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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:64203 term browser browse the term
Definition:A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Synonyms:exact_synonym: 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine
 related_synonym: (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin;   (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin;   1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine;   1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine;   Formula=C20H24N2S2;   InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3;   InChIKey=RLJFTICUTYVZDG-UHFFFAOYSA-N;   Methiothepine;   SMILES=CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1;   metitepina;   metitepine;   metitepinum
 xref: CAS:20229-30-5;   HMDB:HMDB0254534;   LINCS:LSM-4320
 xref_mesh: MESH:D008719
 xref: PMID:18033297;   PMID:18996971;   PMID:19837141;   PMID:19995401;   PMID:20171242;   PMID:20233210;   PMID:20331882;   PMID:20547148;   PMID:21062995;   PMID:21403818;   PMID:21514998;   PMID:21964383;   Patent:NL6608618;   Patent:US3379729;   Patent:US4444778;   Patent:US6331536;   Reaxys:626221;   Wikipedia:Metitepine
 cyclic_relationship: is_conjugate_base_of CHEBI:64204

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methiothepin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Methiothepin binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO
Methiothepin binds to and results in decreased activity of HTR1A protein CTD PMID:2207497 PMID:15482641 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP Methiothepin binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine CTD PMID:10764922 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B multiple interactions EXP methiothepin binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b] RGD PMID:8224165 RGD:2303647 NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Methiothepin binds to and results in decreased activity of HTR7 protein] which results in decreased abundance of Cyclic AMP; Methiothepin binds to and results in decreased activity of HTR7 protein CTD PMID:14578406 PMID:18996971 PMID:19509219 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Methiothepin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

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                                        tertiary amino compound 9922
                                          N-alkylpiperazine 3361
                                            methiothepin 7
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