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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiramide
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Accession:CHEBI:64207 term browser browse the term
Definition:An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Synonyms:exact_synonym: 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
 related_synonym: AMI-193;   Formula=C22H26FN3O2;   InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27);   InChIKey=FJUKDAZEABGEIH-UHFFFAOYSA-N;   SMILES=Fc1ccc(OCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1;   espiramida;   spiramidum
 xref: CAS:510-74-7;   LINCS:LSM-4124;   PMID:11124389;   PMID:17965538;   PMID:19875674;   PMID:4474849;   PMID:4776656;   Patent:US3238216;   Reaxys:631679;   Wikipedia:Spiramide


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Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        pharmacological role 18831
          neurotransmitter agent 16448
            serotonergic drug 3976
              serotonergic antagonist 2285
                spiramide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        tertiary amino compound 8651
                                          spiramide 0
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