CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
Accession: CHEBI:64210
browse the term
Definition: An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms: related_synonym: AM580; Am 580; CD 336; Formula=C22H25NO3; InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26); InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N; SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
xref: Beilstein:3565084; CAS:102121-60-8; KEGG:C15619; LINCS:LSM-2132
xref_mesh: MESH:C068073
xref: PDB:3KMR; PMID:18271925; PMID:18416830; PMID:19700416; PMID:19790202; PMID:20147703; PMID:20453882; PMID:21150871; PMID:21310893; PMID:21715427; PMID:22258322; PMID:22353356; Reaxys:3565084
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Am 580 promotes the reaction [Tretinoin results in increased expression of ABCG2 mRNA]
CTD
PMID:20562004
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Ada
adenosine deaminase
increases expression
ISO
Am 580 results in increased expression of ADA mRNA
CTD
PMID:16982809
NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
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Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4
increases expression
ISO
Am 580 results in increased expression of AGPAT4 mRNA
CTD
PMID:16982809
NCBI chr 1:48,716,094...48,826,292
Ensembl chr 1:48,719,633...48,825,364
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Agrn
agrin
decreases expression
ISO
Am 580 results in decreased expression of AGRN mRNA
CTD
PMID:16982809
NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
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Ajap1
adherens junctions associated protein 1
increases expression
ISO
Am 580 results in increased expression of AJAP1 mRNA
CTD
PMID:16982809
NCBI chr 5:170,615,885...170,679,315
Ensembl chr 5:170,615,886...170,679,315
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Aplp2
amyloid beta precursor like protein 2
increases expression
ISO
Am 580 results in increased expression of APLP2 mRNA
CTD
PMID:16982809
NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
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Ar
androgen receptor
decreases activity
ISO
Am 580 results in decreased activity of AR protein
CTD
PMID:25257666
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Atp2b1
ATPase plasma membrane Ca2+ transporting 1
decreases expression
ISO
Am 580 results in decreased expression of ATP2B1 mRNA
CTD
PMID:16982809
NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
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Bag2
BAG cochaperone 2
increases expression
ISO
Am 580 results in increased expression of BAG2 mRNA
CTD
PMID:16982809
NCBI chr 9:38,456,487...38,467,120
Ensembl chr 9:38,456,468...38,467,118
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Calcrl
calcitonin receptor like receptor
decreases expression
ISO
Am 580 results in decreased expression of CALCRL mRNA
CTD
PMID:16982809
NCBI chr 3:71,747,938...71,845,487
Ensembl chr 3:71,747,956...71,845,232
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Capn1
calpain 1
decreases expression decreases activity
ISO
Am 580 results in decreased expression of CAPN1 mRNA Am 580 results in decreased activity of CAPN1 protein
CTD
PMID:17460283
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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Capn2
calpain 2
decreases expression multiple interactions decreases activity
ISO
Am 580 results in decreased expression of CAPN2 mRNA Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA] Am 580 results in decreased activity of CAPN2 protein
CTD
PMID:17460283
NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
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Cd1d1
CD1d1 molecule
increases expression multiple interactions
ISO
Am 580 results in increased expression of CD1D mRNA Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]
CTD
PMID:16982809 PMID:17392484
NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
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Cd300a
Cd300a molecule
increases expression
ISO
Am 580 results in increased expression of CD300A mRNA
CTD
PMID:16982809
NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
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Cd300lb
CD300 molecule-like family member b
increases expression
ISO
Am 580 results in increased expression of CD300LB mRNA
CTD
PMID:16982809
NCBI chr10:103,471,082...103,481,071
Ensembl chr10:103,467,725...103,481,153
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Cd300lf
Cd300 molecule-like family member F
increases expression
ISO
Am 580 results in increased expression of CD300LF mRNA
CTD
PMID:16982809
NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425
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Cd38
CD38 molecule
increases expression multiple interactions
ISO
Am 580 results in increased expression of CD38 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]; [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein
