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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:K-ATP channel agonist
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Accession:CHEBI:64338 term browser browse the term
Definition:A compound which acts as an agonist at the ATP-sensitive K+ channel.
Synonyms:related_synonym: ATP-sensitive K+ channel agonist;   ATP-sensitive K+ channel agonists;   ATP-sensitive K+ channel opener;   ATP-sensitive K+ channel openers;   K-ATP channel agonists


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diazoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization
multiple interactions
EXP Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]
CTD PMID:21256120 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein] CTD PMID:21256120 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:20650802 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:20650802 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form
CTD PMID:15326191 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein] CTD PMID:21256120 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA
CTD PMID:19052819 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein
CTD PMID:19052819 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic decreases secretion
multiple interactions
EXP Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]
CTD PMID:21256120 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Gcg glucagon multiple interactions ISO Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein] CTD PMID:23200776 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10464266 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA] CTD PMID:9142872 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Diazoxide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Diazoxide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression ISO Diazoxide results in decreased expression of KCNJ11 mRNA CTD PMID:23200776 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Lep leptin multiple interactions
decreases secretion
EXP Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein
CTD PMID:10780946 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein] CTD PMID:15326191 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]
CTD PMID:15795934 PMID:15927086 PMID:16257489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] CTD PMID:11527545 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]
CTD PMID:16257489 PMID:16612254 PMID:18700057 PMID:19012619 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Diazoxide results in decreased expression of TP53 mRNA CTD PMID:16426753 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
rottlerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Agt angiotensinogen multiple interactions EXP rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein] CTD PMID:30366073 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO rottlerin results in decreased phosphorylation of AKT1 protein
rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:15177934 PMID:19393235 PMID:22902833 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]] CTD PMID:20488202 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein] CTD PMID:22902833 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] CTD PMID:25895139 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein] CTD PMID:15917298 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; rottlerin inhibits the reaction [Cisplatin affects the localization of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]
rottlerin results in increased expression of BAX protein
CTD PMID:21633170 PMID:22902833 PMID:25895139 PMID:30366073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO rottlerin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]
CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO rottlerin results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]
CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein] CTD PMID:22902833 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases cleavage
increases activity
EXP
ISO
rottlerin results in decreased activity of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
rottlerin results in increased cleavage of CASP3 protein
rottlerin inhibits the reaction [NSC606985 results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]
rottlerin results in increased activity of CASP3 protein
rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Dieldrin results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]
CTD PMID:11880503 PMID:12831855 PMID:19662097 PMID:21362627 PMID:22410117 PMID:22902833 PMID:25773745 PMID:25895139 PMID:30366073 PMID:30393195 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein] CTD PMID:21362627 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO rottlerin inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP9 protein]; rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]
rottlerin results in increased cleavage of CASP9 protein
CTD PMID:12626342 PMID:22902833 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein CTD PMID:16959960 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein CTD PMID:16959960 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]; rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein] CTD PMID:21393419 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein CTD PMID:16959960 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein CTD PMID:16959960 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15976015 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein]; rottlerin inhibits the reaction [NSC606985 results in increased ubiquitination of CEBPA protein] CTD PMID:19662097 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cldn1 claudin 1 affects localization ISO rottlerin affects the localization of CLDN1 protein CTD PMID:19297429 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn4 claudin 4 multiple interactions ISO rottlerin results in increased expression of and affects the localization of CLDN4 protein CTD PMID:19297429 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO rottlerin results in decreased activity of CYP19A1 protein CTD PMID:15955695 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO
EXP
rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]
rottlerin inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]
rottlerin results in increased expression of DDIT3 protein
CTD PMID:17171638 PMID:22410117 PMID:27658547 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases phosphorylation EXP rottlerin results in decreased phosphorylation of EEF2 protein CTD PMID:12720544 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 PMID:15723263 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO
EXP
rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:12720544 PMID:19771169 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein] CTD PMID:15574884 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] CTD PMID:20599481 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP
rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin inhibits the reaction [Exenatide results in increased expression of GCLC protein]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]
rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
CTD PMID:24211276 PMID:25773745 PMID:25895139 PMID:27939242 PMID:30393195 PMID:30626086 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] CTD PMID:25895139 PMID:30393195 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
affects response to substance
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]
GDF15 affects the susceptibility to rottlerin
rottlerin results in increased expression of GDF15 mRNA; rottlerin results in increased expression of GDF15 protein
CTD PMID:22410117 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
rottlerin inhibits the reaction [Acrolein results in increased secretion of GPT protein]; rottlerin inhibits the reaction [allyl alcohol results in increased secretion of GPT protein]
rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]
CTD PMID:12755590 PMID:30393195 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO rottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:61,563,458...61,576,818
Ensembl chr18:61,563,053...61,576,818
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases expression
multiple interactions
EXP rottlerin results in decreased expression of GSK3A protein
[Cadmium co-treated with rottlerin] results in decreased expression of GSK3A protein
CTD PMID:27658547 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
EXP [Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]
rottlerin results in decreased expression of GSK3B protein
CTD PMID:27658547 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO rottlerin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [exenatide results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
