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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
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Accession:CHEBI:64210 term browser browse the term
Definition:An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms:related_synonym: AM580;   Am 580;   CD 336;   Formula=C22H25NO3;   InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26);   InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N;   SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
 xref: Beilstein:3565084;   CAS:102121-60-8;   KEGG:C15619;   LINCS:LSM-2132
 xref_mesh: MESH:C068073
 xref: PDB:3KMR;   PMID:18271925;   PMID:18416830;   PMID:19700416;   PMID:19790202;   PMID:20147703;   PMID:20453882;   PMID:21150871;   PMID:21310893;   PMID:21715427;   PMID:22258322;   PMID:22353356;   Reaxys:3565084

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4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Am 580 promotes the reaction [Tretinoin results in increased expression of ABCG2 mRNA] CTD PMID:20562004 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Ada adenosine deaminase increases expression ISO Am 580 results in increased expression of ADA mRNA CTD PMID:16982809 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 increases expression ISO Am 580 results in increased expression of AGPAT4 mRNA CTD PMID:16982809 NCBI chr 1:48,716,094...48,826,292
Ensembl chr 1:48,719,633...48,825,364 		JBrowse link
G Agrn agrin decreases expression ISO Am 580 results in decreased expression of AGRN mRNA CTD PMID:16982809 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645 		JBrowse link
G Ajap1 adherens junctions associated protein 1 increases expression ISO Am 580 results in increased expression of AJAP1 mRNA CTD PMID:16982809 NCBI chr 5:170,615,885...170,679,315
Ensembl chr 5:170,615,886...170,679,315 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 increases expression ISO Am 580 results in increased expression of APLP2 mRNA CTD PMID:16982809 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839 		JBrowse link
G Ar androgen receptor decreases activity ISO Am 580 results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO Am 580 results in decreased expression of ATP2B1 mRNA CTD PMID:16982809 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579 		JBrowse link
G Bag2 BAG cochaperone 2 increases expression ISO Am 580 results in increased expression of BAG2 mRNA CTD PMID:16982809 NCBI chr 9:38,456,487...38,467,120
Ensembl chr 9:38,456,468...38,467,118 		JBrowse link
G Calcrl calcitonin receptor like receptor decreases expression ISO Am 580 results in decreased expression of CALCRL mRNA CTD PMID:16982809 NCBI chr 3:71,747,938...71,845,487
Ensembl chr 3:71,747,956...71,845,232 		JBrowse link
G Capn1 calpain 1 decreases expression
decreases activity		 ISO Am 580 results in decreased expression of CAPN1 mRNA
Am 580 results in decreased activity of CAPN1 protein		 CTD PMID:17460283 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Capn2 calpain 2 decreases expression
multiple interactions
decreases activity		 ISO Am 580 results in decreased expression of CAPN2 mRNA
Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]
Am 580 results in decreased activity of CAPN2 protein		 CTD PMID:17460283 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Cd1d1 CD1d1 molecule increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD1D mRNA
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]		 CTD PMID:16982809 PMID:17392484 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805 		JBrowse link
G Cd300a Cd300a molecule increases expression ISO Am 580 results in increased expression of CD300A mRNA CTD PMID:16982809 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947 		JBrowse link
G Cd300lb CD300 molecule-like family member b increases expression ISO Am 580 results in increased expression of CD300LB mRNA CTD PMID:16982809 NCBI chr10:103,471,082...103,481,071
Ensembl chr10:103,467,725...103,481,153 		JBrowse link
G Cd300lf Cd300 molecule-like family member F increases expression ISO Am 580 results in increased expression of CD300LF mRNA CTD PMID:16982809 NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425 		JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD38 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]; [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein		 CTD PMID:16329108 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects localization ISO Am 580 affects the localization of CDKN1B protein CTD PMID:16618747 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdr2l cerebellar degeneration-related protein 2-like decreases expression ISO Am 580 results in decreased expression of CDR2L mRNA CTD PMID:16982809 NCBI chr10:103,934,364...103,948,318
