CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: leupeptin
Accession: CHEBI:6426
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Definition: A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death.
Synonyms: exact_synonym: N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide
related_synonym: Ac-L-Leu-L-Leu-L-Arg-H; Ac-LLR-H; Ac-Leu-Leu-Arg-H; Ac-Leu-Leu-argininal; Formula=C20H38N6O4; InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17?/m0/s1; InChIKey=GDBQQVLCIARPGH-ULQDDVLXSA-N; N-acetyl-L-leucyl-L-leucyl-L-argininal; N-acetyl-leucylleucylargininal; SMILES=C([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)(=O)[H]; acetyl-L-leucyl-L-leucyl-L-argininal
xref: CAS:55123-66-5; HMDB:HMDB0254042; KEGG:C01591
xref_mesh: MESH:C032854
xref: MetaCyc:LEUPEPTIN; PMCID:PMC6750451; PMID:11950531; PMID:14704627; PMID:15106277; PMID:15804428; PMID:15963736; PMID:16707850; PMID:17379854; PMID:18093577; PMID:18443109; PMID:19168046; PMID:20828747; PMID:20844259; PMID:21246210; PMID:21460622; PMID:22169219; PMID:22206578; PMID:22291646; PMID:24393046; PMID:25870226; PMID:26365578; PMID:26399337; PMID:27919045; PMID:28456988; PMID:32609431; PMID:33016476; PMID:33512650; PMID:34579576; PMID:7295735; PMID:9531495; Reaxys:2402463; Reaxys:24140639; Wikipedia:Leupeptin
cyclic_relationship: is_conjugate_base_of CHEBI:192489
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]
CTD
PMID:21818627
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aqp8
aquaporin 8
multiple interactions
EXP
leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein]
CTD
PMID:17110522
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein]
CTD
PMID:16242776
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp6
caspase 6
multiple interactions
ISO
leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein]
CTD
PMID:15086513
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Cdc25c
cell division cycle 25C
multiple interactions increases expression
ISO
leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] leupeptin results in increased expression of CDC25C protein
CTD
PMID:29074359
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdh1
cadherin 1
multiple interactions
EXP
leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein]
CTD
PMID:19464575
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cip2a
cellular inhibitor of PP2A
multiple interactions
ISO
leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein]
CTD
PMID:24493623
NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
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Ctnnb1
catenin beta 1
multiple interactions
EXP
leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein]
CTD
PMID:19464575
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctsb
cathepsin B
multiple interactions
ISO
leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein]
CTD
PMID:11071371
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
CTD
PMID:9143349
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Ddx3x
DEAD-box helicase 3, X-linked
multiple interactions
ISO
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]
CTD
PMID:30821613
NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168
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Egf
epidermal growth factor
decreases degradation
ISO
leupeptin results in decreased degradation of EGF protein
CTD
PMID:23125191
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Eif4a1
eukaryotic translation initiation factor 4A1
multiple interactions
ISO
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]
CTD
PMID:30821613
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
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Eif4h
eukaryotic translation initiation factor 4H
multiple interactions
ISO
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]
CTD
PMID:30821613
NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
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Gja1
gap junction protein, alpha 1
multiple interactions
ISO
leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA]
CTD
PMID:17559834
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]; leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]
CTD
PMID:33458793
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Il1a
interleukin 1 alpha
multiple interactions
ISO
leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein]
CTD
PMID:21818627
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il6
interleukin 6
multiple interactions
ISO
leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]
CTD
PMID:21818627
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Klk8
kallikrein related-peptidase 8
decreases activity
ISO
leupeptin results in decreased activity of KLK8 protein
CTD
PMID:16800733
NCBI chr 1:94,251,803...94,258,646
Ensembl chr 1:94,251,803...94,258,646
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
leupeptin promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]
CTD
PMID:33458793
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mt1
metallothionein 1
multiple interactions
ISO
leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein]
CTD
PMID:28507149
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mt2A
metallothionein 2A
multiple interactions
ISO
leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein]
CTD
PMID:28507149
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Nefl
neurofilament light chain
multiple interactions
ISO
leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein]
CTD
PMID:11071371
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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Plin1
perilipin 1
multiple interactions decreases degradation
ISO
leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein] leupeptin results in decreased degradation of PLIN1 protein
CTD
PMID:17488708
NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
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Tgfbr1
transforming growth factor, beta receptor 1
increases expression
EXP
leupeptin results in increased expression of TGFBR1 protein
CTD
PMID:27826032
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Xaf1
XIAP associated factor 1
multiple interactions
ISO
leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein]
CTD
PMID:28507149
NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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