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G |
A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
Isoproterenol results in increased expression of A2M mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCB1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression |
EXP ISO |
Isoproterenol results in decreased expression of ABCB4 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of ABCC3 mRNA Isoproterenol results in increased expression of ABCC3 mRNA |
CTD |
PMID:21335049 PMID:24286936 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCC4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCG2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Abhd2 |
abhydrolase domain containing 2, acylglycerol lipase |
increases expression |
EXP |
Isoproterenol results in increased expression of ABHD2 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
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G |
Abhd4 |
abhydrolase domain containing 4, N-acyl phospholipase B |
increases expression |
ISO |
Isoproterenol results in increased expression of ABHD4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
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G |
Abi3 |
ABI family, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABI3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
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G |
Ablim3 |
actin binding LIM protein family, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABLIM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions decreases phosphorylation increases phosphorylation |
ISO EXP |
triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] Isoproterenol results in decreased phosphorylation of ACACA protein |
CTD |
PMID:18390901 PMID:27491814 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acadl |
acyl-CoA dehydrogenase, long chain |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADL mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]] |
CTD |
PMID:25045214 PMID:30303030 |
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NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
decreases activity multiple interactions decreases expression |
EXP |
Isoproterenol results in decreased activity of ACADM protein [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADM mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]] |
CTD |
PMID:19826179 PMID:25045214 PMID:30303030 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADS mRNA Isoproterenol results in decreased expression of ACADS mRNA |
CTD |
PMID:30303030 |
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NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of ACADVL mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADVL mRNA |
CTD |
PMID:30303030 |
|
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Ace2 |
angiotensin I converting enzyme 2 |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of ACE2 mRNA Isoproterenol results in increased expression of ACE2 protein |
CTD |
PMID:20003209 PMID:20409916 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acer2 |
alkaline ceramidase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ACER2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACSL1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA] |
CTD |
PMID:10710348 |
|
NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression decreases expression |
ISO EXP |
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] Isoproterenol results in increased expression of ACTA2 mRNA; Isoproterenol results in increased expression of ACTA2 protein |
CTD |
PMID:18089841 PMID:20003209 PMID:24945829 PMID:28526319 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Actb |
actin, beta |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ACTB mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Actg2 |
actin gamma 2, smooth muscle |
increases expression |
ISO |
Isoproterenol results in increased expression of ACTG2 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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G |
Ada |
adenosine deaminase |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Adam22 |
ADAM metallopeptidase domain 22 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAM22 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962
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G |
Adam8 |
ADAM metallopeptidase domain 8 |
increases expression |
EXP |
Isoproterenol results in increased expression of ADAM8 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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G |
Adamtsl2 |
ADAMTS-like 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAMTSL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554
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G |
Adamtsl4 |
ADAMTS-like 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAMTSL4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:183,235,634...183,247,091
Ensembl chr 2:183,235,646...183,246,848
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance multiple interactions |
ISO |
ADCY5 protein results in increased susceptibility to Isoproterenol [ADCY5 protein results in increased susceptibility to Isoproterenol] which results in decreased expression of SOD2 protein; SOD2 protein inhibits the reaction [ADCY5 protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:12869393 PMID:23536361 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Adcy6 |
adenylate cyclase 6 |
affects response to substance |
ISO |
ADCY6 protein affects the susceptibility to Isoproterenol |
CTD |
PMID:12393090 |
|
NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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G |
Adcy9 |
adenylate cyclase 9 |
multiple interactions |
ISO |
[Isoproterenol co-treated with Miconazole] results in increased activity of ADCY9 protein alternative form |
CTD |
PMID:30607468 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Add3 |
adducin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ADD3 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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G |
Adgrd1 |
adhesion G protein-coupled receptor D1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:27,488,908...27,603,714
Ensembl chr12:27,488,908...27,603,696
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G |
Adgrf5 |
adhesion G protein-coupled receptor F5 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRF5 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968
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G |
Adgrl4 |
adhesion G protein-coupled receptor L4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRL4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:240,354,909...240,457,231
Ensembl chr 2:240,354,941...240,457,225
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G |
Adh1 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
increases expression |
ISO |
Isoproterenol results in increased expression of ADH1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adm |
adrenomedullin |
multiple interactions increases expression |
EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP] Isoproterenol results in increased expression of ADM mRNA; Isoproterenol results in increased expression of ADM protein |
CTD |
PMID:12732346 PMID:17250927 PMID:17306419 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Adra1b |
adrenoceptor alpha 1B |
multiple interactions decreases expression |
ISO |
ADRA1B protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP] Isoproterenol results in decreased expression of ADRA1B mRNA |
CTD |
PMID:12649302 PMID:20003209 |
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NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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G |
Adrb1 |
adrenoceptor beta 1 |
multiple interactions decreases expression increases phosphorylation increases activity affects response to substance increases uptake |
ISO EXP |
[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]; Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein] Isoproterenol results in decreased expression of ADRB1 mRNA Isoproterenol results in increased phosphorylation of ADRB1 protein [ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol ADRB1 protein polymorphism affects the susceptibility to Isoproterenol Isoproterenol results in increased uptake of ADRB1 protein ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]; ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA] Isoproterenol results in decreased expression of ADRB1; Isoproterenol results in decreased expression of ADRB1 mRNA |
CTD |
PMID:1312942 PMID:8096834 PMID:8723169 PMID:11159692 PMID:12761341 PMID:12963636 PMID:14502278 PMID:14730417 PMID:15627480 PMID:16731636 PMID:17200720 PMID:17350036 PMID:18194989 PMID:18378355 PMID:18787115 PMID:20003209 More...
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NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
multiple interactions increases activity affects expression increases uptake decreases expression increases phosphorylation increases expression |
ISO EXP |
4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]; imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Isoproterenol binds to and results in increased activity of ADRB2 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein] Isoproterenol affects the expression of ADRB2 mRNA Isoproterenol results in increased uptake of ADRB2 protein [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP] Isoproterenol results in decreased expression of ADRB2; Isoproterenol results in decreased expression of ADRB2 mRNA [GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein; ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein] Isoproterenol results in increased phosphorylation of ADRB2 protein Isoproterenol results in increased expression of ADRB2 mRNA |
CTD |
PMID:9875846 PMID:10226872 PMID:10516654 PMID:11164953 PMID:11752207 PMID:12920204 PMID:12963636 PMID:14730417 PMID:15178407 PMID:16036225 PMID:16980553 PMID:17196553 PMID:17350036 PMID:17925438 PMID:18378355 PMID:18820136 PMID:19483313 PMID:21177286 PMID:21629661 PMID:24705868 PMID:27825928 PMID:34601065 More...
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions increases activity increases expression |
ISO EXP |
[Isoproterenol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Isoproterenol binds to and results in increased activity of ADRB3 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB3 protein]; L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein] Isoproterenol results in increased expression of ADRB3 mRNA; Isoproterenol results in increased expression of ADRB3 protein [ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]; 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased expression of ADRB3 protein]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 mRNA]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 protein]; Isoproterenol binds to and results in increased activity of ADRB3 protein |
CTD |
PMID:1682311 PMID:7815362 PMID:11159692 PMID:14730417 PMID:15009959 PMID:17622774 PMID:18553954 PMID:18820136 PMID:20654104 More...
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NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Aen |
apoptosis enhancing nuclease |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AEN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Agbl5 |
AGBL carboxypeptidase 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AGBL5 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:25,472,333...25,492,173
Ensembl chr 6:25,472,333...25,490,738
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G |
Agt |
angiotensinogen |
multiple interactions increases expression |
ISO EXP |
adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; ICI 118551 inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]] Isoproterenol results in increased expression of AGT protein AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA]; AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein] Isoproterenol results in increased expression of AGT mRNA; Isoproterenol results in increased expression of AGT protein Propranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein] |
CTD |
PMID:1534315 PMID:1653766 PMID:7843740 PMID:11709406 PMID:16731636 PMID:19023134 PMID:19483313 PMID:20003209 PMID:20409916 PMID:24117263 PMID:27890915 More...
