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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
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Accession:CHEBI:64210 term browser browse the term
Definition:An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms:related_synonym: AM580;   Am 580;   CD-336;   Formula=C22H25NO3;   InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26);   InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N;   SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
 xref: Beilstein:3565084;   CAS:102121-60-8;   KEGG:C15619;   LINCS:LSM-2132
 xref_mesh: MESH:C068073
 xref: PDB:3KMR;   PMID:18271925;   PMID:18416830;   PMID:19700416;   PMID:19790202;   PMID:20147703;   PMID:20453882;   PMID:21150871;   PMID:21310893;   PMID:21715427;   PMID:22258322;   PMID:22353356;   Reaxys:3565084


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4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Am 580 promotes the reaction [Tretinoin results in increased expression of ABCG2 mRNA] CTD PMID:20562004 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ada adenosine deaminase increases expression ISO Am 580 results in increased expression of ADA mRNA CTD PMID:16982809 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 increases expression ISO Am 580 results in increased expression of AGPAT4 mRNA CTD PMID:16982809 NCBI chr 1:48,525,131...48,633,798
Ensembl chr 1:48,527,323...48,633,345 		JBrowse link
G Agrn agrin decreases expression ISO Am 580 results in decreased expression of AGRN mRNA CTD PMID:16982809 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Ajap1 adherens junctions associated protein 1 increases expression ISO Am 580 results in increased expression of AJAP1 mRNA CTD PMID:16982809 NCBI chr 5:163,907,846...164,021,004
Ensembl chr 5:163,907,847...164,020,317 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 increases expression ISO Am 580 results in increased expression of APLP2 mRNA CTD PMID:16982809 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855 		JBrowse link
G Ar androgen receptor decreases activity ISO Am 580 results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO Am 580 results in decreased expression of ATP2B1 mRNA CTD PMID:16982809 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Bag2 BAG cochaperone 2 increases expression ISO Am 580 results in increased expression of BAG2 mRNA CTD PMID:16982809 NCBI chr 9:35,970,033...35,980,677
Ensembl chr 9:35,970,033...35,980,721 		JBrowse link
G C19h16orf46 similar to human chromosome 16 open reading frame 46 decreases expression ISO Am 580 results in decreased expression of C16ORF46 mRNA CTD PMID:16982809 NCBI chr19:45,017,499...45,033,453
Ensembl chr19:45,022,280...45,032,683 		JBrowse link
G Calcrl calcitonin receptor like receptor decreases expression ISO Am 580 results in decreased expression of CALCRL mRNA CTD PMID:16982809 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910 		JBrowse link
G Capn1 calpain 1 decreases expression
decreases activity		 ISO Am 580 results in decreased expression of CAPN1 mRNA
Am 580 results in decreased activity of CAPN1 protein		 CTD PMID:17460283 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 decreases expression
decreases activity
multiple interactions		 ISO Am 580 results in decreased expression of CAPN2 mRNA
Am 580 results in decreased activity of CAPN2 protein
Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]		 CTD PMID:17460283 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cd1d1 CD1d1 molecule increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD1D mRNA
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]		 CTD PMID:16982809 PMID:17392484 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd300a Cd300a molecule increases expression ISO Am 580 results in increased expression of CD300A mRNA CTD PMID:16982809 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd300lb CD300 molecule-like family member b increases expression ISO Am 580 results in increased expression of CD300LB mRNA CTD PMID:16982809 NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790 		JBrowse link
G Cd300lf Cd300 molecule-like family member F increases expression ISO Am 580 results in increased expression of CD300LF mRNA CTD PMID:16982809 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041 		JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD38 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]; [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein		 CTD PMID:16329108 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects localization ISO Am 580 affects the localization of CDKN1B protein CTD PMID:16618747 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdr2l cerebellar degeneration-related protein 2-like decreases expression ISO Am 580 results in decreased expression of CDR2L mRNA CTD PMID:16982809 NCBI chr10:100,625,150...100,638,669
Ensembl chr10:100,624,607...100,638,666 		JBrowse link
G Col5a3 collagen type V alpha 3 chain increases expression ISO Am 580 results in increased expression of COL5A3 mRNA CTD PMID:16982809 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853 		JBrowse link
G Cttnbp2 cortactin binding protein 2 decreases expression ISO Am 580 results in decreased expression of CTTNBP2 mRNA CTD PMID:16982809 NCBI chr 4:46,800,975...46,964,681
