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ONTOLOGY REPORT - ANNOTATIONS


Term:4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
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Accession:CHEBI:64210 term browser browse the term
Definition:An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms:related_synonym: AM580;   Am 580;   CD 336;   Formula=C22H25NO3;   InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26);   InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N;   SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
 xref: Beilstein:3565084 "ChemIDplus";   CAS:102121-60-8 "ChemIDplus";   CAS:102121-60-8 "KEGG COMPOUND";   KEGG:C15619;   LINCS:LSM-2132
 xref_mesh: MESH:C068073
 xref: PDB:3KMR;   PMID:18271925 "Europe PMC";   PMID:18416830 "Europe PMC";   PMID:19700416 "Europe PMC";   PMID:19790202 "Europe PMC";   PMID:20147703 "Europe PMC";   PMID:20453882 "Europe PMC";   PMID:21150871 "Europe PMC";   PMID:21310893 "Europe PMC";   PMID:21715427 "Europe PMC";   PMID:22258322 "Europe PMC";   PMID:22353356 "Europe PMC";   Reaxys:3565084 "Reaxys"


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4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:6480464
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 JBrowse link 1 48,716,094 48,826,292 RGD:6480464
G Agrn agrin JBrowse link 5 173,589,910 173,622,813 RGD:6480464
G Ajap1 adherens junctions associated protein 1 JBrowse link 5 170,615,885 170,679,315 RGD:6480464
G Aplp2 amyloid beta precursor like protein 2 JBrowse link 8 32,298,526 32,328,821 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:6480464
G Bag2 Bcl2-associated athanogene 2 JBrowse link 9 38,456,487 38,467,120 RGD:6480464
G Calcrl calcitonin receptor like receptor JBrowse link 3 71,747,938 71,845,487 RGD:6480464
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:6480464
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6480464
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:6480464
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:6480464
G Cd300lb CD300 molecule-like family member b JBrowse link 10 103,471,082 103,481,071 RGD:6480464
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:6480464
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cdr2l cerebellar degeneration-related protein 2-like JBrowse link 10 103,934,364 103,948,318 RGD:6480464
G Col5a3 collagen type V alpha 3 chain JBrowse link 8 21,786,324 21,831,751 RGD:6480464
G Cttnbp2 cortactin binding protein 2 JBrowse link 4 42,932,897 43,096,454 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:6480464
G Dhrs3 dehydrogenase/reductase 3 JBrowse link 5 162,809,090 162,843,385 RGD:6480464
G Dmpk DM1 protein kinase JBrowse link 1 79,988,096 79,999,358 RGD:6480464
G Dmwd DM1 locus, WD repeat containing JBrowse link 1 79,981,270 79,987,997 RGD:6480464
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta JBrowse link 2 104,290,726 104,382,846 RGD:6480464
G Ets2 ETS proto-oncogene 2, transcription factor JBrowse link 11 36,075,709 36,092,495 RGD:6480464
G Fam241a family with sequence similarity 241 member A JBrowse link 2 232,214,331 232,245,319 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fut7 fucosyltransferase 7 JBrowse link 3 2,637,281 2,646,497 RGD:6480464
G Galm galactose mutarotase JBrowse link 6 2,808,988 2,860,742 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like JBrowse link 8 122,957,570 122,987,236 RGD:6480464
G Gusb glucuronidase, beta JBrowse link 12 30,202,066 30,215,583 RGD:6480464
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:6480464
G Hist1h2bd histone cluster 1 H2B family member D JBrowse link 17 44,833,924 44,834,305 RGD:6480464
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:6480464
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6480464
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:6480464
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:6480464
G Inpp5f inositol polyphosphate-5-phosphatase F JBrowse link 1 200,037,749 200,116,524 RGD:6480464
G Ipcef1 interaction protein for cytohesin exchange factors 1 JBrowse link 1 43,563,457 43,743,424 RGD:6480464
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6480464
G Itgae integrin subunit alpha E JBrowse link 10 59,652,324 59,711,885 RGD:6480464
G Kifc2 kinesin family member C2 JBrowse link 7 117,722,732 117,730,702 RGD:6480464
G Lair1 leukocyte-associated immunoglobulin-like receptor 1 JBrowse link 1 73,752,192 73,870,421 RGD:6480464
G Lelp1 late cornified envelope-like proline-rich 1 JBrowse link 2 192,035,927 192,037,885 RGD:6480464
G LOC100302372 hypothetical protein LOC100302372 JBrowse link 13 77,784,516 77,822,333 RGD:6480464
G LOC687399 hypothetical protein LOC687399 JBrowse link 19 49,508,321 49,518,721 RGD:6480464