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AGTR1A mRNA |
CTD |
PMID:17350036 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Ahcy |
adenosylhomocysteinase |
increases expression |
ISO |
Isoproterenol results in increased expression of AHCY mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
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G |
Ahnak2 |
AHNAK nucleoprotein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of AHNAK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:131,830,668...131,876,311
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of AHR mRNA Isoproterenol results in decreased expression of AHR mRNA |
CTD |
PMID:24286936 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahsg |
alpha-2-HS-glycoprotein |
increases expression |
ISO |
Isoproterenol results in increased expression of AHSG mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999
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G |
Aif1 |
allograft inflammatory factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AIF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Ak4 |
adenylate kinase 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AK4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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G |
Akap1 |
A-kinase anchoring protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AKAP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
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G |
Akap13 |
A-kinase anchoring protein 13 |
increases expression |
ISO |
Isoproterenol results in increased expression of AKAP13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased phosphorylation of AKT1 protein 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; [Isoproterenol co-treated with POSTN protein] results in decreased expression of AKT1 mRNA; [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] Isoproterenol results in decreased expression of AKT1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:15178407 PMID:15618457 PMID:15951400 PMID:16716347 PMID:17623046 PMID:18806606 PMID:19167487 PMID:20003209 PMID:30303030 PMID:31009642 PMID:32686902 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ALDH2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ALDH3A2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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G |
Alpk2 |
alpha-kinase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ALPK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
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G |
Alpp |
alkaline phosphatase, placental |
multiple interactions increases expression |
ISO |
Amphetamine promotes the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; norfluoxetine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] |
CTD |
PMID:16036225 |
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NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Amy2a3 |
amylase 2a3 |
multiple interactions |
EXP |
Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein; Propranolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein] |
CTD |
PMID:21173550 |
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NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532
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G |
Ang |
angiogenin |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of ANG mRNA Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr15:24,317,733...24,323,361
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G |
Angpt2 |
angiopoietin 2 |
increases expression |
EXP |
Isoproterenol results in increased expression of ANGPT2 mRNA |
CTD |
PMID:22908232 |
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NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANGPTL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl6 |
angiopoietin-like 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANGPTL6 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925
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G |
Anp32a |
acidic nuclear phosphoprotein 32 family member A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANP32A mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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Ensembl chr 8:62,827,456...62,865,443
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G |
Anxa1 |
annexin A1 |
multiple interactions increases expression |
ISO |
ANXA1 affects the reaction [Isoproterenol results in decreased secretion of IL6 protein] Isoproterenol results in increased expression of ANXA1 mRNA |
CTD |
PMID:16835395 PMID:20003209 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions increases activity |
EXP |
Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; H 35-25 inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein] |
CTD |
PMID:2860926 PMID:6218830 |
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NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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G |
Aoc3 |
amine oxidase, copper containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of AOC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:86,272,757...86,280,702
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G |
Aox1 |
aldehyde oxidase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of AOX1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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G |
Ap1b1 |
adaptor related protein complex 1 subunit beta 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of AP1B1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of APAF1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of APEX1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Apln |
apelin |
multiple interactions decreases expression |
EXP |
Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN mRNA]; Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN protein] Isoproterenol results in decreased expression of APLN mRNA; Isoproterenol results in decreased expression of APLN protein |
CTD |
PMID:19960946 |
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NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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G |
Apoa2 |
apolipoprotein A2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APOA2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Isoproterenol results in increased expression of APOD mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G |
Appbp2 |
amyloid beta precursor protein binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APPBP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835
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G |
Appl2 |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APPL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754
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G |
Arf2 |
ADP-ribosylation factor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ARF2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:88,867,844...88,889,654
Ensembl chr10:88,867,836...88,889,659
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G |
Arf4 |
ADP-ribosylation factor 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARF4 mRNA |
CTD |
PMID:21335049 |
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NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arhgap12 |
Rho GTPase activating protein 12 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP12 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:51,588,810...51,702,417
Ensembl chr17:51,588,842...51,702,080
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G |
Arhgap18 |
Rho GTPase activating protein 18 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ARHGAP18 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256
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G |
Arhgap20 |
Rho GTPase activating protein 20 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP20 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739
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G |
Arhgap24 |
Rho GTPase activating protein 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP24 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
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G |
Arhgdib |
Rho GDP dissociation inhibitor beta |
increases expression |
EXP |
Isoproterenol results in increased expression of ARHGDIB mRNA |
CTD |
PMID:30303030 |
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NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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G |
Arid4b |
AT-rich interaction domain 4B |
increases expression |
ISO |
Isoproterenol results in increased expression of ARID4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:51,138,419...51,262,956
Ensembl chr17:51,138,535...51,262,906
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G |
Arid5b |
AT-rich interaction domain 5B |
increases expression |
ISO |
Isoproterenol results in increased expression of ARID5B mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
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G |
Arl4a |
ADP-ribosylation factor like GTPase 4A |
increases expression |
ISO |
Isoproterenol results in increased expression of ARL4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:57,079,496...57,084,156
Ensembl chr 6:57,078,812...57,085,066
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G |
Arnt2 |
aryl hydrocarbon receptor nuclear translocator 2 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of ARNT2 mRNA Isoproterenol results in increased expression of ARNT2 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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G |
Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
increases expression |
ISO |
Isoproterenol results in increased expression of ARNTL mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein] |
CTD |
PMID:18787115 |
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NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Arrb2 |
arrestin, beta 2 |
affects localization multiple interactions |
ISO EXP |
Isoproterenol affects the localization of ARRB2 protein ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] |
CTD |
PMID:17482545 PMID:17925438 PMID:18787115 PMID:21078978 |
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NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Arrdc2 |
arrestin domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARRDC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
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G |
Arrdc3 |
arrestin domain containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARRDC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
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G |
Asap1 |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ASAP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
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G |
Asb11 |
ankyrin repeat and SOCS box containing 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of ASB11 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:30,014,485...30,037,808
Ensembl chr X:29,992,416...30,037,807
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G |
Ascc3 |
activating signal cointegrator 1 complex subunit 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ASCC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Isoproterenol results in increased expression of ASNS mRNA |
CTD |
PMID:21335049 PMID:21823215 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ASPH mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:22,603,879...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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G |
Aspn |
asporin |
increases expression |
ISO |
Isoproterenol results in increased expression of ASPN mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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G |
Atad2 |
ATPase family, AAA domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATAD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions increases phosphorylation |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:18089841 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of ATF3 mRNA Isoproterenol results in increased expression of ATF3 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of ATF3 protein] |
CTD |
PMID:21823215 PMID:25136830 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atp10d |
ATPase phospholipid transporting 10D (putative) |
increases expression |
ISO |
Isoproterenol results in increased expression of ATP10D mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions decreases expression |
EXP |
astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA]; candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein]; Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein Isoproterenol results in decreased expression of ATP2A2 mRNA; Isoproterenol results in decreased expression of ATP2A2 protein |
CTD |
PMID:16723803 PMID:17509559 |
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NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of ATP5A1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1A mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1d |
ATP synthase F1 subunit delta |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1D mRNA |
CTD |
PMID:30303030 |
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NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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G |
Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5MC1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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G |
Atp5me |
ATP synthase membrane subunit e |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5ME mRNA |
CTD |
PMID:30303030 |
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NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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G |
Atp5pd |
ATP synthase peripheral stalk subunit d |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5PD mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5PO mRNA |
CTD |
PMID:30303030 |
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NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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G |
Atp6ap2 |
ATPase H+ transporting accessory protein 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP6AP2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
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G |
Atp6v1e1 |
ATPase H+ transporting V1 subunit E1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ATP6V1E1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:154,022,360...154,044,486
Ensembl chr 4:154,022,358...154,044,584
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G |
Atp8b1 |
ATPase phospholipid transporting 8B1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATP8B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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G |
Atxn10 |
ataxin 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATXN10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
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G |
Auts2 |
activator of transcription and developmental regulator AUTS2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AUTS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416
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G |
Azi2 |
5-azacytidine induced 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of AZI2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
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G |
Bag1 |
BAG cochaperone 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BAG1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
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G |
Bag4 |
BAG cochaperone 4 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of BAG4 mRNA |
CTD |
PMID:30303030 |
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NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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G |
Bak1 |
BCL2-antagonist/killer 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BAK1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of BAX protein 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein; [Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; erdosteine inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]; Tretinoin inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] Isoproterenol results in decreased expression of BAX mRNA Isoproterenol results in increased expression of BAX mRNA; Isoproterenol results in increased expression of BAX protein |
CTD |
PMID:15052282 PMID:16116328 PMID:17961425 PMID:24286936 PMID:24954035 PMID:27491814 PMID:29414845 PMID:30152906 PMID:32007421 PMID:33210414 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of BCAT1 mRNA |
CTD |
PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions increases expression |
ISO EXP |
Isoproterenol results in decreased expression of BCL2 protein 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein; [erdosteine co-treated with Isoproterenol] affects the expression of BCL2 protein; [Isoproterenol co-treated with POSTN protein] results in increased expression of BCL2 mRNA; [Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein; Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; echinocystic acid affects the reaction [Isoproterenol affects the expression of BCL2 mRNA]; Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]] Isoproterenol results in increased expression of BCL2 mRNA Isoproterenol results in decreased expression of BCL2 mRNA; Isoproterenol results in decreased expression of BCL2 protein |
CTD |
PMID:11218852 PMID:12791704 PMID:15052282 PMID:19573579 PMID:24954035 PMID:27491814 PMID:29414845 PMID:30152906 PMID:30303030 PMID:30623541 PMID:32007421 PMID:33210414 More...
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of BCL2L1 mRNA Isoproterenol results in decreased expression of BCL2L1 mRNA; Isoproterenol results in decreased expression of BCL2L1 protein Isoproterenol results in increased expression of BCL2L1 mRNA alternative form; Isoproterenol results in increased expression of BCL2L1 protein; Isoproterenol results in increased expression of BCL2L1 protein alternative form Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein]; CGP 20712A inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein]; Metoprolol inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein]; Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form]; Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] |
CTD |
PMID:12738230 PMID:16116328 PMID:20003209 PMID:24286936 PMID:26996544 PMID:30152906 More...
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of BCL2L11 protein Isoproterenol results in increased expression of BCL2L11 mRNA |
CTD |
PMID:14996839 PMID:24286936 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bdh1 |
3-hydroxybutyrate dehydrogenase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BDH1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
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G |
Bicd1 |
BICD cargo adaptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BICD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of BIRC2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Bmf |
Bcl2 modifying factor |
increases expression |
EXP |
Isoproterenol results in increased expression of BMF mRNA |
CTD |
PMID:24286936 |
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NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp10 |
bone morphogenetic protein 10 |
multiple interactions decreases response to substance |
ISO |
BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; STAT3 protein affects the reaction [BMP10 protein results in decreased susceptibility to Isoproterenol] BMP10 protein inhibits the reaction [Isoproterenol results in increased cleavage of PARP1 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; STAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]] |
CTD |
PMID:31712309 |
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NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627
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G |
Bnip1 |
BCL2 interacting protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BNIP1 protein |
CTD |
PMID:15052282 |
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NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of BNIP3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bok |
BCL2 family apoptosis regulator BOK |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BOK mRNA |
CTD |
PMID:21335049 |
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NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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G |
Brd4 |
bromodomain containing 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BRD4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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G |
Brwd1 |
bromodomain and WD repeat domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BRWD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:35,286,364...35,378,768
Ensembl chr11:35,288,313...35,378,768
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G |
Bsdc1 |
BSD domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BSDC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:141,798,918...141,827,091
Ensembl chr 5:141,798,981...141,827,092
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G |
C3 |
