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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diquat
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Accession:CHEBI:64163 term browser browse the term
Definition:The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Synonyms:exact_synonym: 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium
 related_synonym: 1,1'-Ethylene-2,2'-bipyridyldylium ion;   1,1'-Ethylene-2,2'-bipyridylium ion;   9,10-Dihydro-8a,10a-diazoniaphenanthrene;   Diquat dication;   Formula=C12H12N2;   InChI=1S/C12H12N2/c1-3-7-13-9-10-14-8-4-2-6-12(14)11(13)5-1/h1-8H,9-10H2/q+2;   InChIKey=SYJFEGQWDCRVNX-UHFFFAOYSA-N;   SMILES=C1C[n+]2ccccc2-c2cccc[n+]12
 xref: CAS:2764-72-9;   KEGG:C18577
 xref_mesh: MESH:D004178
 xref: PPDB:1541;   Reaxys:3670526;   Wikipedia:Diquat



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diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO Diquat results in increased expression of ADM mRNA CTD PMID:21172416 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diquat results in increased expression of ADORA2B mRNA CTD PMID:21172416 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Diquat results in increased expression of AKR1B10 mRNA CTD PMID:21172416 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Diquat results in increased expression of AKR1C1 mRNA CTD PMID:21172416 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Diquat results in increased expression of AKR1C2 mRNA CTD PMID:21172416 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 increases expression ISO Diquat results in increased expression of AKR1C1 mRNA CTD PMID:21172416 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein] CTD PMID:20826540 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Diquat results in increased expression of ANKRD1 mRNA CTD PMID:21172416 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Diquat results in increased expression of ATF3 mRNA CTD PMID:21172416 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Diquat results in increased expression of ATF6 mRNA CTD PMID:32536062 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA] CTD PMID:26785375 PMID:27057282 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Diquat affects the expression of BCL2 mRNA
Diquat results in decreased expression of BCL2 protein
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]
CTD PMID:26785375 PMID:27057282 PMID:29484840 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Diquat results in increased expression of BCL2L11 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]
CTD PMID:26785375 PMID:27057282 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
ISO
EXP
GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; SN50 peptide inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
Diquat results in increased expression of CASP3 mRNA
Diquat results in increased expression of CASP3 mRNA; Diquat results in increased expression of CASP3 protein modified form
[Antioxidants results in decreased susceptibility to Diquat] which results in decreased expression of CASP3 mRNA; Diquat results in increased cleavage of and results in increased activity of CASP3 protein; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:15496407 PMID:18164269 PMID:19815060 PMID:26785375 PMID:27057282 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Antioxidants results in decreased susceptibility to Diquat] which results in decreased expression of CASP8 mRNA CTD PMID:32536062 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO
EXP
Diquat results in increased cleavage of and results in increased activity of CASP9 protein; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]
CTD PMID:18164269 PMID:20826540 PMID:29484840 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]
Diquat results in decreased activity of CAT protein
CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
CTD PMID:21215309 PMID:26785375 PMID:27057282 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Diquat results in increased expression of CLIP4 mRNA CTD PMID:21172416 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Diquat results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Diquat results in increased expression of CYP4A1 mRNA CTD PMID:7676460 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Dao D-amino-acid oxidase multiple interactions
increases activity
ISO Ascorbic Acid inhibits the reaction [Diquat results in increased activity of DAO protein] CTD PMID:33475796 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Diquat results in increased expression of DDIT3 mRNA; Diquat results in increased expression of DDIT3 protein
PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]
CTD PMID:20826540 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO Diquat results in increased expression of DKK1 mRNA CTD PMID:21172416 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Diquat results in increased expression of DUSP1 mRNA CTD PMID:21172416 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA] CTD PMID:20826540 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Diquat results in increased expression of EIF2AK3 mRNA CTD PMID:32536062 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Diquat results in increased expression of ELL2 mRNA CTD PMID:21172416 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Diquat results in increased expression of FOS mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]
CTD PMID:20826540 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
ISO Diquat results in increased expression of FOXO1 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]
CTD PMID:27057282 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Diquat results in increased expression of FTH1 mRNA CTD PMID:21698372 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Diquat results in increased expression of FTL1 mRNA CTD PMID:16962985 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
increases activity
EXP
ISO
Diquat results in increased expression of G6PD mRNA; Diquat results in increased expression of G6PD protein
Diquat results in increased activity of G6PD protein
