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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benserazide
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Accession:CHEBI:64187 term browser browse the term
Definition:A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Synonyms:exact_synonym: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
 related_synonym: DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide;   DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide;   Formula=C10H15N3O5;   InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);   InChIKey=BNQDCRGUHNALGH-UHFFFAOYSA-N;   Ro 4-4602;   Ro 44602;   SMILES=NC(CO)C(=O)NNCc1ccc(O)c(O)c1O;   benserazida;   benserazidum
 xref: CAS:322-35-0;   Drug_Central:314;   KEGG:D03082;   LINCS:LSM-5097
 xref_mesh: MESH:D001545
 xref: PMID:12703659;   PMID:22236652;   Patent:BE619015;   Patent:US3178476;   Reaxys:3984490;   Wikipedia:Benserazide
 cyclic_relationship: is_conjugate_base_of CHEBI:64190


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benserazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO
EXP		 COMT protein results in increased methylation of Benserazide CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO Benserazide binds to and results in decreased activity of DDC protein CTD PMID:35151785 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein] CTD PMID:19399396 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein] CTD PMID:19399396 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
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  CHEBI ontology 19818
    role 19790
      biological role 19788
        pharmacological role 19035
          neurotransmitter agent 16672
            dopaminergic agent 5431
              benserazide 4
Path 2
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  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    main group molecular entity 19761
                      s-block molecular entity 19612
                        hydrogen molecular entity 19601
                          hydrides 19077
                            inorganic hydride 17986
                              pnictogen hydride 17973
                                nitrogen hydride 17870
                                  azane 17655
                                    ammonia 17654
                                      organic amino compound 17654
                                        primary amino compound 9033
                                          benserazide 4
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