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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diquat
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Accession:CHEBI:64163 term browser browse the term
Definition:The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Synonyms:exact_synonym: 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium
 related_synonym: 1,1'-Ethylene-2,2'-bipyridyldylium ion;   1,1'-Ethylene-2,2'-bipyridylium ion;   9,10-Dihydro-8a,10a-diazoniaphenanthrene;   Diquat dication;   Formula=C12H12N2;   InChI=1S/C12H12N2/c1-3-7-13-9-10-14-8-4-2-6-12(14)11(13)5-1/h1-8H,9-10H2/q+2;   InChIKey=SYJFEGQWDCRVNX-UHFFFAOYSA-N;   SMILES=C1C[n+]2ccccc2-c2cccc[n+]12
 xref: CAS:2764-72-9;   KEGG:C18577
 xref_mesh: MESH:D004178
 xref: PPDB:1541;   Reaxys:3670526;   Wikipedia:Diquat


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diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO Diquat results in increased expression of ADM mRNA CTD PMID:21172416 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diquat results in increased expression of ADORA2B mRNA CTD PMID:21172416 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Diquat results in increased expression of AKR1B10 mRNA CTD PMID:21172416 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Diquat results in increased expression of AKR1C2 mRNA CTD PMID:21172416 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein] CTD PMID:20826540 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Diquat results in increased expression of ANKRD1 mRNA CTD PMID:21172416 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Diquat results in increased expression of ATF3 mRNA CTD PMID:21172416 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA] CTD PMID:26785375, PMID:27057282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Diquat affects the expression of BCL2 mRNA
Diquat results in decreased expression of BCL2 protein
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]
CTD PMID:26785375, PMID:27057282, PMID:29484840 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Diquat results in increased expression of BCL2L11 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]
CTD PMID:26785375, PMID:27057282 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
ISO
EXP
GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; SN50 peptide inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
Diquat results in increased expression of CASP3 mRNA
Diquat results in increased expression of CASP3 mRNA; Diquat results in increased expression of CASP3 protein modified form
Diquat results in increased cleavage of and results in increased activity of CASP3 protein; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:15496407, PMID:18164269, PMID:19815060, PMID:26785375, PMID:27057282, PMID:29484840 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO
EXP
Diquat results in increased cleavage of and results in increased activity of CASP9 protein; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]
CTD PMID:18164269, PMID:20826540, PMID:29484840 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]
Diquat results in decreased activity of CAT protein
CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
CTD PMID:21215309, PMID:26785375, PMID:27057282 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Diquat results in increased expression of CLIP4 mRNA CTD PMID:21172416 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Diquat results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Diquat results in increased expression of CYP4A1 mRNA CTD PMID:7676460 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Diquat results in increased expression of DDIT3 mRNA; Diquat results in increased expression of DDIT3 protein
PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]
CTD PMID:20826540 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO Diquat results in increased expression of DKK1 mRNA CTD PMID:21172416 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Diquat results in increased expression of DUSP1 mRNA CTD PMID:21172416 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA] CTD PMID:20826540 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Diquat results in increased expression of ELL2 mRNA CTD PMID:21172416 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Diquat results in increased expression of FOS mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]
CTD PMID:20826540 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
ISO Diquat results in increased expression of FOXO1 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]
CTD PMID:27057282 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Diquat results in increased expression of FTH1 mRNA CTD PMID:21698372 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Diquat results in increased expression of FTL1 mRNA CTD PMID:16962985 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
increases activity
EXP
ISO
Diquat results in increased expression of G6PD mRNA; Diquat results in increased expression of G6PD protein
Diquat results in increased activity of G6PD protein
CTD PMID:8934631, PMID:28108222 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Diquat results in increased expression of GADD45A mRNA CTD PMID:21172416 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
decreases activity
decreases expression
ISO
EXP
Diquat results in increased expression of GCLC mRNA
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA
Diquat results in decreased activity of GCLC protein
Diquat results in decreased expression of GCLC mRNA
CTD PMID:7676460, PMID:16962985, PMID:22762311 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Diquat results in increased expression of GCLM mRNA CTD PMID:16962985, PMID:20826540, PMID:21172416 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glrx glutaredoxin increases response to substance ISO GLRX gene mutant form results in increased susceptibility to Diquat CTD PMID:17893043 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein] CTD PMID:15496407 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
decreases response to substance
affects response to substance
multiple interactions
increases response to substance
ISO Diquat results in decreased expression of GPX1 protein
GPX1 protein results in decreased susceptibility to Diquat
GPX1 protein affects the susceptibility to Diquat
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]; GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]
GPX1 gene mutant form results in increased susceptibility to Diquat; GPX1 protein results in increased susceptibility to Diquat
CTD PMID:10490281, PMID:11568445, PMID:11672444, PMID:15182862 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance
increases expression
multiple interactions
ISO GPX4 protein alternative form results in decreased susceptibility to Diquat
Diquat results in increased expression of GPX4 mRNA
GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]; GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
CTD PMID:15496407, PMID:16962985, PMID:19744930 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Diquat results in increased expression of GSR mRNA CTD PMID:16962985 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Diquat results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Diquat results in decreased expression of GSTA2 mRNA; Diquat results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Diquat results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Diquat results in decreased expression of GSTM2 mRNA CTD PMID:7676460 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Diquat results in increased expression of HAMP mRNA CTD PMID:21698372 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
multiple interactions
ISO Diquat results in increased expression of HMOX1 mRNA; Diquat results in increased expression of HMOX1 protein
Diquat results in increased activity of HMOX1 protein
PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]