CTD PMID:8934631 PMID:28108222 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Diquat results in increased expression of GADD45A mRNA CTD PMID:21172416 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
decreases activity
decreases expression
ISO
EXP
Diquat results in increased expression of GCLC mRNA
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA
Diquat results in decreased activity of GCLC protein
Diquat results in decreased expression of GCLC mRNA
CTD PMID:7676460 PMID:16962985 PMID:22762311 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Diquat results in increased expression of GCLM mRNA CTD PMID:16962985 PMID:20826540 PMID:21172416 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Glrx glutaredoxin increases response to substance ISO GLRX gene mutant form results in increased susceptibility to Diquat CTD PMID:17893043 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
increases activity
ISO GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]
Ascorbic Acid inhibits the reaction [Diquat results in increased expression of GPT protein]
CTD PMID:15496407 PMID:33475796 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
decreases response to substance
affects response to substance
multiple interactions
increases response to substance
ISO Diquat results in decreased expression of GPX1 protein
GPX1 protein results in decreased susceptibility to Diquat
GPX1 protein affects the susceptibility to Diquat
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]; GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]
GPX1 gene mutant form results in increased susceptibility to Diquat; GPX1 protein results in increased susceptibility to Diquat
CTD PMID:10490281 PMID:11568445 PMID:11672444 PMID:15182862 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance
increases expression
multiple interactions
ISO GPX4 protein alternative form results in decreased susceptibility to Diquat
Diquat results in increased expression of GPX4 mRNA
GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]; GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
CTD PMID:15496407 PMID:16962985 PMID:19744930 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Diquat results in increased expression of GSR mRNA CTD PMID:16962985 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Diquat results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Diquat results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Diquat results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Diquat results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Diquat results in decreased expression of GSTM2 mRNA CTD PMID:7676460 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Diquat results in increased expression of HAMP mRNA CTD PMID:21698372 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
increases activity
multiple interactions
ISO Diquat results in increased expression of HMOX1 mRNA; Diquat results in increased expression of HMOX1 protein
Diquat results in decreased expression of HMOX1 protein
Diquat results in increased activity of HMOX1 protein
Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of HMOX1 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]
CTD PMID:20826540 PMID:21172416 PMID:33475796 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Diquat results in increased expression of HSPA1A mRNA CTD PMID:21172416
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diquat results in increased expression of HSPA1B mRNA CTD PMID:21172416 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Ifng interferon gamma multiple interactions ISO Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide] CTD PMID:11498278 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases response to substance ISO IGF1R protein results in increased susceptibility to Diquat CTD PMID:22132081 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il6 interleukin 6 increases expression EXP Diquat results in increased expression of IL6 protein CTD PMID:21698372 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diquat results in increased expression of JUN mRNA CTD PMID:21172416 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat] CTD PMID:22762311 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kynu kynureninase increases expression ISO Diquat results in increased expression of KYNU mRNA CTD PMID:21172416 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Diquat results in increased expression of HSPA6 mRNA CTD PMID:21172416 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Diquat results in increased expression of MAP2 mRNA CTD PMID:21172416 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK1 protein CTD PMID:20826540 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK3 protein CTD PMID:20826540 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein] CTD PMID:20826540 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Diquat results in increased expression of ME1 mRNA CTD PMID:16962985 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Capsaicin inhibits the reaction [Diquat results in increased activity of MPO protein] CTD PMID:15046732 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA] CTD PMID:20826540 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A decreases expression
multiple interactions
ISO Diquat results in decreased expression of MT2 mRNA
PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]
CTD PMID:20826540 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Diquat affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
decreases expression
increases response to substance
decreases response to substance
increases activity
multiple interactions
ISO Diquat results in increased expression of NFE2L2 protein
Diquat results in decreased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Diquat
NFE2L2 results in decreased susceptibility to Diquat
Diquat results in increased activity of NFE2L2 protein
Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 protein]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]
CTD PMID:16962985 PMID:20143881 PMID:20826540 PMID:21172416 PMID:22762311 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
