CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
Accession: CHEBI:64210
browse the term
Definition: An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms: related_synonym: AM580; Am 580; CD-336; Formula=C22H25NO3; InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26); InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N; SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
xref: Beilstein:3565084; CAS:102121-60-8; KEGG:C15619; LINCS:LSM-2132
xref_mesh: MESH:C068073
xref: PDB:3KMR; PMID:18271925; PMID:18416830; PMID:19700416; PMID:19790202; PMID:20147703; PMID:20453882; PMID:21150871; PMID:21310893; PMID:21715427; PMID:22258322; PMID:22353356; Reaxys:3565084
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Am 580 promotes the reaction [Tretinoin results in increased expression of ABCG2 mRNA]
CTD
PMID:20562004
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Ada
adenosine deaminase
increases expression
ISO
Am 580 results in increased expression of ADA mRNA
CTD
PMID:16982809
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4
increases expression
ISO
Am 580 results in increased expression of AGPAT4 mRNA
CTD
PMID:16982809
NCBI chr 1:48,525,131...48,633,798
Ensembl chr 1:48,527,323...48,633,345
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Agrn
agrin
decreases expression
ISO
Am 580 results in decreased expression of AGRN mRNA
CTD
PMID:16982809
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
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Ajap1
adherens junctions associated protein 1
increases expression
ISO
Am 580 results in increased expression of AJAP1 mRNA
CTD
PMID:16982809
NCBI chr 5:163,907,846...164,021,004
Ensembl chr 5:163,907,847...164,020,317
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Aplp2
amyloid beta precursor like protein 2
increases expression
ISO
Am 580 results in increased expression of APLP2 mRNA
CTD
PMID:16982809
NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
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Ar
androgen receptor
decreases activity
ISO
Am 580 results in decreased activity of AR protein
CTD
PMID:25257666
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atp2b1
ATPase plasma membrane Ca2+ transporting 1
decreases expression
ISO
Am 580 results in decreased expression of ATP2B1 mRNA
CTD
PMID:16982809
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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Bag2
BAG cochaperone 2
increases expression
ISO
Am 580 results in increased expression of BAG2 mRNA
CTD
PMID:16982809
NCBI chr 9:35,970,033...35,980,677
Ensembl chr 9:35,970,033...35,980,721
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C19h16orf46
similar to human chromosome 16 open reading frame 46
decreases expression
ISO
Am 580 results in decreased expression of C16ORF46 mRNA
CTD
PMID:16982809
NCBI chr19:45,017,499...45,033,453
Ensembl chr19:45,022,280...45,032,683
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Calcrl
calcitonin receptor like receptor
decreases expression
ISO
Am 580 results in decreased expression of CALCRL mRNA
CTD
PMID:16982809
NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
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Capn1
calpain 1
decreases expression decreases activity
ISO
Am 580 results in decreased expression of CAPN1 mRNA Am 580 results in decreased activity of CAPN1 protein
CTD
PMID:17460283
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Capn2
calpain 2
decreases expression decreases activity multiple interactions
ISO
Am 580 results in decreased expression of CAPN2 mRNA Am 580 results in decreased activity of CAPN2 protein Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]
CTD
PMID:17460283
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Cd1d1
CD1d1 molecule
increases expression multiple interactions
ISO
Am 580 results in increased expression of CD1D mRNA Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]
CTD
PMID:16982809 PMID:17392484
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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Cd300a
Cd300a molecule
increases expression
ISO
Am 580 results in increased expression of CD300A mRNA
CTD
PMID:16982809
NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
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Cd300lb
CD300 molecule-like family member b
increases expression
ISO
Am 580 results in increased expression of CD300LB mRNA
CTD
PMID:16982809
NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790
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Cd300lf
Cd300 molecule-like family member F
increases expression
ISO
Am 580 results in increased expression of CD300LF mRNA
CTD
PMID:16982809
NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
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Cd38
CD38 molecule
increases expression multiple interactions
ISO
Am 580 results in increased expression of CD38 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]; [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein
CTD
PMID:16329108
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
affects localization
ISO
Am 580 affects the localization of CDKN1B protein
CTD
PMID:16618747
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdr2l
cerebellar degeneration-related protein 2-like
decreases expression
ISO
Am 580 results in decreased expression of CDR2L mRNA
CTD
PMID:16982809
NCBI chr10:100,625,150...100,638,669
Ensembl chr10:100,624,607...100,638,666
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Col5a3
collagen type V alpha 3 chain
increases expression
ISO
Am 580 results in increased expression of COL5A3 mRNA
CTD
PMID:16982809
NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
