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ONTOLOGY REPORT - ANNOTATIONS


Term:carmoxirole
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Accession:CHEBI:64200 term browser browse the term
Definition:An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Synonyms:exact_synonym: 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indole-5-carboxylic acid
 related_synonym: 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridyl)butyl)indole-5-carboxylic acid;   Formula=C24H26N2O2;   InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28);   InChIKey=AFSOIHMEOKEZJF-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1;   carmoxirol;   carmoxirolum
 xref: CAS:98323-83-2 "ChemIDplus";   LINCS:LSM-3850
 xref_mesh: MESH:C071485
 xref: PMID:10099036 "Europe PMC";   PMID:12106810 "Europe PMC";   PMID:1352381 "Europe PMC";   PMID:1356782 "Europe PMC";   PMID:1356783 "Europe PMC";   PMID:15109678 "Europe PMC";   PMID:1682817 "Europe PMC";   PMID:22051191 "Europe PMC";   PMID:7757314 "Europe PMC";   PMID:7902890 "Europe PMC";   PMID:8097997 "Europe PMC";   PMID:9825185 "Europe PMC";   Patent:DE3342632;   Patent:EP0548635;   Patent:US5256673;   Reaxys:5772553 "Reaxys"
 cyclic_relationship: is_conjugate_base_of CHEBI:64201


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carmoxirole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            cardiovascular drug 7550
              antihypertensive agent 1637
                carmoxirole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      benzopyrrole 5747
                                        indoles 5526
                                          indolecarboxylic acid 2
                                            carmoxirole 1
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