Ensembl chr 4:46,800,981...46,964,631 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Am 580 results in increased expression of CYP19A1 mRNA CTD PMID:15941851 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] CTD PMID:10953040 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein increases expression ISO Am 580 results in increased expression of DCSTAMP mRNA CTD PMID:16982809 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Am 580 results in increased expression of DHRS3 mRNA CTD PMID:16982809 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dmpk DM1 protein kinase decreases expression ISO Am 580 results in decreased expression of DMPK mRNA CTD PMID:16982809 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593 		JBrowse link
G Dmwd DM1 locus, WD repeat containing decreases expression ISO Am 580 results in decreased expression of DMWD mRNA CTD PMID:16982809 NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593 		JBrowse link
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta increases expression ISO Am 580 results in increased expression of DNAJC5B mRNA CTD PMID:16982809 NCBI chr 2:101,973,726...102,066,275
Ensembl chr 2:101,973,793...102,066,275 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO Am 580 results in increased expression of ETS2 mRNA CTD PMID:16982809 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319 		JBrowse link
G Fam241a family with sequence similarity 241 member A decreases expression ISO Am 580 results in decreased expression of FAM241A mRNA CTD PMID:16982809 NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242 		JBrowse link
G Fas Fas cell surface death receptor increases activity ISO Am 580 results in increased activity of FAS protein CTD PMID:15703382 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Am 580 results in increased expression of FN1 mRNA CTD PMID:16982809 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Am 580 results in decreased expression of FUT7 mRNA CTD PMID:16982809 NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260 		JBrowse link
G Galm galactose mutarotase increases expression ISO Am 580 results in increased expression of GALM mRNA CTD PMID:18052213 NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Am 580 results in increased expression of GDF15 mRNA CTD PMID:16982809 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpd1l1 glycerol-3-phosphate dehydrogenase 1 like 1 decreases expression ISO Am 580 results in decreased expression of GPD1L mRNA CTD PMID:16982809 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Gusb glucuronidase, beta increases expression ISO Am 580 results in increased expression of GUSB mRNA CTD PMID:16982809 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Am 580 results in increased expression of HIPK2 mRNA CTD PMID:16982809 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO Am 580 results in decreased expression of H2BC5 mRNA CTD PMID:16982809 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO Am 580 results in decreased expression of HLX mRNA CTD PMID:16982809 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] CTD PMID:16085646 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Am 580 results in decreased expression of IL1R1 mRNA CTD PMID:16982809 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression ISO Am 580 results in decreased expression of IL1RAP mRNA CTD PMID:16982809 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Am 580 results in increased expression of INPP5F mRNA CTD PMID:16982809 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Am 580 results in decreased expression of IPCEF1 mRNA CTD PMID:16982809 NCBI chr 1:43,237,903...43,451,735
Ensembl chr 1:43,269,202...43,427,969 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions
increases activity
increases expression		 ISO Am 580 affects the localization of [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Tretinoin promotes the reaction [Am 580 results in increased activity of IRF1 protein] CTD PMID:16085646 PMID:16636311 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Am 580 results in increased expression of ITGAE mRNA CTD PMID:16982809 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Kiaa0040 KIAA0040 ortholog decreases expression ISO Am 580 results in decreased expression of KIAA0040 mRNA CTD PMID:16982809 NCBI chr13:72,274,519...72,312,103
Ensembl chr13:72,274,552...72,312,103 		JBrowse link
G Kifc2 kinesin family member C2 decreases expression ISO Am 580 results in decreased expression of KIFC2 mRNA CTD PMID:16982809 NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484 		JBrowse link
G Lair1 leukocyte-associated immunoglobulin-like receptor 1 increases expression ISO Am 580 results in increased expression of LAIR1 mRNA CTD PMID:16982809 NCBI chr 1:70,068,571...70,187,851
Ensembl chr 1:70,157,681...70,185,807 		JBrowse link
G Lelp1 late cornified envelope-like proline-rich 1 decreases expression ISO Am 580 results in decreased expression of LELP1 mRNA CTD PMID:16982809
G Lrp11 LDL receptor related protein 11 decreases expression ISO Am 580 results in decreased expression of LRP11 mRNA CTD PMID:16982809 NCBI chr 1:2,048,307...2,108,115
Ensembl chr 1:2,079,438...2,108,110 		JBrowse link
G Man1c1 mannosidase, alpha, class 1C, member 1 decreases expression ISO Am 580 results in decreased expression of MAN1C1 mRNA CTD PMID:16982809 NCBI chr 5:146,774,282...146,913,257
Ensembl chr 5:146,775,842...146,913,421 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 decreases expression ISO Am 580 results in decreased expression of MAP3K6 mRNA CTD PMID:16982809 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212 		JBrowse link
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 decreases expression ISO Am 580 results in decreased expression of MAP4K1 mRNA CTD PMID:16982809 NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator decreases expression ISO Am 580 results in decreased expression of METRN mRNA CTD PMID:16982809 NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701 		JBrowse link