complement C3 |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of C3 mRNA Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C3 protein] Isoproterenol results in decreased expression of C3 mRNA Isoproterenol results in increased expression of C3 mRNA; Isoproterenol results in increased expression of C3 protein |
CTD |
PMID:20003209 PMID:24286936 PMID:32924446 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4b |
complement C4B (Chido blood group) |
increases expression |
ISO |
Isoproterenol results in increased expression of C4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
C5 |
complement C5 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of C5 protein Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C5 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C5 protein] |
CTD |
PMID:32924446 |
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NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
C9 |
complement C9 |
increases expression |
EXP |
Isoproterenol results in increased expression of C9 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
increases expression |
EXP |
Isoproterenol results in increased expression of CACNA1C mRNA |
CTD |
PMID:17526999 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cadm4 |
cell adhesion molecule 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CADM4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:80,075,232...80,096,511
Ensembl chr 1:80,075,202...80,097,423
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]] |
CTD |
PMID:17306419 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calcrl |
calcitonin receptor like receptor |
multiple interactions increases expression |
EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA Isoproterenol results in increased expression of CALCRL mRNA; Isoproterenol results in increased expression of CALCRL protein |
CTD |
PMID:16987513 PMID:17250927 PMID:17306419 |
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NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
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G |
Calm3 |
calmodulin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CALM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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G |
Calr |
calreticulin |
increases expression |
ISO |
Isoproterenol results in increased expression of CALR mRNA |
CTD |
PMID:21823215 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Calr3 |
calreticulin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CALR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
increases expression |
ISO |
Isoproterenol results in increased expression of CAMK2B mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases phosphorylation |
EXP |
Isoproterenol results in decreased phosphorylation of CAMKK2 protein |
CTD |
PMID:27491814 |
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NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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G |
Capn1 |
calpain 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CAPN1 mRNA Quercetin inhibits the reaction [Isoproterenol results in increased expression of CAPN1 mRNA] |
CTD |
PMID:27527349 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn10 |
calpain 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of CAPN10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494
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G |
Capn2 |
calpain 2 |
multiple interactions increases expression |
EXP |
Quercetin inhibits the reaction [Isoproterenol results in increased expression of CAPN2 mRNA] |
CTD |
PMID:27527349 |
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NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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G |
Car4 |
carbonic anhydrase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of CAR4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
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G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CARMIL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
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G |
Casp1 |
caspase 1 |
decreases expression increases expression |
ISO |
Isoproterenol results in decreased expression of CASP1 mRNA Isoproterenol results in increased expression of CASP1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp2 |
caspase 2 |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of CASP2 mRNA Isoproterenol results in increased expression of CASP2 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases cleavage increases activity |
ISO EXP |
Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein Isoproterenol results in increased cleavage of CASP3 protein Isoproterenol results in increased activity of CASP3 protein [erdosteine co-treated with Isoproterenol] affects the expression of CASP3 protein; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Progesterone inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of CASP3 protein]; sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP3 mRNA] Isoproterenol results in increased expression of CASP3 mRNA; Isoproterenol results in increased expression of CASP3 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; RAPGEF3 mutant form inhibits the reaction [Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; STAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]] |
CTD |
PMID:11218852 PMID:17136323 PMID:17961425 PMID:20726854 PMID:21745194 PMID:24286936 PMID:25794854 PMID:27491814 PMID:28266775 PMID:30152906 PMID:30623541 PMID:31712309 PMID:32865837 PMID:32924446 PMID:33210414 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CASP6 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions decreases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein]; Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein [Isoproterenol co-treated with POSTN protein] results in decreased expression of CASP7 mRNA Isoproterenol results in decreased expression of CASP7 mRNA |
CTD |
PMID:17136323 PMID:24286936 PMID:30303030 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CASP8 mRNA; Isoproterenol results in increased expression of CASP8 protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] |
CTD |
PMID:25794854 PMID:26996544 PMID:30152906 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression increases activity multiple interactions |
EXP |
Isoproterenol results in increased expression of CASP9 mRNA; Isoproterenol results in increased expression of CASP9 protein Isoproterenol results in increased activity of CASP9 protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP9 protein]; Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA] |
CTD |
PMID:24286936 PMID:25794854 PMID:26996544 PMID:30152906 PMID:32865837 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression decreases activity multiple interactions increases activity increases expression |
ISO EXP |
Isoproterenol results in decreased expression of CAT protein Isoproterenol results in decreased activity of CAT protein [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; [Streptozocin co-treated with Isoproterenol] affects the activity of CAT protein; Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; dicarbine inhibits the reaction [Isoproterenol results in increased activity of CAT protein]; Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; erdosteine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Tretinoin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased expression of CAT protein] Isoproterenol results in increased expression of CAT mRNA |
CTD |
PMID:1840475 PMID:12708743 PMID:15740881 PMID:16584858 PMID:16697266 PMID:19146839 PMID:20003209 PMID:21322096 PMID:22391854 PMID:24201307 PMID:24954035 PMID:25537132 PMID:26721194 PMID:27527349 PMID:30152906 PMID:30623541 PMID:32007421 PMID:32946155 PMID:33210414 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cav1 |
caveolin 1 |
multiple interactions |
ISO |
CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] |
CTD |
PMID:18820136 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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Cav3 |
caveolin 3 |
affects localization |
EXP |
Isoproterenol affects the localization of CAV3 protein |
CTD |
PMID:19299911 |
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NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
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Cblb |
Cbl proto-oncogene B |
increases expression |
ISO |
Isoproterenol results in increased expression of CBLB mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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G |
Ccdc80 |
coiled-coil domain containing 80 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCDC80 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137
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Ccdc85a |
coiled-coil domain containing 85A |
increases expression |
ISO |
Isoproterenol results in increased expression of CCDC85A mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:102,126,574...102,359,207
Ensembl chr14:102,129,029...102,359,058
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
decreases secretion |
ISO |
Isoproterenol results in decreased secretion of CCL17 protein |
CTD |
PMID:12871855 |
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NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCL2 mRNA |
CTD |
PMID:21823215 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions increases expression decreases expression |
ISO |
Isoproterenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein] Isoproterenol results in increased expression of CCL3 protein Isoproterenol results in decreased expression of CCL3 mRNA Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] |
CTD |
PMID:9863660 PMID:12538206 PMID:21335049 PMID:24286936 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl6 |
C-C motif chemokine ligand 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCL6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression decreases expression |
EXP ISO |
Isoproterenol results in increased expression of CCL7 mRNA Isoproterenol results in decreased expression of CCL7 mRNA |
CTD |
PMID:20211217 PMID:24286936 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of CCN2 mRNA Isoproterenol results in increased expression of CCN2 mRNA; Isoproterenol results in increased expression of CCN2 protein Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein] Isoproterenol results in decreased expression of CCN2 mRNA |
CTD |
PMID:20003209 PMID:24117263 PMID:24286936 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnd1 |
cyclin D1 |
decreases expression increases expression |
ISO |
Isoproterenol results in decreased expression of CCND1 mRNA Isoproterenol results in increased expression of CCND1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCND3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccng2 |
cyclin G2 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of CCR1 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 8:123,556,286...123,561,841
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Cd14 |
CD14 molecule |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of CD14 mRNA |
CTD |
PMID:20003209 PMID:20211217 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd163 |
CD163 molecule |
increases expression |
ISO |
Isoproterenol results in increased expression of CD163 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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G |
Cd302 |
CD302 molecule |
increases expression |
ISO |
Isoproterenol results in increased expression of CD302 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045
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G |
Cd36 |
CD36 molecule |
decreases expression |
EXP |
Isoproterenol results in decreased expression of CD36 protein |
CTD |
PMID:19826179 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd38 |
CD38 molecule |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein] |
CTD |
PMID:23343681 |
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NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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G |
Cd74 |
CD74 molecule |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CD74 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CDC37 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdc37l1 |
cell division cycle 37-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDC37L1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175
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G |
Cdc42ep3 |
CDC42 effector protein 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDC42EP3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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G |
Cdc42ep4 |
CDC42 effector protein 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDC42EP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695
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Cdh11 |
cadherin 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDH11 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh13 |
cadherin 13 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDH13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDH2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of CDK1 mRNA; Isoproterenol results in increased expression of CDK1 protein Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] |
CTD |
PMID:9593584 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdo1 |
cysteine dioxygenase type 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDO1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
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G |
Cds2 |
CDP-diacylglycerol synthase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541
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G |
Cdv3 |
CDV3 homolog |
increases expression |
ISO |
Isoproterenol results in increased expression of CDV3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:103,934,006...103,947,173
Ensembl chr 8:103,933,996...103,947,192
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G |
Cdyl |
chromodomain Y-like |
increases expression |
ISO |
Isoproterenol results in increased expression of CDYL mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
increases expression |
ISO |
Isoproterenol results in increased expression of CEBPD mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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G |
Cebpg |
CCAAT/enhancer binding protein gamma |
increases expression |
ISO |
Isoproterenol results in increased expression of CEBPG mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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G |
Cenpa |
centromere protein A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CENPA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cep192 |
centrosomal protein 192 |
increases expression |
ISO |
Isoproterenol results in increased expression of CEP192 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:61,346,957...61,458,405
Ensembl chr18:61,332,158...61,458,379
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G |
Cfh |
complement factor H |
increases expression |
ISO |
Isoproterenol results in increased expression of CFH mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity |
ISO EXP |
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein; Baclofen promotes the reaction [Isoproterenol results in increased activity of CFTR protein]; Enkephalin, Leucine-2-Alanine promotes the reaction [Isoproterenol results in increased activity of CFTR protein]; Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein] |
CTD |
PMID:15020588 PMID:15039139 PMID:15151902 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
EXP |
Isoproterenol results in increased expression of CH25H mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CHAC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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G |
Chka |
choline kinase alpha |
increases expression |
ISO |
Isoproterenol results in increased expression of CHKA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CHUK mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cidec |
cell death-inducing DFFA-like effector c |
multiple interactions |
ISO |
Isoproterenol results in increased expression of and results in decreased degradation of CIDEC protein; KT 5720 inhibits the reaction [Isoproterenol results in increased expression of CIDEC protein] |
CTD |
PMID:21097823 |
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NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Cilp |
cartilage intermediate layer protein |
increases expression |
ISO |
Isoproterenol results in increased expression of CILP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251
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G |
Cirbp |
cold inducible RNA binding protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CIRBP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CITED2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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G |
Cited4 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CITED4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
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G |
Ckb |
creatine kinase B |
multiple interactions increases activity |
EXP |
Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]; Isoproterenol results in increased expression of [CKM protein binds to CKB protein]; Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]; Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein] |
CTD |
PMID:19146839 PMID:22391854 PMID:34435724 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions increases secretion |
EXP |
Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]; Isoproterenol results in increased expression of [CKM protein binds to CKB protein]; Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]; Quercetin inhibits the reaction [Isoproterenol results in increased secretion of CKM protein] |
CTD |
PMID:19146839 PMID:22391854 PMID:27527349 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca1 |
chloride channel accessory 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLCA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
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G |
Clcn3 |
chloride voltage-gated channel 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLCN3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Clec1a |
C-type lectin domain family 1, member A |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247
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G |
Clec4a |
C-type lectin domain family 4, member A |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC4N mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
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G |
Clec4d |
C-type lectin domain family 4, member D |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC4D mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:156,589,591...156,598,969
Ensembl chr 4:156,589,792...156,598,848
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G |
Clic5 |
chloride intracellular channel 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLIC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:16,710,980...16,813,427
Ensembl chr 9:16,710,980...16,813,427
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G |
Clip1 |
CAP-GLY domain containing linker protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLIP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
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G |
Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLIP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
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G |
Clpb |
caseinolytic mitochondrial matrix peptidase chaperone subunit B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLPB mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
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G |
Clu |
clusterin |
increases expression |
ISO |
Isoproterenol results in increased expression of CLU mRNA; Isoproterenol results in increased expression of CLU protein |
CTD |
PMID:15052282 PMID:20003209 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cnksr1 |
connector enhancer of kinase suppressor of Ras 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CNKSR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212
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G |
Cnksr3 |
Cnksr family member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CNKSR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:43,499,273...43,591,630
Ensembl chr 1:43,499,487...43,591,635
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G |
Cobll1 |
cordon-bleu WH2 repeat protein-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of COBLL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:49,753,260...49,915,168
Ensembl chr 3:49,753,262...49,915,194
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G |
Col15a1 |
collagen type XV alpha 1 chain |
decreases expression |
ISO |
Isoproterenol results in decreased expression of COL15A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
EXP ISO |
manidipine inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL1A1 mRNA] BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein] Isoproterenol results in increased expression of COL1A1 mRNA; Isoproterenol results in increased expression of COL1A1 protein |
CTD |
PMID:9559417 PMID:24945829 PMID:26692091 PMID:28526319 PMID:31009642 PMID:31712309 More...
