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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
2,4,6-trihydroxyacetophenone inhibits the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:30287234 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA] |
CTD |
PMID:37120126 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA] |
CTD |
PMID:37120126 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA] |
CTD |
PMID:37120126 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] |
CTD |
PMID:22129351 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Cat |
catalase |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] |
CTD |
PMID:15454305 PMID:37120126 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cryz |
crystallin zeta |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] |
CTD |
PMID:15454305 |
|
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NOX2 mRNA] |
CTD |
PMID:37120126 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity multiple interactions |
ISO |
2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein] |
CTD |
PMID:5432368 PMID:15454305 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] |
CTD |
PMID:15454305 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein] |
CTD |
PMID:37120126 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] |
CTD |
PMID:37120126 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mir200a |
microRNA 200a |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A] |
CTD |
PMID:37120126 |
|
NCBI chr 5:166,648,494...166,648,582
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein] |
CTD |
PMID:37120126 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA] |
CTD |
PMID:37120126 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] |
CTD |
PMID:15454305 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein] |
CTD |
PMID:37120126 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein] |
CTD |
PMID:37120126 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases activity increases expression |
ISO EXP |
2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein 2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA |
CTD |
PMID:16308312 PMID:16443358 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases expression |
EXP |
2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA |
CTD |
PMID:16443358 |
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NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein] |
CTD |
PMID:37120126 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein] |
CTD |
PMID:37120126 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Mmp1 |
matrix metallopeptidase 1 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP1 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP2 protein |
CTD |
PMID:21189019 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP3 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp8 |
matrix metallopeptidase 8 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP8 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520
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G |
Ache |
acetylcholinesterase |
affects binding decreases activity |
ISO |
Aminacrine binds to ACHE protein Aminacrine results in decreased activity of ACHE protein |
CTD |
PMID:31176713 PMID:33844597 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases response to substance |
ISO |
BAX protein results in increased susceptibility to Aminacrine |
CTD |
PMID:16177561 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
H2ax |
H2A.X variant histone |
decreases phosphorylation multiple interactions |
ISO |
Aminacrine results in decreased phosphorylation of H2AX protein [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] |
CTD |
PMID:26928355 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases activity |
ISO |
Aminacrine results in increased activity of HIF1A protein |
CTD |
PMID:19502547 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Mdc1 |
mediator of DNA damage checkpoint 1 |
multiple interactions |
ISO |
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] |
CTD |
PMID:26928355 |
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NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] |
CTD |
PMID:25257666 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Tp53 |
tumor protein p53 |
multiple interactions affects activity |
ISO |
Aminacrine results in increased stability of and results in increased activity of TP53 protein Aminacrine analog affects the activity of TP53 protein |
CTD |
PMID:16177561 PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT mRNA]; alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT protein] |
CTD |
PMID:12130563 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression |
ISO |
alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 protein |
CTD |
PMID:26384349 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA] |
CTD |
PMID:31009676 |
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NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
Hk2 |
hexokinase 2 |
decreases expression |
ISO |
alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 protein |
CTD |
PMID:26384349 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
A4galt |
alpha 1,4-galactosyltransferase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] |
CTD |
PMID:16819191 |
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NCBI chr 7:114,368,525...114,392,872
Ensembl chr 7:114,368,276...114,396,071
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of AARS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]] |
CTD |
PMID:33952798 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects response to substance decreases response to substance decreases expression multiple interactions |
ISO |
ABCB1 affects the susceptibility to Curcumin ABCB1 protein results in decreased susceptibility to Curcumin Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein |
CTD |
PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 PMID:18439772 PMID:20816778 PMID:26689174 PMID:27318188 PMID:31628941 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA] Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein |
CTD |
PMID:18006147 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity decreases expression |
ISO |
Curcumin results in decreased activity of ABCC1 protein Curcumin analog results in decreased expression of ABCC1 mRNA |
CTD |
PMID:15885658 PMID:16021489 PMID:26409325 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of ABCC2 protein [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein |
CTD |
PMID:15885658 PMID:35243748 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein |
CTD |
PMID:35243748 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] |
CTD |
PMID:23978416 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
Curcumin results in increased expression of ABCG1 mRNA |
CTD |
PMID:16713233 PMID:21594647 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions decreases expression increases expression |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin results in decreased expression of ABCG2 mRNA |
CTD |
PMID:17077187 PMID:33539684 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation decreases expression affects expression multiple interactions |
ISO EXP |
Curcumin results in increased phosphorylation of ACACA protein Curcumin results in decreased expression of ACACA mRNA Curcumin affects the expression of ACACA mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein] |
CTD |
PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein] |
CTD |
PMID:37701206 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] |
CTD |
PMID:10666014 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions affects binding |
EXP ISO |
Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein] Curcumin binds to ACE2 protein |
CTD |
PMID:26648693 PMID:34138966 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO EXP |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein] Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein] Curcumin results in decreased activity of ACHE protein Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] |
CTD |
PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 PMID:25496357 PMID:28527659 PMID:31714633 PMID:31820278 PMID:36924976 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ackr3 |
atypical chemokine receptor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ACKR3 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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G |
Acly |
ATP citrate lyase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of ACLY mRNA Curcumin results in decreased expression of ACLY mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco2 |
aconitase 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] |
CTD |
PMID:25130536 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP ISO |
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 PMID:31612257 PMID:32718261 PMID:35716765 More...
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] |
CTD |
PMID:17666914 |
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NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Adamts4 |
ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
increases expression |
ISO |
Curcumin results in increased expression of ADAMTS4 mRNA |
CTD |
PMID:18321735 |
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NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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G |
Adcy9 |
adenylate cyclase 9 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADCY9 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADGRE1 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression multiple interactions affects expression |
ISO EXP |
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]] Curcumin affects the expression of ADIPOQ mRNA Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] |
CTD |
PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adora2a |
adenosine A2a receptor |
multiple interactions |
ISO |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] |
CTD |
PMID:31820278 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] |
CTD |
PMID:29480285 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
decreases expression |
ISO |
Curcumin results in decreased expression of AGR2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein] |
CTD |
PMID:26612707 PMID:26648693 PMID:31820278 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein] |
CTD |
PMID:26648693 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects binding increases degradation |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin binds to AHR protein Curcumin results in increased degradation of AHR protein [Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] |
CTD |
PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak1 |
adenylate kinase 1 |
multiple interactions |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein |
CTD |
PMID:25866362 |
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NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Akap6 |
A-kinase anchoring protein 6 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of AKAP6 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA] |
CTD |
PMID:18200517 PMID:18421014 |
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NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression multiple interactions increases activity |
ISO EXP |
Curcumin results in increased expression of AKR1B1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein Curcumin results in increased activity of AKR1B1 protein |
CTD |
PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects phosphorylation decreases expression decreases phosphorylation increases expression increases phosphorylation decreases activity |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin affects the phosphorylation of AKT1 protein Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein Curcumin results in increased expression of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin results in decreased activity of AKT1 protein |
CTD |
PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 PMID:17372590 PMID:17535857 PMID:17596214 PMID:17640564 PMID:17640567 PMID:17918158 PMID:18006147 PMID:18214481 PMID:18660423 PMID:18790744 PMID:19372569 PMID:20605902 PMID:20727180 PMID:20938987 PMID:23222814 PMID:23452621 PMID:23555722 PMID:24211270 PMID:24365254 PMID:24831732 PMID:25541178 PMID:26409325 PMID:27208389 PMID:27966075 PMID:34577062 PMID:34634291 PMID:35752269 PMID:36640941 PMID:37471645 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions decreases phosphorylation decreases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein] Curcumin analog results in decreased expression of AKT2 mRNA |
CTD |
PMID:23452621 PMID:26409325 PMID:36640941 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein] Curcumin results in decreased expression of AKT3 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein] |
CTD |
PMID:36640941 PMID:37471645 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP ISO |
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein] Curcumin inhibits the reaction [Bortezomib results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein] |
CTD |
PMID:22704994 PMID:23292317 PMID:25352650 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ALAS1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alb |
albumin |
multiple interactions |
EXP |
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]] |
CTD |
PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 PMID:32718261 More...
