alt_id: CHEBI:6903
 xref: CAS:17560-51-9 "ChemIDplus";   CAS:17560-51-9 "NIST Chemistry WebBook";   DrugBank:DB00524;   Drug_Central:1783 "DrugCentral";   KEGG:D00431;   LINCS:LSM-1680
 xref_mesh: MESH:D008788
 xref: PMID:12671341 "Europe PMC";   PMID:15095363 "Europe PMC";   PMID:1593359 "Europe PMC";   PMID:16189620 "Europe PMC";   PMID:16538931 "Europe PMC";   PMID:16717105 "Europe PMC";   PMID:16908225 "Europe PMC";   PMID:1886511 "Europe PMC";   PMID:1928234 "Europe PMC";   PMID:1946137 "Europe PMC";   PMID:2071258 "Europe PMC";   PMID:21387350 "Europe PMC";   PMID:21886902 "Europe PMC";   PMID:8199745 "Europe PMC";   PMID:8205244 "Europe PMC";   PMID:8870895 "Europe PMC";   PMID:9089428 "Europe PMC";   Patent:US2008139593;   Patent:US3360518;   Reaxys:965506 "Reaxys";   Wikipedia:Metolazone


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metolazone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            diuretic 967
              metolazone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              oxoacid 18076
                                chalcogen oxoacid 11397
                                  sulfur oxoacid 10987
                                    sulfonic acid 7240
                                      sulfonic acid derivative 7240
                                        sulfonamide 3125
                                          metolazone 1
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