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions decreases expression |
ISO |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; U 0126 inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein] Isoproterenol results in decreased expression of COL2A1 mRNA; Isoproterenol results in decreased expression of COL2A1 protein |
CTD |
PMID:21177286 |
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NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions increases expression |
EXP ISO |
AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; manidipine inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL3A1 mRNA] Isoproterenol results in increased expression of COL3A1 mRNA; Isoproterenol results in increased expression of COL3A1 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein] |
CTD |
PMID:9559417 PMID:20409916 PMID:26692091 PMID:31009642 PMID:31712309 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col5a1 |
collagen type V alpha 1 chain |
decreases expression |
ISO |
Isoproterenol results in decreased expression of COL5A1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
increases expression |
ISO |
Isoproterenol results in increased expression of COL5A2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
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G |
Comt |
catechol-O-methyltransferase |
increases methylation |
ISO |
COMT protein results in increased methylation of Isoproterenol |
CTD |
PMID:11160877 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Cops3 |
COP9 signalosome subunit 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of COPS3 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
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G |
Corin |
corin, serine peptidase |
increases expression |
ISO |
Isoproterenol results in increased expression of CORIN mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
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G |
Cp |
ceruloplasmin |
multiple interactions increases expression decreases activity |
EXP ISO |
allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of CP protein] Isoproterenol results in increased expression of CP protein Isoproterenol results in increased expression of CP mRNA |
CTD |
PMID:1521861 PMID:15261977 PMID:20003209 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpne8 |
copine 8 |
increases expression |
ISO |
Isoproterenol results in increased expression of CPNE8 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
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G |
Cps1 |
carbamoyl-phosphate synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CPS1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT1A mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
multiple interactions decreases expression |
EXP |
Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]] |
CTD |
PMID:25045214 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of CPT2 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT2 mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]] |
CTD |
PMID:25045214 PMID:30303030 |
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NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Crb1 |
crumbs cell polarity complex component 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CRB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:50,801,484...50,989,261
Ensembl chr13:50,800,959...50,989,261
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G |
Crbn |
cereblon |
increases expression |
ISO |
Isoproterenol results in increased expression of CRBN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions increases phosphorylation |
ISO EXP |
oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein] CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:12791704 PMID:17141199 PMID:21745194 PMID:32686902 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crem |
cAMP responsive element modulator |
multiple interactions increases expression affects localization |
EXP |
CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]; CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] Isoproterenol results in increased expression of CREM mRNA; Isoproterenol results in increased expression of CREM protein Isoproterenol affects the localization of CREM protein |
CTD |
PMID:12791704 PMID:20211217 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Crlf1 |
cytokine receptor-like factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CRLF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Isoproterenol inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:8769853 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cryba4 |
crystallin, beta A4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CRYBA4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:44,378,734...44,393,226
Ensembl chr12:44,378,737...44,393,221
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G |
Cs |
citrate synthase |
decreases activity |
EXP |
Isoproterenol results in decreased activity of CS protein |
CTD |
PMID:27491814 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csdc2 |
cold shock domain containing C2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CSDC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
increases expression |
ISO |
Isoproterenol results in increased expression of CSF2RB mRNA; Isoproterenol results in increased expression of CSF2RB2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Csk |
C-terminal Src kinase |
multiple interactions |
ISO |
CSK protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] |
CTD |
PMID:1699227 |
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NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
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G |
Ctf1 |
cardiotrophin 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CTF1 mRNA; Isoproterenol results in increased expression of CTF1 protein Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] |
CTD |
PMID:23288202 |
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NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cth |
cystathionine gamma-lyase |
multiple interactions |
EXP |
[Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA |
CTD |
PMID:29447158 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Cthrc1 |
collagen triple helix repeat containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTHRC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
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G |
Ctnnal1 |
catenin alpha-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTNNAL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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G |
Ctnnbip1 |
catenin, beta-interacting protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CTNNBIP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
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G |
Ctps2 |
CTP synthase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTPS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:31,645,873...31,786,733
Ensembl chr X:31,645,873...31,786,733
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G |
Ctsb |
cathepsin B |
multiple interactions increases activity decreases expression decreases activity |
EXP ISO |
caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] Isoproterenol results in decreased expression of CTSB mRNA |
CTD |
PMID:2015110 PMID:8534267 PMID:17188415 PMID:18294627 PMID:20391626 PMID:21335049 More...
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions affects activity increases activity decreases activity increases expression |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]; caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] Isoproterenol results in increased expression of CTSD mRNA; Isoproterenol results in increased expression of CTSD protein |
CTD |
PMID:894732 PMID:2015110 PMID:8534267 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:17623887 PMID:18294627 PMID:18424012 PMID:19172585 PMID:19641666 PMID:20391626 PMID:21762681 More...
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctsl |
cathepsin L |
increases expression |
ISO |
Isoproterenol results in increased expression of CTSL mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Cul1 |
cullin 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CUL1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
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G |
Cul4b |
cullin 4B |
increases expression |
ISO |
Isoproterenol results in increased expression of CUL4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688
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G |
Cux2 |
cut-like homeobox 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CUX2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
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G |
Cuzd1 |
CUB and zona pellucida-like domains 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CUZD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
increases expression |
ISO |
Isoproterenol results in increased expression of CXCL13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CXCL9 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases activity |
ISO |
Isoproterenol results in increased activity of CXCR2 protein |
CTD |
PMID:15477226 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxxc5 |
CXXC finger protein 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CXXC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673
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G |
Cyba |
cytochrome b-245 alpha chain |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CYBA mRNA CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] |
CTD |
PMID:18594475 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cycs |
cytochrome c, somatic |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CYCS protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein] |
CTD |
PMID:30152906 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of CYP1A1 mRNA Isoproterenol results in increased expression of CYP1A1 mRNA Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] |
CTD |
PMID:15627480 PMID:15710352 PMID:18725507 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO EXP |
Isoproterenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] |
CTD |
PMID:15710352 PMID:18493746 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of CYP1B1 mRNA |
CTD |
PMID:18725507 PMID:20003209 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases activity |
ISO |
Isoproterenol results in increased activity of CYP2A5 protein |
CTD |
PMID:11162586 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CYP2B10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of CYP2C11 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects expression |
EXP |
Isoproterenol affects the expression of CYP2E1 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of CYP4A3 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CYSLTR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:71,661,415...71,690,158
Ensembl chr X:71,663,821...71,690,121
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G |
Cyss |
cystatin S |
multiple interactions increases expression |
EXP |
Reserpine inhibits the reaction [Isoproterenol results in increased expression of CYSS mRNA] |
CTD |
PMID:9447264 |
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NCBI chr 3:137,432,272...137,436,610
Ensembl chr 3:137,432,049...137,436,610
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G |
Dag1 |
dystroglycan 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of DAG1 |
CTD |
PMID:18808529 |
|
NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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G |
Dap |
death-associated protein |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of DAP mRNA Isoproterenol results in increased expression of DAP mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DBP mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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G |
Dcakd |
dephospho-CoA kinase domain containing |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DCAKD mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054
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G |
Dcn |
decorin |
increases expression |
ISO |
Isoproterenol results in increased expression of DCN mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dct |
dopachrome tautomerase |
increases expression |
ISO |
Isoproterenol results in increased expression of DCT mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
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G |
Dctn5 |
dynactin subunit 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of DCTN5 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of DDIT3 mRNA [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]] |
CTD |
PMID:21823215 PMID:29414845 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
|
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
increases expression |
ISO |
Isoproterenol results in increased expression of DDOST mRNA |
CTD |
PMID:21823215 |
|
NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Defb1 |
defensin beta 1 |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of DEFB1 mRNA Isoproterenol results in increased expression of DEFB1 mRNA |
CTD |
PMID:24286936 |
|
NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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G |
Dennd4a |
DENN domain containing 4A |
increases expression |
ISO |
Isoproterenol results in increased expression of DENND4A mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:65,322,920...65,436,331
Ensembl chr 8:65,322,941...65,436,330
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G |
Derl2 |
derlin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DERL2 mRNA |
CTD |
PMID:21823215 |
|
NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
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G |
Derl3 |
derlin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DERL3 mRNA |
CTD |
PMID:21823215 |
|
NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
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G |
Des |
desmin |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of DES protein Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein] |
CTD |
PMID:34435724 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases expression |
ISO |
Isoproterenol results in increased expression of DFFB mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHCR24 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS3 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dhrs7 |
dehydrogenase/reductase 7 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS7 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
|
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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G |
Dhrs7c |
dehydrogenase/reductase 7C |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS7C mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:52,495,262...52,513,338
Ensembl chr10:52,495,262...52,513,338
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G |
Diaph2 |
diaphanous-related formin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DIAPH2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869
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G |
Dio2 |
iodothyronine deiodinase 2 |
increases expression increases activity |
ISO EXP |
Isoproterenol results in increased expression of DIO2 mRNA Isoproterenol results in increased activity of DIO2 protein |
CTD |
PMID:15345674 PMID:20003209 |
|
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dixdc1 |
DIX domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of DIXDC1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DLAT mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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G |
Dmac2l |
distal membrane arm assembly component 2 like |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of DMAC2L mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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G |
Dmd |
dystrophin |
multiple interactions decreases expression |
ISO EXP |
DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol] Isoproterenol results in decreased expression of DMD |
CTD |
PMID:18340010 PMID:18808529 |
|
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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G |
Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNAJB11 mRNA |
CTD |
PMID:21823215 |
|
NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNAJB9 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnm1l |
dynamin 1-like |
increases phosphorylation |
EXP |
Isoproterenol results in increased phosphorylation of DNM1L protein |
CTD |
PMID:27491814 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of DNMT3A mRNA Isoproterenol results in increased expression of DNMT3A protein |
CTD |
PMID:20003209 PMID:24945829 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
increases expression |
ISO |
Isoproterenol results in increased expression of DNMT3B mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
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|
G |
Dnttip2 |
deoxynucleotidyltransferase, terminal, interacting protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNTTIP2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:210,374,240...210,386,366
Ensembl chr 2:210,374,289...210,385,581
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G |
Dock10 |
dedicator of cytokinesis 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of DOCK10 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
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G |
Dock9 |
dedicator of cytokinesis 9 |
increases expression |
ISO |
Isoproterenol results in increased expression of DOCK9 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:98,611,518...98,883,306