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alcam |
activated leukocyte cell adhesion molecule |
decreases expression |
ISO |
Curcumin results in decreased expression of ALCAM mRNA |
CTD |
PMID:33539684 |
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NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions decreases expression |
ISO |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein] Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein |
CTD |
PMID:31628941 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOA mRNA |
CTD |
PMID:16880289 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOC mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions decreases activity |
EXP |
[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein Curcumin results in decreased activity of ALOX5 protein |
CTD |
PMID:16956363 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Amfr |
autocrine motility factor receptor |
increases expression |
ISO |
Curcumin results in increased expression of AMFR mRNA; Curcumin results in increased expression of AMFR protein |
CTD |
PMID:38229314 |
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NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
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G |
Ampd1 |
adenosine monophosphate deaminase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein] |
CTD |
PMID:36924976 |
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NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938
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G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
EXP |
Curcumin results in increased expression of AMPD3 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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G |
Ankrd37 |
ankyrin repeat domain 37 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD37 mRNA |
CTD |
PMID:17198877 |
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NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
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G |
Ankrd50 |
ankyrin repeat domain containing 50 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD50 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 2:121,466,275...121,500,758
Ensembl chr 2:121,468,573...121,500,752
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G |
Ankzf1 |
ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKZF1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein] |
CTD |
PMID:20885979 PMID:35817260 |
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NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of APAF1 protein Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] |
CTD |
PMID:17277231 PMID:20869986 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apc |
APC regulator of WNT signaling pathway |
decreases expression |
ISO |
Curcumin results in decreased expression of APC mRNA |
CTD |
PMID:15713895 |
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NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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G |
Apoe |
apolipoprotein E |
affects expression |
ISO |
Curcumin affects the expression of APOE mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions increases expression |
ISO EXP |
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein] Curcumin results in increased expression of APP mRNA [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] |
CTD |
PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of AQP3 protein Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein] |
CTD |
PMID:18214481 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Aqp9 |
aquaporin 9 |
increases expression |
ISO |
Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein |
CTD |
PMID:34675983 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Ar |
androgen receptor |
multiple interactions increases expression decreases activity decreases expression |
ISO |
[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein] Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein Curcumin results in decreased activity of AR protein Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein |
CTD |
PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap24 |
Rho GTPase activating protein 24 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
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G |
Arhgap30 |
Rho GTPase activating protein 30 |
decreases expression |
ISO |
Curcumin results in decreased expression of ARHGAP30 mRNA |
CTD |
PMID:18421014 |
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NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885
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G |
Arhgdib |
Rho GDP dissociation inhibitor beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions increases degradation decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] Curcumin results in decreased expression of ARNT protein |
CTD |
PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Atf2 |
activating transcription factor 2 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of ATF2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein |
CTD |
PMID:15713895 PMID:18555241 PMID:18719366 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions decreases expression |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein] ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein] |
CTD |
PMID:36640941 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of ATF6 protein Curcumin results in increased expression of ATF6 mRNA |
CTD |
PMID:21793155 PMID:29723631 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg4b |
autophagy related 4B, cysteine peptidase |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG4B protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein] |
CTD |
PMID:36640941 |
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NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
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G |
Atg5 |
autophagy related 5 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG5 protein Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein] |
CTD |
PMID:36640941 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions increases phosphorylation |
ISO |
[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein Curcumin results in increased phosphorylation of ATM protein |
CTD |
PMID:19401701 PMID:21134073 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Aurka |
aurora kinase A |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKA mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKB mRNA |
CTD |
PMID:26409325 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Axin1 |
axin 1 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA] Curcumin results in increased expression of AXIN1 mRNA |
CTD |
PMID:25963729 |
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NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
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G |
B3galt6 |
Beta-1,3-galactosyltransferase 6 |
increases expression |
ISO |
Curcumin results in increased expression of B3GALT6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
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G |
Bace1 |
beta-secretase 1 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA] Curcumin results in increased expression of BACE1 mRNA |
CTD |
PMID:18583042 PMID:31521693 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein [arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein] |
CTD |
PMID:15569404 PMID:19235267 PMID:27430728 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions decreases expression increases expression increases response to substance |
ISO |
TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein] Curcumin results in decreased expression of BAK1 mRNA Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein BAK1 protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions affects expression decreases expression increases expression affects localization increases response to substance |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein] Curcumin affects the expression of BAX protein Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] BAX protein results in increased susceptibility to Curcumin [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein] |
CTD |
PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 PMID:17671742 PMID:18226269 PMID:19235267 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:23222814 PMID:23267840 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:27793699 PMID:27966075 PMID:28681665 PMID:30463061 PMID:30935902 PMID:31628941 PMID:33582110 PMID:34577062 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:36352148 PMID:38056816 PMID:38348716 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of BBC3 mRNA Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] Curcumin results in decreased expression of BBC3 mRNA |
CTD |
PMID:17332930 PMID:22714040 PMID:34047412 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl10 |
BCL10, immune signaling adaptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein] Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein] 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] |
CTD |
PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 PMID:16243823 PMID:17096185 PMID:17332930 PMID:17440100 PMID:17531121 PMID:17596214 PMID:17640567 PMID:17671737 PMID:17671742 PMID:18226269 PMID:18593936 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:19373661 PMID:19944674 PMID:20127174 PMID:20727180 PMID:20869986 PMID:21397623 PMID:21594647 PMID:21595920 PMID:21793155 PMID:22714040 PMID:23452621 PMID:24952339 PMID:25256401 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:28681665 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30935902 PMID:31628941 PMID:32569592 PMID:33582110 PMID:33617879 PMID:34577062 PMID:34675983 PMID:34758851 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:36352148 PMID:38056816 PMID:38348716 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] Curcumin results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:16219905 PMID:17596214 |
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NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein] Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein] [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein Curcumin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:17148446 PMID:17332930 PMID:17440100 PMID:17596214 PMID:17640567 PMID:17671737 PMID:18226269 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:23452621 PMID:30463061 More...
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L11 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein |
CTD |
PMID:17332930 PMID:27430728 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bcl2l2 |
Bcl2-like 2 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L2 mRNA [arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein |
CTD |
PMID:16101141 PMID:27430728 |
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NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Bcl3 |
BCL3, transcription coactivator |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA] |
CTD |
PMID:18200517 PMID:23452621 |
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NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcor |
BCL6 co-repressor |
increases expression |
ISO |
Curcumin results in increased expression of BCOR mRNA |
CTD |
PMID:17198877 |
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NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression affects expression |
EXP ISO |
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein] Curcumin results in increased expression of BDNF protein Curcumin affects the expression of BDNF protein [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] |
CTD |
PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 PMID:34577062 More...
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of BECN1 protein Curcumin results in decreased expression of BECN1 protein |
CTD |
PMID:34634291 PMID:36640941 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bgn |
biglycan |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] |
CTD |
PMID:20605902 PMID:27430728 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 PMID:17671737 PMID:20727180 PMID:23452621 More...
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression decreases expression |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein Curcumin results in increased expression of BIRC3 mRNA Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein |
CTD |
PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 PMID:17596214 PMID:19372569 PMID:27430728 More...
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein] Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein] Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein |
CTD |
PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 PMID:19235267 PMID:19372569 PMID:20727180 PMID:23452621 PMID:24664296 PMID:26409325 PMID:27430728 PMID:34047412 PMID:34233590 More...
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Birc7 |
baculoviral IAP repeat-containing 7 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BIRC7 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein |
CTD |
PMID:15911101 PMID:27430728 |
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NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
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G |
Bmp2 |
bone morphogenetic protein 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of BMP2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] |
CTD |
PMID:27996348 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Bsg |
basigin |
decreases response to substance |
ISO |
BSG protein results in decreased susceptibility to Curcumin |
CTD |
PMID:18379992 |
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NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
Curcumin results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C1qb |
complement C1q B chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
C3 |
complement C3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4b |
complement C4B |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] |
CTD |
PMID:18200517 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
ISO EXP |
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein] |
CTD |
PMID:22911773 PMID:29723552 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Capg |
capping actin protein, gelsolin like |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
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G |
Car9 |
carbonic anhydrase 9 |
decreases expression |
EXP |
Curcumin results in decreased expression of CAR9 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Casp1 |
caspase 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP1 mRNA Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP1 mRNA] [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA] |
CTD |
PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475 PMID:38301994 PMID:38369055 More...
