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ONTOLOGY REPORT - ANNOTATIONS


Term:dimercaprol
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Accession:CHEBI:64198 term browser browse the term
Definition:A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Synonyms:exact_synonym: 2,3-disulfanylpropan-1-ol
 related_synonym: 1,2-dimercapto-3-propanol;   1,2-dithioglycerol;   2,3-Mercaptopropanol;   2,3-dimercaptol-1-propanol;   2,3-dimercaptopropanol;   2,3-dithiopropanol;   2,3-mercaptopropan-1-ol;   3-hydroxy-1,2-propanedithiol;   BAL;   British anti-Lewisite;   British antilewisite;   Formula=C3H8OS2;   InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2;   InChIKey=WQABCVAJNWAXTE-UHFFFAOYSA-N;   SMILES=OCC(S)CS;   alpha,beta-dithioglycerol;   dimercaprolum;   dimercaptopropanol;   dithioglycerine;   dithioglycerol;   sulfactin
 xref: CAS:59-52-9 "ChemIDplus";   CAS:59-52-9 "KEGG COMPOUND";   CAS:59-52-9 "NIST Chemistry WebBook";   DrugBank:DB06782;   Drug_Central:3150 "DrugCentral";   KEGG:C02924;   KEGG:D00167
 xref_mesh: MESH:D004112
 xref: PMID:12605205 "Europe PMC";   PMID:14882450 "Europe PMC";   PMID:21006485 "Europe PMC";   PMID:21803782 "Europe PMC";   PMID:9292286 "Europe PMC";   Patent:US2402665;   Reaxys:1732058 "Reaxys";   Wikipedia:Dimercaprol


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dimercaprol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adpgk ADP-dependent glucokinase JBrowse link 8 64,088,871 64,116,832 RGD:6480464
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6480464
G Gas1 growth arrest-specific 1 JBrowse link 17 4,846,116 4,849,350 RGD:6480464
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Kif16b kinesin family member 16B JBrowse link 3 136,596,621 136,936,809 RGD:6480464
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:6480464
G Kifap3 kinesin-associated protein 3 JBrowse link 13 82,072,497 82,217,256 RGD:6480464
G Krt17 keratin 17 JBrowse link 10 88,158,993 88,163,712 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Mafk MAF bZIP transcription factor K JBrowse link 12 16,923,989 16,934,706 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Mycl MYCL proto-oncogene, bHLH transcription factor JBrowse link 5 140,691,947 140,698,837 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6480464
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:6480464
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:6480464
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6480464
G Rbl2 RB transcriptional corepressor like 2 JBrowse link 19 17,300,088 17,346,865 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Stag1 stromal antigen 1 JBrowse link 8 108,958,099 109,342,738 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:6480464
G Tyr tyrosinase JBrowse link 1 151,012,598 151,106,802 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      chemical role 19227
        ligand 5751
          chelator 5728
            dimercaprol 39
              dithioglycerophosphocholine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    main group molecular entity 19646
                      s-block molecular entity 19408
                        hydrogen molecular entity 19397
                          hydrides 18356
                            inorganic hydride 17210
                              chalcogen hydride 2371
                                sulfur hydride 1987
                                  hydrogen sulfide 1987
                                    thiol group 1921
                                      thiol 1921
                                        dithiol 1336
                                          dimercaprol 39
                                            dithioglycerophosphocholine + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.