Ensembl chr15:98,618,084...98,883,153
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G |
Dpep1 |
dipeptidase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of DPEP1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
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G |
Dpp7 |
dipeptidylpeptidase 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of DPP7 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355
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G |
Dsg2 |
desmoglein 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DSG2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156
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G |
Dtx4 |
deltex E3 ubiquitin ligase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of DTX4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21177286 |
|
NCBI chr10:16,680,489...16,683,276
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|
G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of DUSP4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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G |
Dusp8 |
dual specificity phosphatase 8 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DUSP8 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
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G |
Dxo |
decapping exoribonuclease |
increases expression |
ISO |
Isoproterenol results in increased expression of DXO mRNA |
CTD |
PMID:21335049 |
|
NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494
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G |
Ecm1 |
extracellular matrix protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ECM1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of EDEM1 mRNA |
CTD |
PMID:21335049 PMID:21823215 |
|
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Edn1 |
endothelin 1 |
multiple interactions increases activity increases expression |
EXP |
Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]; Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] Isoproterenol results in increased expression of EDN1 mRNA; Isoproterenol results in increased expression of EDN1 protein |
CTD |
PMID:9861301 PMID:11435416 PMID:27174236 PMID:27890915 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ednra |
endothelin receptor type A |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of EDNRA mRNA Isoproterenol results in increased expression of EDNRA mRNA; Isoproterenol results in increased expression of EDNRA protein CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] |
CTD |
PMID:18594475 PMID:20003209 PMID:20307649 PMID:27174236 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Ednrb |
endothelin receptor type B |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRB mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDNRB protein] Isoproterenol results in increased expression of EDNRB mRNA; Isoproterenol results in increased expression of EDNRB protein |
CTD |
PMID:18594475 PMID:27174236 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eef1akmt1 |
EEF1A lysine methyltransferase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EEF1AKMT1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:31,694,289...31,711,959
Ensembl chr15:31,694,292...31,711,336
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G |
Efhd2 |
EF-hand domain family, member D2 |
increases expression |
ISO |
Isoproterenol results in increased expression of EFHD2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980
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G |
Egfr |
epidermal growth factor receptor |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of EGFR mRNA Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein] |
CTD |
PMID:18787115 PMID:20003209 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] Isoproterenol results in increased expression of EGR1 protein 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein] Isoproterenol results in decreased expression of EGR1 mRNA |
CTD |
PMID:10710348 PMID:15621046 PMID:20003209 |
|
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1a |
eukaryotic translation initiation factor 1A |
increases expression |
ISO |
Isoproterenol results in increased expression of EIF1A mRNA |
CTD |
PMID:20003209 PMID:21335049 |
|
NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
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|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of EIF2AK3 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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|
G |
Eif4a2 |
eukaryotic translation initiation factor 4A2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EIF4A2 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EIF4E mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Ell2 |
elongation factor for RNA polymerase II 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ELL2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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G |
Eln |
elastin |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with Hydralazine] results in increased expression of ELN protein Isoproterenol results in increased expression of ELN protein |
CTD |
PMID:3446201 |
|
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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|
G |
Elovl1 |
ELOVL fatty acid elongase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ELOVL1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
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|
G |
Elp1 |
elongator acetyltransferase complex subunit 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ELP1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
|
|
G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ENC1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
|
|
G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ENO1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
|
|
G |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of ENPP1 protein |
CTD |
PMID:21414308 |
|
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
|
|
G |
Entpd1 |
ectonucleoside triphosphate diphosphohydrolase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ENTPD1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
|
|
G |
Eps8 |
epidermal growth factor receptor pathway substrate 8 |
increases expression |
ISO |
Isoproterenol results in increased expression of EPS8 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
|
|
G |
Ereg |
epiregulin |
increases expression |
ISO |
Isoproterenol results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
|
|
G |
Erp29 |
endoplasmic reticulum protein 29 |
increases expression |
ISO |
Isoproterenol results in increased expression of ERP29 mRNA |
CTD |
PMID:21335049 |
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NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ERRFI1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
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G |
Etf1 |
eukaryotic translation termination factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ETF1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
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G |
Ezh1 |
enhancer of zeste 1 polycomb repressive complex 2 subunit |
increases expression |
ISO |
Isoproterenol results in increased expression of EZH1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
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G |
F13a1 |
coagulation factor XIII A1 chain |
increases expression |
ISO |
Isoproterenol results in increased expression of F13A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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G |
Fabp3 |
fatty acid binding protein 3 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of FABP3 protein Isoproterenol results in decreased expression of FABP3 protein |
CTD |
PMID:19549929 PMID:19826179 PMID:19854236 PMID:22878004 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp5 |
fatty acid binding protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of FABP5 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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G |
Fam110d |
family with sequence similarity 110, member D |
increases expression |
ISO |
Isoproterenol results in increased expression of FAM110D mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:146,471,048...146,474,019
Ensembl chr 5:146,471,049...146,474,056
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G |
Fam117b |
family with sequence similarity 117, member B |
increases expression |
ISO |
Isoproterenol results in increased expression of FAM117B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:61,340,291...61,418,531
Ensembl chr 9:61,340,249...61,408,483
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G |
Farp1 |
FERM, ARH/RhoGEF and pleckstrin domain protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FARP1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of FAS mRNA Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein]; Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] Isoproterenol results in increased expression of FAS mRNA; Isoproterenol results in increased expression of FAS protein |
CTD |
PMID:11218852 PMID:20003209 PMID:24286936 PMID:25794854 PMID:26996544 PMID:30152906 More...
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
Isoproterenol results in increased expression of FASLG protein |
CTD |
PMID:19001025 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fblim1 |
filamin binding LIM protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBLIM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:153,883,946...153,915,524
Ensembl chr 5:153,883,960...153,913,757
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G |
Fbln2 |
fibulin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBLN2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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G |
Fbxl20 |
F-box and leucine-rich repeat protein 20 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXL20 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162
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G |
Fbxo31 |
F-box protein 31 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXO31 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:49,624,818...49,656,083
Ensembl chr19:49,627,686...49,656,010
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G |
Fbxo32 |
F-box protein 32 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXO32 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
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G |
Fbxo9 |
f-box protein 9 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBXO9 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
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G |
Fbxw7 |
F-box and WD repeat domain containing 7 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBXW7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
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G |
Fcgr2a |
Fc gamma receptor 2A |
increases expression |
ISO |
Isoproterenol results in increased expression of FCGR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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G |
Fcgr2b |
Fc gamma receptor 2B |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of FCGR2B mRNA |
CTD |
PMID:20003209 PMID:20211217 |
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NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
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G |
Fcgr3a |
Fc gamma receptor 3A |
increases expression |
ISO |
Isoproterenol results in increased expression of FCGR4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Fen1 |
flap structure-specific endonuclease 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FEN1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Fetub |
fetuin B |
increases expression |
ISO |
Isoproterenol results in increased expression of FETUB mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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G |
Fgf16 |
fibroblast growth factor 16 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FGF16 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr X:70,816,658...70,827,270
Ensembl chr X:70,817,433...70,878,717
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G |
Fgfr3 |
fibroblast growth factor receptor 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of FGFR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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G |
Fhl1 |
four and a half LIM domains 1 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of FHL1 mRNA Isoproterenol results in increased expression of FHL1 mRNA |
CTD |
PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of FIS1 protein |
CTD |
PMID:27491814 |
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NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Fkbp1b |
FKBP prolyl isomerase 1B |
multiple interactions decreases expression |
EXP |
1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] Isoproterenol results in decreased expression of FKBP1B mRNA; Isoproterenol results in decreased expression of FKBP1B protein |
CTD |
PMID:20723002 |
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NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
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G |
Fkbp4 |
FKBP prolyl isomerase 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FKBP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
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G |
Fkbp5 |
FKBP prolyl isomerase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of FKBP5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FLT1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FMO1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of FMO2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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G |
Fn1 |
fibronectin 1 |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of FN1 protein Isoproterenol results in increased expression of FN1 protein Quercetin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein] Isoproterenol results in increased expression of FN1 mRNA |
CTD |
PMID:11821714 PMID:20003209 PMID:24117263 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO EXP |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] Isoproterenol results in increased expression of FOS mRNA; Isoproterenol results in increased expression of FOS protein Isoproterenol results in increased expression of FOS; Isoproterenol results in increased expression of FOS mRNA CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; Isoproterenol promotes the reaction [JUN protein binds to FOS protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of FOS] |
CTD |
PMID:7544033 PMID:7905536 PMID:10710348 PMID:12791704 PMID:14764439 PMID:18089841 PMID:21177286 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Isoproterenol results in increased expression of FOSB |
CTD |
PMID:7905536 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of FOSL1 mRNA [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA] Isoproterenol results in increased expression of FOSL1 mRNA; Isoproterenol results in increased expression of FOSL1 protein |
CTD |
PMID:20211217 PMID:21177286 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of FOSL2 mRNA; Isoproterenol results in increased expression of FOSL2 protein [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA] |
CTD |
PMID:21177286 |
|
NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxo1 |
forkhead box O1 |
increases phosphorylation |
ISO |
Isoproterenol results in increased phosphorylation of FOXO1 protein |
CTD |
PMID:15618457 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxo3 |
forkhead box O3 |
increases expression |
ISO |
Isoproterenol results in increased expression of FOXO3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fry |
FRY microtubule binding protein |
increases expression |
ISO |
Isoproterenol results in increased expression of FRY mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of FSHB protein] |
CTD |
PMID:20307649 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FTL1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
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G |
Fus |
Fus RNA binding protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FUS mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
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G |
G3bp2 |
G3BP stress granule assembly factor 2 |
multiple interactions increases expression |
EXP |
G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB protein]; Isoproterenol promotes the reaction [G3BP2 protein binds to NFKBIA protein] Isoproterenol results in increased expression of G3BP2 mRNA; Isoproterenol results in increased expression of G3BP2 protein |
CTD |
PMID:28816235 |
|
NCBI chr14:15,932,356...16,020,555
Ensembl chr14:15,987,417...16,020,548
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions increases activity |
EXP |
Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Gallopamil inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] |
CTD |
PMID:1978808 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabarapl1 |
GABA type A receptor associated protein like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GABARAPL1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
Isoproterenol results in increased expression of GADD45G mRNA |
CTD |
PMID:21823215 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Gal |
galanin and GMAP prepropeptide |
multiple interactions increases activity increases expression decreases activity |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA] |
CTD |
PMID:2015110 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:19294532 More...