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP12 protein Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein] |
CTD |
PMID:21793155 PMID:25541178 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp2 |
caspase 2 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP2 mRNA Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA] |
CTD |
PMID:16101141 PMID:38369055 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases cleavage increases activity decreases activity increases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]] Curcumin results in decreased expression of CASP3 protein modified form Curcumin results in increased cleavage of CASP3 protein Curcumin results in decreased activity of CASP3 protein [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form] Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein |
CTD |
PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 PMID:17096185 PMID:17148446 PMID:17277231 PMID:17332930 PMID:17351913 PMID:17363495 PMID:17440100 PMID:17640567 PMID:17671742 PMID:17885582 PMID:18555241 PMID:19235267 PMID:19294764 PMID:19373661 PMID:19401701 PMID:20127174 PMID:20605902 PMID:20869986 PMID:21397623 PMID:21450334 PMID:21594647 PMID:21595920 PMID:22523229 PMID:23267840 PMID:23555722 PMID:23710286 PMID:24863870 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27375190 PMID:27430728 PMID:27535828 PMID:27966075 PMID:28681665 PMID:29315967 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30463061 PMID:30935902 PMID:31712109 PMID:31820278 PMID:32569592 PMID:33582110 PMID:33617879 PMID:33729022 PMID:34042043 PMID:34577062 PMID:34675983 PMID:34994998 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:37955270 PMID:38348716 PMID:38369055 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
ISO |
Curcumin results in increased expression of CASP4 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
multiple interactions increases expression decreases expression |
ISO EXP |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA] Curcumin results in increased expression of CASP7 protein Curcumin results in decreased expression of CASP7 mRNA |
CTD |
PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 PMID:38369055 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions increases cleavage decreases expression |
ISO EXP |
Curcumin results in increased activity of CASP8 protein Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP8 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA] Curcumin results in increased cleavage of CASP8 protein Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein] |
CTD |
PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 PMID:23267840 PMID:23452621 PMID:25541178 PMID:27430728 PMID:33582110 PMID:38369055 More...
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
decreases expression multiple interactions increases activity increases expression increases cleavage |
ISO EXP |
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA] Curcumin results in increased activity of CASP9 protein Curcumin results in increased expression of CASP9 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein Curcumin results in increased cleavage of CASP9 protein [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]] |
CTD |
PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 PMID:17440100 PMID:17671742 PMID:18555241 PMID:19095035 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:27375190 PMID:28681665 PMID:31628941 PMID:31712109 PMID:33582110 PMID:33729022 PMID:34994998 PMID:36037877 PMID:38369055 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein] Curcumin results in increased expression of CAT protein Curcumin results in increased activity of CAT protein Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein] Curcumin results in increased expression of CAT mRNA [Curcumin co-treated with alpha-Tocopherol] inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein] |
CTD |
PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 PMID:18392098 PMID:19481068 PMID:19631675 PMID:19913070 PMID:19914224 PMID:20112103 PMID:20593964 PMID:21574897 PMID:21976817 PMID:22704994 PMID:24113306 PMID:24347089 PMID:24760747 PMID:25123790 PMID:25169090 PMID:25233897 PMID:25461551 PMID:27375190 PMID:28951138 PMID:29205955 PMID:29315967 PMID:30138604 PMID:30423402 PMID:30934151 PMID:30946834 PMID:31081568 PMID:31199764 PMID:31330227 PMID:31407471 PMID:31521693 PMID:31714633 PMID:32735850 PMID:33350580 PMID:34577062 PMID:34758851 PMID:34802538 PMID:35063475 PMID:35817260 PMID:36924976 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] |
CTD |
PMID:25541467 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCAR1 protein |
CTD |
PMID:21594647 |
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NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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G |
Ccdc116 |
coiled-coil domain containing 116 |
increases expression |
ISO |
Curcumin results in increased expression of CCDC116 mRNA |
CTD |
PMID:18200517 |
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NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression increases expression |
ISO EXP |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]] Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] Curcumin results in increased expression of CCL2 mRNA |
CTD |
PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 PMID:19152916 PMID:20712904 PMID:22683883 PMID:23452621 PMID:33952798 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA] |
CTD |
PMID:17965732 PMID:19764552 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein] Curcumin results in decreased expression of CCNA2 protein |
CTD |
PMID:23222814 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein |
CTD |
PMID:17148446 PMID:18719366 PMID:19401701 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression decreases expression increases degradation |
ISO EXP |
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] Curcumin results in increased expression of CCND1 mRNA Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA] Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein |
CTD |
PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16959222 PMID:17041101 PMID:17148446 PMID:17440100 PMID:17531121 PMID:17602960 PMID:17640567 PMID:17885582 PMID:18156803 PMID:18226269 PMID:18316600 PMID:18593936 PMID:18640131 PMID:18790744 PMID:18829502 PMID:19189304 PMID:19372569 PMID:19501152 PMID:19573523 PMID:20727180 PMID:24211270 PMID:24508477 PMID:25822711 PMID:25963729 PMID:27996348 PMID:30935902 PMID:34233590 PMID:36640941 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein] Curcumin results in decreased expression of CCND3 protein |
CTD |
PMID:23222814 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions increases degradation |
ISO EXP |
Curcumin results in decreased expression of CCNE1 protein Curcumin results in decreased expression of CCNE1 mRNA Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] |
CTD |
PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccpg1 |
cell cycle progression 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCPG1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCR2 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] |
CTD |
PMID:18180316 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd36 |
CD36 molecule |
decreases expression increases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CD36 mRNA Curcumin results in increased expression of CD36 mRNA Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein] Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein |
CTD |
PMID:16713233 PMID:23386263 PMID:23603106 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40 |
CD40 molecule |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CD40 mRNA CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein] [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein |
CTD |
PMID:16101141 PMID:27430728 PMID:35549587 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein |
CTD |
PMID:27430728 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Curcumin results in increased expression of CD44 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd47 |
Cd47 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
decreases expression |
ISO |
Curcumin results in decreased expression of CD55 mRNA |
CTD |
PMID:17999991 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cdc14b |
cell division cycle 14B |
increases expression |
ISO |
Curcumin results in increased expression of CDC14B mRNA |
CTD |
PMID:17198877 |
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NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
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G |
Cdc20 |
cell division cycle 20 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDC20 mRNA |
CTD |
PMID:22258452 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc25c |
cell division cycle 25C |
increases phosphorylation |
ISO |
Curcumin results in increased phosphorylation of CDC25C protein |
CTD |
PMID:19401701 |
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NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of CDH1 protein Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein] [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein] |
CTD |
PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 PMID:36640941 More...
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh11 |
cadherin 11 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH11 protein |
CTD |
PMID:18025290 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh17 |
cadherin 17 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH17 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
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G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]] |
CTD |
PMID:26191140 PMID:34233590 PMID:35549587 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
EXP ISO |
Curcumin results in decreased expression of CDK1 mRNA Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein |
CTD |
PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein] Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 mRNA]; Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 protein] Curcumin results in decreased expression of CDK2 protein Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein |
CTD |
PMID:19501152 PMID:23222814 PMID:26409325 PMID:38301994 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein |
CTD |
PMID:18156803 PMID:24211270 PMID:26409325 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk5 |
cyclin-dependent kinase 5 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK5 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDK6 protein |
CTD |
PMID:18156803 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK7 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdk9 |
cyclin-dependent kinase 9 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK9 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein] [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein] Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] |
CTD |
PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 PMID:18156803 PMID:18161303 PMID:18226269 PMID:18316600 PMID:18593936 PMID:20153625 PMID:23222814 PMID:25644192 PMID:25822711 PMID:27132804 PMID:27430728 PMID:28681665 PMID:30935902 PMID:33582110 PMID:38301994 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein] Curcumin results in decreased expression of CDKN1B protein |
CTD |
PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 PMID:21594647 PMID:25822711 PMID:27132804 PMID:27430728 PMID:36352148 More...