CTD PMID:17535857 PMID:18048804 PMID:18357586 PMID:20060010 PMID:21238556 PMID:24211276 PMID:25773745 PMID:27658547 PMID:27939242 PMID:30626086 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein] CTD PMID:19747914 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO rottlerin results in increased expression of HSPA5 protein CTD PMID:22410117 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Ifng interferon gamma multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein] CTD PMID:30366073 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO rottlerin promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16330529 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il2 interleukin 2 multiple interactions ISO rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein] CTD PMID:30366073 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP rottlerin results in decreased expression of IRS2 protein CTD PMID:18308779 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein] CTD PMID:18628248 PMID:20599481 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]] CTD PMID:20488202 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
rottlerin results in decreased phosphorylation of MAPK1 protein
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
[sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK1 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 PMID:17080406 PMID:17620283 PMID:18628248 PMID:19393235 PMID:20599481 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAPK14 protein CTD PMID:15949478 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
[sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK3 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
rottlerin results in decreased phosphorylation of MAPK3 protein
CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 PMID:17080406 PMID:17620283 PMID:18628248 PMID:19393235 PMID:20599481 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein] CTD PMID:15917298 PMID:20599481 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein] CTD PMID:20599481 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 decreases activity ISO rottlerin results in decreased activity of MAPKAPK2 protein CTD PMID:10998351 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO rottlerin results in decreased activity of MAPKAPK5 protein CTD PMID:10998351 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate multiple interactions ISO rottlerin inhibits the reaction [sodium arsenate results in increased phosphorylation of MARCKS protein] CTD PMID:11796722 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein] CTD PMID:16872482 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] CTD PMID:16571779 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA] CTD PMID:16571779 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] CTD PMID:16872482 PMID:20599481 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO rottlerin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA] CTD PMID:15557194 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
rottlerin results in decreased phosphorylation of MTOR protein
CTD PMID:19771169 PMID:22902833 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:30366073 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO rottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein] CTD PMID:17662968 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]
rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CTD PMID:18048804 PMID:21787730 PMID:24211276 PMID:25773745 PMID:25895139 PMID:30393195 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions ISO rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]; rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein] CTD PMID:23827392 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein] CTD PMID:21787730 PMID:30626086 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
rottlerin results in increased activity of NTS protein
CTD PMID:15177934 PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Ocln occludin affects localization ISO rottlerin affects the localization of OCLN protein modified form CTD PMID:19297429 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G P2ry1 purinergic receptor P2Y1 multiple interactions EXP rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]] CTD PMID:17620283 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
rottlerin results in increased cleavage of PARP1 protein
rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:22902833 PMID:27658547 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA]; rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein] CTD PMID:16260419 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
decreases response to substance
decreases activity
decreases phosphorylation
ISO
EXP
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein]
PRKCD protein results in decreased susceptibility to rottlerin
rottlerin results in decreased phosphorylation of PRKCD protein
[rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to 2-methylcyclopentadienyl manganese tricarbonyl; rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased cleavage of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [manganese chloride results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]; rottlerin inhibits the reaction [sodium arsenite results in increased phosphorylation of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to Methamphetamine; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [p-Chloroamphetamine results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]
CTD PMID:11880503 PMID:12720544 PMID:15574884 PMID:15681813 PMID:15949478 PMID:15955695 PMID:16260419 PMID:17171638 PMID:19393235 PMID:19662097 PMID:20488202 PMID:20830294 PMID:21310168 PMID:21633170 PMID:22512859 PMID:22643241 PMID:22902833 PMID:25773745 PMID:25895139 PMID:27658547 PMID:30366073 PMID:32437895 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcq protein kinase C, theta decreases activity ISO rottlerin results in decreased activity of PRKCQ protein CTD PMID:15691325 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Prl prolactin multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]
CTD PMID:17363696 PMID:17640750 PMID:19084589 PMID:30366073 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RAF1 protein CTD PMID:15949478 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RB1 protein CTD PMID:15949478 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases activity
EXP rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]
rottlerin results in decreased activity of RPS6KB1 protein
CTD PMID:12720544 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
decreases activity
EXP rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]
rottlerin results in decreased activity of RPS6KB2 protein
CTD PMID:12720544 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:22512859 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein] CTD PMID:22512859 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] CTD PMID:21705328 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sts steroid sulfatase multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter] CTD PMID:21499124 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] CTD PMID:22643241 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein] CTD PMID:15723263 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP
ISO
rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
CTD PMID:21310168 PMID:22512859 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tjp1 tight junction protein 1 affects localization ISO rottlerin affects the localization of TJP1 protein CTD PMID:19297429 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tyr tyrosinase decreases expression ISO rottlerin results in decreased expression of TYR mRNA; rottlerin results in decreased expression of TYR protein CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ulbp1 UL16 binding protein 1 multiple interactions
increases expression
ISO rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]
rottlerin results in increased expression of ULBP1 mRNA
CTD PMID:21499124 PMID:21951556 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO rottlerin inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol] CTD PMID:14704231 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO rottlerin results in decreased expression of XIAP protein CTD PMID:22902833 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
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  CHEBI ontology 19817
    role 19767
      biological role 19767
        pharmacological role 18836
          agonist 18231
            K-ATP channel agonist 126
              diazoxide 25
              rottlerin 109
paths to the root