Ensembl chr10:103,934,797...103,948,322 		JBrowse link
G Col5a3 collagen type V alpha 3 chain increases expression ISO Am 580 results in increased expression of COL5A3 mRNA CTD PMID:16982809 NCBI chr 8:21,786,324...21,831,751
Ensembl chr 8:21,786,324...21,831,668 		JBrowse link
G Cttnbp2 cortactin binding protein 2 decreases expression ISO Am 580 results in decreased expression of CTTNBP2 mRNA CTD PMID:16982809 NCBI chr 4:42,932,897...43,096,454
Ensembl chr 4:42,932,903...43,096,399 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Am 580 results in increased expression of CYP19A1 mRNA CTD PMID:15941851 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] CTD PMID:10953040 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein increases expression ISO Am 580 results in increased expression of DCSTAMP mRNA CTD PMID:16982809 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Am 580 results in increased expression of DHRS3 mRNA CTD PMID:16982809 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383 		JBrowse link
G Dmpk DM1 protein kinase decreases expression ISO Am 580 results in decreased expression of DMPK mRNA CTD PMID:16982809 NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364 		JBrowse link
G Dmwd DM1 locus, WD repeat containing decreases expression ISO Am 580 results in decreased expression of DMWD mRNA CTD PMID:16982809 NCBI chr 1:79,981,270...79,987,997
Ensembl chr 1:79,981,355...79,987,562 		JBrowse link
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta increases expression ISO Am 580 results in increased expression of DNAJC5B mRNA CTD PMID:16982809 NCBI chr 2:104,290,726...104,382,846
Ensembl chr 2:104,290,726...104,382,878 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO Am 580 results in increased expression of ETS2 mRNA CTD PMID:16982809 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495 		JBrowse link
G Fam241a family with sequence similarity 241 member A decreases expression ISO Am 580 results in decreased expression of FAM241A mRNA CTD PMID:16982809 NCBI chr 2:232,214,331...232,245,319
Ensembl chr 2:232,214,331...232,245,319 		JBrowse link
G Fas Fas cell surface death receptor increases activity ISO Am 580 results in increased activity of FAS protein CTD PMID:15703382 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Am 580 results in increased expression of FN1 mRNA CTD PMID:16982809 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Am 580 results in decreased expression of FUT7 mRNA CTD PMID:16982809 NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648 		JBrowse link
G Galm galactose mutarotase increases expression ISO Am 580 results in increased expression of GALM mRNA CTD PMID:18052213 NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Am 580 results in increased expression of GDF15 mRNA CTD PMID:16982809 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like decreases expression ISO Am 580 results in decreased expression of GPD1L mRNA CTD PMID:16982809 NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191 		JBrowse link
G Gusb glucuronidase, beta increases expression ISO Am 580 results in increased expression of GUSB mRNA CTD PMID:16982809 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Am 580 results in increased expression of HIPK2 mRNA CTD PMID:16982809 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912 		JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO Am 580 results in decreased expression of H2BC5 mRNA CTD PMID:16982809 NCBI chr17:44,833,924...44,834,305
Ensembl chr17:44,833,924...44,834,305 		JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO Am 580 results in decreased expression of HLX mRNA CTD PMID:16982809 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223 		JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] CTD PMID:16085646 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Am 580 results in decreased expression of IL1R1 mRNA CTD PMID:16982809 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression ISO Am 580 results in decreased expression of IL1RAP mRNA CTD PMID:16982809 NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Am 580 results in increased expression of INPP5F mRNA CTD PMID:16982809 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524 		JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Am 580 results in decreased expression of IPCEF1 mRNA CTD PMID:16982809 NCBI chr 1:43,563,457...43,743,424
Ensembl chr 1:43,567,842...43,638,161 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions
