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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cysteine protease inhibitor
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Accession:CHEBI:64152 term browser browse the term
Definition:Any protease inhibitor that restricts the action of a cysteine protease.
Synonyms:related_synonym: cysteine protease inhibitors;   cysteine proteinase inhibitor;   cysteine proteinase inhibitors


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acetylleucyl-leucyl-norleucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Apob apolipoprotein B multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein CTD PMID:19342510, PMID:19383982 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] CTD PMID:29974605 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:15618349, PMID:27481217, PMID:29111403 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] CTD PMID:29974605 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] CTD PMID:11895924, PMID:16024653 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] CTD PMID:16024653 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] CTD PMID:20054826 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] CTD PMID:29974605 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Antimycin A inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Rotenone inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA] CTD PMID:12208513 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:27481217 NCBI chr16:16,312,228...16,359,038
Ensembl chr16:16,312,230...16,358,959
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 3:138,526,191...138,559,696
Ensembl chr 3:138,526,179...138,559,696
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] CTD PMID:17291458 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Ins1 insulin I decreases secretion EXP acetylleucyl-leucyl-norleucinal results in decreased secretion of INS1 protein CTD PMID:15618349 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Itgam integrin alpha M multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Jun jun proto-oncogene increases phosphorylation EXP acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein CTD PMID:15618349 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein CTD PMID:15618349 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression EXP
ISO
acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr 2:92,383,671...92,401,346
Ensembl chr 2:92,383,676...92,401,263
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] CTD PMID:29974605 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
decreases degradation
ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein]
acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein
CTD PMID:15930313, PMID:17291458, PMID:18606398 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr 2:119,112,814...119,136,073
Ensembl chr 2:119,112,793...119,147,445
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr 5:53,555,779...53,657,445
Ensembl chr 5:53,466,152...53,657,362
JBrowse link
G Scnn1g sodium channel, nonvoltage-gated 1 gamma increases methylation
decreases expression
ISO acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter
acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA
CTD PMID:15564131 NCBI chr 7:121,734,420...121,768,482
Ensembl chr 7:121,734,479...121,768,475
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 9:107,651,154...107,668,968
Ensembl chr 9:107,650,634...107,669,530
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] CTD PMID:31225620 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Ttn titin multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] CTD PMID:22532871 NCBI chr 2:76,703,980...76,982,557
Ensembl chr 2:76,703,980...76,982,547
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] CTD PMID:21444628, PMID:30796972 NCBI chr15:89,371,631...89,377,036
Ensembl chr15:89,371,931...89,377,039
JBrowse link
G Tyms thymidylate synthase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] CTD PMID:21444628 NCBI chr 5:30,038,546...30,073,645
Ensembl chr 5:30,058,202...30,073,617
JBrowse link
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn7 calpain 7 multiple interactions ISO aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr14:31,336,622...31,371,987
Ensembl chr14:31,336,638...31,371,986
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein] CTD PMID:26853465 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806, PMID:32186374 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsd cathepsin D multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctsl cathepsin L multiple interactions ISO aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:38,399,647...38,456,460
Ensembl chr  X:38,401,357...38,456,454
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein CTD PMID:32186374 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr17:35,170,986...35,176,083
Ensembl chr17:35,170,991...35,176,068
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD PMID:28185818 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr14:118,012,790...118,052,246
Ensembl chr14:118,012,790...118,052,244
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression
multiple interactions
ISO
EXP
amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:12144868, PMID:28185818 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) affects binding ISO amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 2:25,466,709...25,470,110
Ensembl chr 2:25,466,709...25,470,046
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD PMID:12144868 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tyr tyrosinase decreases activity ISO amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr 7:87,424,771...87,493,512
Ensembl chr 7:87,424,771...87,493,512
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 decreases activity ISO amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 decreases activity ISO amentoflavone results in decreased activity of UGT1A10 protein CTD PMID:29470958 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 decreases activity ISO amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 1:88,166,012...88,220,002
Ensembl chr 1:88,166,012...88,218,997
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases activity
multiple interactions
ISO amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD PMID:29470958, PMID:32421801 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 decreases activity ISO amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases activity ISO amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr 5:86,916,639...86,926,503
Ensembl chr 5:86,916,638...86,926,530
JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 2:118,598,202...118,641,592
Ensembl chr 2:118,598,211...118,641,591
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdc34 cell division cycle 34 decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr10:79,682,193...79,688,398
Ensembl chr10:79,682,195...79,688,398
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr16:18,780,447...18,811,972
Ensembl chr16:18,780,447...18,811,987
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:46,760,461...46,771,530
Ensembl chr14:46,760,541...46,771,669
JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:189,640,606...189,688,107
Ensembl chr 1:189,640,606...189,688,086
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 5:138,164,583...138,172,111
Ensembl chr 5:138,164,583...138,172,422
