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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carmoxirole
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Accession:CHEBI:64200 term browser browse the term
Definition:An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Synonyms:exact_synonym: 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indole-5-carboxylic acid
 related_synonym: 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridyl)butyl)indole-5-carboxylic acid;   Formula=C24H26N2O2;   InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28);   InChIKey=AFSOIHMEOKEZJF-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1;   carmoxirol;   carmoxirolum
 xref: CAS:98323-83-2;   LINCS:LSM-3850
 xref_mesh: MESH:C071485
 xref: PMID:10099036;   PMID:12106810;   PMID:1352381;   PMID:1356782;   PMID:1356783;   PMID:15109678;   PMID:1682817;   PMID:22051191;   PMID:7757314;   PMID:7902890;   PMID:8097997;   PMID:9825185;   Patent:DE3342632;   Patent:EP0548635;   Patent:US5256673;   Reaxys:5772553
 cyclic_relationship: is_conjugate_base_of CHEBI:64201


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carmoxirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin multiple interactions EXP carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein] CTD PMID:12106810 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            cardiovascular drug 8619
              antihypertensive agent 1945
                carmoxirole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      benzopyrrole 9724
                                        indoles 9414
                                          indolecarboxylic acid 2
                                            carmoxirole 1
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