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of CDKN2A protein Curcumin results in increased expression of CDKN2A protein |
CTD |
PMID:17148446 PMID:18156803 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2d |
cyclin dependent kinase inhibitor 2D |
decreases expression |
EXP |
Curcumin results in decreased expression of CDKN2D mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
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G |
Cdx2 |
caudal type homeo box 2 |
increases expression |
EXP ISO |
Curcumin results in increased expression of CDX2 mRNA |
CTD |
PMID:18299980 PMID:27237783 |
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NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] |
CTD |
PMID:19297423 PMID:28595985 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces3a |
carboxylesterase 3a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:32,992,386...33,000,562
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] Curcumin results in decreased expression of CFLAR protein |
CTD |
PMID:16173963 PMID:16219905 PMID:23452621 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity affects localization |
ISO |
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form Curcumin affects the localization of CFTR protein mutant form Curcumin affects the folding of and affects the localization of CFTR protein mutant form |
CTD |
PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] |
CTD |
PMID:21839772 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chek1 |
checkpoint kinase 1 |
decreases response to substance multiple interactions increases activity increases phosphorylation |
ISO |
CHEK1 protein results in decreased susceptibility to Curcumin Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] Curcumin results in increased activity of CHEK1 protein Curcumin results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:18602917 PMID:19401701 PMID:27996348 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein] Curcumin results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:21134073 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] |
CTD |
PMID:24952339 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions decreases activity |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein] Curcumin results in decreased activity of CHUK protein |
CTD |
PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Ckb |
creatine kinase B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [Gentamicins results in increased secretion of CKM protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 PMID:38056816 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca4 |
chloride channel accessory 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
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G |
Clcn6 |
chloride voltage-gated channel 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CLCN6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
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G |
Cldn1 |
claudin 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein] |
CTD |
PMID:35817260 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cldn2 |
claudin 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] |
CTD |
PMID:25119790 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
EXP ISO |
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]] Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA] Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein |
CTD |
PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 PMID:18006644 PMID:28700904 PMID:32718261 More...
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col27a1 |
collagen type XXVII alpha 1 chain |
increases expression |
EXP |
Curcumin results in increased expression of COL27A1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:76,647,302...76,765,989
Ensembl chr 5:76,647,429...76,765,174
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G |
Col2a1 |
collagen type II alpha 1 chain |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein [resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein |
CTD |
PMID:18321735 PMID:19889203 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] |
CTD |
PMID:22683883 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a1 |
collagen type IV alpha 1 chain |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of COL4A1 mRNA Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA] Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA] |
CTD |
PMID:18200517 PMID:21594647 PMID:28700904 |
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NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a2 |
collagen type IV alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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G |
Col4a5 |
collagen type IV alpha 5 chain |
decreases expression |
ISO |
Curcumin results in decreased expression of COL4A5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692
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G |
Col5a1 |
collagen type V alpha 1 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Curcumin results in increased expression of CPT1A mRNA |
CTD |
PMID:19297423 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions increases phosphorylation |
EXP ISO |
Curcumin results in increased expression of CREB1 mRNA 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein] [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein] Curcumin results in increased phosphorylation of CREB1 protein |
CTD |
PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 More...
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3 |
cAMP responsive element binding protein 3 |
increases expression |
EXP |
Curcumin results in increased expression of CREB3 mRNA |
CTD |
PMID:18299980 |
|
NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
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G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Crp |
C-reactive protein |
multiple interactions |
EXP ISO |
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein] |
CTD |
PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
ISO EXP |
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] [Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:9764755 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cs |
citrate synthase |
affects expression |
EXP |
Curcumin affects the expression of CS mRNA |
CTD |
PMID:18539377 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] |
CTD |
PMID:15129424 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Csf1r |
colony stimulating factor 1 receptor |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] Curcumin results in increased expression of CSF1R mRNA |
CTD |
PMID:15129424 PMID:22714040 |
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NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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G |
Csf2ra |
colony stimulating factor 2 receptor subunit alpha |
increases expression |
ISO |
Curcumin results in increased expression of CSF2RA mRNA |
CTD |
PMID:22714040 |
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NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression increases expression multiple interactions decreases phosphorylation increases degradation |
ISO EXP |
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein Curcumin results in increased expression of CTNNB1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein Curcumin results in decreased phosphorylation of CTNNB1 protein [piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein] Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein |
CTD |
PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 PMID:27645308 PMID:30935902 More...
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] Curcumin analog results in decreased expression of CTSB mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] Curcumin analog results in decreased expression of CTSD mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctsl |
cathepsin L |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSL protein |
CTD |
PMID:34138966 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
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NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cul3 |
cullin 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA] |
CTD |
PMID:38272317 |
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NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions decreases expression |
ISO |
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein |
CTD |
PMID:17999991 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:18660423 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
Curcumin results in decreased expression of CXCL14 mRNA |
CTD |
PMID:19555370 |
|
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA] Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA] |
CTD |
PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] |
CTD |
PMID:17999991 PMID:27194111 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR1 protein |
CTD |
PMID:12216086 |
|
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR2 protein |
CTD |
PMID:12216086 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCR4 mRNA Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA] |
CTD |
PMID:17198877 PMID:18660423 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cycs |
cytochrome c, somatic |
affects localization multiple interactions |
ISO |
Curcumin affects the localization of CYCS protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein |
CTD |
PMID:19235267 PMID:27430728 PMID:33617879 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases activity increases expression decreases activity decreases expression |
ISO EXP |
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA] Curcumin results in increased activity of CYP1A1 protein Curcumin results in increased expression of CYP1A1 mRNA Curcumin results in decreased activity of CYP1A1 protein Curcumin results in decreased expression of CYP1A1 mRNA Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 PMID:17880909 PMID:18321868 PMID:19018768 PMID:20015472 PMID:20816778 PMID:22867086 PMID:27041069 PMID:34802538 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO EXP |
Curcumin results in decreased activity of CYP1A2 protein Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA] Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
CTD |
PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Curcumin results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:17637178 PMID:19018768 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA Curcumin results in increased expression of CYP24A1 protein |
CTD |
PMID:20153625 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
affects expression multiple interactions |
EXP |
Curcumin affects the expression of CYP2B1 protein Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine] |
CTD |
PMID:16805852 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c7 |
cytochrome P450, family 2, subfamily c, polypeptide 7 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein] |
CTD |
PMID:16288784 |
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NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of CYP2D6 mRNA |
CTD |
PMID:33582110 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Curcumin affects the expression of CYP2E1 protein Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA] Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein] Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein] Curcumin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases expression multiple interactions increases expression |
ISO |
Curcumin results in decreased expression of CYP3A4 mRNA [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] Curcumin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 PMID:20816778 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Curcumin results in increased expression of CYP4A3 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyth4 |
cytohesin 4 |
increases expression |
ISO |
Curcumin results in increased expression of CYTH4 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
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G |
Daxx |
death-domain associated protein |
increases expression |
ISO |
Curcumin results in increased expression of DAXX mRNA |
CTD |
PMID:16101141 |
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NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Dbn1 |
drebrin 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] |
CTD |
PMID:23333261 |
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NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
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G |
Dcn |
decorin |
increases expression |
ISO |
Curcumin results in increased expression of DCN mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dcx |
doublecortin |
multiple interactions increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA] Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein] Curcumin results in increased expression of DCX mRNA |
CTD |
PMID:25963729 PMID:32735850 |
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NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein |
CTD |
PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 PMID:27996348 PMID:29723631 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
decreases expression increases expression |
ISO EXP |
Curcumin results in decreased expression of DDIT4L mRNA Curcumin results in increased expression of DDIT4L mRNA |
CTD |
PMID:17999991 PMID:18299980 |
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NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Derl1 |
derlin 1 |
increases expression |
ISO |
Curcumin results in increased expression of DERL1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
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G |
Des |
desmin |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Gentamicins results in increased expression of DES mRNA] |
CTD |
PMID:38056816 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein Curcumin results in decreased expression of DFFB protein |
CTD |
PMID:21397623 PMID:22714040 |
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NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of DHCR24 mRNA Curcumin affects the expression of DHCR24 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of DHCR7 mRNA Curcumin results in decreased expression of DHCR7 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhrs1 |
dehydrogenase/reductase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of DHRS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects localization multiple interactions increases expression increases response to substance |
ISO |
Curcumin affects the localization of DIABLO protein [arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein Curcumin results in increased expression of DIABLO mRNA DIABLO protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:23555722 PMID:27430728 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
decreases expression multiple interactions |
EXP |
Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein] |
CTD |
PMID:25963729 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] |
CTD |
PMID:29723552 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Curcumin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein] |
CTD |
PMID:32980475 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression affects expression multiple interactions increases activity |
ISO |
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein Curcumin analog affects the expression of DNMT1 protein Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein] Curcumin analog results in decreased expression of DNMT1 protein |
CTD |
PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3A mRNA Curcumin analog results in decreased expression of DNMT3A protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3B mRNA Curcumin analog results in decreased expression of DNMT3B protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of DRAM1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] |
CTD |
PMID:27966075 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of DUSP1 mRNA Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein] |
CTD |
PMID:15713895 PMID:20885979 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP10 mRNA |
CTD |
PMID:15713895 PMID:17151092 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP5 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dvl1 |
dishevelled segment polarity protein 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein] Curcumin results in decreased expression of DVL1 protein Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein |
CTD |
PMID:19573523 PMID:25963729 |
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NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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G |
Dynll1 |
dynein light chain LC8-type 1 |
increases expression |
ISO |
Curcumin results in increased expression of DYNLL1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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G |
Dyrk2 |
dual specificity tyrosine phosphorylation regulated kinase 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of DYRK2 protein [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein |
CTD |
PMID:33617879 |
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NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of E2F1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f5 |
E2F transcription factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of E2F5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ECH1 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Edaradd |
EDAR associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] |
CTD |
PMID:23452621 |
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NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Curcumin results in increased expression of EDEM1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Edil3 |
EGF like repeats and discoidin domains 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of EDIL3 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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G |
Egf |
epidermal growth factor |
multiple interactions decreases activity |
ISO EXP |
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] Curcumin results in decreased activity of EGF protein Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein] |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein] Curcumin results in decreased phosphorylation of EGFR protein Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; Curcumin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA] Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 PMID:18006644 PMID:18214481 PMID:18332871 PMID:18719366 PMID:24508477 PMID:26409325 PMID:34994998 PMID:37858842 More...