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 2:132,816,137...132,844,197
Ensembl chr 2:132,816,141...132,844,197
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 2:181,763,332...181,827,775
Ensembl chr 2:181,763,332...181,827,797
JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:191,821,449...191,833,049
Ensembl chr 1:191,821,444...191,833,050
JBrowse link
G Trp53 transformation related protein 53 increases expression
increases activity
ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 9:83,834,651...83,872,390
Ensembl chr 9:83,834,689...83,872,389
JBrowse link
geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 2610507B11Rik RIKEN cDNA 2610507B11 gene increases expression ISO geldanamycin results in increased expression of KIAA0100 mRNA CTD PMID:26705709 NCBI chr11:78,261,650...78,290,625
Ensembl chr11:78,261,752...78,290,623
JBrowse link
G 6030458C11Rik RIKEN cDNA 6030458C11 gene increases expression ISO geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr15:12,808,177...12,824,679
Ensembl chr15:12,808,177...12,824,649
JBrowse link
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression ISO geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr16:31,092,412...31,201,285
Ensembl chr16:31,092,412...31,201,245
JBrowse link
G Actr2 ARP2 actin-related protein 2 increases expression ISO geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr11:20,062,304...20,112,951
Ensembl chr11:20,062,304...20,112,913
JBrowse link
G Aff3 AF4/FMR2 family, member 3 increases expression ISO geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 1:38,175,393...38,630,178
Ensembl chr 1:38,177,326...38,664,955
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr11:53,350,640...53,421,830
Ensembl chr11:53,350,833...53,421,830
JBrowse link
G Agfg1 ArfGAP with FG repeats 1 increases expression ISO geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 1:82,839,017...82,901,001
Ensembl chr 1:82,839,483...82,901,182
JBrowse link
G Ahr aryl-hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
ISO
EXP
geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232, PMID:12237327, PMID:12606767, PMID:16226227, PMID:20057149, PMID:27105554 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649, PMID:17293044, PMID:19167484, PMID:24211270, PMID:24450340 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Akt3 thymoma viral proto-oncogene 3 increases expression ISO geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr 1:177,020,076...177,261,781
Ensembl chr 1:177,020,073...177,258,203
JBrowse link
G Amotl1 angiomotin-like 1 increases expression ISO geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr 9:14,541,966...14,662,974
Ensembl chr 9:14,541,966...14,645,056
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr15:42,424,667...42,676,977
Ensembl chr15:42,424,723...42,676,977
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr 1:156,839,023...156,861,078
Ensembl chr 1:156,838,562...156,861,078
JBrowse link
G Ankrd1 ankyrin repeat domain 1 (cardiac muscle) increases expression ISO geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr19:36,111,965...36,119,844
Ensembl chr19:36,111,961...36,120,099
JBrowse link
G Ap5m1 adaptor-related protein complex 5, mu 1 subunit increases expression ISO geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr14:49,066,408...49,094,114
Ensembl chr14:49,066,097...49,094,234
JBrowse link
G Apela apelin receptor early endogenous ligand increases expression ISO geldanamycin results in increased expression of APELA mRNA CTD PMID:26705709 NCBI chr 8:65,028,417...65,037,336
Ensembl chr 8:65,028,417...65,037,336
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 increases expression ISO geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr10:83,600,033...83,648,877
Ensembl chr10:83,600,033...83,648,738
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 3:84,496,093...84,582,751
Ensembl chr 3:84,496,426...85,887,518
Ensembl chr 3:84,496,426...85,887,518
JBrowse link
G Aspm abnormal spindle microtubule assembly increases expression ISO geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr 1:139,454,188...139,494,088
Ensembl chr 1:139,454,772...139,494,091
JBrowse link
G Atp11b ATPase, class VI, type 11B increases expression ISO geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 3:35,754,044...35,856,276
Ensembl chr 3:35,754,106...35,856,276
JBrowse link
G Atp11c ATPase, class VI, type 11C increases expression ISO geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:60,223,283...60,404,853
Ensembl chr  X:60,223,290...60,592,698
JBrowse link
G Atp13a3 ATPase type 13A3 increases expression ISO geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr16:30,312,423...30,388,871
Ensembl chr16:30,312,423...30,405,975
JBrowse link
G Atp13a5 ATPase type 13A5 increases expression ISO geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr16:29,230,490...29,378,766
Ensembl chr16:29,231,851...29,378,732
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:105,797,615...105,929,372
Ensembl chr  X:105,797,615...105,929,403
JBrowse link
G Atxn7l3b ataxin 7-like 3B increases expression ISO geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr10:112,925,428...112,929,026
Ensembl chr10:112,925,430...112,929,001
JBrowse link
G B230219D22Rik RIKEN cDNA B230219D22 gene increases expression ISO geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr13:55,693,124...55,703,500
Ensembl chr13:55,693,124...55,703,500
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649, PMID:28673683 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases response to substance
multiple interactions
ISO BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcor BCL6 interacting corepressor increases expression ISO geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:12,036,737...12,160,516
Ensembl chr  X:12,036,740...12,160,355
JBrowse link
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression ISO geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr13:100,017,994...100,104,090
Ensembl chr13:100,017,994...100,104,070
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Bod1l biorientation of chromosomes in cell division 1-like increases expression ISO geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr 5:41,787,538...41,844,355
Ensembl chr 5:41,787,538...41,844,315
JBrowse link
G Cab39 calcium binding protein 39 increases expression ISO geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 1:85,793,441...85,851,577
Ensembl chr 1:85,793,441...85,851,576
JBrowse link
G Cald1 caldesmon 1 increases expression ISO geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) increases expression ISO geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:13,517,080...13,846,783
Ensembl chr  X:13,517,080...13,851,367
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584, PMID:12530016, PMID:14576064, PMID:24998639 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 multiple interactions ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cbl Casitas B-lineage lymphoma increases expression ISO geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr 9:44,142,976...44,234,259
Ensembl chr 9:44,142,976...44,234,049
JBrowse link
G Ccdc186 coiled-coil domain containing 186 increases expression ISO geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr19:56,787,485...56,822,199
Ensembl chr19:56,787,481...56,822,190
