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ONTOLOGY REPORT - ANNOTATIONS


Term:2,3-dimethoxynaphthalene-1,4-dione
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Accession:CHEBI:64215 term browser browse the term
Definition:A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Synonyms:exact_synonym: 2,3-dimethoxy-1,4-naphthoquinone
 related_synonym: 2,3-dimethoxy-1,4-naphthalenedione;   DMNQ;   Formula=C12H10O4;   InChI=1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3;   InChIKey=ZEGDFCCYTFPECB-UHFFFAOYSA-N;   NSC 69355;   SMILES=COC1=C(OC)C(=O)c2ccccc2C1=O
 xref: CAS:6956-96-3
 xref_mesh: MESH:C063002
 xref: PMID:19338340;   PMID:20803752;   PMID:8103030;   PMID:8393647;   Patent:US4628062;   Patent:US5314914;   Reaxys:2049895


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2,3-dimethoxynaphthalene-1,4-dione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acot2 acyl-CoA thioesterase 2 JBrowse link 6 107,460,596 107,468,324 RGD:6480464
G Acp2 acid phosphatase 2, lysosomal JBrowse link 3 80,020,346 80,030,365 RGD:6480464
G Acsl1 acyl-CoA synthetase long-chain family member 1 JBrowse link 16 48,937,456 49,003,898 RGD:6480464
G Adh6 alcohol dehydrogenase 6 (class V) JBrowse link 2 243,656,568 243,687,857 RGD:6480464
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:6480464
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:6480464
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 JBrowse link 6 108,146,552 108,167,185 RGD:6480464
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:6480464
G Arse arylsulfatase E JBrowse link 2 122,876,645 122,884,673 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:6480464
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:6480464
G Azgp1 alpha-2-glycoprotein 1, zinc-binding JBrowse link 12 19,196,565 19,203,094 RGD:6480464
G Bcat1 branched chain amino acid transaminase 1 JBrowse link 4 179,259,305 179,340,021 RGD:6480464
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 4 140,703,619 140,709,319 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B JBrowse link 3 110,367,949 110,420,471 RGD:6480464
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6480464
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:6480464
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:6480464
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:6480464
G Cetn2 centrin 2 JBrowse link X 152,927,852 152,933,095 RGD:6480464
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:6480464
G Chpt1 choline phosphotransferase 1 JBrowse link 7 29,019,518 29,070,928 RGD:6480464
G Cideb cell death-inducing DFFA-like effector b JBrowse link 15 34,439,844 34,444,244 RGD:6480464
G Cks2 CDC28 protein kinase regulatory subunit 2 JBrowse link 17 13,587,664 13,593,423 RGD:6480464
G Clgn calmegin JBrowse link 19 24,545,257 24,578,527 RGD:6480464
G Clptm1 CLPTM1 regulator of GABA type A receptor forward trafficking JBrowse link 1 80,549,051 80,580,665 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:6480464
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:6480464
G Dusp13 dual specificity phosphatase 13 JBrowse link 15 2,524,435 2,541,734 RGD:6480464
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:6480464
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:6480464
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:6480464
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fosl1 FOS like 1, AP-1 transcription factor subunit JBrowse link 1 220,826,560 220,835,066 RGD:6480464
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Ggcx gamma-glutamyl carboxylase JBrowse link 4 100,277,345 100,293,097 RGD:6480464
G Ghitm growth hormone inducible transmembrane protein JBrowse link 16 14,370,269 14,382,647 RGD:6480464
G Gla galactosidase, alpha JBrowse link X 105,405,915 105,417,331 RGD:6480464
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:6480464
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:6480464
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6480464
G Gtpbp6 GTP binding protein 6 (putative) JBrowse link 12 52,637,000 52,640,869 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:6480464
G Hmgn2 high mobility group nucleosomal binding domain 2 JBrowse link 5 152,195,359 152,198,813 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ier2 immediate early response 2 JBrowse link 19 25,774,146 25,775,670 RGD:6480464
G Ifrd1 interferon-related developmental regulator 1 JBrowse link 6 60,132,025 60,151,354 RGD:6480464
G Igsf1 immunoglobulin superfamily, member 1 JBrowse link X 136,792,637 136,808,107 RGD:6480464
G Il17rb interleukin 17 receptor B JBrowse link 16 6,064,287 6,077,978 RGD:6480464
G Itgb3bp integrin subunit beta 3 binding protein JBrowse link 5 118,476,410 118,541,928 RGD:6480464
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 JBrowse link 16 6,983,779 7,007,288 RGD:6480464
G Kif20b kinesin family member 20B JBrowse link 1 253,220,038 253,275,523 RGD:6480464
G Kif22 kinesin family member 22 JBrowse link 1 198,461,406 198,476,430 RGD:6480464
G Kif23 kinesin family member 23 JBrowse link 8 66,866,043 66,893,241 RGD:6480464
G Kif2c kinesin family member 2C JBrowse link 5 136,027,923 136,053,268 RGD:6480464
G Krt19 keratin 19 JBrowse link 10 88,055,843 88,060,560 RGD:6480464
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:6480464
G Mad2l1 mitotic arrest deficient 2 like 1 JBrowse link 4 97,530,993 97,543,179 RGD:6480464
G Maff MAF bZIP transcription factor F JBrowse link 7 120,580,743 120,592,095 RGD:6480464
G Mapre2 microtubule-associated protein, RP/EB family, member 2 JBrowse link 18 14,814,149 15,780,290 RGD:6480464
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:6480464
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase JBrowse link 6 91,476,698 91,479,187 RGD:6480464