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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|
G |
Galnt15 |
polypeptide N-acetylgalactosaminyltransferase 15 |
increases expression |
ISO |
Isoproterenol results in increased expression of GALNT15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:7,227,232...7,267,002
Ensembl chr16:7,227,271...7,267,014
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G |
Gas5 |
growth arrest specific 5 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of GAS5 mRNA Isoproterenol results in decreased expression of GAS5 mRNA |
CTD |
PMID:20003209 PMID:28526319 |
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NCBI chr13:73,303,611...73,306,932
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G |
Gas6 |
growth arrest specific 6 |
multiple interactions decreases expression |
EXP |
natakalim inhibits the reaction [Isoproterenol results in decreased expression of GAS6 protein] |
CTD |
PMID:27890915 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
ISO EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA Isoproterenol promotes the reaction [NFATC1 protein binds to GATA4 protein] |
CTD |
PMID:10710348 PMID:11435416 |
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NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gbp6 |
guanylate binding protein family member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of GBP6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GCLC mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of GCLM mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of GCLM mRNA Isoproterenol results in decreased expression of GCLM mRNA |
CTD |
PMID:20003209 PMID:21335049 PMID:30303030 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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|
G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GCNT2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:23,796,859...23,901,625 NCBI chr17:23,866,602...23,868,691
Ensembl chr17:23,796,859...23,901,611
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G |
Gda |
guanine deaminase |
increases expression |
ISO |
Isoproterenol results in increased expression of GDA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
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G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] |
CTD |
PMID:18089841 |
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NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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|
G |
Gfpt2 |
glutamine-fructose-6-phosphate transaminase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GFPT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329
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G |
Ggt5 |
gamma-glutamyltransferase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of GGT5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
increases expression |
EXP |
Isoproterenol results in increased expression of GHRL protein |
CTD |
PMID:20572026 |
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NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Ghsr |
growth hormone secretagogue receptor |
increases expression |
EXP |
Isoproterenol results in increased expression of GHSR mRNA; Isoproterenol results in increased expression of GHSR protein |
CTD |
PMID:20572026 |
|
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
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G |
Gigyf2 |
GRB10 interacting GYF protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GIGYF2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
[Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein Isoproterenol results in decreased expression of GJA1 mRNA Isoproterenol results in increased expression of GJA1 mRNA; Isoproterenol results in increased expression of GJA1 protein Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] |
CTD |
PMID:16352648 PMID:18089841 PMID:20003209 PMID:20215810 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gk |
glycerol kinase |
increases activity |
EXP |
Isoproterenol results in increased activity of GK protein |
CTD |
PMID:12736183 |
|
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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G |
Glb1 |
galactosidase, beta 1 |
multiple interactions affects activity |
EXP |
caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein] |
CTD |
PMID:20391626 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G |
Glg1 |
golgi glycoprotein 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of GLG1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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G |
Glul |
glutamate-ammonia ligase |
increases expression |
ISO |
Isoproterenol results in increased expression of GLUL mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gna15 |
G protein subunit alpha 15 |
multiple interactions increases response to substance |
ISO |
[GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein |
CTD |
PMID:9875846 |
|
NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
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G |
Gnal |
G protein subunit alpha L |
increases response to substance multiple interactions |
ISO |
GNAL protein results in increased susceptibility to Isoproterenol Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:15598656 |
|
NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
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G |
Gnas |
GNAS complex locus |
multiple interactions increases response to substance |
EXP ISO |
GNAS protein affects the susceptibility to [Potassium Chloride co-treated with Isoproterenol]; Isoproterenol affects the expression of and affects the localization of GNAS protein Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:10696522 PMID:12376418 PMID:15598656 |
|
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gng2 |
G protein subunit gamma 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GNG2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
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G |
Gng3 |
G protein subunit gamma 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with Atorvastatin] affects the localization of GNG3 protein |
CTD |
PMID:19136528 |
|
NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603
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G |
Gns |
glucosamine (N-acetyl)-6-sulfatase |
increases expression |
ISO |
Isoproterenol results in increased expression of GNS mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:56,889,139...56,923,170
Ensembl chr 7:56,889,232...56,923,151
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of GOT2 protein |
CTD |
PMID:19826179 |
|
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GPAM mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gpcpd1 |
glycerophosphocholine phosphodiesterase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GPCPD1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517
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G |
Gpihbp1 |
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPIHBP1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
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G |
Gpnmb |
glycoprotein nmb |
increases expression |
ISO |
Isoproterenol results in increased expression of GPNMB mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpr160 |
G protein-coupled receptor 160 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPR160 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:112,483,364...112,563,072
Ensembl chr 2:112,484,935...112,563,148
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G |
Gpr182 |
G protein-coupled receptor 182 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPR182 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of GPX1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPX3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GRINA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:107,962,194...107,965,368
Ensembl chr 7:107,962,207...107,965,366
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of GRK2 mRNA Isoproterenol results in increased expression of GRK2 mRNA; Isoproterenol results in increased expression of GRK2 protein AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA] |
CTD |
PMID:9788834 PMID:16731636 |
|
NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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G |
Grk5 |
G protein-coupled receptor kinase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of GRK5 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases phosphorylation decreases phosphorylation |
EXP ISO |
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:15951400 PMID:16716347 PMID:18806606 PMID:31009642 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity increases activity decreases expression |
EXP |
abana inhibits the reaction [Isoproterenol results in decreased expression of GSR]; allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Catechin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; dicarbine inhibits the reaction [Isoproterenol results in increased activity of GSR protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of GSR protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Tretinoin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] Isoproterenol results in decreased expression of GSR; Isoproterenol results in decreased expression of GSR protein |
CTD |
PMID:1840475 PMID:12557918 PMID:15261977 PMID:15740881 PMID:16697266 PMID:16757080 PMID:19146839 PMID:23261676 PMID:32007421 More...
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GSTO1 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gtf2a1 |
general transcription factor 2A subunit 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GTF2A1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:110,488,891...110,521,059
Ensembl chr 6:110,488,931...110,521,511
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G |
Gusb |
glucuronidase, beta |
multiple interactions increases activity decreases activity increases expression |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] |
CTD |
PMID:2015110 PMID:8534267 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:18294627 PMID:19172585 PMID:19294532 PMID:20391626 PMID:21762681 More...
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NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
H1f2 |
H1.2 linker histone, cluster member |
increases expression |
ISO |
Isoproterenol results in increased expression of H1F2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:41,391,106...41,392,611
Ensembl chr17:41,388,477...41,392,635
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G |
H1f4 |
H1.4 linker histone, cluster member |
increases expression |
ISO |
Isoproterenol results in increased expression of H1F4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:41,486,634...41,487,293
Ensembl chr17:41,486,560...41,487,403
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Isoproterenol results in increased expression of H2AX mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of HADHA mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Haghl |
hydroxyacylglutathione hydrolase-like |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HAGHL mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665
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G |
Hamp |
hepcidin antimicrobial peptide |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of HAMP mRNA |
CTD |
PMID:20211217 PMID:21335049 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hap1 |
huntingtin-associated protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HAP1 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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G |
Harbi1 |
harbinger transposase derived 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HARBI1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 3:77,681,431...77,689,749
Ensembl chr 3:77,681,431...77,689,724
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G |
Hdac2 |
histone deacetylase 2 |
increases phosphorylation multiple interactions |
ISO EXP |
Isoproterenol results in increased phosphorylation of HDAC2 protein plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] |
CTD |
PMID:31009642 |
|
NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Heatr5b |
HEAT repeat containing 5B |
increases expression |
ISO |
Isoproterenol results in increased expression of HEATR5B mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:16,243,424...16,323,439
Ensembl chr 6:16,243,461...16,323,435
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G |
Heca |
hdc homolog, cell cycle regulator |
increases expression |
ISO |
Isoproterenol results in increased expression of HECA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:12,525,135...12,575,358
Ensembl chr 1:12,525,135...12,576,427
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G |
Heph |
hephaestin |
increases expression |
ISO |
Isoproterenol results in increased expression of HEPH mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HERPUD1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Herpud2 |
HERPUD family member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of HERPUD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:23,573,374...23,617,874
Ensembl chr 8:23,573,379...23,617,874
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G |
Hes1 |
hes family bHLH transcription factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HES1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hexa |
hexosaminidase subunit alpha |
increases expression |
ISO |
Isoproterenol results in increased expression of HEXA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013
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G |
Hfe |
homeostatic iron regulator |
increases expression |
ISO |
Isoproterenol results in increased expression of HFE mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIF1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hif1an |
hypoxia inducible factor 1 subunit alpha inhibitor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIF1AN mRNA |
CTD |
PMID:24286936 |
|
NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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G |
Hif3a |
hypoxia inducible factor 3 subunit alpha |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of HIF3A mRNA |
CTD |
PMID:24286936 |
|
NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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G |
Hipk1 |
homeodomain interacting protein kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HIPK1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902
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G |
Hipk2 |
homeodomain interacting protein kinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIPK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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G |
Hipk3 |
homeodomain interacting protein kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of HIPK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759
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G |
Hk2 |
hexokinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HK2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hlf |
HLF transcription factor, PAR bZIP family member |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HLF mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases activity |
EXP |
7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] |
CTD |
PMID:16640830 PMID:16906524 PMID:19595682 PMID:26995004 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HMGCS1 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein] Isoproterenol results in increased expression of HMOX1 mRNA; Isoproterenol results in increased expression of HMOX1 protein [erdosteine co-treated with Isoproterenol] results in increased expression of HMOX1 protein; Doxorubicin inhibits the reaction [Isoproterenol results in increased expression of HMOX1 mRNA] |
CTD |
PMID:15179140 PMID:19483313 PMID:20003209 PMID:21823215 PMID:22908232 PMID:24929186 PMID:33210414 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnph3 |
heterogeneous nuclear ribonucleoprotein H3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HNRNPH3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
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G |
Hnrnpr |
heterogeneous nuclear ribonucleoprotein R |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HNRNPR mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867
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G |
Homer1 |
homer scaffold protein 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of HOMER1 mRNA alternative form |
CTD |
PMID:16786172 |
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NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hopx |
HOP homeobox |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HOPX mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
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G |
Hpca |
hippocalcin |
affects localization |
EXP |
Isoproterenol affects the localization of HPCA protein |
CTD |
PMID:21078978 |
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NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
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G |
Hpse |
heparanase |
increases expression |
EXP |
Isoproterenol results in increased expression of HPSE protein |
CTD |
PMID:16327176 |
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NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
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G |
Hras |
HRas proto-oncogene, GTPase |
increases activity |
EXP |
Isoproterenol results in increased activity of HRAS protein |
CTD |
PMID:8484791 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hs2st1 |
heparan sulfate 2-O-sulfotransferase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HS2ST1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:233,508,018...233,641,769
Ensembl chr 2:233,508,021...233,641,769
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSD3B1 mRNA; Isoproterenol results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of HSPA1L mRNA Isoproterenol results in decreased expression of HSPA1L mRNA |
CTD |
PMID:20003209 PMID:24286936 |
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NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of HSPA2 mRNA |
CTD |
PMID:20211217 PMID:24286936 |
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NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of HSPA5 mRNA [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]] Isoproterenol results in decreased expression of HSPA5 mRNA |
CTD |
PMID:21335049 PMID:24286936 PMID:29414845 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSPA8 mRNA |
CTD |
PMID:20003209 PMID:24286936 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions increases expression |
EXP |
Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein] Isoproterenol results in increased expression of HSP27 protein; Isoproterenol results in increased expression of HSPB1 protein |
CTD |
PMID:10559386 PMID:20125031 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb7 |
heat shock protein family B (small) member 7 |
increases expression |
EXP |
