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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benserazide
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Accession:CHEBI:64187 term browser browse the term
Definition:A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Synonyms:exact_synonym: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
 related_synonym: DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide;   DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide;   Formula=C10H15N3O5;   InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);   InChIKey=BNQDCRGUHNALGH-UHFFFAOYSA-N;   Ro 4-4602;   Ro 44602;   SMILES=NC(CO)C(=O)NNCc1ccc(O)c(O)c1O;   benserazida;   benserazidum
 xref: CAS:322-35-0;   Drug_Central:314;   KEGG:D03082;   LINCS:LSM-5097
 xref_mesh: MESH:D001545
 xref: PMID:12703659;   PMID:22236652;   Patent:BE619015;   Patent:US3178476;   Reaxys:3984490;   Wikipedia:Benserazide
 cyclic_relationship: is_conjugate_base_of CHEBI:64190


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benserazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO
EXP 		COMT protein results in increased methylation of Benserazide CTD PMID:11160877 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO Benserazide binds to and results in decreased activity of DDC protein CTD PMID:35151785 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein] CTD PMID:19399396 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein] CTD PMID:19399396 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
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  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          neurotransmitter agent 16947
            dopaminergic agent 5561
              benserazide 4
Path 2
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  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        primary amino compound 9437
                                          benserazide 4
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