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Cttnbp2
cortactin binding protein 2
decreases expression
ISO
Am 580 results in decreased expression of CTTNBP2 mRNA
CTD
PMID:16982809
NCBI chr 4:46,800,975...46,964,681
Ensembl chr 4:46,800,981...46,964,631
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
ISO
Am 580 results in increased expression of CYP19A1 mRNA
CTD
PMID:15941851
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA]
CTD
PMID:10953040
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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Dcstamp
dendrocyte expressed seven transmembrane protein
increases expression
ISO
Am 580 results in increased expression of DCSTAMP mRNA
CTD
PMID:16982809
NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
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Dhrs3
dehydrogenase/reductase 3
increases expression
ISO
Am 580 results in increased expression of DHRS3 mRNA
CTD
PMID:16982809
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dmpk
DM1 protein kinase
decreases expression
ISO
Am 580 results in decreased expression of DMPK mRNA
CTD
PMID:16982809
NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593
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Dmwd
DM1 locus, WD repeat containing
decreases expression
ISO
Am 580 results in decreased expression of DMWD mRNA
CTD
PMID:16982809
NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593
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Dnajc5b
DnaJ heat shock protein family (Hsp40) member C5 beta
increases expression
ISO
Am 580 results in increased expression of DNAJC5B mRNA
CTD
PMID:16982809
NCBI chr 2:101,973,726...102,066,275
Ensembl chr 2:101,973,793...102,066,275
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Ets2
ETS proto-oncogene 2, transcription factor
increases expression
ISO
Am 580 results in increased expression of ETS2 mRNA
CTD
PMID:16982809
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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Fam241a
family with sequence similarity 241 member A
decreases expression
ISO
Am 580 results in decreased expression of FAM241A mRNA
CTD
PMID:16982809
NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242
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Fas
Fas cell surface death receptor
increases activity
ISO
Am 580 results in increased activity of FAS protein
CTD
PMID:15703382
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fn1
fibronectin 1
increases expression
ISO
Am 580 results in increased expression of FN1 mRNA
CTD
PMID:16982809
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fut7
fucosyltransferase 7
decreases expression
ISO
Am 580 results in decreased expression of FUT7 mRNA
CTD
PMID:16982809
NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260
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Galm
galactose mutarotase
increases expression
ISO
Am 580 results in increased expression of GALM mRNA
CTD
PMID:18052213
NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310
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Gdf15
growth differentiation factor 15
increases expression
ISO
Am 580 results in increased expression of GDF15 mRNA
CTD
PMID:16982809
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gpd1l1
glycerol-3-phosphate dehydrogenase 1 like 1
decreases expression
ISO
Am 580 results in decreased expression of GPD1L mRNA
CTD
PMID:16982809
NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723
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Gusb
glucuronidase, beta
increases expression
ISO
Am 580 results in increased expression of GUSB mRNA
CTD
PMID:16982809
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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Hipk2
homeodomain interacting protein kinase 2
increases expression
ISO
Am 580 results in increased expression of HIPK2 mRNA
CTD
PMID:16982809
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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Hist1h2bd
histone cluster 1 H2B family member D
decreases expression
ISO
Am 580 results in decreased expression of H2BC5 mRNA
CTD
PMID:16982809
NCBI chr17:42,792,887...42,793,268
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Hlx
H2.0-like homeobox
decreases expression
ISO
Am 580 results in decreased expression of HLX mRNA
CTD
PMID:16982809
NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
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Ifngr1
interferon gamma receptor 1
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]
CTD
PMID:16085646
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Il1r1
interleukin 1 receptor type 1
decreases expression
ISO
Am 580 results in decreased expression of IL1R1 mRNA
CTD
PMID:16982809
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Il1rap
interleukin 1 receptor accessory protein
decreases expression
ISO
Am 580 results in decreased expression of IL1RAP mRNA
CTD
PMID:16982809
NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
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Inpp5f
inositol polyphosphate-5-phosphatase F
increases expression
ISO
Am 580 results in increased expression of INPP5F mRNA
CTD
PMID:16982809
NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276
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Ipcef1
interaction protein for cytohesin exchange factors 1
decreases expression
ISO
Am 580 results in decreased expression of IPCEF1 mRNA
CTD
PMID:16982809
NCBI chr 1:43,237,903...43,451,735
Ensembl chr 1:43,269,202...43,427,969
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Irf1
interferon regulatory factor 1
multiple interactions increases activity increases expression
ISO