decreases expression
multiple interactions
increases activity
ISO Diquat results in increased expression of NQO1 mRNA
Diquat results in decreased expression of NQO1 protein
Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of NQO1 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]
Diquat results in increased expression of NQO1 mRNA; Diquat results in increased expression of NQO1 protein
Diquat results in increased activity of NQO1 protein
CTD PMID:20826540 PMID:21172416 PMID:33475796 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Diquat results in increased cleavage of PARP1 protein CTD PMID:25693864 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Diquat results in increased expression of PGD mRNA CTD PMID:16962985 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing
ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; NADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; POR protein results in increased metabolism of Diquat
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; [POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen; POR protein results in increased metabolism of Diquat
CTD PMID:21215309 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO Diquat results in increased expression of PPIF mRNA CTD PMID:21172416 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Diquat results in increased expression of PPP1R15A mRNA CTD PMID:21172416 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Diquat results in increased expression of PRDX1 mRNA CTD PMID:16962985 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Diquat results in increased expression of PRDX3 mRNA CTD PMID:16962985 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance
affects response to substance
multiple interactions
ISO PROP1 gene mutant form results in decreased susceptibility to Diquat
PROP1 protein affects the susceptibility to Diquat
PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein]
CTD PMID:19414510 PMID:20826540 NCBI chr10:35,271,959...35,274,434
Ensembl chr10:35,271,973...35,274,434
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Diquat results in increased expression of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of PTGS2 protein]
CTD PMID:29484840 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rasgef1b RasGEF domain family, member 1B increases expression ISO Diquat results in increased expression of RASGEF1B mRNA CTD PMID:21172416 NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741
JBrowse link
G Rgs20 regulator of G-protein signaling 20 increases expression ISO Diquat results in increased expression of RGS20 mRNA CTD PMID:21172416 NCBI chr 5:14,484,320...14,614,321
Ensembl chr 5:14,534,775...14,614,084
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Diquat results in increased expression of RGS4 mRNA CTD PMID:21172416 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Diquat results in increased expression of RND3 mRNA CTD PMID:21172416 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Diquat results in increased expression of SAT1 mRNA CTD PMID:21172416 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Diquat results in increased expression of SERPINB8 mRNA CTD PMID:21172416 NCBI chr13:23,626,945...23,650,270
Ensembl chr13:23,626,945...23,650,835
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Diquat results in increased expression of SERPINE1 mRNA CTD PMID:21172416 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression EXP Diquat results in decreased expression of SLC40A1 mRNA CTD PMID:21698372 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Diquat results in increased expression of SLC7A11 mRNA CTD PMID:21172416 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
Diquat results in decreased expression of SOD1 mRNA
CTD PMID:7676460 PMID:11672444 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
Diquat results in increased expression of SOD2 protein
CTD PMID:11672444 PMID:29484840 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Diquat results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Diquat results in increased expression of SPINK1 mRNA CTD PMID:21172416 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Diquat results in increased expression of SRXN1 mRNA CTD PMID:21172416 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Diquat results in increased expression of STC2 mRNA CTD PMID:21172416 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Tfrc transferrin receptor increases expression EXP Diquat results in increased expression of TFRC mRNA CTD PMID:21698372 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diquat results in increased expression of and affects the localization of TP53 protein; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein] CTD PMID:29484840 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO Diquat results in increased expression of TRIM16 mRNA CTD PMID:21172416 NCBI chr10:47,485,982...47,509,010 JBrowse link
G Txn2 thioredoxin 2 increases expression
decreases response to substance
multiple interactions
ISO Diquat results in increased expression of TXN2 mRNA
TXN2 protein results in decreased susceptibility to Diquat
TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
CTD PMID:16962985 PMID:18164269 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Diquat results in increased expression of TXNRD1 mRNA CTD PMID:20826540 PMID:21172416 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Diquat results in increased expression of UPP1 mRNA CTD PMID:21172416 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Diquat results in increased expression of ZFAND2A mRNA CTD PMID:21172416 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pesticide 17134
          herbicide 13005
            diquat 103
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organonitrogen heterocyclic compound 17661
                                    bipyridines 2946
                                      bipyridine 2924
                                        2,2'-bipyridine 111
                                          diquat 103
paths to the root