CTD
PMID:16329108
NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
affects localization
ISO
Am 580 affects the localization of CDKN1B protein
CTD
PMID:16618747
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Cdr2l
cerebellar degeneration-related protein 2-like
decreases expression
ISO
Am 580 results in decreased expression of CDR2L mRNA
CTD
PMID:16982809
NCBI chr10:103,934,364...103,948,318
Ensembl chr10:103,934,797...103,948,322
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Col5a3
collagen type V alpha 3 chain
increases expression
ISO
Am 580 results in increased expression of COL5A3 mRNA
CTD
PMID:16982809
NCBI chr 8:21,786,324...21,831,751
Ensembl chr 8:21,786,324...21,831,668
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Cttnbp2
cortactin binding protein 2
decreases expression
ISO
Am 580 results in decreased expression of CTTNBP2 mRNA
CTD
PMID:16982809
NCBI chr 4:42,932,897...43,096,454
Ensembl chr 4:42,932,903...43,096,399
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
ISO
Am 580 results in increased expression of CYP19A1 mRNA
CTD
PMID:15941851
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA]
CTD
PMID:10953040
NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
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Dcstamp
dendrocyte expressed seven transmembrane protein
increases expression
ISO
Am 580 results in increased expression of DCSTAMP mRNA
CTD
PMID:16982809
NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
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Dhrs3
dehydrogenase/reductase 3
increases expression
ISO
Am 580 results in increased expression of DHRS3 mRNA
CTD
PMID:16982809
NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
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Dmpk
DM1 protein kinase
decreases expression
ISO
Am 580 results in decreased expression of DMPK mRNA
CTD
PMID:16982809
NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364
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Dmwd
DM1 locus, WD repeat containing
decreases expression
ISO
Am 580 results in decreased expression of DMWD mRNA
CTD
PMID:16982809
NCBI chr 1:79,981,270...79,987,997
Ensembl chr 1:79,981,355...79,987,562
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Dnajc5b
DnaJ heat shock protein family (Hsp40) member C5 beta
increases expression
ISO
Am 580 results in increased expression of DNAJC5B mRNA
CTD
PMID:16982809
NCBI chr 2:104,290,726...104,382,846
Ensembl chr 2:104,290,726...104,382,878
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Ets2
ETS proto-oncogene 2, transcription factor
increases expression
ISO
Am 580 results in increased expression of ETS2 mRNA
CTD
PMID:16982809
NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
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Fam241a
family with sequence similarity 241 member A
decreases expression
ISO
Am 580 results in decreased expression of FAM241A mRNA
CTD
PMID:16982809
NCBI chr 2:232,214,331...232,245,319
Ensembl chr 2:232,214,331...232,245,319
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Fas
Fas cell surface death receptor
increases activity
ISO
Am 580 results in increased activity of FAS protein
CTD
PMID:15703382
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Fn1
fibronectin 1
increases expression
ISO
Am 580 results in increased expression of FN1 mRNA
CTD
PMID:16982809
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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Fut7
fucosyltransferase 7
decreases expression
ISO
Am 580 results in decreased expression of FUT7 mRNA
CTD
PMID:16982809
NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648
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Galm
galactose mutarotase
increases expression
ISO
Am 580 results in increased expression of GALM mRNA
CTD
PMID:18052213
NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744
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Gdf15
growth differentiation factor 15
increases expression
ISO
Am 580 results in increased expression of GDF15 mRNA
CTD
PMID:16982809
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
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Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
decreases expression
ISO
Am 580 results in decreased expression of GPD1L mRNA
CTD
PMID:16982809
NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191
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Gusb
glucuronidase, beta
increases expression
ISO
Am 580 results in increased expression of GUSB mRNA
CTD
PMID:16982809
NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
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Hipk2
homeodomain interacting protein kinase 2
increases expression
ISO
Am 580 results in increased expression of HIPK2 mRNA
CTD
PMID:16982809
NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
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Hist1h2bd
histone cluster 1 H2B family member D