G Mgat4c MGAT4 family, member C decreases expression ISO Am 580 results in decreased expression of MGAT4C mRNA CTD PMID:16982809 NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571 		JBrowse link
G Myorg myogenesis regulating glycosidase decreases expression ISO Am 580 results in decreased expression of MYORG mRNA CTD PMID:16982809 NCBI chr 5:56,654,257...56,664,467
Ensembl chr 5:56,648,643...56,664,440 		JBrowse link
G Ndrg2 NDRG family member 2 decreases expression ISO Am 580 results in decreased expression of NDRG2 mRNA CTD PMID:16982809 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO Am580 increases expression of Nphs1 mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity		 ISO Am 580 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Am 580 results in increased activity of NR1H4 protein		 CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Am 580 results in increased expression of NRIP1 mRNA CTD PMID:16982809 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression ISO Am 580 results in increased expression of NRIP3 mRNA CTD PMID:16982809 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600 		JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO Am 580 results in decreased expression of NUDT7 mRNA CTD PMID:16982809 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA] CTD PMID:16636311 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371 		JBrowse link
G Ocln occludin increases expression ISO Am 580 results in increased expression of OCLN mRNA CTD PMID:16982755 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Am 580 results in increased expression of OLR1 mRNA CTD PMID:16982809 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase increases expression ISO Am 580 results in increased expression of OMA1 mRNA CTD PMID:16982809 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Pald1 phosphatase domain containing, paladin 1 decreases expression ISO Am 580 results in decreased expression of PALD1 mRNA CTD PMID:16982809 NCBI chr20:29,269,814...29,334,850
Ensembl chr20:29,270,193...29,334,858 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Am 580 results in increased expression of PAPSS2 mRNA CTD PMID:16982809 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331 		JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Am 580 results in decreased expression of PDLIM2 mRNA CTD PMID:16982809 NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242 		JBrowse link
G Pdlim4 PDZ and LIM domain 4 decreases expression ISO Am 580 results in decreased expression of PDLIM4 mRNA CTD PMID:16982809 NCBI chr10:38,198,686...38,212,935
Ensembl chr10:38,198,689...38,212,938 		JBrowse link
G Pheta1 PH domain containing endocytic trafficking adaptor 1 decreases expression ISO Am 580 results in decreased expression of PHETA1 mRNA CTD PMID:16982809 NCBI chr12:34,711,831...34,717,601
Ensembl chr12:34,711,810...34,717,081 		JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 decreases expression ISO Am 580 results in decreased expression of PHLDA2 mRNA CTD PMID:16982809 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836 		JBrowse link
G Plbd1 phospholipase B domain containing 1 increases expression ISO Am 580 results in increased expression of PLBD1 mRNA CTD PMID:16982809 NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277 		JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression ISO Am 580 results in increased expression of PLPP3 mRNA CTD PMID:16982809 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Am 580 results in decreased expression of PON2 mRNA CTD PMID:16982809 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 increases expression ISO Am 580 results in increased expression of PRAM1 mRNA CTD PMID:16982809 NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression ISO Am 580 results in decreased expression of QPRT mRNA CTD PMID:16982809 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486 		JBrowse link
G Rab15 RAB15, member RAS oncogene family decreases expression ISO Am 580 results in decreased expression of RAB15 mRNA CTD PMID:16982809 NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942 		JBrowse link
G Rab20 RAB20, member RAS oncogene family increases expression ISO Am 580 results in increased expression of RAB20 mRNA CTD PMID:16982809 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein decreases expression ISO Am 580 results in decreased expression of RAP1GAP mRNA CTD PMID:16982809 NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression
multiple interactions
decreases expression		 ISO Am 580 results in increased expression of RARA protein
2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein]; Am 580 binds to and results in increased activity of RARA protein; Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]		 CTD PMID:10779427 PMID:16178010 PMID:16636311 PMID:17290005 PMID:30076181 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbp1 retinol binding protein 1 increases expression ISO Am 580 results in increased expression of RBP1 mRNA CTD PMID:16982809 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Reps2 RALBP1 associated Eps domain containing 2 decreases expression ISO Am 580 results in decreased expression of REPS2 mRNA CTD PMID:16982809 NCBI chr  X:32,049,455...32,322,317
Ensembl chr  X:32,049,399...32,317,414 		JBrowse link
G Rflnb refilin B increases expression ISO Am 580 results in increased expression of RFLNB mRNA CTD PMID:16982809 NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976 		JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Am 580 results in decreased expression of RFXAP mRNA CTD PMID:16982809 NCBI chr 2:139,008,052...139,012,235
