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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diquat
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Accession:CHEBI:64163 term browser browse the term
Definition:The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Synonyms:exact_synonym: 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium
 related_synonym: 1,1'-Ethylene-2,2'-bipyridyldylium ion;   1,1'-Ethylene-2,2'-bipyridylium ion;   9,10-Dihydro-8a,10a-diazoniaphenanthrene;   Diquat dication;   Formula=C12H12N2;   InChI=1S/C12H12N2/c1-3-7-13-9-10-14-8-4-2-6-12(14)11(13)5-1/h1-8H,9-10H2/q+2;   InChIKey=SYJFEGQWDCRVNX-UHFFFAOYSA-N;   SMILES=C1C[n+]2ccccc2-c2cccc[n+]12
 xref: CAS:2764-72-9;   KEGG:C18577
 xref_mesh: MESH:D004178
 xref: PPDB:1541;   Reaxys:3670526;   Wikipedia:Diquat


show annotations for term's descendants           Sort by:
diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase affects activity
multiple interactions
decreases expression		 EXP Diquat affects the activity of CAT protein
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA]		 CTD PMID:22558963 PMID:32280687 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CLDN1 claudin 1 decreases expression EXP Diquat results in decreased expression of CLDN1 protein CTD PMID:26338884 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLDN3 claudin 3 decreases expression
multiple interactions		 EXP Diquat results in decreased expression of CLDN3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]		 CTD PMID:26338884 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102 		JBrowse link
G CLDN4 claudin 4 decreases expression
multiple interactions		 EXP Diquat results in decreased expression of CLDN4 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]		 CTD PMID:26338884 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression		 EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression
multiple interactions		 EXP Diquat results in increased expression of IL1B mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]		 CTD PMID:32280687
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 EXP Diquat results in decreased expression of NFE2L2 mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]		 CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G OCLN occludin increases expression EXP Diquat results in increased expression of OCLN protein CTD PMID:26338884 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases expression		 EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase increases expression EXP Diquat results in increased expression of TDO2 mRNA CTD PMID:22558963 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,962 		JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP Diquat results in decreased expression of TJP1 protein CTD PMID:26338884 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
G TJP2 tight junction protein 2 multiple interactions
decreases expression		 EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein] CTD PMID:26338884 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
G TJP3 tight junction protein 3 decreases expression
multiple interactions		 EXP Diquat results in decreased expression of TJP3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]		 CTD PMID:26338884 NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531 		JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions		 EXP Diquat results in increased expression of TNF mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]		 CTD PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      application 869
        pesticide 184
          herbicide 105
            diquat 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 5066
    subatomic particle 5057
      composite particle 5057
        hadron 5057
          baryon 5057
            nucleon 5057
              atomic nucleus 5057
                atom 5057
                  main group element atom 5026
                    p-block element atom 5023
                      carbon group element atom 4940
                        carbon atom 4939
                          organic molecular entity 4939
                            organic molecule 4887
                              organic cyclic compound 4825
                                organic heterocyclic compound 4614
                                  organonitrogen heterocyclic compound 267
                                    bipyridines 50
                                      bipyridine 50
                                        2,2'-bipyridine 14
                                          diquat 14
paths to the root