Am 580 affects the localization of [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Tretinoin promotes the reaction [Am 580 results in increased activity of IRF1 protein]
CTD
PMID:16085646 PMID:16636311
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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Itgae
integrin subunit alpha E
increases expression
ISO
Am 580 results in increased expression of ITGAE mRNA
CTD
PMID:16982809
NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093 Ensembl chr10:57,591,753...57,764,093
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Kiaa0040
KIAA0040 ortholog
decreases expression
ISO
Am 580 results in decreased expression of KIAA0040 mRNA
CTD
PMID:16982809
NCBI chr13:72,274,519...72,312,103
Ensembl chr13:72,274,552...72,312,103
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Kifc2
kinesin family member C2
decreases expression
ISO
Am 580 results in decreased expression of KIFC2 mRNA
CTD
PMID:16982809
NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484
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Lair1
leukocyte-associated immunoglobulin-like receptor 1
increases expression
ISO
Am 580 results in increased expression of LAIR1 mRNA
CTD
PMID:16982809
NCBI chr 1:70,068,571...70,187,851
Ensembl chr 1:70,157,681...70,185,807
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Lelp1
late cornified envelope-like proline-rich 1
decreases expression
ISO
Am 580 results in decreased expression of LELP1 mRNA
CTD
PMID:16982809
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Lrp11
LDL receptor related protein 11
decreases expression
ISO
Am 580 results in decreased expression of LRP11 mRNA
CTD
PMID:16982809
NCBI chr 1:2,048,307...2,108,115
Ensembl chr 1:2,079,438...2,108,110
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Man1c1
mannosidase, alpha, class 1C, member 1
decreases expression
ISO
Am 580 results in decreased expression of MAN1C1 mRNA
CTD
PMID:16982809
NCBI chr 5:146,774,282...146,913,257
Ensembl chr 5:146,775,842...146,913,421
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Map3k6
mitogen-activated protein kinase kinase kinase 6
decreases expression
ISO
Am 580 results in decreased expression of MAP3K6 mRNA
CTD
PMID:16982809
NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
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Map4k1
mitogen activated protein kinase kinase kinase kinase 1
decreases expression
ISO
Am 580 results in decreased expression of MAP4K1 mRNA
CTD
PMID:16982809
NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:15383624
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:15383624
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Metrn
meteorin, glial cell differentiation regulator
decreases expression
ISO
Am 580 results in decreased expression of METRN mRNA
CTD
PMID:16982809
NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701
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Mgat4c
MGAT4 family, member C
decreases expression
ISO
Am 580 results in decreased expression of MGAT4C mRNA
CTD
PMID:16982809
NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571
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Myorg
myogenesis regulating glycosidase
decreases expression
ISO
Am 580 results in decreased expression of MYORG mRNA
CTD
PMID:16982809
NCBI chr 5:56,654,257...56,664,467
Ensembl chr 5:56,648,643...56,664,440
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Ndrg2
NDRG family member 2
decreases expression
ISO
Am 580 results in decreased expression of NDRG2 mRNA
CTD
PMID:16982809
NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
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Nphs1
NPHS1 adhesion molecule, nephrin
increases expression
ISO
Am580 increases expression of Nphs1 mRNA in podocytes
RGD
PMID:22125642
RGD:40902998
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions increases activity
ISO
Am 580 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] Am 580 results in increased activity of NR1H4 protein
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
Am 580 results in increased expression of NRIP1 mRNA
CTD
PMID:16982809
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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Nrip3
nuclear receptor interacting protein 3
increases expression
ISO
Am 580 results in increased expression of NRIP3 mRNA
CTD
PMID:16982809
NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600
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Nudt7
nudix hydrolase 7
decreases expression
ISO
Am 580 results in decreased expression of NUDT7 mRNA
CTD
PMID:16982809
NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
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Oas2
2'-5' oligoadenylate synthetase 2
multiple interactions increases expression
ISO
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]
CTD
PMID:16636311
NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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Ocln
occludin
increases expression
ISO
Am 580 results in increased expression of OCLN mRNA
CTD
PMID:16982755
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Olr1
oxidized low density lipoprotein receptor 1
increases expression
ISO
Am 580 results in increased expression of OLR1 mRNA
CTD
PMID:16982809
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Oma1
OMA1 zinc metallopeptidase
increases expression
ISO
Am 580 results in increased expression of OMA1 mRNA
CTD
PMID:16982809
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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Pald1
phosphatase domain containing, paladin 1
decreases expression
ISO
Am 580 results in decreased expression of PALD1 mRNA
CTD
PMID:16982809
NCBI chr20:29,269,814...29,334,850
Ensembl chr20:29,270,193...29,334,858