G Mxra7 matrix remodeling associated 7 JBrowse link 10 105,743,669 105,772,038 RGD:6480464
G Ncapg non-SMC condensin I complex, subunit G JBrowse link 14 69,898,268 69,927,885 RGD:6480464
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 JBrowse link 17 22,984,792 23,179,701 RGD:6480464
G Nek2 NIMA-related kinase 2 JBrowse link 13 110,511,546 110,524,750 RGD:6480464
G Nek4 NIMA-related kinase 4 JBrowse link 16 7,035,002 7,080,272 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nolc1 nucleolar and coiled-body phosphoprotein 1 JBrowse link 1 265,829,055 265,839,819 RGD:6480464
G Nucb2 nucleobindin 2 JBrowse link 1 185,106,773 185,143,278 RGD:6480464
G Nup107 nucleoporin 107 JBrowse link 7 60,781,724 60,825,225 RGD:6480464
G Nusap1 nucleolar and spindle associated protein 1 JBrowse link 3 111,422,267 111,452,600 RGD:6480464
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:6480464
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6480464
G Pbk PDZ binding kinase JBrowse link 15 42,489,253 42,500,377 RGD:6480464
G Pgc progastricsin JBrowse link 9 15,266,699 15,274,917 RGD:6480464
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6480464
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:6480464
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:6480464
G Pon2 paraoxonase 2 JBrowse link 4 30,344,705 30,380,119 RGD:6480464
G Ppih peptidylprolyl isomerase H JBrowse link 5 138,343,934 138,361,743 RGD:6480464
G Psph phosphoserine phosphatase JBrowse link 12 30,514,128 30,526,551 RGD:6480464
G Pttg1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 10 29,014,332 29,026,088 RGD:6480464
G Racgap1 Rac GTPase-activating protein 1 JBrowse link 7 141,277,303 141,308,849 RGD:6480464
G Rad23b RAD23 homolog B, nucleotide excision repair protein JBrowse link 5 72,103,704 72,141,701 RGD:6480464
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:6480464
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:6480464
G Rbpms RNA binding protein, mRNA processing factor JBrowse link 16 61,954,569 62,109,998 RGD:6480464
G Recql RecQ like helicase JBrowse link 4 176,581,892 176,606,520 RGD:6480464
G Rfc2 replication factor C subunit 2 JBrowse link 12 25,130,375 25,143,480 RGD:6480464
G Rfc4 replication factor C subunit 4 JBrowse link 11 81,358,592 81,373,044 RGD:6480464
G Rnaseh2a ribonuclease H2, subunit A JBrowse link 19 26,074,980 26,084,780 RGD:6480464
G Ruvbl2 RuvB-like AAA ATPase 2 JBrowse link 1 101,413,766 101,426,970 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:6480464
G Serpina6 serpin family A member 6 JBrowse link 6 127,523,948 127,534,178 RGD:6480464
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:6480464
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6480464
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6480464
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6480464
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:6480464
G Smc4 structural maintenance of chromosomes 4 JBrowse link 2 165,600,934 165,629,415 RGD:6480464
G Snrpa small nuclear ribonucleoprotein polypeptide A JBrowse link 1 83,999,670 84,008,429 RGD:6480464
G Spag5 sperm associated antigen 5 JBrowse link 10 65,552,780 65,585,773 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Sqor sulfide quinone oxidoreductase JBrowse link 3 114,894,944 114,939,375 RGD:6480464
G Srsf2 serine and arginine rich splicing factor 2 JBrowse link 10 105,792,779 105,795,986 RGD:6480464
G Srsf7 serine and arginine rich splicing factor 7 JBrowse link 6 2,879,312 2,886,505 RGD:6480464
G St6galnac4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 JBrowse link 3 11,607,103 11,619,595 RGD:6480464
G Tcap titin-cap JBrowse link 10 86,337,705 86,338,414 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tnfaip8 TNF alpha induced protein 8 JBrowse link 18 44,664,310 44,779,914 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tpx2 TPX2, microtubule nucleation factor JBrowse link 3 148,327,965 148,370,187 RGD:6480464
G Trip13 thyroid hormone receptor interactor 13 JBrowse link 1 31,967,980 32,012,923 RGD:6480464
G Tspan7 tetraspanin 7 JBrowse link X 13,261,551 13,282,886 RGD:6480464
G Tst thiosulfate sulfurtransferase JBrowse link 7 119,616,323 119,623,072 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ube2c ubiquitin-conjugating enzyme E2C JBrowse link 3 161,236,971 161,239,371 RGD:6480464
G Ube2v2 ubiquitin conjugating enzyme E2 V2 JBrowse link 11 89,557,273 89,591,175 RGD:6480464
G Vtn vitronectin JBrowse link 10 65,767,960 65,771,040 RGD:6480464
G Zw10 zw10 kinetochore protein JBrowse link 8 53,365,881 53,390,742 RGD:6480464
G Zwint ZW10 interacting kinetochore protein JBrowse link 20 17,075,781 17,091,715 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19789
    role 19735
      chemical role 19268
        environmental contaminant 18604
          naphthalene 2335
            1,4-naphthoquinone 169
              2,3-dimethoxynaphthalene-1,4-dione 143
Path 2
Term Annotations click to browse term
  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19569
                        carbon atom 19558
                          organic molecular entity 19558
                            organic group 18473
                              organic divalent group 18467
                                organodiyl group 18467
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      ketone 15993
                                        cyclic ketone 13469
                                          quinone 8246
                                            naphthoquinone 1424
                                              1,4-naphthoquinones 1400
                                                1,4-naphthoquinone 169
                                                  2,3-dimethoxynaphthalene-1,4-dione 143
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.