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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carmoxirole
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Accession:CHEBI:64200 term browser browse the term
Definition:An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Synonyms:exact_synonym: 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indole-5-carboxylic acid
 related_synonym: 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridyl)butyl)indole-5-carboxylic acid;   Formula=C24H26N2O2;   InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28);   InChIKey=AFSOIHMEOKEZJF-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1;   carmoxirol;   carmoxirolum
 xref: CAS:98323-83-2;   LINCS:LSM-3850
 xref_mesh: MESH:C071485
 xref: PMID:10099036;   PMID:12106810;   PMID:1352381;   PMID:1356782;   PMID:1356783;   PMID:15109678;   PMID:1682817;   PMID:22051191;   PMID:7757314;   PMID:7902890;   PMID:8097997;   PMID:9825185;   Patent:DE3342632;   Patent:EP0548635;   Patent:US5256673;   Reaxys:5772553
 cyclic_relationship: is_conjugate_base_of CHEBI:64201



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carmoxirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin multiple interactions EXP carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein] CTD PMID:12106810 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19730
    role 19703
      application 19534
        pharmaceutical 19410
          drug 19410
            cardiovascular drug 8449
              antihypertensive agent 1885
                carmoxirole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19730
    subatomic particle 19728
      composite particle 19728
        hadron 19728
          baryon 19728
            nucleon 19728
              atomic nucleus 19728
                atom 19728
                  main group element atom 19676
                    p-block element atom 19676
                      carbon group element atom 19620
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19575
                              organic cyclic compound 19381
                                organic heterocyclic compound 18751
                                  organic heteropolycyclic compound 18240
                                    organic heterobicyclic compound 17213
                                      benzopyrrole 9602
                                        indoles 9275
                                          indolecarboxylic acid 2
                                            carmoxirole 1
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