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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methylquipazine
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Accession:CHEBI:64164 term browser browse the term
Definition:An aminoquinoline that consists of quinoline in which the hydrogen at position 2 is substituted by a 4-methylpiperazin-1-yl group. A 5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites.
Synonyms:related_synonym: Formula=C14H17N3;   InChI=1S/C14H17N3/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14/h2-7H,8-11H2,1H3;   InChIKey=HOMWNUXPSJQSSU-UHFFFAOYSA-N;   SMILES=CN1CCN(CC1)c1ccc2ccccc2n1
 xref: LINCS:LSM-3379
 xref_mesh: MESH:C109625
 xref: PMID:10638822;   PMID:15848758;   PMID:2583244;   PMID:9290075;   PMID:9622544;   Reaxys:887071


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N-methylquipazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity 		ISO [N-methylquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP CTD PMID:19725810 NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      biological role 20829
        pharmacological role 19920
          neurotransmitter agent 16950
            serotonergic drug 4419
              serotonergic agonist 1033
                N-methylquipazine 1
                  N-methylquipazine dimaleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    main group molecular entity 20794
                      s-block molecular entity 20589
                        hydrogen molecular entity 20573
                          hydrides 19703
                            inorganic hydride 18601
                              pnictogen hydride 18588
                                nitrogen hydride 18501
                                  azane 18260
                                    ammonia 18259
                                      organic amino compound 18259
                                        aromatic amine 15826
                                          aminoquinoline 1772
                                            N-methylquipazine 1
                                              N-methylquipazine dimaleate 0
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