decreases expression
ISO
Am 580 results in decreased expression of H2BC5 mRNA
CTD
PMID:16982809
NCBI chr17:44,833,924...44,834,305
Ensembl chr17:44,833,924...44,834,305
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Hlx
H2.0-like homeobox
decreases expression
ISO
Am 580 results in decreased expression of HLX mRNA
CTD
PMID:16982809
NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
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Ifngr1
interferon gamma receptor 1
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]
CTD
PMID:16085646
NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
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Il1r1
interleukin 1 receptor type 1
decreases expression
ISO
Am 580 results in decreased expression of IL1R1 mRNA
CTD
PMID:16982809
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
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Il1rap
interleukin 1 receptor accessory protein
decreases expression
ISO
Am 580 results in decreased expression of IL1RAP mRNA
CTD
PMID:16982809
NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207
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Inpp5f
inositol polyphosphate-5-phosphatase F
increases expression
ISO
Am 580 results in increased expression of INPP5F mRNA
CTD
PMID:16982809
NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
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Ipcef1
interaction protein for cytohesin exchange factors 1
decreases expression
ISO
Am 580 results in decreased expression of IPCEF1 mRNA
CTD
PMID:16982809
NCBI chr 1:43,563,457...43,743,424
Ensembl chr 1:43,567,842...43,638,161
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Irf1
interferon regulatory factor 1
multiple interactions increases expression increases activity
ISO
Am 580 affects the localization of [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Tretinoin promotes the reaction [Am 580 results in increased activity of IRF1 protein]
CTD
PMID:16085646 PMID:16636311
NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
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Itgae
integrin subunit alpha E
increases expression
ISO
Am 580 results in increased expression of ITGAE mRNA
CTD
PMID:16982809
NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
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Kifc2
kinesin family member C2
decreases expression
ISO
Am 580 results in decreased expression of KIFC2 mRNA
CTD
PMID:16982809
NCBI chr 7:117,722,732...117,730,702
Ensembl chr 7:117,723,263...117,730,702
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Lair1
leukocyte-associated immunoglobulin-like receptor 1
increases expression
ISO
Am 580 results in increased expression of LAIR1 mRNA
CTD
PMID:16982809
NCBI chr 1:73,752,192...73,870,421
Ensembl chr 1:73,837,944...73,868,695
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Lelp1
late cornified envelope-like proline-rich 1
decreases expression
ISO
Am 580 results in decreased expression of LELP1 mRNA
CTD
PMID:16982809
NCBI chr 2:192,035,927...192,037,885
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LOC100302372
hypothetical protein LOC100302372
decreases expression
ISO
Am 580 results in decreased expression of KIAA0040 mRNA
CTD
PMID:16982809
NCBI chr13:77,784,516...77,822,333
Ensembl chr13:77,784,808...77,822,333
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LOC687399
hypothetical protein LOC687399
decreases expression
ISO
Am 580 results in decreased expression of C16ORF46 mRNA
CTD
PMID:16982809
NCBI chr19:49,508,321...49,518,721
Ensembl chr19:49,508,288...49,518,721
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Lrp11
LDL receptor related protein 11
decreases expression
ISO
Am 580 results in decreased expression of LRP11 mRNA
CTD
PMID:16982809
NCBI chr 1:1,702,696...1,731,210
Ensembl chr 1:1,702,696...1,731,210
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Man1c1
mannosidase, alpha, class 1C, member 1
decreases expression
ISO
Am 580 results in decreased expression of MAN1C1 mRNA
CTD
PMID:16982809
NCBI chr 5:152,775,031...152,920,130
Ensembl chr 5:152,774,855...152,920,343
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Map3k6
mitogen-activated protein kinase kinase kinase 6
decreases expression
ISO
Am 580 results in decreased expression of MAP3K6 mRNA
CTD
PMID:16982809
NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328
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Map4k1
mitogen activated protein kinase kinase kinase kinase 1
decreases expression
ISO
Am 580 results in decreased expression of MAP4K1 mRNA
CTD
PMID:16982809
NCBI chr 1:87,937,126...87,959,514
Ensembl chr 1:87,938,042...87,959,569
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:15383624
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:15383624
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Metrn
meteorin, glial cell differentiation regulator
decreases expression
ISO
Am 580 results in decreased expression of METRN mRNA
CTD