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein] Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein Curcumin results in decreased expression of EGR1 mRNA |
CTD |
PMID:17198877 PMID:17999991 PMID:18316600 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of EIF1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 Ensembl chr 5:85,246,764...85,427,327
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of EIF2AK3 protein] |
CTD |
PMID:34784780 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein] Curcumin results in decreased expression of EIF4EBP1 protein |
CTD |
PMID:18790744 PMID:23222814 PMID:34634291 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eif4g1 |
eukaryotic translation initiation factor 4 gamma 1 |
decreases phosphorylation |
ISO |
Curcumin results in decreased phosphorylation of EIF4G1 protein |
CTD |
PMID:18790744 |
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NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
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G |
Elf2 |
E74 like ETS transcription factor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of ELF2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions increases phosphorylation |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:18316600 PMID:23452621 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Emb |
embigin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ENO1 mRNA |
CTD |
PMID:16880289 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
increases expression |
EXP |
Curcumin results in increased expression of ENTPD5 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions decreases activity decreases expression affects localization |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]] Curcumin results in decreased activity of EP300 protein Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein] Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein |
CTD |
PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 |
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NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:20554536 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Epcam |
epithelial cell adhesion molecule |
multiple interactions decreases expression |
ISO |
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein] Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein |
CTD |
PMID:33539684 |
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NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Epo |
erythropoietin |
decreases expression |
ISO |
Curcumin results in decreased expression of EPO mRNA |
CTD |
PMID:16880289 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Epx |
eosinophil peroxidase |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein] |
CTD |
PMID:34998855 |
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NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions increases response to substance increases degradation decreases expression |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog Curcumin analog results in increased degradation of ERBB2 protein Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein |
CTD |
PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 PMID:34291863 More...
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
multiple interactions decreases expression |
ISO |
Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein] Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA |
CTD |
PMID:15713895 PMID:17918158 PMID:26409325 |
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NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
multiple interactions decreases expression |
ISO EXP |
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein] Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein |
CTD |
PMID:17596214 PMID:21493726 PMID:22228707 |
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NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA] Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein] Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein |
CTD |
PMID:22228707 |
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NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 Ensembl chr10:2,419,038...2,448,369
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G |
Erlec1 |
endoplasmic reticulum lectin 1 |
increases expression |
ISO |
Curcumin results in increased expression of ERLEC1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of ERN1 mRNA Curcumin results in increased expression of ERN1 mRNA |
CTD |
PMID:17999991 PMID:29723631 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein] Curcumin results in decreased expression of ESR1 protein |
CTD |
PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 PMID:38229314 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of ETS2 protein |
CTD |
PMID:17332326 |
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NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] |
CTD |
PMID:18565277 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] |
CTD |
PMID:18983524 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fabp3 |
fatty acid binding protein 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Gentamicins results in increased expression of FABP3 mRNA] |
CTD |
PMID:38056816 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fadd |
Fas associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fads1 |
fatty acid desaturase 1 |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FADS1 mRNA Curcumin results in decreased expression of FADS1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of FADS2 mRNA Curcumin affects the expression of FADS2 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fam120b |
family with sequence similarity 120 member B |
decreases expression |
ISO |
Curcumin results in decreased expression of FAM120B mRNA |
CTD |
PMID:17999991 |
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NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
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G |
Fam8a1 |
family with sequence similarity 8, member A1 |
increases expression |
ISO |
Curcumin results in increased expression of FAM8A1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr17:18,026,601...18,035,509
Ensembl chr17:18,026,601...18,035,470
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] Curcumin results in decreased expression of FANCD2 mRNA |
CTD |
PMID:24124520 |
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NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fanci |
FA complementation group I |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] Curcumin results in decreased expression of FANCI mRNA |
CTD |
PMID:24124520 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO EXP |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein Curcumin inhibits the reaction [fenpropathrin results in increased expression of FAS mRNA] |
CTD |
PMID:27430728 PMID:38369055 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions decreases expression |
ISO EXP |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA] Curcumin inhibits the reaction [fenpropathrin results in increased expression of FASL mRNA] Curcumin results in decreased expression of FASLG mRNA |
CTD |
PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 PMID:38369055 More...
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein Curcumin results in decreased expression of FASN mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbln2 |
fibulin 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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G |
Fbxo6 |
F-box protein 6 |
increases expression |
ISO |
Curcumin results in increased expression of FBXO6 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
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G |
Fcgr3a |
Fc gamma receptor 3A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of FDFT1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression decreases expression affects expression |
ISO EXP |
Curcumin results in increased expression of FDPS mRNA Curcumin results in decreased expression of FDPS mRNA Curcumin affects the expression of FDPS mRNA |
CTD |
PMID:16713233 PMID:27208389 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of FGF2 protein Curcumin results in increased expression of FGF2 protein |
CTD |
PMID:23555722 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgf5 |
fibroblast growth factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGF5 mRNA |
CTD |
PMID:27237783 |
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NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGFR2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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G |
Filip1l |
filamin A interacting protein 1-like |
increases expression |
ISO |
Curcumin results in increased expression of FILIP1L mRNA |
CTD |
PMID:21594647 |
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NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] |
CTD |
PMID:28698153 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein] Curcumin results in decreased expression of FLT1 protein |
CTD |
PMID:18593936 PMID:23845850 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein] Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] Curcumin results in decreased expression of FN1 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA] |
CTD |
PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fntb |
farnesyltransferase, CAAX box, subunit beta |
increases expression |
ISO |
Curcumin results in increased expression of FNTB mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression multiple interactions increases expression |
ISO EXP |
Curcumin results in decreased expression of FOS mRNA Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA] Curcumin results in increased expression of FOS mRNA [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein] |
CTD |
PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein] Curcumin results in increased ubiquitination of FOSL1 protein |
CTD |
PMID:17148446 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of FOSL2 mRNA Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein] |
CTD |
PMID:17148446 PMID:17999991 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxa1 |
forkhead box A1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxa2 |
forkhead box A2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXA2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Foxf2 |
forkhead box F2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXF2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
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G |
Foxo1 |
forkhead box O1 |
increases expression decreases phosphorylation |
ISO |
Curcumin results in increased expression of FOXO1 mRNA Curcumin results in decreased phosphorylation of FOXO1 protein |
CTD |
PMID:18403477 PMID:18790744 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:31199764 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FTH1 protein] |
CTD |
PMID:34787501 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of FTL1 mRNA |
CTD |
PMID:24634837 |
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NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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G |
Fus |
Fus RNA binding protein |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of FUS mRNA Curcumin results in decreased expression of FUS mRNA |
CTD |
PMID:17198877 PMID:17999991 |
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NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
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G |
Fzd1 |
frizzled class receptor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of FZD1 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643 Ensembl chr 4:29,310,091...29,312,643
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
affects expression |
ISO |
Curcumin affects the expression of G6PC1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression multiple interactions |
EXP ISO |
Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein] |
CTD |
PMID:18299980 PMID:36924976 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of GABRA1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] |
CTD |
PMID:23267840 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP ISO |
Curcumin results in increased expression of GADD45A mRNA |
CTD |
PMID:16101141 PMID:18299980 PMID:18719366 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gas6 |
growth arrest specific 6 |
increases expression |
ISO |
Curcumin results in increased expression of GAS6 mRNA |
CTD |
PMID:21594647 |
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NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] |
CTD |
PMID:22258452 |
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NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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G |
Gata4 |
GATA binding protein 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein |
CTD |
PMID:27237783 |
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NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases activity multiple interactions increases expression |
ISO EXP |
Curcumin results in increased activity of GCLC protein Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein] |
CTD |
PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 PMID:19183254 PMID:23710286 PMID:23954767 PMID:27837179 PMID:29571711 PMID:31521693 PMID:34272803 PMID:35063475 PMID:35817260 PMID:36305173 More...