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649, PMID:17959518, PMID:24211270 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Ccne2 cyclin E2 increases expression ISO geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Ccnk cyclin K increases expression ISO geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr12:108,179,308...108,203,359
Ensembl chr12:108,179,579...108,203,359
JBrowse link
G Cdc27 cell division cycle 27 increases expression ISO geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr11:104,502,524...104,550,620
Ensembl chr11:104,502,745...104,550,620
JBrowse link
G Cdc37 cell division cycle 37 multiple interactions ISO geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr 9:21,139,431...21,149,934
Ensembl chr 9:21,133,222...21,149,982
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr14:67,673,180...67,715,841
Ensembl chr14:67,676,331...67,715,841
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh4 cadherin 4 increases expression ISO geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr 2:179,442,423...179,899,377
Ensembl chr 2:179,442,431...179,899,373
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr13:17,711,676...17,805,212
Ensembl chr13:17,710,315...17,805,097
JBrowse link
G Cdk14 cyclin-dependent kinase 14 increases expression ISO geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 5:4,803,384...5,380,251
Ensembl chr 5:4,803,391...5,420,312
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Cenpj centromere protein J increases expression ISO geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr14:56,526,761...56,575,489
Ensembl chr14:56,526,761...56,575,425
JBrowse link
G Cep89 centrosomal protein 89 increases expression ISO geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr 7:35,396,999...35,439,830
Ensembl chr 7:35,397,035...35,438,689
JBrowse link
G Cep95 centrosomal protein 95 increases expression ISO geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr11:106,788,640...106,818,861
Ensembl chr11:106,789,252...106,819,930
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 2:68,861,145...69,114,284
Ensembl chr 2:68,861,441...69,114,282
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase increases degradation ISO geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr 5:123,577,794...123,684,606
Ensembl chr 5:123,577,795...123,684,618
JBrowse link
G Clk4 CDC like kinase 4 increases expression ISO geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr11:51,263,114...51,281,770
Ensembl chr11:51,261,730...51,281,766
JBrowse link
G Col12a1 collagen, type XII, alpha 1 increases expression ISO geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 9:79,598,987...79,721,141
Ensembl chr 9:79,598,991...79,718,831
JBrowse link
G Col25a1 collagen, type XXV, alpha 1 increases expression ISO geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 3:130,180,358...130,599,884
Ensembl chr 3:130,131,501...130,599,877
JBrowse link
G Col8a1 collagen, type VIII, alpha 1 increases expression ISO geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr16:57,624,256...57,754,737
Ensembl chr16:57,624,258...57,754,737
JBrowse link
G Cpne3 copine III increases expression ISO geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108
JBrowse link
G Crcp calcitonin gene-related peptide-receptor component protein increases expression ISO geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr 5:130,029,306...130,060,787
Ensembl chr 5:130,029,290...130,060,789
JBrowse link
G Csk c-src tyrosine kinase multiple interactions
decreases activity
EXP geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr 9:57,626,646...57,653,631
Ensembl chr 9:57,626,646...57,653,631
JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide increases expression ISO geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr 2:152,226,535...152,281,856
Ensembl chr 2:152,226,839...152,281,852
JBrowse link
G Ctdspl2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 increases expression ISO geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr 2:121,955,398...122,015,326
Ensembl chr 2:121,956,001...122,013,642
JBrowse link
G Ctnna1 catenin (cadherin associated protein), alpha 1 increases expression ISO geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr18:35,118,902...35,254,776
Ensembl chr18:35,118,859...35,254,779
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cul5 cullin 5 increases expression ISO geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr 9:53,614,581...53,667,507
Ensembl chr 9:53,614,582...53,670,014
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein] CTD PMID:11472980 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327, PMID:20057149 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Ddr2 discoidin domain receptor family, member 2 increases expression ISO geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr 1:169,972,307...170,110,836
Ensembl chr 1:169,972,307...170,110,762
JBrowse link
G Ddx17 DEAD box helicase 17 increases expression ISO geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr15:79,527,696...79,546,764
Ensembl chr15:79,527,736...79,546,741
JBrowse link
G Ddx3x DEAD box helicase 3, X-linked increases expression ISO geldanamycin results in increased expression of DDX3X mRNA CTD PMID:26705709 NCBI chr  X:13,280,496...13,293,988
Ensembl chr  X:13,280,970...13,294,052
JBrowse link
G Ddx42 DEAD box helicase 42 increases expression ISO geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr11:106,216,887...106,249,140
Ensembl chr11:106,216,926...106,249,139
JBrowse link
G Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 increases expression ISO geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr 9:44,602,983...44,640,731
Ensembl chr 9:44,604,892...44,640,731
JBrowse link
G Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 increases expression ISO geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr 1:153,455,756...153,487,688
Ensembl chr 1:153,455,758...153,487,660
JBrowse link
G Dip2a disco interacting protein 2 homolog A increases expression ISO geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr10:76,263,034...76,345,360
Ensembl chr10:76,259,429...76,345,291
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression ISO geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr16:31,663,443...31,873,356
Ensembl chr16:31,663,443...31,875,129
JBrowse link
G Dmd dystrophin, muscular dystrophy increases expression ISO geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:82,814,664...85,205,050
Ensembl chr  X:82,948,870...85,206,141
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 increases expression ISO geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 9:104,151,597...104,263,608
Ensembl chr 9:104,151,282...104,262,930
JBrowse link
G Dst dystonin increases expression ISO geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 1:33,907,888...34,308,662
Ensembl chr 1:33,908,225...34,308,661
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr13:29,906,575...29,986,064
Ensembl chr13:29,906,575...29,986,063
JBrowse link
G Edil3 EGF-like repeats and discoidin I-like domains 3 increases expression ISO geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr13:88,821,472...89,323,225
Ensembl chr13:88,821,472...89,323,223
JBrowse link
G Edn1 endothelin 1 increases expression ISO geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eea1 early endosome antigen 1 increases expression ISO geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr10:95,940,663...96,045,518
Ensembl chr10:95,940,650...96,045,518