PMID:16982809
NCBI chr10:15,164,439...15,166,457
Ensembl chr10:15,164,439...15,166,457
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Mgat4c
MGAT4 family, member C
decreases expression
ISO
Am 580 results in decreased expression of MGAT4C mRNA
CTD
PMID:16982809
NCBI chr 7:43,249,369...44,024,278
Ensembl chr 7:44,009,069...44,024,456
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Myorg
myogenesis regulating glycosidase
decreases expression
ISO
Am 580 results in decreased expression of MYORG mRNA
CTD
PMID:16982809
NCBI chr 5:57,873,404...57,882,008
Ensembl chr 5:57,876,498...57,881,944
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Ndrg2
NDRG family member 2
decreases expression
ISO
Am 580 results in decreased expression of NDRG2 mRNA
CTD
PMID:16982809
NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
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Nphs1
NPHS1 adhesion molecule, nephrin
increases expression
ISO
Am580 increases expression of Nphs1 mRNA in podocytes
RGD
PMID:22125642
RGD:40902998
NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions increases activity
ISO
Am 580 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] Am 580 results in increased activity of NR1H4 protein
CTD
PMID:25257666
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
Am 580 results in increased expression of NRIP1 mRNA
CTD
PMID:16982809
NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
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Nrip3
nuclear receptor interacting protein 3
increases expression
ISO
Am 580 results in increased expression of NRIP3 mRNA
CTD
PMID:16982809
NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141
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Nudt7
nudix hydrolase 7
decreases expression
ISO
Am 580 results in decreased expression of NUDT7 mRNA
CTD
PMID:16982809
NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050
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Oas2
2'-5' oligoadenylate synthetase 2
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]
CTD
PMID:16636311
NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
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Ocln
occludin
increases expression
ISO
Am 580 results in increased expression of OCLN mRNA
CTD
PMID:16982755
NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
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Olr1
oxidized low density lipoprotein receptor 1
increases expression
ISO
Am 580 results in increased expression of OLR1 mRNA
CTD
PMID:16982809
NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
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Oma1
OMA1 zinc metallopeptidase
increases expression
ISO
Am 580 results in increased expression of OMA1 mRNA
CTD
PMID:16982809
NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475
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Pald1
phosphatase domain containing, paladin 1
decreases expression
ISO
Am 580 results in decreased expression of PALD1 mRNA
CTD
PMID:16982809
NCBI chr20:30,938,901...30,983,907
Ensembl chr20:30,938,901...30,975,472
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Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
increases expression
ISO
Am 580 results in increased expression of PAPSS2 mRNA
CTD
PMID:16982809
NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
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Pdlim2
PDZ and LIM domain 2
decreases expression
ISO
Am 580 results in decreased expression of PDLIM2 mRNA
CTD
PMID:16982809
NCBI chr15:51,843,562...51,856,785
Ensembl chr15:51,843,564...51,855,325
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Pdlim4
PDZ and LIM domain 4
decreases expression
ISO
Am 580 results in decreased expression of PDLIM4 mRNA
CTD
PMID:16982809
NCBI chr10:39,390,578...39,405,322
Ensembl chr10:39,390,581...39,405,311
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Pheta1
PH domain containing endocytic trafficking adaptor 1
decreases expression
ISO
Am 580 results in decreased expression of PHETA1 mRNA
CTD
PMID:16982809
NCBI chr12:40,225,316...40,230,573
Ensembl chr12:40,226,593...40,227,297
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Phlda2
pleckstrin homology-like domain, family A, member 2
decreases expression
ISO
Am 580 results in decreased expression of PHLDA2 mRNA
CTD
PMID:16982809
NCBI chr 1:216,701,345...216,704,479
Ensembl chr 1:216,702,319...216,703,534
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Plbd1
phospholipase B domain containing 1
increases expression
ISO
Am 580 results in increased expression of PLBD1 mRNA
CTD
PMID:16982809
NCBI chr 4:170,564,387...170,620,681
Ensembl chr 4:170,564,367...170,620,703
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Plpp3
phospholipid phosphatase 3
increases expression
ISO
Am 580 results in increased expression of PLPP3 mRNA
CTD
PMID:16982809
NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
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Pon2