increases expression
increases activity		 ISO Am 580 affects the localization of [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Tretinoin promotes the reaction [Am 580 results in increased activity of IRF1 protein] CTD PMID:16085646 PMID:16636311 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531 		JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Am 580 results in increased expression of ITGAE mRNA CTD PMID:16982809 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874 		JBrowse link
G Kifc2 kinesin family member C2 decreases expression ISO Am 580 results in decreased expression of KIFC2 mRNA CTD PMID:16982809 NCBI chr 7:117,722,732...117,730,702
Ensembl chr 7:117,723,263...117,730,702 		JBrowse link
G Lair1 leukocyte-associated immunoglobulin-like receptor 1 increases expression ISO Am 580 results in increased expression of LAIR1 mRNA CTD PMID:16982809 NCBI chr 1:73,752,192...73,870,421
Ensembl chr 1:73,837,944...73,868,695 		JBrowse link
G Lelp1 late cornified envelope-like proline-rich 1 decreases expression ISO Am 580 results in decreased expression of LELP1 mRNA CTD PMID:16982809 NCBI chr 2:192,035,927...192,037,885 JBrowse link
G LOC100302372 hypothetical protein LOC100302372 decreases expression ISO Am 580 results in decreased expression of KIAA0040 mRNA CTD PMID:16982809 NCBI chr13:77,784,516...77,822,333
Ensembl chr13:77,784,808...77,822,333 		JBrowse link
G LOC687399 hypothetical protein LOC687399 decreases expression ISO Am 580 results in decreased expression of C16ORF46 mRNA CTD PMID:16982809 NCBI chr19:49,508,321...49,518,721
Ensembl chr19:49,508,288...49,518,721 		JBrowse link
G Lrp11 LDL receptor related protein 11 decreases expression ISO Am 580 results in decreased expression of LRP11 mRNA CTD PMID:16982809 NCBI chr 1:1,702,696...1,731,210
Ensembl chr 1:1,702,696...1,731,210 		JBrowse link
G Man1c1 mannosidase, alpha, class 1C, member 1 decreases expression ISO Am 580 results in decreased expression of MAN1C1 mRNA CTD PMID:16982809 NCBI chr 5:152,775,031...152,920,130
Ensembl chr 5:152,774,855...152,920,343 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 decreases expression ISO Am 580 results in decreased expression of MAP3K6 mRNA CTD PMID:16982809 NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328 		JBrowse link
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 decreases expression ISO Am 580 results in decreased expression of MAP4K1 mRNA CTD PMID:16982809 NCBI chr 1:87,937,126...87,959,514
Ensembl chr 1:87,938,042...87,959,569 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator decreases expression ISO Am 580 results in decreased expression of METRN mRNA CTD PMID:16982809 NCBI chr10:15,164,439...15,166,457
Ensembl chr10:15,164,439...15,166,457 		JBrowse link
G Mgat4c MGAT4 family, member C decreases expression ISO Am 580 results in decreased expression of MGAT4C mRNA CTD PMID:16982809 NCBI chr 7:43,249,369...44,024,278
Ensembl chr 7:44,009,069...44,024,456 		JBrowse link
G Myorg myogenesis regulating glycosidase decreases expression ISO Am 580 results in decreased expression of MYORG mRNA CTD PMID:16982809 NCBI chr 5:57,873,404...57,882,008
Ensembl chr 5:57,876,498...57,881,944 		JBrowse link
G Ndrg2 NDRG family member 2 decreases expression ISO Am 580 results in decreased expression of NDRG2 mRNA CTD PMID:16982809 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO Am580 increases expression of Nphs1 mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity		 ISO Am 580 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Am 580 results in increased activity of NR1H4 protein		 CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Am 580 results in increased expression of NRIP1 mRNA CTD PMID:16982809 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression ISO Am 580 results in increased expression of NRIP3 mRNA CTD PMID:16982809 NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141 		JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO Am 580 results in decreased expression of NUDT7 mRNA CTD PMID:16982809 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA] CTD PMID:16636311 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161 		JBrowse link
G Ocln occludin increases expression ISO Am 580 results in increased expression of OCLN mRNA CTD PMID:16982755 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Am 580 results in increased expression of OLR1 mRNA CTD PMID:16982809 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase increases expression ISO Am 580 results in increased expression of OMA1 mRNA CTD PMID:16982809 NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475 		JBrowse link