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Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
increases expression
ISO
Am 580 results in increased expression of PAPSS2 mRNA
CTD
PMID:16982809
NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
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Pdlim2
PDZ and LIM domain 2
decreases expression
ISO
Am 580 results in decreased expression of PDLIM2 mRNA
CTD
PMID:16982809
NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242
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Pdlim4
PDZ and LIM domain 4
decreases expression
ISO
Am 580 results in decreased expression of PDLIM4 mRNA
CTD
PMID:16982809
NCBI chr10:38,198,686...38,212,935
Ensembl chr10:38,198,689...38,212,938
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Pheta1
PH domain containing endocytic trafficking adaptor 1
decreases expression
ISO
Am 580 results in decreased expression of PHETA1 mRNA
CTD
PMID:16982809
NCBI chr12:34,711,831...34,717,601
Ensembl chr12:34,711,810...34,717,081
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Phlda2
pleckstrin homology-like domain, family A, member 2
decreases expression
ISO
Am 580 results in decreased expression of PHLDA2 mRNA
CTD
PMID:16982809
NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
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Plbd1
phospholipase B domain containing 1
increases expression
ISO
Am 580 results in increased expression of PLBD1 mRNA
CTD
PMID:16982809
NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277
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Plpp3
phospholipid phosphatase 3
increases expression
ISO
Am 580 results in increased expression of PLPP3 mRNA
CTD
PMID:16982809
NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
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Pon2
paraoxonase 2
decreases expression
ISO
Am 580 results in decreased expression of PON2 mRNA
CTD
PMID:16982809
NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
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Pram1
PML-RARA regulated adaptor molecule 1
increases expression
ISO
Am 580 results in increased expression of PRAM1 mRNA
CTD
PMID:16982809
NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166
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Qprt
quinolinate phosphoribosyltransferase
decreases expression
ISO
Am 580 results in decreased expression of QPRT mRNA
CTD
PMID:16982809
NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486
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Rab15
RAB15, member RAS oncogene family
decreases expression
ISO
Am 580 results in decreased expression of RAB15 mRNA
CTD
PMID:16982809
NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942
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Rab20
RAB20, member RAS oncogene family
increases expression
ISO
Am 580 results in increased expression of RAB20 mRNA
CTD
PMID:16982809
NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529
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Rap1gap
Rap1 GTPase-activating protein
decreases expression
ISO
Am 580 results in decreased expression of RAP1GAP mRNA
CTD
PMID:16982809
NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253
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Rara
retinoic acid receptor, alpha
increases expression multiple interactions decreases expression
ISO
Am 580 results in increased expression of RARA protein 2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein]; Am 580 binds to and results in increased activity of RARA protein; Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]
CTD
PMID:10779427 PMID:16178010 PMID:16636311 PMID:17290005 PMID:30076181
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein
CTD
PMID:15383624
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rbp1
retinol binding protein 1
increases expression
ISO
Am 580 results in increased expression of RBP1 mRNA
CTD
PMID:16982809
NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
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Reps2
RALBP1 associated Eps domain containing 2
decreases expression
ISO
Am 580 results in decreased expression of REPS2 mRNA
CTD
PMID:16982809
NCBI chr X:32,049,455...32,322,317
Ensembl chr X:32,049,399...32,317,414
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Rflnb
refilin B
increases expression
ISO
Am 580 results in increased expression of RFLNB mRNA
CTD
PMID:16982809
NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976
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Rfxap
regulatory factor X-associated protein
decreases expression
ISO
Am 580 results in decreased expression of RFXAP mRNA
CTD
PMID:16982809
NCBI chr 2:139,008,052...139,012,235
Ensembl chr 2:139,008,055...139,012,259
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Rhobtb3
Rho-related BTB domain containing 3
increases expression
ISO
Am 580 results in increased expression of RHOBTB3 mRNA
CTD
PMID:16982809
NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041
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Rxra
retinoid X receptor alpha
increases activity
ISO
Am 580 results in increased activity of RXRA protein
CTD
PMID:21543282
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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Sel1l3
SEL1L family member 3
increases expression
ISO
Am 580 results in increased expression of SEL1L3 mRNA
CTD
PMID:16982809
NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
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Selplg
selectin P ligand
decreases expression
ISO
Am 580 results in decreased expression of SELPLG mRNA
CTD
PMID:16982809
NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585