paraoxonase 2
decreases expression
ISO
Am 580 results in decreased expression of PON2 mRNA
CTD
PMID:16982809
NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
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Pram1
PML-RARA regulated adaptor molecule 1
increases expression
ISO
Am 580 results in increased expression of PRAM1 mRNA
CTD
PMID:16982809
NCBI chr 7:18,507,878...18,516,321
Ensembl chr 7:18,510,354...18,515,503
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Qprt
quinolinate phosphoribosyltransferase
decreases expression
ISO
Am 580 results in decreased expression of QPRT mRNA
CTD
PMID:16982809
NCBI chr 1:198,544,262...198,559,556
Ensembl chr 1:198,544,262...198,559,568
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Rab15
RAB15, member RAS oncogene family
decreases expression
ISO
Am 580 results in decreased expression of RAB15 mRNA
CTD
PMID:16982809
NCBI chr 6:99,845,952...99,870,320
Ensembl chr 6:99,845,954...99,870,024
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Rab20
RAB20, member RAS oncogene family
increases expression
ISO
Am 580 results in increased expression of RAB20 mRNA
CTD
PMID:16982809
NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326
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Rap1gap
Rap1 GTPase-activating protein
decreases expression
ISO
Am 580 results in decreased expression of RAP1GAP mRNA
CTD
PMID:16982809
NCBI chr 5:156,008,868...156,074,350
Ensembl chr 5:156,026,911...156,074,395
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Rara
retinoic acid receptor, alpha
increases expression decreases expression multiple interactions
ISO
Am 580 results in increased expression of RARA protein Am 580 results in decreased expression of RARA protein 2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein]; Am 580 binds to and results in increased activity of RARA protein; Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]
CTD
PMID:10779427 PMID:16178010 PMID:16636311 PMID:17290005 PMID:30076181
NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
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Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein
CTD
PMID:15383624
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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Rbp1
retinol binding protein 1
increases expression
ISO
Am 580 results in increased expression of RBP1 mRNA
CTD
PMID:16982809
NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
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Reps2
RALBP1 associated Eps domain containing 2
decreases expression
ISO
Am 580 results in decreased expression of REPS2 mRNA
CTD
PMID:16982809
NCBI chr X:33,786,611...34,062,941
Ensembl chr X:33,884,499...34,057,399
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Rflnb
refilin B
increases expression
ISO
Am 580 results in increased expression of RFLNB mRNA
CTD
PMID:16982809
NCBI chr10:64,196,103...64,202,380
Ensembl chr10:64,196,127...64,202,380
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Rfxap
regulatory factor X-associated protein
decreases expression
ISO
Am 580 results in decreased expression of RFXAP mRNA
CTD
PMID:16982809
NCBI chr 2:144,003,453...144,007,636
Ensembl chr 2:144,003,454...144,007,636
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Rhobtb3
Rho-related BTB domain containing 3
increases expression
ISO
Am 580 results in increased expression of RHOBTB3 mRNA
CTD
PMID:16982809
NCBI chr 2:2,627,655...2,683,305
Ensembl chr 2:2,627,393...2,683,116
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Rxra
retinoid X receptor alpha
increases activity
ISO
Am 580 results in increased activity of RXRA protein
CTD
PMID:21543282
NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
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Sel1l3
SEL1L family member 3
increases expression
ISO
Am 580 results in increased expression of SEL1L3 mRNA
CTD
PMID:16982809
NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
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Selplg
selectin P ligand
decreases expression
ISO
Am 580 results in decreased expression of SELPLG mRNA
CTD
PMID:16982809
NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
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Slc26a11
solute carrier family 26 member 11
increases expression
ISO
Am 580 results in increased expression of SLC26A11 mRNA
CTD
PMID:16982809
NCBI chr10:108,479,105...108,504,188
Ensembl chr10:108,480,368...108,503,706
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Slitrk4
SLIT and NTRK-like family, member 4
increases expression
ISO
Am 580 results in increased expression of SLITRK4 mRNA
CTD
PMID:16982809
NCBI chr X:147,582,195...147,589,529
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Snai3
snail family transcriptional repressor 3
increases expression
ISO
Am 580 results in increased expression of SNAI3 mRNA
CTD
PMID:16982809
NCBI chr19:55,276,211...55,290,031
Ensembl chr19:55,277,549...55,284,663