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
EXP ISO |
Curcumin results in increased activity of [GCLC protein binds to GCLM protein] Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA] Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA] |
CTD |
PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 PMID:19168576 PMID:19183254 PMID:19188863 PMID:23386263 PMID:23710286 PMID:23954767 PMID:29571711 PMID:34272803 More...
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gda |
guanine deaminase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GFAP mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA] |
CTD |
PMID:19555370 PMID:25963729 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of GGT1 mRNA Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] |
CTD |
PMID:18299980 PMID:24704557 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Ggta1 |
glycoprotein alpha-galactosyltransferase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:18,732,985...18,824,916
Ensembl chr 3:18,732,991...18,809,908
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein] |
CTD |
PMID:20395211 PMID:31612257 |
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NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]] |
CTD |
PMID:31612257 |
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NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Glo1 |
glyoxalase 1 |
decreases activity |
ISO |
Curcumin results in decreased activity of GLO1 protein |
CTD |
PMID:18946510 |
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NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] |
CTD |
PMID:16956363 PMID:36037877 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Got1l1 |
glutamic-oxaloacetic transaminase 1-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression affects expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GPAM mRNA Curcumin affects the expression of GPAM mRNA Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA] |
CTD |
PMID:19297423 PMID:27208389 |
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NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of GPER1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Gphn |
gephyrin |
affects expression |
EXP |
Curcumin affects the expression of GPHN mRNA |
CTD |
PMID:18539377 |
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NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein] |
CTD |
PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 PMID:29421648 PMID:30423402 PMID:32718261 PMID:34802538 PMID:35063475 PMID:36037877 PMID:37701206 More...
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression multiple interactions |
EXP ISO |
Curcumin results in decreased expression of GPX1 mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein] Curcumin inhibits the reaction [Atrazine results in decreased activity of GPX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA] |
CTD |
PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976 PMID:38301994 More...
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of GPX4 protein] |
CTD |
PMID:34787501 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Grb10 |
growth factor receptor bound protein 10 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of GRB2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Grem1 |
gremlin 1, DAN family BMP antagonist |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
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G |
Gria4 |
glutamate ionotropic receptor AMPA type subunit 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] |
CTD |
PMID:23267840 |
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NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein] |
CTD |
PMID:23267840 PMID:29723552 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein] |
CTD |
PMID:25496357 PMID:29723552 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein] |
CTD |
PMID:25496357 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grm2 |
glutamate metabotropic receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of GRM2 protein |
CTD |
PMID:25406541 |
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NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
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G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO EXP |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of GSDMD protein] Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA] |
CTD |
PMID:34998855 PMID:35063475 PMID:38301994 PMID:38369055 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation decreases expression multiple interactions increases phosphorylation increases expression |
ISO EXP |
Curcumin results in decreased phosphorylation of GSK3B protein Curcumin results in decreased expression of GSK3B mRNA Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein Curcumin results in increased phosphorylation of GSK3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] Curcumin results in increased expression of GSK3B protein |
CTD |
PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 PMID:27645308 PMID:27966075 PMID:29723552 PMID:34577062 More...
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of GSR mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein] [Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA] |
CTD |
PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 PMID:25632966 PMID:31407471 PMID:34802538 PMID:36924976 More...
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of GSS mRNA Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA] |
CTD |
PMID:19183254 PMID:35063475 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
Curcumin results in increased expression of GSTA2 mRNA |
CTD |
PMID:18200517 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
increases activity |
ISO |
Curcumin results in increased activity of GSTA4 protein |
CTD |
PMID:10514034 |
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NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Curcumin results in increased expression of GSTA5 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA] |
CTD |
PMID:31521693 |
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NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of GSTO1 mRNA Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA] |
CTD |
PMID:34272803 |
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NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions affects expression increases expression decreases expression |
ISO EXP |
[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA] Curcumin affects the expression of GSTP1 protein Curcumin results in increased expression of GSTP1 mRNA Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein |
CTD |
PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 PMID:17449203 PMID:18299980 PMID:18414057 PMID:22830632 More...
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] |
CTD |
PMID:8534267 |
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
Gzma |
granzyme A |
multiple interactions |
EXP |
Curcumin inhibits the reaction [fenpropathrin results in increased expression of GZMA mRNA] |
CTD |
PMID:38369055 |
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NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
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G |
H19 |
H19 imprinted maternally expressed transcript |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of H19 mRNA curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells] curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment] |
CTD RGD |
PMID:18348204 PMID:34487706 PMID:34487706 |
RGD:156430326, RGD:156430326 |
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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G |
H1f10 |
H1.10 linker histone |
decreases expression |
ISO |
Curcumin results in decreased expression of H1-10 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein Curcumin results in increased phosphorylation of H2AX protein |
CTD |
PMID:19401701 PMID:21134073 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
H2bu1 |
H2B.U histone 1 |
increases expression |
ISO |
Curcumin results in increased expression of H2BC26 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:43,732,737...43,733,484
Ensembl chr10:43,732,864...43,736,277
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G |
H3f4 |
H3.4 histone, cluster member |
increases acetylation increases phosphorylation |
EXP |
Curcumin results in increased acetylation of H3F4 protein Curcumin results in increased phosphorylation of H3F4 protein |
CTD |
PMID:18204486 |
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NCBI chr10:43,740,702...43,741,262
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression |
ISO |
Curcumin results in decreased expression of HAMP mRNA |
CTD |
PMID:24634837 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hand1 |
heart and neural crest derivatives expressed 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA] Curcumin results in decreased expression of HAND1 mRNA |
CTD |
PMID:24857828 |
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NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213
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G |
Hand2 |
heart and neural crest derivatives expressed 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA] Curcumin results in decreased expression of HAND2 mRNA |
CTD |
PMID:24857828 |
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NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of HAVCR1 mRNA]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein] |
CTD |
PMID:25119790 PMID:29421648 PMID:30431687 PMID:38056816 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hbs1l |
HBS1-like translational GTPase |
decreases expression |
ISO |
Curcumin results in decreased expression of HBS1L mRNA |
CTD |
PMID:18421014 |
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NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074
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G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
decreases activity multiple interactions |
ISO |
Curcumin analog results in decreased activity of HCK protein [Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein |
CTD |
PMID:33617879 |
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NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions decreases expression affects localization |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein] Curcumin analog results in decreased expression of HDAC1 protein Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein |
CTD |
PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac11 |
histone deacetylase 11 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC11 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405
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G |
Hdac2 |
histone deacetylase 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein] Curcumin analog results in decreased expression of HDAC2 mRNA |
CTD |
PMID:18421014 PMID:26409325 |
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NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Hdac3 |
histone deacetylase 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of HDAC3 protein |
CTD |
PMID:17927689 |
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NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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G |
Hdac4 |
histone deacetylase 4 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC4 mRNA Curcumin analog results in decreased expression of HDAC4 protein |
CTD |
PMID:26409325 PMID:26991801 PMID:29228771 |
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NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hdac6 |
histone deacetylase 6 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC6 mRNA |
CTD |
PMID:26409325 |
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NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
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G |
Hdac7 |
histone deacetylase 7 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC7 protein |
CTD |
PMID:29228771 |
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NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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G |
Hdac8 |
histone deacetylase 8 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC8 mRNA |
CTD |
PMID:26409325 |
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NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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G |
Hebp2 |
heme binding protein 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA |
CTD |
PMID:22982865 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hgf |
hepatocyte growth factor |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of HGF protein Curcumin results in decreased expression of HGF protein |
CTD |
PMID:23555722 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions decreases expression decreases activity |
ISO EXP |
[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein] Curcumin results in decreased expression of HIF1A mRNA Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA Curcumin results in decreased activity of HIF1A protein |
CTD |
PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 PMID:26409325 More...