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431, PMID:9664232 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431, PMID:9664232, PMID:20007406 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr11:22,005,825...22,287,083
Ensembl chr11:22,005,828...22,342,292
JBrowse link
G Ehmt1 euchromatic histone methyltransferase 1 increases expression ISO geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 2:24,790,769...24,919,643
Ensembl chr 2:24,789,928...24,919,614
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr13:75,707,484...75,772,361
Ensembl chr13:75,706,757...75,772,364
JBrowse link
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 increases expression ISO geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr 1:119,545,032...119,649,096
Ensembl chr 1:119,545,037...119,649,000
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression ISO geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr 1:185,361,417...185,428,360
Ensembl chr 1:185,363,044...185,428,360
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
ISO geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772, PMID:11071886, PMID:17959518, PMID:18655187, PMID:24450340 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Ercc6l2 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 increases expression ISO geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr13:63,810,979...63,900,302
Ensembl chr13:63,815,240...63,900,302
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression ISO geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:10,566,507...10,610,863
Ensembl chr18:10,566,507...10,610,352
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr14:65,819,027...65,833,969
Ensembl chr14:65,819,038...65,833,994
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression
decreases stability
increases degradation
ISO geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926, PMID:16037132, PMID:24211270 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain increases expression ISO geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr 9:32,636,241...32,757,820
Ensembl chr 9:32,636,221...32,757,820
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr 5:107,744,795...107,875,107
Ensembl chr 5:107,744,795...107,875,107
JBrowse link
G Fam126a family with sequence similarity 126, member A increases expression ISO geldanamycin results in increased expression of FAM126A mRNA CTD PMID:26705709 NCBI chr 5:23,915,276...24,030,696
Ensembl chr 5:23,915,276...24,030,690
JBrowse link
G Fam172a family with sequence similarity 172, member A increases expression ISO geldanamycin results in increased expression of FAM172A mRNA CTD PMID:26705709 NCBI chr13:77,708,677...78,166,240
Ensembl chr13:77,702,033...78,166,235
JBrowse link
G Fancb Fanconi anemia, complementation group B increases expression ISO geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:164,980,480...164,997,272
Ensembl chr  X:164,980,592...164,997,272
JBrowse link
G Fancm Fanconi anemia, complementation group M increases expression ISO geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr12:65,074,110...65,131,842
Ensembl chr12:65,075,603...65,132,058
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr 2:125,300,594...125,506,485
Ensembl chr 2:125,300,594...125,507,993
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO
EXP
geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr 2:126,034,658...126,091,185
Ensembl chr 2:126,034,658...126,091,185
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 increases expression ISO geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fn1 fibronectin 1 increases expression ISO geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fryl FRY like transcription coactivator increases expression ISO geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr 5:73,020,191...73,256,699
Ensembl chr 5:73,019,987...73,256,619
JBrowse link
G G3bp1 GTPase activating protein (SH3 domain) binding protein 1 increases expression ISO geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr11:55,469,657...55,500,888
Ensembl chr11:55,469,685...55,504,838
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression ISO geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 2:57,997,850...58,041,027
Ensembl chr 2:57,997,884...58,045,860
JBrowse link
G Gls glutaminase increases expression ISO geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 1:52,163,449...52,235,009
Ensembl chr 1:52,163,448...52,233,232
JBrowse link
G Gng12 guanine nucleotide binding protein (G protein), gamma 12 increases expression ISO geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 6:66,896,397...67,021,361
Ensembl chr 6:66,896,397...67,021,350
JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 3:75,876,183...75,956,956
Ensembl chr 3:75,875,084...75,956,949
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) increases expression ISO geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:41,400,819...41,678,601
Ensembl chr  X:41,400,854...41,678,601
JBrowse link
G Gtf2a1 general transcription factor II A, 1 increases expression ISO geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr12:91,555,262...91,590,487
Ensembl chr12:91,555,262...91,590,487
JBrowse link
G H1f3 H1.3 linker histone, cluster member increases expression ISO geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr13:23,555,032...23,555,807
Ensembl chr13:23,553,262...23,560,686
JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 increases expression ISO geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr16:35,022,421...35,109,190
Ensembl chr16:35,022,428...35,109,177
JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 increases expression ISO geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr13:117,602,320...117,981,028
Ensembl chr13:117,602,320...117,987,418
JBrowse link
G Heatr1 HEAT repeat containing 1 increases expression ISO geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr13:12,395,375...12,438,893
Ensembl chr13:12,395,027...12,440,289
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 increases expression ISO geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr12:51,743,721...51,829,757
Ensembl chr12:51,743,722...51,829,536
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636, PMID:12811834, PMID:14726529, PMID:15319539, PMID:16432534 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) multiple interactions ISO geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr 8:56,294,552...56,321,046
Ensembl chr 8:56,294,585...56,321,043
JBrowse link
G Hsf1 heat shock factor 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574, PMID:25645596 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 affects binding
multiple interactions
ISO geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586, PMID:17223712, PMID:18655187, PMID:21749116 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 affects binding
increases expression
ISO geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116, PMID:26705709 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 affects binding
multiple interactions
ISO geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa1a heat shock protein 1A increases expression
multiple interactions
ISO geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926, PMID:19723345, PMID:25477506 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa4 heat shock protein 4 increases expression
multiple interactions