Isoproterenol results in increased expression of HSPB7 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
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G |
Hspg2 |
heparan sulfate proteoglycan 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSPG2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HSPH1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Htra2 |
HtrA serine peptidase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HTRA2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
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G |
Htra3 |
HtrA serine peptidase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of HTRA3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315
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G |
Hyou1 |
hypoxia up-regulated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HYOU1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ICAM1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id1 |
inhibitor of DNA binding 1, HLH protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ID1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Ier3 |
immediate early response 3 |
multiple interactions affects response to substance |
ISO |
IER3 protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; Pertussis Toxin affects the reaction [IER3 protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP]]; Pertussis Toxin affects the reaction [IER3 protein affects the susceptibility to Isoproterenol] |
CTD |
PMID:20713914 |
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NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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G |
Ifna1 |
interferon, alpha 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of IFNA1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifng |
interferon gamma |
decreases secretion |
ISO |
Isoproterenol results in decreased secretion of IFNG protein |
CTD |
PMID:15342205 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr2 |
interferon gamma receptor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IFNGR2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
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G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of IFRD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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G |
Ift74 |
intraflagellar transport 74 |
increases expression |
ISO |
Isoproterenol results in increased expression of IFT74 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of IGF1 mRNA Isoproterenol results in increased expression of IGF1 mRNA; Isoproterenol results in increased expression of IGF1 protein candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 mRNA]; candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 protein] |
CTD |
PMID:10547078 PMID:20003209 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
Isoproterenol results in increased expression of IGF1R mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2bp2 |
insulin-like growth factor 2 mRNA binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of IGF2BP2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of IGFBP3 SI 27 inhibits the reaction [Isoproterenol results in decreased expression of IGFBP3] |
CTD |
PMID:12883319 |
|
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
ISO EXP |
Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] Quercetin inhibits the reaction [Isoproterenol results in decreased expression of IL10 protein] |
CTD |
PMID:9038718 PMID:27527349 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
decreases expression |
EXP |
Isoproterenol results in decreased expression of IL12A protein |
CTD |
PMID:24286936 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
Isoproterenol results in increased expression of IL12B protein |
CTD |
PMID:24286936 |
|
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
increases expression |
EXP |
Isoproterenol results in increased expression of IL17A protein |
CTD |
PMID:19909738 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17rd |
interleukin 17 receptor D |
increases expression |
ISO |
Isoproterenol results in increased expression of IL17RD mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:2,228,467...2,295,126
Ensembl chr16:2,228,287...2,292,556
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression decreases expression |
ISO EXP |
ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein]; Isoproterenol results in increased expression of and results in increased secretion of IL18 protein; Isoproterenol results in increased expression of and results in increased stability of IL18 mRNA; Pertussis Toxin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL18 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]; wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] Isoproterenol results in decreased expression of IL18 mRNA |
CTD |
PMID:15178407 PMID:21335049 PMID:24286936 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of IL1A mRNA Isoproterenol results in increased expression of IL1A mRNA |
CTD |
PMID:24286936 PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions decreases expression increases expression |
ISO EXP |
SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of IL1B protein] Isoproterenol results in decreased expression of IL1B mRNA Isoproterenol results in decreased expression of IL1B mRNA; Isoproterenol results in decreased expression of IL1B protein Isoproterenol results in increased expression of IL1B mRNA; Isoproterenol results in increased expression of IL1B protein Isoproterenol results in increased expression of IL1B; Isoproterenol results in increased expression of IL1B mRNA Isoproterenol results in increased expression of IL1B; Isoproterenol results in increased expression of IL1B mRNA; Isoproterenol results in increased expression of IL1B protein Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]] |
CTD |
PMID:9387890 PMID:12215284 PMID:15302781 PMID:18487443 PMID:19023134 PMID:19904010 PMID:21335049 PMID:21762681 PMID:24286936 PMID:25045214 PMID:32816093 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
affects response to substance |
ISO |
IL1RN protein affects the susceptibility to Isoproterenol |
CTD |
PMID:10487780 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of IL2 mRNA; Isoproterenol results in increased expression of IL2 protein Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]] |
CTD |
PMID:25045214 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il4 |
interleukin 4 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of IL4 mRNA Isoproterenol results in increased expression of IL4 mRNA Isoproterenol results in increased expression of IL4 protein |
CTD |
PMID:24286936 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il4r |
interleukin 4 receptor |
increases expression |
ISO |
Isoproterenol results in increased expression of IL4RA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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G |
Il5ra |
interleukin 5 receptor subunit alpha |
affects response to substance |
ISO |
IL5RA protein affects the susceptibility to Isoproterenol |
CTD |
PMID:10487780 |
|
NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
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G |
Il6 |
interleukin 6 |
multiple interactions increases secretion increases expression decreases expression decreases secretion |
ISO EXP |
ANXA1 affects the reaction [Isoproterenol results in decreased secretion of IL6 protein]; Genistein promotes the reaction [Isoproterenol results in increased secretion of IL6 protein]; Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]; SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL6]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] Isoproterenol results in increased expression of IL6 mRNA; Isoproterenol results in increased expression of IL6 protein Isoproterenol results in decreased expression of IL6 mRNA Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; erdosteine inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Isoproterenol inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Isoproterenol results in increased expression of and results in increased secretion of IL6 protein; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] Isoproterenol results in increased expression of IL6; Isoproterenol results in increased expression of IL6 mRNA; Isoproterenol results in increased expression of IL6 protein Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:9038718 PMID:9688336 PMID:10525314 PMID:11406463 PMID:15302781 PMID:16835395 PMID:17141199 PMID:18487443 PMID:19023134 PMID:19909738 PMID:21088047 PMID:21762681 PMID:21823215 PMID:24286936 PMID:24842192 PMID:26277537 PMID:27527349 PMID:30152906 PMID:30623541 PMID:32007421 PMID:32946155 PMID:33210414 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7 |
interleukin 7 |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of IL7 protein |
CTD |
PMID:24286936 |
|
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Immt |
inner membrane mitochondrial protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IMMT mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
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G |
Inhbb |
inhibin subunit beta B |
increases expression |
ISO |
Isoproterenol results in increased expression of INHBB mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
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G |
Ins2 |
insulin 2 |
multiple interactions increases expression affects expression |
EXP |
INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]] Isoproterenol results in increased expression of INS protein Isoproterenol affects the expression of INS protein |
CTD |
PMID:1129332 PMID:1170870 PMID:19167487 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Ints3 |
integrator complex subunit 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of INTS3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709
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G |
Ipo13 |
importin 13 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IPO13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:131,433,770...131,454,044
Ensembl chr 5:131,433,776...131,454,043
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of IRAK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Irs1 |
insulin receptor substrate 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of IRS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irx4 |
iroquois homeobox 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IRX4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]] |
CTD |
PMID:9762784 |
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NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions decreases expression |
ISO EXP |
DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol] Isoproterenol results in decreased expression of ITGB1 |
CTD |
PMID:18340010 PMID:18808529 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgbl1 |
integrin subunit beta like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITGBL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733
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G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITIH3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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G |
Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITIH4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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G |
Itk |
IL2-inducible T-cell kinase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ITK mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:30,753,339...30,814,685
Ensembl chr10:30,753,344...30,814,685
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G |
Itpkb |
inositol-trisphosphate 3-kinase B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ITPKB mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004
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G |
Jade2 |
jade family PHD finger 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of JADE2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:36,076,483...36,124,210
Ensembl chr10:36,078,917...36,116,984
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G |
Jarid2 |
jumonji and AT-rich interaction domain containing 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of JARID2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression increases expression |
ISO EXP |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA]; [Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA] Isoproterenol results in decreased expression of JUN mRNA Isoproterenol results in increased expression of JUN mRNA; Isoproterenol results in increased expression of JUN protein [Isoproterenol co-treated with POSTN protein] results in decreased expression of JUN mRNA; Isoproterenol promotes the reaction [JUN protein binds to FOS protein] |
CTD |
PMID:10710348 PMID:14764439 PMID:21177286 PMID:30303030 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of JUNB [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA] Isoproterenol results in increased expression of JUNB mRNA; Isoproterenol results in increased expression of JUNB protein |
CTD |
PMID:7905536 PMID:21177286 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Kank3 |
KN motif and ankyrin repeat domains 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of KANK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:14,594,358...14,607,675
Ensembl chr 7:14,594,422...14,607,675
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNA5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Kcnb1 |
potassium voltage-gated channel subfamily B member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KCNB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
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G |
Kcnd2 |
potassium voltage-gated channel subfamily D member 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KCND2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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G |
Kcne1 |
potassium voltage-gated channel subfamily E regulatory subunit 1 |
multiple interactions decreases expression |
ISO |
Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] Isoproterenol results in decreased expression of KCNE1 mRNA |
CTD |
PMID:16909339 PMID:20003209 |
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NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
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G |
Kcnh6 |
potassium voltage-gated channel subfamily H member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNH6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:90,949,240...90,970,746
Ensembl chr10:90,949,846...90,970,701
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G |
Kcnq1 |
potassium voltage-gated channel subfamily Q member 1 |
multiple interactions |
ISO EXP |
Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] [Isoproterenol co-treated with POSTN protein] results in decreased expression of KCNQ1 mRNA |
CTD |
PMID:16909339 PMID:30303030 |
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NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
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G |
Kcnt2 |
potassium sodium-activated channel subfamily T member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:51,664,129...52,059,209
Ensembl chr13:51,664,686...52,056,987
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G |
Kdm6b |
lysine demethylase 6B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KDM6B mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
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G |
Kdr |
kinase insert domain receptor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KDR mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of KEAP1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of KEAP1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kif1b |
kinesin family member 1B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KIF1B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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G |
Klf15 |
Kruppel-like factor 15 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLF15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
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G |
Klf3 |
Kruppel like factor 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:43,474,767...43,505,801
Ensembl chr14:43,474,767...43,497,209
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G |
Klhdc8a |
kelch domain containing 8A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KLHDC8A mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277
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G |
Klhl2 |
kelch-like family member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:24,860,763...24,973,348
Ensembl chr16:24,860,667...24,973,341
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G |
Klhl24 |
kelch-like family member 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL24 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
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G |
Klhl40 |
kelch-like family member 40 |
increases expression |
EXP |
Isoproterenol results in increased expression of KLHL40 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 8:121,441,275...121,446,806
Ensembl chr 8:121,441,287...121,446,800
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G |
Klhl41 |
kelch-like family member 41 |
increases expression |
EXP |
Isoproterenol results in increased expression of KLHL41 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222
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G |
Klhl7 |
kelch-like family member 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
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G |
Kmt5a |
lysine methyltransferase 5A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KMT5A mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
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G |
Kpna3 |
karyopherin subunit alpha 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA3 mRNA |
CTD |
PMID:30303030 |
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NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
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G |
Kpna6 |
karyopherin subunit alpha 6 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA6 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 5:141,988,111...142,021,483
Ensembl chr 5:141,991,568...142,021,120
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G |
Kras |
KRAS proto-oncogene, GTPase |
increases expression |
ISO |
Isoproterenol results in increased expression of KRAS mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Krt18 |
keratin 18 |
increases expression |
ISO |
Isoproterenol results in increased expression of KRT18 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Krt222 |
keratin 222 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KRT222 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:84,184,137...84,196,124
Ensembl chr10:84,186,173...84,196,015
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G |
Ky |
kyphoscoliosis peptidase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KY mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:103,086,630...103,126,305
