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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:memantine
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Accession:CHEBI:64312 term browser browse the term
Definition:A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Synonyms:exact_synonym: 3,5-dimethyladamantan-1-amine
 related_synonym: 1-Amino-3,5-dimethyladamantane;   3,5-Dimethyl-1-adamantanamine;   3,5-Dimethyl-1-aminoadamantane;   3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine;   Formula=C12H21N;   InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3;   InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N;   SMILES=CC12CC3CC(C)(C1)CC(N)(C3)C2;   memantina;   memantinum
 alt_id: CHEBI:34832
 xref: CAS:19982-08-2;   DrugBank:DB01043;   Drug_Central:1679;   KEGG:C13736;   KEGG:D08174;   LINCS:LSM-5154
 xref_mesh: MESH:D008559
 xref: PMID:20104942;   PMID:21953515;   PMID:21955815;   PMID:22030128;   PMID:22134197;   PMID:22245025;   PMID:22248638;   PMID:22290557;   PMID:22297273;   PMID:22300835;   PMID:22311362;   PMID:22327556;   PMID:22329473;   PMID:22392787;   PMID:22414570;   PMID:22425751;   Patent:US2011282100;   Reaxys:2075983;   Wikipedia:Memantine
 cyclic_relationship: is_conjugate_base_of CHEBI:64325



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memantine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP asoxime chloride inhibits the reaction [Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein] CTD PMID:2241428 PMID:30682440 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:21290839 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Memantine analog inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; Memantine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein] CTD PMID:32092300 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein] CTD PMID:24333387 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP3 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [salsolinol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Memantine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CASP3 protein]
Memantine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]
CTD PMID:17996985 PMID:19959636 PMID:20347921 PMID:24333387 PMID:29800586 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP7 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP7 protein] CTD PMID:19959636 PMID:20347921 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein] CTD PMID:23562514 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] CTD PMID:24333387 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA] CTD PMID:24333387 NCBI chr16:74,786,771...75,496,402
Ensembl chr16:74,791,509...75,496,407
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein] CTD PMID:24333387 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein] CTD PMID:32092300 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM protein] CTD PMID:24333387 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein] CTD PMID:23562514 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein] CTD PMID:23562514 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Penk proenkephalin multiple interactions EXP Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] CTD PMID:14642644 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP Memantine results in increased expression of PRKCG mRNA CTD PMID:11169168 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Memantine inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:24333387 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        pharmacological role 18850
          neurotransmitter agent 16461
            dopaminergic agent 5109
              memantine 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            inorganic hydride 17700
                              pnictogen hydride 17681
                                nitrogen hydride 17552
                                  azane 17289
                                    ammonia 17288
                                      organic amino compound 17288
                                        primary amino compound 7981
                                          primary amine 5726
                                            primary aliphatic amine 139
                                              memantine 18
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