Ensembl chr 2:139,008,055...139,012,259 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 increases expression ISO Am 580 results in increased expression of RHOBTB3 mRNA CTD PMID:16982809 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041 		JBrowse link
G Rxra retinoid X receptor alpha increases activity ISO Am 580 results in increased activity of RXRA protein CTD PMID:21543282 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO Am 580 results in increased expression of SEL1L3 mRNA CTD PMID:16982809 NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644 		JBrowse link
G Selplg selectin P ligand decreases expression ISO Am 580 results in decreased expression of SELPLG mRNA CTD PMID:16982809 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Slc26a11 solute carrier family 26 member 11 increases expression ISO Am 580 results in increased expression of SLC26A11 mRNA CTD PMID:16982809 NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970 		JBrowse link
G Slitrk4 SLIT and NTRK-like family, member 4 increases expression ISO Am 580 results in increased expression of SLITRK4 mRNA CTD PMID:16982809 NCBI chr  X:142,706,495...142,718,968
Ensembl chr  X:142,706,338...142,718,575 		JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO Am 580 results in increased expression of SNAI3 mRNA CTD PMID:16982809 NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486 		JBrowse link
G Ssmem1 serine-rich single-pass membrane protein 1 decreases expression ISO Am 580 results in decreased expression of SSMEM1 mRNA CTD PMID:16982809 NCBI chr 4:59,128,730...59,139,029
Ensembl chr 4:59,128,730...59,145,007 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein; Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:16085646 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 increases expression EXP Am580 increases expression of Stra6 mRNA in lung RGD PMID:28734946 RGD:155631297 NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860 		JBrowse link
G Sts steroid sulfatase increases activity ISO Am 580 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Synpo synaptopodin increases expression ISO AM580 increases expression of Synpo mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126 		JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO Am 580 results in decreased expression of TACSTD2 mRNA CTD PMID:16982809 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650 		JBrowse link
G Tbc1d2 TBC1 domain family, member 2 increases expression ISO Am 580 results in increased expression of TBC1D2 mRNA CTD PMID:16982809 NCBI chr 5:60,884,114...60,931,717
Ensembl chr 5:60,884,124...60,931,352 		JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked decreases expression ISO Am 580 results in decreased expression of TBL1X mRNA CTD PMID:16982809 NCBI chr  X:41,574,558...41,731,117
Ensembl chr  X:41,576,047...41,731,101 		JBrowse link
G Tbl2 transducin (beta)-like 2 increases expression ISO Am 580 results in increased expression of TBL2 mRNA CTD PMID:16982809 NCBI chr12:21,517,600...21,531,896
Ensembl chr12:21,520,682...21,531,896 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA CTD PMID:16482212 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
increases expression
increases activity		 ISO [Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein
Am 580 results in increased expression of TGM2 mRNA
Am 580 results in increased activity of TGM2 protein		 CTD PMID:2884032 PMID:9516142 PMID:16982809 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Thbs3 thrombospondin 3 increases expression ISO Am 580 results in increased expression of THBS3 mRNA CTD PMID:16982809 NCBI chr 2:174,621,788...174,633,594
Ensembl chr 2:174,621,812...174,633,594 		JBrowse link
G Tmem14a transmembrane protein 14A decreases expression ISO Am 580 results in decreased expression of TMEM14A mRNA CTD PMID:16982809 NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463 		JBrowse link
G Tnf tumor necrosis factor increases activity ISO Am 580 results in increased activity of TNF protein CTD PMID:15703382 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases activity ISO Am 580 results in increased activity of TNFSF10 protein CTD PMID:15703382 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression ISO Am 580 results in decreased expression of TNFSF12 mRNA CTD PMID:16982809 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213 		JBrowse link
G Tns1 tensin 1 decreases expression ISO Am 580 results in decreased expression of TNS1 mRNA CTD PMID:16982809 NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B decreases expression ISO Am 580 results in decreased expression of ZBTB7B mRNA CTD PMID:16982809 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      application 19732
        pharmaceutical 19559
          drug 19559
            antineoplastic agent 17702
              4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 116
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      carboxylic acid 18622
                                        carboacyl group 17704
                                          univalent carboacyl group 17704
                                            carbamoyl group 17550
                                              carboxamide 17550
                                                monocarboxylic acid amide 15653
                                                  amidobenzoic acid 141
                                                    4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 116
paths to the root