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hist1h2bd |
histone cluster 1 H2B family member D |
increases expression |
ISO |
Curcumin results in increased expression of H2BC5 mRNA |
CTD |
PMID:17999991 |
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NCBI chr17:42,792,887...42,793,268
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G |
Hist1h2bq |
histone cluster 1 H2B family member Q |
increases expression |
EXP |
Curcumin results in increased expression of HIST1H2BQ mRNA |
CTD |
PMID:18299980 |
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NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153 Ensembl chr17:41,429,164...41,442,153 Ensembl chr17:41,429,164...41,442,153
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G |
Hk1 |
hexokinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein] |
CTD |
PMID:36924976 |
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NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hk2 |
hexokinase 2 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of HK2 protein 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein] |
CTD |
PMID:36640941 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein] |
CTD |
PMID:22683883 PMID:29480285 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression multiple interactions decreases expression affects expression |
ISO EXP |
Curcumin results in increased expression of HMGCR mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein] Curcumin results in decreased expression of HMGCR mRNA Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein |
CTD |
PMID:16713233 PMID:27208389 PMID:37701206 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases expression increases expression decreases response to substance increases activity |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein] Curcumin results in decreased expression of HMOX1 mRNA Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein HMOX1 protein results in decreased susceptibility to Curcumin 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of HMOX mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein] |
CTD |
PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 PMID:17973899 PMID:17999991 PMID:18001810 PMID:18006204 PMID:18299980 PMID:18357586 PMID:18719366 PMID:18784349 PMID:19168576 PMID:19177192 PMID:19188863 PMID:20080166 PMID:20938987 PMID:22771723 PMID:23266269 PMID:23386263 PMID:23452621 PMID:23710286 PMID:23871787 PMID:23942037 PMID:23954767 PMID:24211270 PMID:24863870 PMID:24952339 PMID:25123790 PMID:25169090 PMID:25268984 PMID:25387343 PMID:25541178 PMID:26260164 PMID:26361869 PMID:26991801 PMID:27375190 PMID:27837179 PMID:27966075 PMID:27996348 PMID:29228771 PMID:29480285 PMID:29571711 PMID:30946834 PMID:31187328 PMID:31330227 PMID:31454128 PMID:31521693 PMID:32718261 PMID:33350580 PMID:34272803 PMID:34758851 PMID:35063475 PMID:35817260 PMID:36037877 PMID:36305173 PMID:38056816 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
decreases expression |
ISO |
Curcumin results in decreased expression of HNRNPA1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
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G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
decreases expression |
ISO |
Curcumin results in decreased expression of HNRNPD mRNA |
CTD |
PMID:17999991 |
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NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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G |
Hopx |
HOP homeobox |
increases expression |
EXP |
Curcumin results in increased expression of HOPX mRNA |
CTD |
PMID:18299980 |
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NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
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G |
Hoxb5 |
homeo box B5 |
increases expression |
ISO |
Curcumin results in increased expression of HOXB5 mRNA |
CTD |
PMID:18421014 |
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NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases expression |
ISO |
Curcumin results in increased expression of HPRT1 mRNA |
CTD |
PMID:16101141 |
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NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions |
EXP ISO |
[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein] |
CTD |
PMID:9764755 PMID:11322385 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HSP90AA1 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
multiple interactions |
EXP |
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA] |
CTD |
PMID:26361869 |
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NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA] Curcumin results in decreased expression of HSPA1A protein |
CTD |
PMID:23555722 PMID:26361869 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
increases expression |
ISO |
Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein |
CTD |
PMID:11322385 |
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NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions decreases expression |
ISO |
Curcumin results in increased expression of HSPA5 mRNA Curcumin inhibits the reaction [bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of HSPA5 protein] Curcumin results in decreased expression of HSPA5 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] |
CTD |
PMID:18200517 PMID:27996348 PMID:29723631 PMID:34784780 PMID:36640941 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein] |
CTD |
PMID:18204486 PMID:20125031 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb7 |
heat shock protein family B (small) member 7 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
EXP ISO |
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein |
CTD |
PMID:26361869 PMID:27430728 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
affects expression |
EXP |
Curcumin affects the expression of HTR1A mRNA |
CTD |
PMID:17617388 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression affects expression |
ISO EXP |
[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA] Curcumin results in decreased expression of ICAM1 protein Curcumin affects the expression of ICAM1 mRNA |
CTD |
PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 PMID:18200517 PMID:18752423 PMID:20885979 PMID:28700904 PMID:29244817 PMID:35549587 More...
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id1 |
inhibitor of DNA binding 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID2 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID3 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of IDO1 mRNA |
CTD |
PMID:18348204 |
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NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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G |
Ifna1 |
interferon, alpha 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein] |
CTD |
PMID:17979888 PMID:23452621 |
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NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifnar1 |
interferon alpha and beta receptor subunit 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein] |
CTD |
PMID:17979888 |
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NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
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G |
Ifnar2 |
interferon alpha and beta receptor subunit 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein] |
CTD |
PMID:17979888 |
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NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein] |
CTD |
PMID:17979888 |
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NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions increases secretion |
ISO EXP |
Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA] [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] Curcumin results in increased secretion of IFNG protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] |
CTD |
PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 PMID:23452621 PMID:23942037 PMID:25541178 PMID:34047412 PMID:34272803 PMID:34470535 More...
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifnk |
interferon kappa |
decreases expression |
ISO |
Curcumin results in decreased expression of IFNK mRNA |
CTD |
PMID:18421014 |
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NCBI chr 5:49,732,073...49,734,281
Ensembl chr 5:49,732,073...49,734,281
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G |
Igf1 |
insulin-like growth factor 1 |
decreases activity multiple interactions decreases expression decreases secretion |
ISO |
Curcumin results in decreased activity of IGF1 protein Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein] Curcumin analog results in decreased expression of IGF1 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA] Curcumin results in decreased secretion of IGF1 protein |
CTD |
PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein] Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA |
CTD |
PMID:17499312 PMID:17918158 PMID:26409325 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2 |
insulin-like growth factor 2 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of IGF2 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein |
CTD |
PMID:26409325 PMID:27430728 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein |
CTD |
PMID:27430728 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein |
CTD |
PMID:27430728 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression multiple interactions increases secretion increases expression |
ISO EXP |
Curcumin results in decreased expression of IGFBP3 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein Curcumin results in increased secretion of IGFBP3 protein Curcumin results in increased expression of IGFBP3 mRNA |
CTD |
PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Igfbp4 |
insulin-like growth factor binding protein 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein |
CTD |
PMID:18200517 PMID:27430728 |
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NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein |
CTD |
PMID:18200517 PMID:27430728 |
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NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
increases expression |
ISO |
Curcumin results in increased expression of IGFBP7 mRNA |
CTD |
PMID:21594647 |
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NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions decreases activity |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA] Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] Curcumin results in decreased activity of IKBKB protein |
CTD |
PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 PMID:23452621 PMID:29793316 More...
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA] |
CTD |
PMID:23452621 |
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NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein] Curcumin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein] Curcumin results in decreased expression of IL10 protein CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]] |
CTD |
PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 PMID:23452621 PMID:30016632 PMID:30431687 PMID:35549587 PMID:36178099 PMID:37955270 More...