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Slc26a11
solute carrier family 26 member 11
increases expression
ISO
Am 580 results in increased expression of SLC26A11 mRNA
CTD
PMID:16982809
NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970
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Slitrk4
SLIT and NTRK-like family, member 4
increases expression
ISO
Am 580 results in increased expression of SLITRK4 mRNA
CTD
PMID:16982809
NCBI chr X:142,706,495...142,718,968
Ensembl chr X:142,706,338...142,718,575
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Snai3
snail family transcriptional repressor 3
increases expression
ISO
Am 580 results in increased expression of SNAI3 mRNA
CTD
PMID:16982809
NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486
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Ssmem1
serine-rich single-pass membrane protein 1
decreases expression
ISO
Am 580 results in decreased expression of SSMEM1 mRNA
CTD
PMID:16982809
NCBI chr 4:59,128,730...59,139,029
Ensembl chr 4:59,128,730...59,145,007
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein; Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD
PMID:16085646
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stra6
signaling receptor and transporter of retinol STRA6
increases expression
EXP
Am580 increases expression of Stra6 mRNA in lung
RGD
PMID:28734946
RGD:155631297
NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
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Sts
steroid sulfatase
increases activity
ISO
Am 580 results in increased activity of STS protein
CTD
PMID:16178010
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Synpo
synaptopodin
increases expression
ISO
AM580 increases expression of Synpo mRNA in podocytes
RGD
PMID:22125642
RGD:40902998
NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126
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Tacstd2
tumor-associated calcium signal transducer 2
decreases expression
ISO
Am 580 results in decreased expression of TACSTD2 mRNA
CTD
PMID:16982809
NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
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Tbc1d2
TBC1 domain family, member 2
increases expression
ISO
Am 580 results in increased expression of TBC1D2 mRNA
CTD
PMID:16982809
NCBI chr 5:60,884,114...60,931,717
Ensembl chr 5:60,884,124...60,931,352
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Tbl1x
transducin (beta)-like 1 X-linked
decreases expression
ISO
Am 580 results in decreased expression of TBL1X mRNA
CTD
PMID:16982809
NCBI chr X:41,574,558...41,731,117
Ensembl chr X:41,576,047...41,731,101
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Tbl2
transducin (beta)-like 2
increases expression
ISO
Am 580 results in increased expression of TBL2 mRNA
CTD
PMID:16982809
NCBI chr12:21,517,600...21,531,896
Ensembl chr12:21,520,682...21,531,896
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Tert
telomerase reverse transcriptase
multiple interactions
ISO
[Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA
CTD
PMID:16482212
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tgm2
transglutaminase 2
multiple interactions increases expression increases activity
ISO
[Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein Am 580 results in increased expression of TGM2 mRNA Am 580 results in increased activity of TGM2 protein
CTD
PMID:2884032 PMID:9516142 PMID:16982809
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Thbs3
thrombospondin 3
increases expression
ISO
Am 580 results in increased expression of THBS3 mRNA
CTD
PMID:16982809
NCBI chr 2:174,621,788...174,633,594
Ensembl chr 2:174,621,812...174,633,594
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Tmem14a
transmembrane protein 14A
decreases expression
ISO
Am 580 results in decreased expression of TMEM14A mRNA
CTD
PMID:16982809
NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463 Ensembl chr 9:23,733,039...23,734,463
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Tnf
tumor necrosis factor
increases activity
ISO
Am 580 results in increased activity of TNF protein
CTD
PMID:15703382
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
increases activity
ISO
Am 580 results in increased activity of TNFSF10 protein
CTD
PMID:15703382
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnfsf12
TNF superfamily member 12
decreases expression
ISO
Am 580 results in decreased expression of TNFSF12 mRNA
CTD
PMID:16982809
NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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Tns1
tensin 1
decreases expression
ISO
Am 580 results in decreased expression of TNS1 mRNA
CTD
PMID:16982809
NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225
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Zbtb7b
zinc finger and BTB domain containing 7B
decreases expression
ISO
Am 580 results in decreased expression of ZBTB7B mRNA
CTD
PMID:16982809
NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19921
role
19896
application
19732
pharmaceutical
19559
drug
19559
antineoplastic agent
17702
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
116
Path 2
CHEBI ontology
19921
subatomic particle
19919
composite particle
19919
hadron
19919
baryon
19919
nucleon
19919
atomic nucleus
19919
atom
19919
main group element atom
19867
p-block element atom
19867
carbon group element atom
19812
carbon atom
19807
organic molecular entity
19807
organic group
18971
organic divalent group
18952
organodiyl group
18952
carbonyl group
18905
carbonyl compound
18905
carboxylic acid
18622
carboacyl group
17704
univalent carboacyl group
17704
carbamoyl group
17550
carboxamide
17550
monocarboxylic acid amide
15653
amidobenzoic acid
141
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
116