CTD PMID:20826540, PMID:21172416 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Diquat results in increased expression of HSPA1A mRNA CTD PMID:21172416 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diquat results in increased expression of HSPA1B mRNA CTD PMID:21172416 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ifng interferon gamma multiple interactions ISO Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide] CTD PMID:11498278 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases response to substance ISO IGF1R protein results in increased susceptibility to Diquat CTD PMID:22132081 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il6 interleukin 6 increases expression EXP Diquat results in increased expression of IL6 protein CTD PMID:21698372 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diquat results in increased expression of JUN mRNA CTD PMID:21172416 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat] CTD PMID:22762311 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kynu kynureninase increases expression ISO Diquat results in increased expression of KYNU mRNA CTD PMID:21172416 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Diquat results in increased expression of MAP2 mRNA CTD PMID:21172416 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK1 protein CTD PMID:20826540 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK3 protein CTD PMID:20826540 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein] CTD PMID:20826540 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Diquat results in increased expression of ME1 mRNA CTD PMID:16962985 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Capsaicin inhibits the reaction [Diquat results in increased activity of MPO protein] CTD PMID:15046732 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA] CTD PMID:20826540 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A decreases expression
multiple interactions
ISO Diquat results in decreased expression of MT2 mRNA
PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]
CTD PMID:20826540 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nefh neurofilament heavy affects expression EXP Diquat affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases response to substance
decreases response to substance
increases activity
multiple interactions
ISO Diquat results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Diquat
NFE2L2 results in decreased susceptibility to Diquat
Diquat results in increased activity of NFE2L2 protein
KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]
CTD PMID:16962985, PMID:20143881, PMID:20826540, PMID:21172416, PMID:22762311, PMID:23056183 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity
ISO Diquat results in increased expression of NQO1 mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]
Diquat results in increased expression of NQO1 mRNA; Diquat results in increased expression of NQO1 protein
Diquat results in increased activity of NQO1 protein
CTD PMID:20826540, PMID:21172416 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Diquat results in increased cleavage of PARP1 protein CTD PMID:25693864 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Diquat results in increased expression of PGD mRNA CTD PMID:16962985 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing
ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; NADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; POR protein results in increased metabolism of Diquat
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; [POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen; POR protein results in increased metabolism of Diquat
CTD PMID:21215309 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO Diquat results in increased expression of PPIF mRNA CTD PMID:21172416 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Diquat results in increased expression of PPP1R15A mRNA CTD PMID:21172416 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Diquat results in increased expression of PRDX1 mRNA CTD PMID:16962985 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Diquat results in increased expression of PRDX3 mRNA CTD PMID:16962985 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance
affects response to substance
multiple interactions
ISO PROP1 gene mutant form results in decreased susceptibility to Diquat
PROP1 protein affects the susceptibility to Diquat
PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein]
CTD PMID:19414510, PMID:20826540 NCBI chr10:36,449,920...36,452,381
Ensembl chr10:36,449,920...36,452,378
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Diquat results in increased expression of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of PTGS2 protein]
CTD PMID:29484840 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasgef1b RasGEF domain family, member 1B increases expression ISO Diquat results in increased expression of RASGEF1B mRNA CTD PMID:21172416 NCBI chr14:11,499,692...12,028,513
Ensembl chr14:11,988,671...12,027,381
JBrowse link
G Rgs20 regulator of G-protein signaling 20 increases expression ISO Diquat results in increased expression of RGS20 mRNA CTD PMID:21172416 NCBI chr 5:14,367,498...14,494,048
Ensembl chr 5:14,415,606...14,494,756
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Diquat results in increased expression of RGS4 mRNA CTD PMID:21172416 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Diquat results in increased expression of RND3 mRNA CTD PMID:21172416 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Diquat results in increased expression of SAT1 mRNA CTD PMID:21172416 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Diquat results in increased expression of SERPINB8 mRNA CTD PMID:21172416 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Diquat results in increased expression of SERPINE1 mRNA CTD PMID:21172416 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression EXP Diquat results in decreased expression of SLC40A1 mRNA CTD PMID:21698372 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Diquat results in increased expression of SLC7A11 mRNA CTD PMID:21172416 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
Diquat results in decreased expression of SOD1 mRNA
CTD PMID:7676460, PMID:11672444 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
Diquat results in increased expression of SOD2 protein
CTD PMID:11672444, PMID:29484840 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Diquat results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Diquat results in increased expression of SPINK1 mRNA CTD PMID:21172416 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Diquat results in increased expression of SRXN1 mRNA CTD PMID:21172416 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Diquat results in increased expression of STC2 mRNA CTD PMID:21172416 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tfrc transferrin receptor increases expression EXP Diquat results in increased expression of TFRC mRNA CTD PMID:21698372 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diquat results in increased expression of and affects the localization of TP53 protein; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein] CTD PMID:29484840 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO Diquat results in increased expression of TRIM16 mRNA CTD PMID:21172416 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Txn2 thioredoxin 2 increases expression
decreases response to substance
multiple interactions
ISO Diquat results in increased expression of TXN2 mRNA
TXN2 protein results in decreased susceptibility to Diquat
TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
CTD PMID:16962985, PMID:18164269 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Diquat results in increased expression of TXNRD1 mRNA CTD PMID:20826540, PMID:21172416 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Diquat results in increased expression of UPP1 mRNA CTD PMID:21172416 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Diquat results in increased expression of ZFAND2A mRNA CTD PMID:21172416 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pesticide 16264
          herbicide 11202
            diquat 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organonitrogen heterocyclic compound 17461
                                    bipyridines 1393
                                      bipyridine 1362
                                        2,2'-bipyridine 103
                                          diquat 95
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.