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ONTOLOGY REPORT - ANNOTATIONS
Term:benserazide
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Accession:CHEBI:64187 term browser browse the term
Definition:A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Synonyms:exact_synonym: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
 related_synonym: DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide;   DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide;   Formula=C10H15N3O5;   InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);   InChIKey=BNQDCRGUHNALGH-UHFFFAOYSA-N;   Ro 4-4602;   Ro 44602;   SMILES=NC(CO)C(=O)NNCc1ccc(O)c(O)c1O;   benserazida;   benserazidum
 xref: CAS:322-35-0 "ChemIDplus";   Drug_Central:314 "DrugCentral";   KEGG:D03082;   LINCS:LSM-5097
 xref_mesh: MESH:D001545
 xref: PMID:12703659 "Europe PMC";   PMID:22236652 "Europe PMC";   Patent:BE619015;   Patent:US3178476;   Reaxys:3984490 "Reaxys";   Wikipedia:Benserazide
 cyclic_relationship: is_conjugate_base_of CHEBI:64190

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benserazide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        pharmacological role 18755
          neurotransmitter agent 16393
            dopaminergic agent 5041
              benserazide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  azane 16693
                                    ammonia 16690
                                      organic amino compound 16689
                                        primary amino compound 7790
                                          benserazide 3
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