CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dimercaprol
Accession: CHEBI:64198
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Definition: A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Synonyms: exact_synonym: 2,3-disulfanylpropan-1-ol
related_synonym: 1,2-dimercapto-3-propanol; 1,2-dithioglycerol; 2,3-Mercaptopropanol; 2,3-dimercaptol-1-propanol; 2,3-dimercaptopropanol; 2,3-dithiopropanol; 2,3-mercaptopropan-1-ol; 3-hydroxy-1,2-propanedithiol; BAL; British anti-Lewisite; British antilewisite; Formula=C3H8OS2; InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2; InChIKey=WQABCVAJNWAXTE-UHFFFAOYSA-N; SMILES=OCC(S)CS; alpha,beta-dithioglycerol; dimercaprolum; dimercaptopropanol; dithioglycerine; dithioglycerol; sulfactin
xref: CAS:59-52-9; DrugBank:DB06782; Drug_Central:3150; KEGG:C02924; KEGG:D00167
xref_mesh: MESH:D004112
xref: PMID:12605205; PMID:14882450; PMID:21006485; PMID:21803782; PMID:9292286; Patent:US2402665; Reaxys:1732058; Wikipedia:Dimercaprol
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Adpgk
ADP-dependent glucokinase
multiple interactions
ISO
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to ADPGK protein]
CTD
PMID:26598702
NCBI chr 8:64,088,871...64,116,832
Ensembl chr 8:64,088,913...64,116,832
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Alad
aminolevulinate dehydratase
increases expression decreases expression
ISO
Dimercaprol results in increased expression of ALAD protein Dimercaprol results in decreased expression of ALAD protein
CTD
PMID:15755317
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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App
amyloid beta precursor protein
affects binding multiple interactions
ISO
Dimercaprol binds to APP 5' UTR [Dimercaprol binds to APP 5' UTR] which results in decreased expression of APP protein; [Dimercaprol binds to APP 5' UTR] which results in decreased secretion of APP protein modified form
CTD
PMID:15681799
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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Clcf1
cardiotrophin-like cytokine factor 1
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]
CTD
PMID:16377760
NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CXCL2 mRNA]
CTD
PMID:16377760
NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CXCL1 mRNA]
CTD
PMID:16377760
NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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Fgfr3
fibroblast growth factor receptor 3
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of FGFR3 mRNA]
CTD
PMID:16377760
NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
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Gas1
growth arrest-specific 1
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of GAS1 mRNA]
CTD
PMID:16377760
NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
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Gsta5
glutathione S-transferase alpha 5
multiple interactions increases expression
ISO
Tetradecanoylphorbol Acetate promotes the reaction [Dimercaprol results in increased expression of GSTA1 mRNA]
CTD
PMID:7568053
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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Hk2
hexokinase 2
multiple interactions
ISO
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to HK2 protein]
CTD
PMID:26598702
NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
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Hmox1
heme oxygenase 1
increases expression
ISO
Dimercaprol results in increased expression of HMOX1 mRNA
CTD
PMID:8612205
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
Dimercaprol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]
CTD
PMID:10967126
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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Ins2
insulin 2
multiple interactions
EXP
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]
CTD
PMID:8048502
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Itgb5
integrin subunit beta 5
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of ITGB5 mRNA]
CTD
PMID:16377760
NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
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Keap1
Kelch-like ECH-associated protein 1
affects binding
ISO
Dimercaprol binds to KEAP1 protein
CTD
PMID:19808700
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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Kif16b
kinesin family member 16B
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF16B mRNA]
CTD
PMID:16377760
NCBI chr 3:136,596,621...136,936,809
Ensembl chr 3:136,657,480...136,936,674
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Kif1b
kinesin family member 1B
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA]
CTD
PMID:16377760
NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
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Kifap3
kinesin-associated protein 3
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIFAP3 mRNA]
CTD
PMID:16377760
NCBI chr13:82,072,497...82,217,256
Ensembl chr13:82,072,497...82,217,252
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Krt17
keratin 17
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT17 mRNA]
CTD
PMID:16377760
NCBI chr10:88,158,993...88,163,712
Ensembl chr10:88,118,001...88,163,723
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Krt18
keratin 18
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT18 mRNA]
CTD
PMID:16377760
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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Mafk
MAF bZIP transcription factor K
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of MAFK mRNA]
CTD
PMID:16377760
NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]
CTD
PMID:16183647
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Mycl
MYCL proto-oncogene, bHLH transcription factor
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of MYCL mRNA]
CTD
PMID:16377760
NCBI chr 5:140,691,947...140,698,837
Ensembl chr 5:140,692,779...140,698,609
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
[Dimercaprol co-treated with Mercuric Chloride] inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Dimercaprol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]
CTD
PMID:18838692
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases activity
ISO
[Dimercaprol co-treated with Mercuric Chloride] results in increased activity of NQO1 protein Dimercaprol results in increased activity of NQO1 protein
CTD
PMID:18838692
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Pgk1
phosphoglycerate kinase 1
multiple interactions
ISO
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to PGK1 protein]
CTD
PMID:26598702
NCBI chr X:77,263,399...77,279,373
Ensembl chr X:77,263,359...77,279,367
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Pml
PML nuclear body scaffold
multiple interactions
ISO
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to PML protein]
CTD
PMID:26598702
NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
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Ppbp
pro-platelet basic protein
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of PPBP mRNA]
CTD
PMID:16377760
NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
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Ppp2r5c
protein phosphatase 2, regulatory subunit B', gamma
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP2R5C mRNA]
CTD
PMID:16377760
NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA]
CTD
PMID:16377760
NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
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Rbl2
RB transcriptional corepressor like 2
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of RBL2 mRNA]
CTD
PMID:16377760
NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
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Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
ISO
Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:16183647
NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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Rptor
regulatory associated protein of MTOR, complex 1
multiple interactions
ISO
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]
CTD
PMID:16183647
NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
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Slc2a4
solute carrier family 2 member 4
multiple interactions
EXP
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]
CTD
PMID:8048502
NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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Socs3
suppressor of cytokine signaling 3
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA]
CTD
PMID:16377760
NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
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Stag1
stromal antigen 1
multiple interactions
ISO
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of STAG1 mRNA]
CTD
PMID:16377760
NCBI chr 8:108,958,099...109,342,738
Ensembl chr 8:108,958,046...109,342,738
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Txnrd1
thioredoxin reductase 1
multiple interactions
EXP
Dimercaprol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD
PMID:20810785
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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Tyr
tyrosinase
decreases activity
ISO
Dimercaprol results in decreased activity of TYR protein
CTD
PMID:16928136
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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