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA] |
CTD |
PMID:16867261 PMID:23452621 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of IL17A protein] |
CTD |
PMID:34998855 PMID:35716765 PMID:36178099 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL18 protein] Curcumin results in decreased expression of IL18 mRNA Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein |
CTD |
PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475 PMID:38301994 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein] Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein] |
CTD |
PMID:18719352 PMID:19782127 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
affects expression multiple interactions decreases expression |
ISO EXP |
Curcumin affects the expression of IL1B mRNA Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA] [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA] [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of IL1B mRNA]]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]] |
CTD |
PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 PMID:16867261 PMID:17151092 PMID:17273796 PMID:17291458 PMID:17383825 PMID:17887948 PMID:18001810 PMID:18200517 PMID:18368483 PMID:18549505 PMID:18752423 PMID:18946510 PMID:19782127 PMID:20712904 PMID:20816778 PMID:25123790 PMID:25541178 PMID:27393034 PMID:27645308 PMID:29315967 PMID:29571711 PMID:30016632 PMID:30098273 PMID:31407471 PMID:31454128 PMID:31712109 PMID:32718261 PMID:33350580 PMID:34272803 PMID:34470535 PMID:34719837 PMID:34998855 PMID:35063475 PMID:35817260 PMID:36156276 PMID:36178099 PMID:38301994 PMID:38369055 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Cisplatin results in increased expression of IL1RL1 protein] |
CTD |
PMID:36178099 |
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NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Curcumin results in decreased expression of and results in decreased secretion of IL2 protein |
CTD |
PMID:19761891 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Cisplatin results in increased expression of IL23A protein] |
CTD |
PMID:36178099 |
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NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein] |
CTD |
PMID:18340409 |
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NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il4 |
interleukin 4 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein] Curcumin results in decreased expression of IL4 protein |
CTD |
PMID:16782535 PMID:16867261 PMID:21397623 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein] |
CTD |
PMID:34998855 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression increases expression affects expression |
ISO EXP |
Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA] Curcumin results in increased expression of IL6 protein Curcumin results in increased expression of IL6 mRNA 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]] Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein |
CTD |
PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 PMID:18006644 PMID:18025290 PMID:18200517 PMID:18209571 PMID:18357586 PMID:18379247 PMID:18549505 PMID:18676361 PMID:18752423 PMID:19074641 PMID:19782127 PMID:20712904 PMID:21397623 PMID:21594647 PMID:21811692 PMID:22142850 PMID:22465177 PMID:22683883 PMID:23396138 PMID:24760747 PMID:25123790 PMID:25387343 PMID:28063877 PMID:28700904 PMID:28951138 PMID:29480285 PMID:29571711 PMID:29793316 PMID:30016632 PMID:30138604 PMID:31199764 PMID:31454128 PMID:31820278 PMID:33350580 PMID:33952798 PMID:34042043 PMID:34272803 PMID:34577062 PMID:34787501 PMID:35549587 PMID:35716765 PMID:35817260 PMID:37955270 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6r |
interleukin 6 receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein] |
CTD |
PMID:34233590 |
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NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein] |
CTD |
PMID:34233590 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Lamotrigine results in increased expression of INS1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] |
CTD |
PMID:23267840 PMID:25541178 PMID:27208389 PMID:38050455 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein] Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]] |
CTD |
PMID:25268984 PMID:26713546 PMID:28595985 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig2 |
insulin induced gene 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA] |
CTD |
PMID:18704882 |
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NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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G |
Insr |
insulin receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form] |
CTD |
PMID:29793316 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Irag2 |
inositol 1,4,5-triphosphate receptor associated 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of IRAG2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 4:178,088,902...178,143,569
Ensembl chr 4:178,088,507...178,143,557
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA] |
CTD |
PMID:16678799 PMID:23452621 |
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NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein] |
CTD |
PMID:16678799 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Irf5 |
interferon regulatory factor 5 |
increases expression |
ISO |
Curcumin analog results in increased expression of IRF5 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions affects phosphorylation |
EXP ISO |
Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] Curcumin affects the phosphorylation of IRS1 protein |
CTD |
PMID:26713546 PMID:27208389 PMID:29793316 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
affects phosphorylation |
ISO |
Curcumin affects the phosphorylation of IRS2 protein |
CTD |
PMID:27208389 |
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NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein] |
CTD |
PMID:18565277 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM] |
CTD |
PMID:9112257 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein] Curcumin results in increased expression of ITGB1 protein |
CTD |
PMID:17291458 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein] |
CTD |
PMID:18565277 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Itm2a |
integral membrane protein 2A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Ivl |
involucrin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA] |
CTD |
PMID:17148446 |
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NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Jak2 |
Janus kinase 2 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of JAK2 protein Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:16959222 PMID:34233590 PMID:36352148 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jak3 |
Janus kinase 3 |
decreases activity |
ISO |
Curcumin results in decreased activity of JAK3 protein |
CTD |
PMID:16932349 |
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NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation multiple interactions increases expression decreases activity |
ISO EXP |
Curcumin results in decreased phosphorylation of JUN protein Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein] Curcumin results in increased expression of JUN mRNA [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein] Curcumin results in decreased activity of JUN protein |
CTD |
PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 PMID:17827730 PMID:18628248 PMID:23452621 PMID:26191140 PMID:27535828 PMID:31587482 PMID:35716765 PMID:36178099 More...
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein] Curcumin results in increased ubiquitination of JUNB protein |
CTD |
PMID:17148446 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein] |
CTD |
PMID:17148446 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Curcumin results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnmb2 |
potassium calcium-activated channel subfamily M regulatory beta subunit 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of KCNMB2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 2:114,670,027...114,975,374
Ensembl chr 2:114,935,976...114,975,173
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G |
Kdr |
kinase insert domain receptor |
affects expression multiple interactions |
ISO EXP |
Curcumin affects the expression of KDR mRNA [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein] Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA] |
CTD |
PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA] Curcumin results in decreased expression of KEAP1 mRNA Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein] Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of KEAP1 mRNA]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] Curcumin results in increased expression of KEAP1 mRNA |
CTD |
PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 PMID:34758851 PMID:35063475 PMID:36037877 PMID:38056816 More...
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
EXP |
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein |
CTD |
PMID:26612707 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Klf10 |
KLF transcription factor 10 |
decreases expression |
ISO |
Curcumin results in decreased expression of KLF10 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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G |
Klf6 |
KLF transcription factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of KLF6 mRNA |
CTD |
PMID:15713895 |
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NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Klhl21 |
kelch-like family member 21 |
increases expression |
ISO |
Curcumin results in increased expression of KLHL21 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545
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G |
Klhl24 |
kelch-like family member 24 |
decreases expression |
ISO |
Curcumin results in decreased expression of KLHL24 mRNA |
CTD |
PMID:17198877 |
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NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of KLK3 mRNA; Curcumin results in decreased expression of KLK3 protein Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of KLK3 protein; trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA] |
CTD |
PMID:12497104 PMID:18676361 PMID:18719366 PMID:21134073 PMID:22258452 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Kmt5a |
lysine methyltransferase 5A |
decreases expression |
ISO |
Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein |
CTD |
PMID:25256401 |
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NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
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G |
Kras |
KRAS proto-oncogene, GTPase |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] |
CTD |
PMID:17041101 PMID:21519798 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Krtap2-1 |
keratin associated protein 2-1 |
decreases expression |
ISO |
Curcumin results in decreased expression of KRTAP2-1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr10:84,572,164...84,572,587
Ensembl chr10:84,572,164...84,572,556
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G |
Kynu |
kynureninase |
increases expression |
ISO |
Curcumin results in increased expression of KYNU mRNA |
CTD |
PMID:18421014 |
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NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
affects expression multiple interactions |
EXP ISO |
Curcumin affects the expression of LAMP1 mRNA Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]] |
CTD |
PMID:18539377 PMID:34758851 |
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NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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G |
Lbp |
lipopolysaccharide binding protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA] Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of LCN2 mRNA]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein] |
CTD |
PMID:18200517 PMID:25119790 PMID:29421648 PMID:38056816 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lcp1 |
lymphocyte cytosolic protein 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
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G |
Lcp2 |
lymphocyte cytosolic protein 2 |
increases expression |
ISO |
Curcumin results in increased expression of LCP2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions decreases expression |
ISO EXP |
ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein] Curcumin inhibits the reaction [Gentamicins results in increased expression of LDHA protein] |
CTD |
PMID:36640941 PMID:36924976 PMID:38056816 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions affects expression increases expression |
ISO |
Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein Curcumin affects the expression of LDLR mRNA Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein |
CTD |
PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389 |
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NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Lef1 |
lymphoid enhancer binding factor 1 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of LEF1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA] |
CTD |
PMID:25963729 |
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NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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G |
Lgmn |
legumain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] |
CTD |
PMID:31199764 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhx5 |
LIM homeobox 5 |
affects expression |
EXP |
Curcumin affects the expression of LHX5 mRNA |
CTD |
PMID:18539377 |
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NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625
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G |
Lig3 |
DNA ligase 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein] |
CTD |
PMID:21332098 |
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NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414
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G |
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