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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benserazide
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Accession:CHEBI:64187 term browser browse the term
Definition:A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Synonyms:exact_synonym: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
 related_synonym: DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide;   DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide;   Formula=C10H15N3O5;   InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);   InChIKey=BNQDCRGUHNALGH-UHFFFAOYSA-N;   Ro 4-4602;   Ro 44602;   SMILES=NC(CO)C(=O)NNCc1ccc(O)c(O)c1O;   benserazida;   benserazidum
 xref: CAS:322-35-0;   Drug_Central:314;   KEGG:D03082;   LINCS:LSM-5097
 xref_mesh: MESH:D001545
 xref: PMID:12703659;   PMID:22236652;   Patent:BE619015;   Patent:US3178476;   Reaxys:3984490;   Wikipedia:Benserazide
 cyclic_relationship: is_conjugate_base_of CHEBI:64190


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benserazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO
EXP
COMT protein results in increased methylation of Benserazide CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein] CTD PMID:19399396 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein] CTD PMID:19399396 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link

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  CHEBI ontology 19841
    role 19792
      biological role 19792
        pharmacological role 18847
          neurotransmitter agent 16446
            dopaminergic agent 5085
              benserazide 3
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            inorganic hydride 17483
                              pnictogen hydride 17456
                                nitrogen hydride 17300
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        primary amino compound 7881
                                          benserazide 3
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