G Lrp11 LDL receptor related protein 11 JBrowse link 1 1,702,696 1,731,210 RGD:6480464
G Man1c1 mannosidase, alpha, class 1C, member 1 JBrowse link 5 152,775,031 152,920,130 RGD:6480464
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6480464
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 JBrowse link 1 87,937,126 87,959,514 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Metrn meteorin, glial cell differentiation regulator JBrowse link 10 15,164,439 15,166,457 RGD:6480464
G Mgat4c MGAT4 family, member C JBrowse link 7 43,249,369 44,024,278 RGD:6480464
G Myorg myogenesis regulating glycosidase JBrowse link 5 57,873,404 57,882,008 RGD:6480464
G Ndrg2 NDRG family member 2 JBrowse link 15 28,305,820 28,314,459 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nrip1 nuclear receptor interacting protein 1 JBrowse link 11 14,658,225 14,742,478 RGD:6480464
G Nrip3 nuclear receptor interacting protein 3 JBrowse link 1 174,385,424 174,411,141 RGD:6480464
G Nudt7 nudix hydrolase 7 JBrowse link 19 46,455,745 46,470,070 RGD:6480464
G Oas2 2'-5' oligoadenylate synthetase 2 JBrowse link 12 41,341,417 41,363,124 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6480464
G Oma1 OMA1 zinc metallopeptidase JBrowse link 5 122,847,624 122,900,475 RGD:6480464
G Pald1 phosphatase domain containing, paladin 1 JBrowse link 20 30,938,901 30,983,907 RGD:6480464
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 JBrowse link 1 251,145,264 251,230,716 RGD:6480464
G Pdlim2 PDZ and LIM domain 2 JBrowse link 15 51,843,562 51,856,785 RGD:6480464
G Pdlim4 PDZ and LIM domain 4 JBrowse link 10 39,390,578 39,405,322 RGD:6480464
G Pheta1 PH domain containing endocytic trafficking adaptor 1 JBrowse link 12 40,225,316 40,230,573 RGD:6480464
G Phlda2 pleckstrin homology-like domain, family A, member 2 JBrowse link 1 216,701,345 216,704,479 RGD:6480464
G Plbd1 phospholipase B domain containing 1 JBrowse link 4 170,564,387 170,620,681 RGD:6480464
G Plpp3 phospholipid phosphatase 3 JBrowse link 5 124,690,214 124,765,499 RGD:6480464
G Pon2 paraoxonase 2 JBrowse link 4 30,344,705 30,380,119 RGD:6480464
G Pram1 PML-RARA regulated adaptor molecule 1 JBrowse link 7 18,507,878 18,516,321 RGD:6480464
G Qprt quinolinate phosphoribosyltransferase JBrowse link 1 198,544,262 198,559,556 RGD:6480464
G Rab15 RAB15, member RAS oncogene family JBrowse link 6 99,845,952 99,870,320 RGD:6480464
G Rab20 RAB20, member RAS oncogene family JBrowse link 16 83,358,116 83,382,326 RGD:6480464
G Rap1gap Rap1 GTPase-activating protein JBrowse link 5 156,008,868 156,074,350 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rbp1 retinol binding protein 1 JBrowse link 8 106,449,321 106,470,842 RGD:6480464
G Reps2 RALBP1 associated Eps domain containing 2 JBrowse link X 33,786,611 34,062,941 RGD:6480464
G Rflnb refilin B JBrowse link 10 64,196,103 64,202,380 RGD:6480464
G Rfxap regulatory factor X-associated protein JBrowse link 2 144,003,453 144,007,636 RGD:6480464
G Rhobtb3 Rho-related BTB domain containing 3 JBrowse link 2 2,627,655 2,683,305 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Sel1l3 SEL1L family member 3 JBrowse link 14 60,122,968 60,229,565 RGD:6480464
G Selplg selectin P ligand JBrowse link 12 48,577,905 48,579,196 RGD:6480464
G Slc26a11 solute carrier family 26 member 11 JBrowse link 10 108,479,105 108,504,188 RGD:6480464
G Slitrk4 SLIT and NTRK-like family, member 4 JBrowse link X 147,582,195 147,589,529 RGD:6480464
G Snai3 snail family transcriptional repressor 3 JBrowse link 19 55,276,211 55,290,031 RGD:6480464
G Ssmem1 serine-rich single-pass membrane protein 1 JBrowse link 4 57,823,411 57,833,706 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Tacstd2 tumor-associated calcium signal transducer 2 JBrowse link 4 98,341,187 98,342,887 RGD:6480464
G Tbc1d2 TBC1 domain family, member 2 JBrowse link 5 62,213,001 62,261,467 RGD:6480464
G Tbl1x transducin (beta)-like 1 X-linked JBrowse link X 44,959,883 44,988,551 RGD:6480464
G Tbl2 transducin (beta)-like 2 JBrowse link 12 24,565,843 24,578,855 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6480464
G Thbs3 thrombospondin 3 JBrowse link 2 188,528,979 188,540,738 RGD:6480464
G Tmem14a transmembrane protein 14A JBrowse link 9
9
27,333,956
27,334,103
27,345,612
27,351,302
RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tnfsf12 TNF superfamily member 12 JBrowse link 10 56,290,780 56,300,137 RGD:6480464
G Tns1 tensin 1 JBrowse link 9 81,190,192 81,401,020 RGD:6480464
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 113
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  amidobenzoic acid 120
                                                    4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 113
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.