ISO geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509, PMID:26705709 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
increases expression
affects expression
ISO Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064, PMID:15141013 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression ISO geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Htt huntingtin multiple interactions ISO geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr 5:34,761,721...34,912,534
Ensembl chr 5:34,761,740...34,912,534
JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 increases expression ISO geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr 9:69,397,904...69,433,078
Ensembl chr 9:69,397,906...69,433,122
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865, PMID:15808840 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il24 interleukin 24 multiple interactions ISO IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr 1:130,882,074...130,887,411
Ensembl chr 1:130,882,074...130,887,454
JBrowse link
G Il6 interleukin 6 multiple interactions EXP geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6st interleukin 6 signal transducer increases expression ISO geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr13:112,464,070...112,506,860
Ensembl chr13:112,464,070...112,510,086
JBrowse link
G Inhba inhibin beta-A increases expression ISO geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr13:16,004,256...16,031,609
Ensembl chr13:16,011,851...16,031,621
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A increases expression ISO geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr 7:139,389,074...139,579,652
Ensembl chr 7:139,389,109...139,579,652
JBrowse link
G Ipo8 importin 8 increases expression ISO geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr 6:148,770,683...148,832,931
Ensembl chr 6:148,770,683...148,831,467
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr 7:80,711,583...80,815,549
Ensembl chr 7:80,711,583...80,825,974
JBrowse link
G Itga1 integrin alpha 1 increases expression ISO geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr13:114,958,079...115,101,964
Ensembl chr13:114,953,096...115,101,964
JBrowse link
G Itgb3 integrin beta 3 increases expression ISO geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Itprid2 ITPR interacting domain containing 2 increases expression ISO geldanamycin results in increased expression of ITPRID2 mRNA CTD PMID:26705709 NCBI chr 2:79,588,863...79,672,966
Ensembl chr 2:79,635,352...79,672,966
JBrowse link
G Jmjd1c jumonji domain containing 1C increases expression ISO geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr10:67,096,351...67,256,326
Ensembl chr10:67,096,125...67,256,326
JBrowse link
G Kat6a K(lysine) acetyltransferase 6A increases expression ISO geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr 8:22,859,442...22,943,259
Ensembl chr 8:22,859,535...22,943,259
JBrowse link
G Kbtbd2 kelch repeat and BTB (POZ) domain containing 2 increases expression ISO geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 6:56,777,525...56,797,813
Ensembl chr 6:56,777,524...56,797,813
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
ISO geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586, PMID:24052561 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A increases expression ISO geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:18,160,862...18,279,936
Ensembl chr  X:18,162,575...18,279,936
JBrowse link
G Kirrel kirre like nephrin family adhesion molecule 1 increases expression ISO geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 3:87,078,593...87,174,777
Ensembl chr 3:87,078,593...87,174,747
JBrowse link
G Klf12 Kruppel-like factor 12 increases expression ISO geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr14:99,866,181...100,285,891
Ensembl chr14:99,870,632...100,284,679
JBrowse link
G Klhl24 kelch-like 24 increases expression ISO geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr16:20,097,553...20,129,226
Ensembl chr16:20,097,542...20,129,221
JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases expression ISO geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr 9:44,803,355...44,881,352
Ensembl chr 9:44,803,355...44,881,296
JBrowse link
G Knl1 kinetochore scaffold 1 increases expression ISO geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr 2:119,047,119...119,110,497
Ensembl chr 2:119,047,119...119,105,501
JBrowse link
G Lama4 laminin, alpha 4 increases expression ISO geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr10:38,965,515...39,110,188
Ensembl chr10:38,965,515...39,110,188
JBrowse link
G Larp1b La ribonucleoprotein domain family, member 1B increases expression ISO geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 3:40,949,770...41,040,207
Ensembl chr 3:40,949,828...41,040,234
JBrowse link
G Larp4 La ribonucleoprotein domain family, member 4 increases expression ISO geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr15:99,970,065...100,016,358
Ensembl chr15:99,970,065...100,016,358
JBrowse link
G Lars leucyl-tRNA synthetase increases expression ISO geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr18:42,202,298...42,262,237
Ensembl chr18:42,202,298...42,262,194
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr15:99,778,468...99,875,477
Ensembl chr15:99,778,470...99,875,456
JBrowse link
G Lin7a lin-7 homolog A (C. elegans) increases expression ISO geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr10:107,271,549...107,425,146
Ensembl chr10:107,271,686...107,421,474
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:65,980,739...66,002,635
Ensembl chr18:65,980,738...66,022,580
JBrowse link
G Lmo7 LIM domain only 7 increases expression ISO geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr14:101,729,928...101,934,708
Ensembl chr14:101,729,957...101,934,710
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma increases expression ISO geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr16:24,393,350...24,992,578
Ensembl chr16:24,393,507...24,992,578
JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr16:37,868,400...37,888,857
Ensembl chr16:37,868,389...37,888,858
JBrowse link
G Lsm14b LSM family member 14B increases expression ISO geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr 2:180,024,900...180,035,466
Ensembl chr 2:180,024,987...180,035,465
JBrowse link
G Malat1 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) increases expression ISO geldanamycin results in increased expression of MALAT1 mRNA CTD PMID:26705709 NCBI chr19:5,795,690...5,802,672
Ensembl chr19:5,795,690...5,802,672
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression ISO geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 3:100,562,203...100,685,473
Ensembl chr 3:100,562,208...100,685,503
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr13:99,421,464...99,516,602
Ensembl chr13:99,421,446...99,516,540
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498, PMID:19167484 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 decreases phosphorylation ISO geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr13:111,746,428...111,818,269
Ensembl chr13:111,746,428...111,808,993
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr12:69,803,757...69,893,163
Ensembl chr12:69,803,750...69,893,200
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484, PMID:30166341 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 increases expression ISO geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr 1:131,053,700...131,097,871