Ensembl chr 8:103,086,630...103,126,024
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G |
Lama2 |
laminin subunit alpha 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of LAMA2 |
CTD |
PMID:18808529 |
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NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
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G |
Lamb1 |
laminin subunit beta 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LAMB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
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G |
Lbh |
LBH regulator of WNT signaling pathway |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LBH mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
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G |
Lbp |
lipopolysaccharide binding protein |
increases expression |
ISO |
Isoproterenol results in increased expression of LBP mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions decreases activity |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:15740881 PMID:16640830 PMID:16906524 PMID:19595682 PMID:20024955 |
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NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Lcn2 |
lipocalin 2 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions increases expression increases secretion |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHA protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] |
CTD |
PMID:17188415 PMID:19146839 PMID:21322096 PMID:21472895 PMID:21671307 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Ldhb |
lactate dehydrogenase B |
multiple interactions increases expression increases secretion |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHB protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] |
CTD |
PMID:17188415 PMID:19146839 PMID:21322096 PMID:21472895 PMID:21671307 |
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NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Lep |
leptin |
decreases secretion increases secretion increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased secretion of LEP protein Isoproterenol results in increased secretion of LEP protein Isoproterenol results in increased expression of LEP protein CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] |
CTD |
PMID:11022189 PMID:20307649 PMID:25111128 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lepr |
leptin receptor |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR protein] Isoproterenol results in increased expression of LEPR mRNA; Isoproterenol results in increased expression of LEPR protein |
CTD |
PMID:20307649 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of LGALS3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lgi1 |
leucine-rich, glioma inactivated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LGI1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:236,043,376...236,084,270
Ensembl chr 1:236,042,954...236,084,616
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G |
Lgr6 |
leucine-rich repeat-containing G protein-coupled receptor 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LGR6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:46,424,382...46,544,074
Ensembl chr13:46,424,383...46,543,945
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G |
Limd1 |
LIM domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LIMD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714
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G |
Lin7a |
lin-7 homolog A, crumbs cell polarity complex component |
increases expression |
ISO |
Isoproterenol results in increased expression of LIN7A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
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G |
Lipe |
lipase E, hormone sensitive type |
increases phosphorylation affects localization multiple interactions increases activity |
ISO EXP |
Isoproterenol results in increased phosphorylation of LIPE protein Isoproterenol affects the localization of LIPE protein Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] Sirolimus promotes the reaction [Isoproterenol results in increased phosphorylation of LIPE protein] |
CTD |
PMID:10894095 PMID:11160373 PMID:21042876 |
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NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
increases expression |
ISO |
Isoproterenol results in increased expression of LITAF mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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G |
Lman1 |
lectin, mannose-binding, 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LMAN1 mRNA |
CTD |
PMID:21823215 |
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NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
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G |
Lmcd1 |
LIM and cysteine-rich domains 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of LMCD1 mRNA |
CTD |
PMID:20211217 PMID:23558518 |
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NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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G |
Lmod3 |
leiomodin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LMOD3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244
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G |
LOC100909593 |
class II histocompatibility antigen, M alpha chain-like |
decreases expression |
ISO |
Isoproterenol results in decreased expression of H2-DMA mRNA |
CTD |
PMID:20003209 |
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G |
LOC690171 |
similar to H3 histone, family 3B |
increases expression |
ISO |
Isoproterenol results in increased expression of H3C3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:11,421,502...11,422,456
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G |
Lonrf3 |
LON peptidase N-terminal domain and ring finger 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of LONRF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:115,565,214...115,603,886
Ensembl chr X:115,565,267...115,598,809
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G |
Lox |
lysyl oxidase |
increases expression |
ISO |
Isoproterenol results in increased expression of LOX mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
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G |
Lpl |
lipoprotein lipase |
multiple interactions decreases expression increases expression decreases activity |
EXP ISO |
cirazoline promotes the reaction [Isoproterenol results in increased expression of LPL mRNA]; naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein] Isoproterenol results in decreased expression of LPL mRNA |
CTD |
PMID:9032464 PMID:16906524 PMID:21335049 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrat |
lecithin retinol acyltransferase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LRAT mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619
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G |
Lrg1 |
leucine-rich alpha-2-glycoprotein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRG1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
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G |
Lrpprc |
leucine-rich pentatricopeptide repeat containing |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of LRPPRC mRNA |
CTD |
PMID:30303030 |
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NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293
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G |
Lrrc52 |
leucine rich repeat containing 52 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC52 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:79,597,244...79,620,640
Ensembl chr13:79,597,245...79,620,640
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G |
Lrrc58 |
leucine rich repeat containing 58 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC58 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829
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Lrrc8c |
leucine rich repeat containing 8 VRAC subunit C |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC8C mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:4,223,901...4,315,590
Ensembl chr14:4,227,832...4,315,249
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Lsm14a |
LSM14A mRNA processing body assembly factor |
increases expression |
ISO |
Isoproterenol results in increased expression of LSM14A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:86,964,800...87,009,325
Ensembl chr 1:86,964,828...87,009,276
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Lsm3 |
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LSM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269
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Ltbp2 |
latent transforming growth factor beta binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of LTBP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
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Lyve1 |
lymphatic vessel endothelial hyaluronan receptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LYVE1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
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Maf |
MAF bZIP transcription factor |
increases expression |
EXP |
Isoproterenol results in increased expression of MAF mRNA |
CTD |
PMID:30303030 |
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NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
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Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Isoproterenol results in increased expression of MAFF mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
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Man1a1 |
mannosidase, alpha, class 1A, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAN1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824
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Man2a1 |
mannosidase, alpha, class 2A, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAN2A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
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Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
EXP ISO |
MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein] MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:10888249 PMID:21177286 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP2K4 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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Map3k2 |
mitogen activated protein kinase kinase kinase 2 |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP3K2 mRNA Isoproterenol results in decreased expression of MAP3K2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MAP3K5 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Map3k6 |
mitogen-activated protein kinase kinase kinase 6 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
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Map3k8 |
mitogen-activated protein kinase kinase kinase 8 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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Map7 |
microtubule-associated protein 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAP7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574
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Mapk1 |
mitogen activated protein kinase 1 |
increases activity increases phosphorylation multiple interactions |
ISO EXP |
Isoproterenol results in increased activity of MAPK1 protein Isoproterenol results in increased phosphorylation of MAPK1 protein DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein] erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK1 protein; Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein] [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:10888249 PMID:11093795 PMID:15292328 PMID:16980553 PMID:17623046 PMID:17925438 PMID:19002953 PMID:19483313 PMID:21177286 PMID:26692091 PMID:33210414 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:18089841 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation increases activity |
ISO EXP |
[Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein] DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein; Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:10888249 PMID:11093795 PMID:15292328 PMID:16980553 PMID:17623046 PMID:17925438 PMID:19002953 PMID:19483313 PMID:20215810 PMID:21177286 PMID:26692091 PMID:33210414 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases activity increases phosphorylation |
ISO EXP |
candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] Isoproterenol results in increased activity of MAPK8 protein 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:10591028 PMID:15951400 PMID:20562518 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Marchf7 |
membrane associated ring-CH-type finger 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of MARCHF7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168
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Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MAS1 protein |
CTD |
PMID:20409916 |
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NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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Mb |
myoglobin |
increases expression multiple interactions increases secretion |
EXP |
Isoproterenol results in increased expression of MB protein sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein] Isoproterenol results in increased secretion of MB protein |
CTD |
PMID:533011 PMID:19628585 PMID:32627257 |
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NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Mbd1 |
methyl-CpG binding domain protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MBD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
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Mbd5 |
methyl-CpG binding domain protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of MBD5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:33,588,854...33,738,730
Ensembl chr 3:33,333,554...33,730,156
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Mccc2 |
methylcrotonyl-CoA carboxylase subunit 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MCCC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
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Mcf2l |
MCF.2 cell line derived transforming sequence-like |
increases expression |
ISO |
Isoproterenol results in increased expression of MCF2L mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733
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Mdga1 |
MAM domain containing glycosylphosphatidylinositol anchor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MDGA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:7,900,327...7,963,471
Ensembl chr20:7,904,358...7,963,471
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Mef2c |
myocyte enhancer factor 2C |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of MEF2C mRNA Isoproterenol results in increased expression of MEF2C mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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Meig1 |
meiosis/spermiogenesis associated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MEIG1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:74,810,791...74,828,433
Ensembl chr17:74,814,632...74,828,433
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Metrn |
meteorin, glial cell differentiation regulator |
decreases expression |
ISO |
Isoproterenol results in decreased expression of METRN mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701
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Mfap5 |
microfibril associated protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of MFAP5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458
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G |
Mfn1 |
mitofusin 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MFN1 protein |
CTD |
PMID:27491814 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mfn2 |
mitofusin 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MFN2 protein |
CTD |
PMID:26692091 PMID:27491814 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mgll |
monoglyceride lipase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MGLL mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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Mgp |
matrix Gla protein |
increases expression |
ISO |
Isoproterenol results in increased expression of MGP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
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Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MGST1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Miat |
myocardial infarction associated transcript |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of MIAT Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT] |
CTD |
PMID:34435724 |
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NCBI chr12:44,414,620...44,429,852
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G |
Mib1 |
MIB E3 ubiquitin protein ligase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MIB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689
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Mir133a1 |
microRNA 133a-1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MIR133A1 |
CTD |
PMID:19893015 |
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NCBI chr18:1,885,082...1,885,168
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Mir142 |
microRNA 142 |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR142 mRNA |
CTD |
PMID:29355689 |
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NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
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Mir155 |
microRNA 155 |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR155 mRNA |
CTD |
PMID:29355689 |
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NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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G |
Mir19a |
microRNA 19a |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR19A mRNA |
CTD |
PMID:29355689 |
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NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
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G |
Mir200a |
microRNA 200a |
multiple interactions decreases expression |
EXP |
Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA] |
CTD |
PMID:34435724 |
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NCBI chr 5:166,648,494...166,648,582
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G |
Mir208a |
microRNA 208a |
increases expression decreases expression |
EXP |
Isoproterenol results in increased expression of MIR208A Isoproterenol results in decreased expression of MIR208A mRNA |
CTD |
PMID:26454886 PMID:29355689 |
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NCBI chr15:28,425,570...28,425,652
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G |
Mir208b |
microRNA 208b |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR208B mRNA |
CTD |
PMID:29355689 |
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NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749
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Mir21 |
microRNA 21 |
increases expression |
EXP |