G Pald1 phosphatase domain containing, paladin 1 decreases expression ISO Am 580 results in decreased expression of PALD1 mRNA CTD PMID:16982809 NCBI chr20:30,938,901...30,983,907
Ensembl chr20:30,938,901...30,975,472 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Am 580 results in increased expression of PAPSS2 mRNA CTD PMID:16982809 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715 		JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Am 580 results in decreased expression of PDLIM2 mRNA CTD PMID:16982809 NCBI chr15:51,843,562...51,856,785
Ensembl chr15:51,843,564...51,855,325 		JBrowse link
G Pdlim4 PDZ and LIM domain 4 decreases expression ISO Am 580 results in decreased expression of PDLIM4 mRNA CTD PMID:16982809 NCBI chr10:39,390,578...39,405,322
Ensembl chr10:39,390,581...39,405,311 		JBrowse link
G Pheta1 PH domain containing endocytic trafficking adaptor 1 decreases expression ISO Am 580 results in decreased expression of PHETA1 mRNA CTD PMID:16982809 NCBI chr12:40,225,316...40,230,573
Ensembl chr12:40,226,593...40,227,297 		JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 decreases expression ISO Am 580 results in decreased expression of PHLDA2 mRNA CTD PMID:16982809 NCBI chr 1:216,701,345...216,704,479
Ensembl chr 1:216,702,319...216,703,534 		JBrowse link
G Plbd1 phospholipase B domain containing 1 increases expression ISO Am 580 results in increased expression of PLBD1 mRNA CTD PMID:16982809 NCBI chr 4:170,564,387...170,620,681
Ensembl chr 4:170,564,367...170,620,703 		JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression ISO Am 580 results in increased expression of PLPP3 mRNA CTD PMID:16982809 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Am 580 results in decreased expression of PON2 mRNA CTD PMID:16982809 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119 		JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 increases expression ISO Am 580 results in increased expression of PRAM1 mRNA CTD PMID:16982809 NCBI chr 7:18,507,878...18,516,321
Ensembl chr 7:18,510,354...18,515,503 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression ISO Am 580 results in decreased expression of QPRT mRNA CTD PMID:16982809 NCBI chr 1:198,544,262...198,559,556
Ensembl chr 1:198,544,262...198,559,568 		JBrowse link
G Rab15 RAB15, member RAS oncogene family decreases expression ISO Am 580 results in decreased expression of RAB15 mRNA CTD PMID:16982809 NCBI chr 6:99,845,952...99,870,320
Ensembl chr 6:99,845,954...99,870,024 		JBrowse link
G Rab20 RAB20, member RAS oncogene family increases expression ISO Am 580 results in increased expression of RAB20 mRNA CTD PMID:16982809 NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein decreases expression ISO Am 580 results in decreased expression of RAP1GAP mRNA CTD PMID:16982809 NCBI chr 5:156,008,868...156,074,350
Ensembl chr 5:156,026,911...156,074,395 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression
decreases expression
multiple interactions		 ISO Am 580 results in increased expression of RARA protein
Am 580 results in decreased expression of RARA protein
2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein]; Am 580 binds to and results in increased activity of RARA protein; Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]		 CTD PMID:10779427 PMID:16178010 PMID:16636311 PMID:17290005 PMID:30076181 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbp1 retinol binding protein 1 increases expression ISO Am 580 results in increased expression of RBP1 mRNA CTD PMID:16982809 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842 		JBrowse link
G Reps2 RALBP1 associated Eps domain containing 2 decreases expression ISO Am 580 results in decreased expression of REPS2 mRNA CTD PMID:16982809 NCBI chr  X:33,786,611...34,062,941
Ensembl chr  X:33,884,499...34,057,399 		JBrowse link
G Rflnb refilin B increases expression ISO Am 580 results in increased expression of RFLNB mRNA CTD PMID:16982809 NCBI chr10:64,196,103...64,202,380
Ensembl chr10:64,196,127...64,202,380 		JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Am 580 results in decreased expression of RFXAP mRNA CTD PMID:16982809 NCBI chr 2:144,003,453...144,007,636
Ensembl chr 2:144,003,454...144,007,636 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 increases expression ISO Am 580 results in increased expression of RHOBTB3 mRNA CTD PMID:16982809 NCBI chr 2:2,627,655...2,683,305
Ensembl chr 2:2,627,393...2,683,116 		JBrowse link
G Rxra retinoid X receptor alpha increases activity ISO Am 580 results in increased activity of RXRA protein CTD PMID:21543282 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO Am 580 results in increased expression of SEL1L3 mRNA CTD PMID:16982809 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734 		JBrowse link