Ensembl chr 1:131,053,700...131,097,826
JBrowse link
G Matr3 matrin 3 increases expression ISO geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr18:35,562,158...35,592,045
Ensembl chr18:35,562,138...35,593,835
JBrowse link
G Mbnl1 muscleblind like splicing factor 1 increases expression ISO geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 3:60,472,559...60,629,750
Ensembl chr 3:60,472,830...60,629,750
JBrowse link
G Mbnl2 muscleblind like splicing factor 2 increases expression ISO geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr14:120,275,652...120,431,698
Ensembl chr14:120,275,669...120,431,697
JBrowse link
G Mbtd1 mbt domain containing 1 increases expression ISO geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr11:93,885,850...93,946,989
Ensembl chr11:93,885,852...93,946,985
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr 9:44,134,658...44,142,727
Ensembl chr 9:44,134,469...44,142,727
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mdfic MyoD family inhibitor domain containing increases expression ISO geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 6:15,720,566...15,802,169
Ensembl chr 6:15,720,661...15,802,169
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Med13 mediator complex subunit 13 increases expression ISO geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr11:86,267,033...86,357,596
Ensembl chr11:86,267,033...86,357,602
JBrowse link
G Med7 mediator complex subunit 7 increases expression ISO geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr11:46,436,936...46,442,721
Ensembl chr11:46,436,925...46,442,721
JBrowse link
G Met met proto-oncogene increases expression ISO geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Mettl16 methyltransferase like 16 increases expression ISO geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr11:74,770,815...74,826,855
Ensembl chr11:74,770,830...74,828,525
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mier1 MEIR1 treanscription regulator increases expression ISO geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 4:103,114,324...103,165,754
Ensembl chr 4:103,114,390...103,165,754
JBrowse link
G Mir21a microRNA 21a increases expression ISO geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr11:86,584,067...86,584,158
Ensembl chr11:86,584,067...86,584,158
JBrowse link
G Mis18bp1 MIS18 binding protein 1 increases expression ISO geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr12:65,132,734...65,172,581
Ensembl chr12:65,132,734...65,172,604
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) multiple interactions
decreases expression
ISO [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357, PMID:26705709 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial increases expression ISO geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Myo5a myosin VA increases expression ISO geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr 9:75,069,799...75,223,688
Ensembl chr 9:75,071,015...75,223,688
JBrowse link
G Myocd myocardin increases expression ISO geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr11:65,173,608...65,269,989
Ensembl chr11:65,176,561...65,269,989
JBrowse link
G Mzt1 mitotic spindle organizing protein 1 increases expression ISO geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr14:99,034,544...99,046,453
Ensembl chr14:99,034,544...99,046,134
JBrowse link
G Nasp nuclear autoantigenic sperm protein (histone-binding) increases expression ISO geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 4:116,601,052...116,628,676
Ensembl chr 4:116,601,052...116,627,941
JBrowse link
G Nbas neuroblastoma amplified sequence increases expression ISO geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr12:13,269,101...13,637,380
Ensembl chr12:13,269,133...13,583,811
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 increases expression ISO geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr13:41,309,916...41,487,362
Ensembl chr13:41,309,581...41,487,362
JBrowse link
G Nes nestin increases expression ISO geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 3:87,971,093...87,980,451
Ensembl chr 3:87,971,078...87,980,451
JBrowse link
G Nf1 neurofibromin 1 increases expression ISO geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr11:79,339,590...79,581,609
Ensembl chr11:79,339,693...79,581,612
JBrowse link
G Nf2 neurofibromin 2 increases expression ISO geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr11:4,757,639...4,849,544
Ensembl chr11:4,765,845...4,849,536
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 increases expression ISO geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr 8:107,293,435...107,379,517
Ensembl chr 8:107,293,470...107,379,517
JBrowse link
G Nipbl NIPBL cohesin loading factor increases expression ISO geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr15:8,289,824...8,465,315
Ensembl chr15:8,290,617...8,444,463
JBrowse link
G Nktr natural killer tumor recognition sequence increases expression ISO geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 9:121,713,881...121,756,842
Ensembl chr 9:121,719,169...121,756,843
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases expression
ISO geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313, PMID:15583003 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Npr3 natriuretic peptide receptor 3 increases expression ISO geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr15:11,839,896...11,907,837
Ensembl chr15:11,839,896...11,907,287
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases reduction ISO NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression ISO geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 6:92,091,418...92,173,058
Ensembl chr 6:92,091,390...92,174,294
JBrowse link
G Nrk Nik related kinase increases expression ISO geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:138,914,231...139,010,532
Ensembl chr  X:138,914,430...139,010,532
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr10:111,164,742...111,297,249
Ensembl chr10:111,164,752...111,297,249
JBrowse link
G Otud4 OTU domain containing 4 increases expression ISO geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr 8:79,639,676...79,677,755
Ensembl chr 8:79,639,618...79,677,724
JBrowse link
G Oxtr oxytocin receptor increases expression ISO geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 6:112,473,683...112,491,035
Ensembl chr 6:112,473,683...112,489,943
JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 multiple interactions ISO geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr11:72,999,056...73,015,200
Ensembl chr11:72,999,103...73,015,200
JBrowse link
G Pappa pregnancy-associated plasma protein A increases expression ISO geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 4:65,124,174...65,357,509
Ensembl chr 4:65,124,174...65,357,509
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases degradation
ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509, PMID:17293044 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcbp2 poly(rC) binding protein 2 increases expression ISO geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr15:102,470,450...102,500,068
Ensembl chr15:102,470,539...102,500,061
JBrowse link
G Pcm1 pericentriolar material 1 increases expression ISO geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr 8:41,239,484...41,334,088
Ensembl chr 8:41,239,752...41,332,344
