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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:leupeptin
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Accession:CHEBI:6426 term browser browse the term
Definition:A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death.
Synonyms:exact_synonym: N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide
 related_synonym: Ac-L-Leu-L-Leu-L-Arg-H;   Ac-LLR-H;   Ac-Leu-Leu-Arg-H;   Ac-Leu-Leu-argininal;   Formula=C20H38N6O4;   InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17?/m0/s1;   InChIKey=GDBQQVLCIARPGH-ULQDDVLXSA-N;   N-acetyl-L-leucyl-L-leucyl-L-argininal;   N-acetyl-leucylleucylargininal;   SMILES=C([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)(=O)[H];   acetyl-L-leucyl-L-leucyl-L-argininal
 xref: CAS:55123-66-5;   HMDB:HMDB0254042;   KEGG:C01591
 xref_mesh: MESH:C032854
 xref: MetaCyc:LEUPEPTIN;   PMCID:PMC6750451;   PMID:11950531;   PMID:14704627;   PMID:15106277;   PMID:15804428;   PMID:15963736;   PMID:16707850;   PMID:17379854;   PMID:18093577;   PMID:18443109;   PMID:19168046;   PMID:20828747;   PMID:20844259;   PMID:21246210;   PMID:21460622;   PMID:22169219;   PMID:22206578;   PMID:22291646;   PMID:24393046;   PMID:25870226;   PMID:26365578;   PMID:26399337;   PMID:27919045;   PMID:28456988;   PMID:32609431;   PMID:33016476;   PMID:33512650;   PMID:34579576;   PMID:7295735;   PMID:9531495;   Reaxys:2402463;   Reaxys:24140639;   Wikipedia:Leupeptin
 cyclic_relationship: is_conjugate_base_of CHEBI:192489



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leupeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:21818627 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp8 aquaporin 8 multiple interactions EXP leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein] CTD PMID:17110522 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein] CTD PMID:16242776 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp6 caspase 6 multiple interactions ISO leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein] CTD PMID:15086513 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
increases expression
ISO leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]
leupeptin results in increased expression of CDC25C protein
CTD PMID:29074359 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein] CTD PMID:19464575 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cip2a cellular inhibitor of PP2A multiple interactions ISO leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein] CTD PMID:19464575 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] CTD PMID:30821613 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Egf epidermal growth factor decreases degradation ISO leupeptin results in decreased degradation of EGF protein CTD PMID:23125191 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] CTD PMID:30821613 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] CTD PMID:30821613 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]; leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:33458793 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein] CTD PMID:21818627 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] CTD PMID:21818627 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klk8 kallikrein related-peptidase 8 decreases activity ISO leupeptin results in decreased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:94,251,803...94,258,646
Ensembl chr 1:94,251,803...94,258,646
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO leupeptin promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] CTD PMID:33458793 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein] CTD PMID:28507149 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein] CTD PMID:28507149 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nefl neurofilament light chain multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Plin1 perilipin 1 multiple interactions
decreases degradation
ISO leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein]
leupeptin results in decreased degradation of PLIN1 protein
CTD PMID:17488708 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP leupeptin results in increased expression of TGFBR1 protein CTD PMID:27826032 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein] CTD PMID:28507149 NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        solvent 17050
          formic acid 9050
            formyl group 9012
              aldehyde 9012
                leupeptin 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                peptide 11133
                                                  oligopeptide 1336
                                                    tripeptide 972
                                                      leupeptin 26
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