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Ssmem1
serine-rich single-pass membrane protein 1
decreases expression
ISO
Am 580 results in decreased expression of SSMEM1 mRNA
CTD
PMID:16982809
NCBI chr 4:57,823,411...57,833,706
Ensembl chr 4:57,823,411...57,834,115
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein; Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD
PMID:16085646
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Sts
steroid sulfatase
increases activity
ISO
Am 580 results in increased activity of STS protein
CTD
PMID:16178010
NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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Synpo
synaptopodin
increases expression
ISO
AM580 increases expression of Synpo mRNA in podocytes
RGD
PMID:22125642
RGD:40902998
NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220
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Tacstd2
tumor-associated calcium signal transducer 2
decreases expression
ISO
Am 580 results in decreased expression of TACSTD2 mRNA
CTD
PMID:16982809
NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
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Tbc1d2
TBC1 domain family, member 2
increases expression
ISO
Am 580 results in increased expression of TBC1D2 mRNA
CTD
PMID:16982809
NCBI chr 5:62,213,001...62,261,467
Ensembl chr 5:62,212,982...62,260,105
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Tbl1x
transducin (beta)-like 1 X-linked
decreases expression
ISO
Am 580 results in decreased expression of TBL1X mRNA
CTD
PMID:16982809
NCBI chr X:44,959,883...44,988,551
Ensembl chr X:44,830,849...44,988,551
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Tbl2
transducin (beta)-like 2
increases expression
ISO
Am 580 results in increased expression of TBL2 mRNA
CTD
PMID:16982809
NCBI chr12:24,565,843...24,578,855
Ensembl chr12:24,565,849...24,578,786
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Tert
telomerase reverse transcriptase
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA
CTD
PMID:16482212
NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
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Tgm2
transglutaminase 2
multiple interactions increases activity increases expression
ISO
[Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein Am 580 results in increased activity of TGM2 protein Am 580 results in increased expression of TGM2 mRNA
CTD
PMID:2884032 PMID:9516142 PMID:16982809
NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
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Thbs3
thrombospondin 3
increases expression
ISO
Am 580 results in increased expression of THBS3 mRNA
CTD
PMID:16982809
NCBI chr 2:188,528,979...188,540,738
Ensembl chr 2:188,528,979...188,540,736
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Tmem14a
transmembrane protein 14A
decreases expression
ISO
Am 580 results in decreased expression of TMEM14A mRNA
CTD
PMID:16982809
NCBI chr 9:27,333,956...27,345,612 NCBI chr 9:27,334,103...27,351,302
Ensembl chr 9:27,343,853...27,345,070 Ensembl chr 9:27,343,853...27,345,070
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Tnf
tumor necrosis factor
increases activity
ISO
Am 580 results in increased activity of TNF protein
CTD
PMID:15703382
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfsf10
TNF superfamily member 10
increases activity
ISO
Am 580 results in increased activity of TNFSF10 protein
CTD
PMID:15703382
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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Tnfsf12
TNF superfamily member 12
decreases expression
ISO
Am 580 results in decreased expression of TNFSF12 mRNA
CTD
PMID:16982809
NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077
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Tns1
tensin 1
decreases expression
ISO
Am 580 results in decreased expression of TNS1 mRNA
CTD
PMID:16982809
NCBI chr 9:81,190,192...81,401,020
Ensembl chr 9:81,194,119...81,400,987
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Zbtb7b
zinc finger and BTB domain containing 7B
decreases expression
ISO
Am 580 results in decreased expression of ZBTB7B mRNA
CTD
PMID:16982809
NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19841
role
19792
application
19465
pharmaceutical
19338
drug
19338
antineoplastic agent
17009
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
115
Path 2
CHEBI ontology
19841
subatomic particle
19839
composite particle
19839
hadron
19839
baryon
19839
nucleon
19839
atomic nucleus
19839
atom
19839
main group element atom
19732
p-block element atom
19732
carbon group element atom
19636
carbon atom
19625
organic molecular entity
19625
organic group
18537
organic divalent group
18528
organodiyl group
18528
carbonyl group
18436
carbonyl compound
18436
carboxylic acid
18113
carboacyl group
17377
univalent carboacyl group
17377
carbamoyl group
17164
carboxamide
17164
monocarboxylic acid amide
14583
amidobenzoic acid
126
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
115