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein (myomegalin) increases expression ISO geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 3:97,689,828...97,888,707
Ensembl chr 3:97,689,824...97,888,707
JBrowse link
G Pdgfa platelet derived growth factor, alpha increases expression ISO geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr 5:138,976,014...139,000,792
Ensembl chr 5:138,976,014...138,997,370
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 6:4,747,306...4,760,517
Ensembl chr 6:4,747,306...4,760,517
JBrowse link
G Pgr progesterone receptor decreases expression ISO geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Phactr2 phosphatase and actin regulator 2 increases expression ISO geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr10:13,207,717...13,474,525
Ensembl chr10:13,207,717...13,474,412
JBrowse link
G Phldb2 pleckstrin homology like domain, family B, member 2 increases expression ISO geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr16:45,746,230...45,953,598
Ensembl chr16:45,746,243...45,953,598
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 increases expression ISO geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 5:20,758,664...20,882,137
Ensembl chr 5:20,758,663...20,882,124
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha increases expression ISO geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plppr4 phospholipid phosphatase related 4 increases expression ISO geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 3:117,319,145...117,360,876
Ensembl chr 3:117,319,139...117,360,876
JBrowse link
G Plxna2 plexin A2 increases expression ISO geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr 1:194,619,791...194,816,869
Ensembl chr 1:194,618,218...194,816,869
JBrowse link
G Polr2b polymerase (RNA) II (DNA directed) polypeptide B decreases expression ISO geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr 5:77,310,484...77,349,328
Ensembl chr 5:77,310,147...77,349,324
JBrowse link
G Ppm1k protein phosphatase 1K (PP2C domain containing) increases expression ISO geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 6:57,506,502...57,535,552
Ensembl chr 6:57,506,502...57,535,468
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I increases expression ISO geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr19:30,564,487...31,765,268
Ensembl chr19:30,564,489...31,765,033
JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 increases expression ISO geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr10:76,207,226...76,237,865
Ensembl chr10:76,207,222...76,237,865
JBrowse link
G Prpf6 pre-mRNA splicing factor 6 increases expression ISO geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr 2:181,601,319...181,655,661
Ensembl chr 2:181,591,868...181,655,660
JBrowse link
G Prr14l proline rich 14-like increases expression ISO geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr 5:32,789,207...32,854,337
Ensembl chr 5:32,789,820...32,854,256
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr 1:162,671,785...162,740,560
Ensembl chr 1:162,670,725...162,740,556
JBrowse link
G Psme4 proteasome (prosome, macropain) activator subunit 4 increases expression ISO geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr11:30,771,775...30,881,150
Ensembl chr11:30,771,726...30,880,361
JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 increases expression ISO geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr19:23,687,361...23,732,885
Ensembl chr19:23,687,429...23,731,668
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 increases expression ISO geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 4:59,471,868...59,549,378
Ensembl chr 4:59,471,868...59,549,364
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pthlh parathyroid hormone-like peptide multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr 6:147,252,109...147,264,013
Ensembl chr 6:147,252,101...147,264,183
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
ISO
EXP
geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544, PMID:12811834 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr 5:121,130,533...121,191,397
Ensembl chr 5:121,130,533...121,191,397
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 increases expression ISO geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 5:20,986,645...21,055,911
Ensembl chr 5:20,986,645...21,055,911
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr 2:130,450,278...130,554,300
Ensembl chr 2:130,450,278...130,556,124
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 4:75,941,237...78,211,742
Ensembl chr 4:75,941,238...78,211,961
JBrowse link
G Pygo1 pygopus 1 increases expression ISO geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr 9:72,925,645...72,952,586
Ensembl chr 9:72,925,645...72,952,181
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 4:108,879,070...108,943,324
Ensembl chr 4:108,879,063...108,943,324
JBrowse link
G Rabep1 rabaptin, RAB GTPase binding effector protein 1 increases expression ISO geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr11:70,844,724...70,943,105
Ensembl chr11:70,844,778...70,943,105
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 increases expression
decreases expression
multiple interactions
EXP
ISO
geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498, PMID:19167484, PMID:24450340 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 increases expression ISO geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 3:79,062,511...79,286,545
Ensembl chr 3:79,062,516...79,286,517
JBrowse link
G Rassf8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 increases expression ISO geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr 6:145,746,561...145,821,079
Ensembl chr 6:145,746,748...145,821,079
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr 5:143,172,186...143,180,775
Ensembl chr 5:143,172,186...143,180,775
JBrowse link
G Rbm26 RNA binding motif protein 26 increases expression ISO geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr14:105,106,751...105,181,039
Ensembl chr14:105,106,751...105,177,327
JBrowse link
G Rbms3 RNA binding motif, single stranded interacting protein increases expression ISO geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 9:116,572,746...117,629,913
Ensembl chr 9:116,572,746...117,872,584
Ensembl chr 9:116,572,746...117,872,584
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr16:92,391,951...92,466,169
Ensembl chr16:92,391,953...92,470,867
JBrowse link
G Rdh10 retinol dehydrogenase 10 (all-trans) increases expression ISO geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 1:16,105,882...16,132,550
Ensembl chr 1:16,105,774...16,133,734
JBrowse link
G Resf1 retroelement silencing factor 1 increases expression ISO geldanamycin results in increased expression of RESF1 mRNA CTD PMID:26705709 NCBI chr 6:149,309,409...149,335,663
Ensembl chr 6:149,309,414...149,335,663
JBrowse link
G Rfx7 regulatory factor X, 7 increases expression ISO geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr 9:72,532,169...72,622,949
Ensembl chr 9:72,532,240...72,622,937
JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
ISO geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709, PMID:30166341 NCBI chr 4:33,310,300...33,502,614
Ensembl chr 4:33,310,311...33,502,614
JBrowse link
G Ro60 Ro60, Y RNA binding protein increases expression ISO geldanamycin results in increased expression of RO60 mRNA CTD PMID:26705709 NCBI chr 1:143,750,790...143,777,063
Ensembl chr 1:143,750,790...143,777,068
