Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carmoxirole
go back to main search page
Accession:CHEBI:64200 term browser browse the term
Definition:An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Synonyms:exact_synonym: 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indole-5-carboxylic acid
 related_synonym: 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridyl)butyl)indole-5-carboxylic acid;   Formula=C24H26N2O2;   InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28);   InChIKey=AFSOIHMEOKEZJF-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1;   carmoxirol;   carmoxirolum
 xref: CAS:98323-83-2;   LINCS:LSM-3850
 xref_mesh: MESH:C071485
 xref: PMID:10099036;   PMID:12106810;   PMID:1352381;   PMID:1356782;   PMID:1356783;   PMID:15109678;   PMID:1682817;   PMID:22051191;   PMID:7757314;   PMID:7902890;   PMID:8097997;   PMID:9825185;   Patent:DE3342632;   Patent:EP0548635;   Patent:US5256673;   Reaxys:5772553
 cyclic_relationship: is_conjugate_base_of CHEBI:64201


show annotations for term's descendants           Sort by:
 
carmoxirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin multiple interactions EXP carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein] CTD PMID:12106810 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            cardiovascular drug 7613
              antihypertensive agent 1676
                carmoxirole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      benzopyrrole 9339
                                        indoles 9193
                                          indolecarboxylic acid 2
                                            carmoxirole 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.