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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulindac sulfone
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Accession:CHEBI:64212 term browser browse the term
Definition:A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: 5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid;   Formula=C20H17FO4S;   InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)(=O)=O;   cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid;   exisulind
 xref: CAS:59973-80-7;   Drug_Central:3219
 xref_mesh: MESH:C025463
 xref: PMID:17016604;   PMID:20332437;   PMID:20374023;   PMID:21515355;   PMID:21735687;   PMID:22364235;   Patent:EP1336602;   Patent:US5696159;   Patent:US5776962;   Reaxys:7887099;   Wikipedia:Exisulind


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sulindac sulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
multiple interactions
ISO
EXP
sulindac sulfone affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form
CTD PMID:15570007 PMID:17908994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
increases expression
ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]; GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in increased expression of ALOX15 mRNA; sulindac sulfone results in increased expression of ALOX15 protein
CTD PMID:11861401 PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP
AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]; sulindac sulfone results in decreased expression of and results in decreased activity of AR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein
CTD PMID:14581372 PMID:17908994 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfone CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]; sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein
sulindac sulfone results in increased activity of CASP3 protein
CTD PMID:11051267 PMID:14555707 PMID:15548677 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO sulindac sulfone results in increased activity of CASP8 protein CTD PMID:11559570 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
sulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein
CTD PMID:12392815 PMID:15188006 PMID:17908994 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sulindac sulfone results in increased expression of CDKN1A mRNA; sulindac sulfone results in increased expression of CDKN1A protein CTD PMID:18593937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO sulindac sulfone results in increased expression of CDKN1B mRNA; sulindac sulfone results in increased expression of CDKN1B protein CTD PMID:18593937 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]
sulindac sulfone results in increased expression of CTNNB1 protein
CTD PMID:10910034 PMID:11602670 PMID:12392815 PMID:14555707 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases ubiquitination
increases phosphorylation
decreases phosphorylation
decreases expression
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]
sulindac sulfone results in increased ubiquitination of EGFR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form
sulindac sulfone results in increased phosphorylation of EGFR protein
sulindac sulfone results in decreased phosphorylation of EGFR protein
CTD PMID:17908994 PMID:20332299 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO sulindac sulfone results in decreased expression of ERBB2 protein CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfone results in decreased expression of ESR1 mRNA; sulindac sulfone results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
decreases expression
ISO GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in decreased expression of GATA6 protein
CTD PMID:11861401 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO sulindac sulfone results in increased expression of HINT1 mRNA; sulindac sulfone results in increased expression of HINT1 protein CTD PMID:18593937 NCBI chr10:38,989,516...38,993,259 JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
increases expression
ISO sulindac sulfone results in increased activity of HPGD protein
sulindac sulfone results in increased expression of HPGD mRNA
CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Il24 interleukin 24 increases expression ISO sulindac sulfone results in increased expression of IL24 protein CTD PMID:15713900 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15548677 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] CTD PMID:15548677 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein] CTD PMID:15548677 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfone results in increased activity of MAPK8 protein CTD PMID:11051267 PMID:11278263 PMID:15970671 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO sulindac sulfone results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sulindac sulfone results in increased degradation of and results in decreased expression of NFKBIA protein CTD PMID:18059344 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO sulindac sulfone results in increased expression of NGFR mRNA; sulindac sulfone results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
ISO sulindac sulfone results in increased activity of NQO1 protein
sulindac sulfone results in increased expression of NQO1 mRNA
CTD PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO sulindac sulfone results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde2a phosphodiesterase 2A decreases activity
multiple interactions
ISO sulindac sulfone results in decreased activity of PDE2A protein
sulindac sulfone binds to and results in decreased activity of PDE2A protein
CTD PMID:10910034 PMID:11602670 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions
decreases activity
ISO sulindac sulfone binds to and results in decreased activity of PDE5A protein
sulindac sulfone results in decreased activity of PDE5A protein
CTD PMID:10910034 PMID:11602670 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfone results in decreased expression of PGR mRNA; sulindac sulfone results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfone results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO sulindac sulfone results in increased expression of PPARD mRNA CTD PMID:11948457 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]
sulindac sulfone results in increased expression of PPARG mRNA
CTD PMID:11948457 PMID:14506281 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO sulindac sulfone results in increased expression of PRKG1 protein CTD PMID:11602670 PMID:16731751 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Psca prostate stem cell antigen increases expression ISO sulindac sulfone results in increased expression of PSCA mRNA CTD PMID:16949054 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form CTD PMID:11375891 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
sulindac sulfone results in decreased expression of PTGS2 protein
sulindac sulfone results in decreased expression of PTGS2 mRNA
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]
[sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
sulindac sulfone results in increased expression of PTGS2 mRNA
CTD PMID:11118042 PMID:11375891 PMID:11948457 PMID:17908994 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sulindac sulfone affects the localization of RELA protein CTD PMID:18059344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA] CTD PMID:14506281 PMID:16262603 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein] CTD PMID:17908994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases glucuronidation
increases expression
ISO sulindac sulfone results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of sulindac sulfone
sulindac sulfone results in increased expression of UGT1A1 mRNA
CTD PMID:15843492 PMID:17985343 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO sulindac sulfone results in increased phosphorylation of VASP protein CTD PMID:16166323 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO sulindac sulfone results in decreased expression of YWHAE protein CTD PMID:17409426 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          apoptosis inducer 13236
            sulindac sulfone 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          acetic acid 10853
                                            sulindac 785
                                              sulindac sulfone 50
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