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ONTOLOGY REPORT - ANNOTATIONS


Term:leupeptin
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Accession:CHEBI:6426 term browser browse the term
Definition:A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequence.
Synonyms:exact_synonym: N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide
 related_synonym: Ac-L-Leu-L-Leu-L-Arg-H;   Ac-LLR-H;   Ac-Leu-Leu-Arg-H;   Formula=C20H38N6O4;   InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17?/m0/s1;   InChIKey=GDBQQVLCIARPGH-ULQDDVLXSA-N;   N-acetyl-L-leucyl-L-leucyl-L-argininal;   N-acetyl-leucylleucylargininal;   SMILES=C([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)(=O)[H]
 xref: CAS:55123-66-5 "ChemIDplus";   KEGG:C01591
 xref_mesh: MESH:C032854
 xref: MetaCyc:LEUPEPTIN;   PMID:24393046 "Europe PMC";   PMID:26365578 "Europe PMC";   PMID:26399337 "Europe PMC";   Reaxys:2402463 "Reaxys";   Reaxys:24140639 "Reaxys";   Wikipedia:Leupeptin


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leupeptin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aqp8 aquaporin 8 JBrowse link 1 193,424,818 193,430,665 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Klk8 kallikrein related-peptidase 8 JBrowse link 1 99,735,168 99,742,011 RGD:6480464
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:6480464
G Plin1 perilipin 1 JBrowse link 1 141,458,907 141,470,927 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        solvent 16073
          formic acid 7714
            formyl group 7680
              aldehyde 7680
                leupeptin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                peptide 9295
                                                  oligopeptide 1073
                                                    tripeptide 864
                                                      leupeptin 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.