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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tanespimycin
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Accession:CHEBI:64153 term browser browse the term
Definition:A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Synonyms:exact_synonym: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
 related_synonym: 17-(Allylamino)-17-demethoxygeldanamycin;   17-(Allylamino)geldanamycin;   17-AAG;   17-Demethoxy-17-allylamino geldanamycin;   17-N-allylamino-17-demethoxygeldanamycin;   17-allylaminogeldanamycin;   17-demethoxy-17-(2-propenylamino)geldanamycin;   17AAG;   Formula=C31H43N3O8;   InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1;   InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N;   NSC 330507;   SMILES=C=1C(C(=C2C(C1NC(=O)C(C)=CC=C[C@@H]([C@@H](OC(N)=O)C(C)=C[C@@H]([C@H]([C@H](C[C@@H](C2)C)OC)O)C)OC)=O)NCC=C)=O;   tanespimycina;   tanespimycine;   tanespimycinum
 alt_id: MESH:C112765
 xref: CAS:75747-14-7;   KEGG:D06650
 xref_mesh: MESH:C112765
 xref: PMID:20646760;   PMID:20652703;   PMID:20683637;   PMID:21219297;   PMID:21283735;   PMID:21454186;   PMID:21534941;   PMID:21558407;   PMID:21594721;   PMID:21670086;   PMID:21791475;   PMID:21856392;   PMID:22047770;   PMID:22209975;   PMID:22377218;   PMID:22621282;   PMID:23564374;   PMID:24317439;   PMID:25096912;   PMID:25633180;   PMID:25952464;   PMID:26277605;   PMID:26408708;   PMID:26872308;   PMID:26913406;   PMID:26922527;   PMID:27045471;   Reaxys:7402240;   Wikipedia:17-N-Allylamino-17-demethoxygeldanamycin


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tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr12:24,722,277...24,725,760
Ensembl chr12:24,722,283...24,724,997
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr 1:266,123,864...266,142,621
Ensembl chr 1:266,123,870...266,142,538
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein
CTD PMID:31370342 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Ak9 adenylate kinase 9 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr20:46,044,901...46,162,015
Ensembl chr20:46,044,892...46,162,073
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO
EXP
Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:16923571, PMID:17157164, PMID:18566239, PMID:22810956 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]
CTD PMID:18393300 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alk ALK receptor tyrosine kinase decreases activity
decreases expression
ISO tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form
CTD PMID:21030459, PMID:21502504 NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
JBrowse link
G Anxa1 annexin A1 increases expression ISO tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
ISO Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor decreases expression ISO tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571, PMID:28673683 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase increases expression
decreases expression
ISO
EXP
tanespimycin analog results in increased expression of BRAF protein
tanespimycin results in decreased expression of BRAF protein
CTD PMID:22810956, PMID:31370342 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
[tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15993848, PMID:17157164, PMID:18194434, PMID:19913524, PMID:22810956, PMID:24189122 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein
CTD PMID:17121904 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein
CTD PMID:17121904 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein
CTD PMID:17121904, PMID:17157164 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO
EXP
[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein
CTD PMID:21156818, PMID:22810956 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein
CTD PMID:21156818, PMID:24784839 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164, PMID:28673683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr12:10,496,273...10,561,335 JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr 1:192,169,634...192,173,228
Ensembl chr 1:192,169,841...192,173,253
JBrowse link
G Commd1 copper metabolism domain containing 1 multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 2:205,525,194...205,552,987
Ensembl chr 2:205,525,204...205,552,991
JBrowse link
G Cttn cortactin multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein
CTD PMID:31370342 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression ISO tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr15:43,905,099...44,103,742
Ensembl chr15:43,905,099...44,103,742
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein
CTD PMID:31370342 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein
CTD PMID:31370342 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein
CTD PMID:16061882, PMID:17010675, PMID:22810956, PMID:31370342 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein
CTD PMID:31370342 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
JBrowse link
G Eml5 EMAP like 5 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein
CTD PMID:31370342 NCBI chr 6:122,768,939...122,898,046
Ensembl chr 6:122,770,055...122,897,997
JBrowse link
G Eno1 enolase 1 increases expression ISO tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein
CTD PMID:16061882, PMID:24784839 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Eri1 exoribonuclease 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr16:60,307,148...60,327,237
Ensembl chr16:60,307,148...60,327,236
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
CTD PMID:31370342 NCBI chr 9:84,324,456...84,383,674
Ensembl chr 9:84,324,442...84,383,687
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Fubp1 far upstream element binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 increases expression ISO tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 4:112,662,556...112,700,505
Ensembl chr 4:112,662,609...112,699,711
JBrowse link
G Gls glutaminase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression ISO tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr 8:76,422,341...76,435,587
Ensembl chr 8:76,422,359...76,435,473
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein
CTD PMID:31370342 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions
ISO tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
CTD PMID:20090934 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
affects binding
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein
CTD PMID:18830594, PMID:22895790, PMID:31370342 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding ISO tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
ISO [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein
CTD PMID:20090934, PMID:31370342 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein
CTD PMID:23144451, PMID:31370342 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of IGF1R protein
tanespimycin results in decreased expression of IGF1R protein
CTD PMID:22810956 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Kcnv2 potassium voltage-gated channel modifier subfamily V member 2 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of KCNV2 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
CTD PMID:31370342 NCBI chr 1:245,396,880...245,475,011
Ensembl chr 1:245,396,989...245,416,531
JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kdr kinase insert domain receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of KDR protein
tanespimycin results in decreased expression of KDR protein
CTD PMID:22810956 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
ISO
EXP
tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein
CTD PMID:16061882, PMID:16213582, PMID:22810956 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 2:231,866,888...231,882,002
Ensembl chr 2:231,867,135...231,881,939
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of LCP1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
CTD PMID:31370342 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lmna lamin A/C multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr 6:7,984,043...8,066,874
Ensembl chr 6:7,984,019...8,066,868
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene increases degradation ISO tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP
ISO
tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein
CTD PMID:31370342 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr17:84,847,660...84,981,134
Ensembl chr17:84,881,414...84,979,543
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msn moesin increases expression ISO tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mtap methylthioadenosine phosphorylase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr 7:98,820,799...98,960,878
Ensembl chr 7:98,820,812...98,960,837
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nans N-acetylneuraminate synthase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 5:62,109,352...62,126,492
Ensembl chr 5:62,109,328...62,126,494
JBrowse link
G Ncl nucleolin multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
decreases phosphorylation
EXP
ISO
tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein
CTD PMID:11835313, PMID:22810956 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases reduction
increases abundance
ISO [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
CTD PMID:10564678, PMID:21156818, PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
CTD PMID:31370342 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage EXP
ISO
tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases expression ISO tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO
EXP
tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pfn1 profilin 1 increases expression ISO tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr10:57,273,003...57,275,708
Ensembl chr10:57,273,005...57,275,708
JBrowse link
G Pgr progesterone receptor decreases expression ISO tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr 7:70,483,948...70,498,995
Ensembl chr 7:70,483,942...70,498,995
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pnn pinin, desmosome associated protein increases expression ISO tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr 6:80,159,364...80,167,677
Ensembl chr 6:80,159,364...80,167,677
JBrowse link
G Prkrip1 PRKR interacting protein 1 increases expression ISO tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr12:23,514,987...23,533,278
Ensembl chr12:23,514,981...23,535,968
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:28,435,275...28,472,882
Ensembl chr  X:28,435,507...28,472,880
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr 6:76,174,460...76,205,429
Ensembl chr 6:76,174,452...76,205,426
JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr 3:175,420,042...175,426,384
Ensembl chr 3:175,420,039...175,426,395
JBrowse link
G Rab17 RAB17, member RAS oncogene family multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 9:98,118,907...98,131,883
Ensembl chr 9:98,118,908...98,131,883
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein
CTD PMID:17121904 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rdx radixin increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein
CTD PMID:31370342 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
ISO tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein
CTD PMID:17121904, PMID:27255535 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Selenbp1 selenium binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 decreases expression ISO tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance
increases response to substance
ISO SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin
CTD PMID:21156818 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein
CTD PMID:31370342 NCBI chr10:85,460,059...85,517,671
Ensembl chr10:85,460,059...85,517,683
JBrowse link
G Tagln2 transgelin 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr13:90,807,196...90,814,119
Ensembl chr13:90,807,199...90,814,119
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 increases expression ISO tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr16:74,552,859...74,662,194
Ensembl chr16:74,558,529...74,662,194
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
CTD PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr14:106,208,174...106,249,322
Ensembl chr14:106,208,176...106,248,539
JBrowse link
G Vil1 villin 1 increases expression ISO tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
tanespimycin analog results in increased expression of ZYG11B protein
CTD PMID:31370342 NCBI chr 5:127,844,062...127,878,792
Ensembl chr 5:127,847,129...127,878,792
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          geldanamycin 476
            tanespimycin 139
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  ansamycin 835
                                                    geldanamycin 476
                                                      tanespimycin 139
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.