G Selplg selectin P ligand decreases expression ISO Am 580 results in decreased expression of SELPLG mRNA CTD PMID:16982809 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196 		JBrowse link
G Slc26a11 solute carrier family 26 member 11 increases expression ISO Am 580 results in increased expression of SLC26A11 mRNA CTD PMID:16982809 NCBI chr10:108,479,105...108,504,188
Ensembl chr10:108,480,368...108,503,706 		JBrowse link
G Slitrk4 SLIT and NTRK-like family, member 4 increases expression ISO Am 580 results in increased expression of SLITRK4 mRNA CTD PMID:16982809 NCBI chr  X:147,582,195...147,589,529 JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO Am 580 results in increased expression of SNAI3 mRNA CTD PMID:16982809 NCBI chr19:55,276,211...55,290,031
Ensembl chr19:55,277,549...55,284,663 		JBrowse link
G Ssmem1 serine-rich single-pass membrane protein 1 decreases expression ISO Am 580 results in decreased expression of SSMEM1 mRNA CTD PMID:16982809 NCBI chr 4:57,823,411...57,833,706
Ensembl chr 4:57,823,411...57,834,115 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein; Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:16085646 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Sts steroid sulfatase increases activity ISO Am 580 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
G Synpo synaptopodin increases expression ISO AM580 increases expression of Synpo mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220 		JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO Am 580 results in decreased expression of TACSTD2 mRNA CTD PMID:16982809 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887 		JBrowse link
G Tbc1d2 TBC1 domain family, member 2 increases expression ISO Am 580 results in increased expression of TBC1D2 mRNA CTD PMID:16982809 NCBI chr 5:62,213,001...62,261,467
Ensembl chr 5:62,212,982...62,260,105 		JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked decreases expression ISO Am 580 results in decreased expression of TBL1X mRNA CTD PMID:16982809 NCBI chr  X:44,959,883...44,988,551
Ensembl chr  X:44,830,849...44,988,551 		JBrowse link
G Tbl2 transducin (beta)-like 2 increases expression ISO Am 580 results in increased expression of TBL2 mRNA CTD PMID:16982809 NCBI chr12:24,565,843...24,578,855
Ensembl chr12:24,565,849...24,578,786 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA CTD PMID:16482212 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
increases activity
increases expression		 ISO [Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein
Am 580 results in increased activity of TGM2 protein
Am 580 results in increased expression of TGM2 mRNA		 CTD PMID:2884032 PMID:9516142 PMID:16982809 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257 		JBrowse link
G Thbs3 thrombospondin 3 increases expression ISO Am 580 results in increased expression of THBS3 mRNA CTD PMID:16982809 NCBI chr 2:188,528,979...188,540,738
Ensembl chr 2:188,528,979...188,540,736 		JBrowse link
G Tmem14a transmembrane protein 14A decreases expression ISO Am 580 results in decreased expression of TMEM14A mRNA CTD PMID:16982809 NCBI chr 9:27,333,956...27,345,612
NCBI chr 9:27,334,103...27,351,302
Ensembl chr 9:27,343,853...27,345,070
Ensembl chr 9:27,343,853...27,345,070 		JBrowse link
G Tnf tumor necrosis factor increases activity ISO Am 580 results in increased activity of TNF protein CTD PMID:15703382 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases activity ISO Am 580 results in increased activity of TNFSF10 protein CTD PMID:15703382 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression ISO Am 580 results in decreased expression of TNFSF12 mRNA CTD PMID:16982809 NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077 		JBrowse link
G Tns1 tensin 1 decreases expression ISO Am 580 results in decreased expression of TNS1 mRNA CTD PMID:16982809 NCBI chr 9:81,190,192...81,401,020
Ensembl chr 9:81,194,119...81,400,987 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B decreases expression ISO Am 580 results in decreased expression of ZBTB7B mRNA CTD PMID:16982809 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            antineoplastic agent 17009
              4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                monocarboxylic acid amide 14583
                                                  amidobenzoic acid 126
                                                    4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 115
paths to the root