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr12:16,894,978...16,988,274
Ensembl chr12:16,894,895...16,987,823
JBrowse link
G Rplp0 ribosomal protein, large, P0 decreases expression ISO geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr 5:115,559,467...115,563,729
Ensembl chr 5:115,559,467...115,563,727
JBrowse link
G Rttn rotatin increases expression ISO geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:88,971,736...89,131,014
Ensembl chr18:88,971,790...89,131,016
JBrowse link
G Rufy2 RUN and FYVE domain-containing 2 increases expression ISO geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr10:62,980,174...63,017,209
Ensembl chr10:62,980,223...63,017,210
JBrowse link
G S100a4 S100 calcium binding protein A4 decreases expression ISO geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G Samd5 sterile alpha motif domain containing 5 increases expression ISO geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr10:9,262,461...9,675,926
Ensembl chr10:9,622,936...9,675,208
JBrowse link
G Sar1b secretion associated Ras related GTPase 1B increases expression ISO geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr11:51,763,663...51,791,953
Ensembl chr11:51,763,687...51,791,925
JBrowse link
G Scrn3 secernin 3 increases expression ISO geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 2:73,312,650...73,337,818
Ensembl chr 2:73,312,601...73,337,818
JBrowse link
G Scyl2 SCY1-like 2 (S. cerevisiae) increases expression ISO geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr10:89,638,720...89,686,317
Ensembl chr10:89,638,721...89,686,285
JBrowse link
G Sema3d sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D increases expression ISO geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 5:12,383,161...12,588,953
Ensembl chr 5:12,383,385...12,588,948
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 increases expression ISO geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr15:98,038,744...98,093,569
Ensembl chr15:98,038,744...98,093,744
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sesn3 sestrin 3 increases expression ISO geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr 9:14,276,301...14,326,134
Ensembl chr 9:14,275,067...14,333,101
JBrowse link
G Setd2 SET domain containing 2 increases expression ISO geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 9:110,532,500...110,618,633
Ensembl chr 9:110,532,597...110,618,633
JBrowse link
G Setx senataxin increases expression ISO geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 2:29,123,588...29,182,471
Ensembl chr 2:29,124,181...29,182,471
JBrowse link
G Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) increases expression ISO geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 4:127,020,716...127,051,101
Ensembl chr 4:127,021,324...127,037,013
JBrowse link
G Sgms2 sphingomyelin synthase 2 increases expression ISO geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 3:131,318,985...131,491,443
Ensembl chr 3:131,318,985...131,491,411
JBrowse link
G Sike1 suppressor of IKBKE 1 increases expression ISO geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 3:102,995,740...103,003,914
Ensembl chr 3:102,995,708...103,008,459
JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr 5:72,914,362...72,978,841
Ensembl chr 5:72,914,304...72,978,829
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 increases expression ISO geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 increases expression ISO geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr10:125,219,270...125,389,586
Ensembl chr10:125,219,270...125,389,465
JBrowse link
G Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 increases expression ISO geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr15:91,267,691...91,573,261
Ensembl chr15:91,267,696...91,573,261
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression ISO geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr15:96,571,418...96,643,438
Ensembl chr15:96,571,418...96,642,913
JBrowse link
G Slc39a6 solute carrier family 39 (metal ion transporter), member 6 increases expression ISO geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:24,579,881...24,603,817
Ensembl chr18:24,579,881...24,603,817
JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 increases expression ISO geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr17:81,373,105...81,738,387
Ensembl chr17:81,373,105...81,738,377
JBrowse link
G Slfn5 schlafen 5 increases expression ISO geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr11:82,951,349...82,964,850
Ensembl chr11:82,951,349...82,964,840
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression ISO geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr19:26,605,073...26,778,321
Ensembl chr19:26,605,050...26,778,322
JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases expression ISO geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:152,016,428...152,061,973
Ensembl chr  X:152,016,428...152,062,694
JBrowse link
G Smchd1 SMC hinge domain containing 1 increases expression ISO geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr17:71,344,489...71,475,366
Ensembl chr17:71,344,489...71,475,343
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr12:69,583,761...69,681,852
Ensembl chr12:69,583,762...69,681,852
JBrowse link
G Sp4 trans-acting transcription factor 4 increases expression ISO geldanamycin results in increased expression of SP4 mRNA CTD PMID:26705709 NCBI chr12:118,231,686...118,301,440
Ensembl chr12:118,234,933...118,301,440
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 increases expression ISO geldanamycin results in increased expression of SPTBN1 mRNA CTD PMID:26705709 NCBI chr11:30,099,395...30,268,384
Ensembl chr11:30,099,395...30,268,175
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]
CTD PMID:10401681, PMID:17223712 NCBI chr 2:157,423,906...157,471,838
Ensembl chr 2:157,418,444...157,471,862
JBrowse link
G Srpr signal recognition particle receptor ('docking protein') increases expression ISO geldanamycin results in increased expression of SRPR mRNA CTD PMID:26705709 NCBI chr 9:35,211,203...35,217,003
Ensembl chr 9:35,200,175...35,247,973
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO geldanamycin results in increased expression of SRRM2 mRNA CTD PMID:26705709 NCBI chr17:23,790,527...23,824,741
Ensembl chr17:23,790,532...23,824,741
JBrowse link
G Srrt serrate RNA effector molecule homolog (Arabidopsis) increases expression ISO geldanamycin results in increased expression of SRRT mRNA CTD PMID:26705709 NCBI chr 5:137,295,704...137,307,716
Ensembl chr 5:137,295,704...137,307,674
JBrowse link
G Strn4 striatin, calmodulin binding protein 4 decreases expression ISO geldanamycin results in decreased expression of STRN4 mRNA CTD PMID:30166341 NCBI chr 7:16,815,889...16,840,931
Ensembl chr 7:16,815,889...16,840,931
JBrowse link
G Stub1 STIP1 homology and U-Box containing protein 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] CTD PMID:16037132, PMID:25645596 NCBI chr17:25,830,634...25,832,919
Ensembl chr17:25,830,505...25,833,404
JBrowse link
G Supt16 SPT16, facilitates chromatin remodeling subunit increases expression ISO geldanamycin results in increased expression of SUPT16H mRNA CTD PMID:26705709 NCBI chr14:52,160,419...52,197,239
Ensembl chr14:52,160,414...52,197,416
JBrowse link
G Tead1 TEA domain family member 1 increases expression ISO geldanamycin results in increased expression of TEAD1 mRNA CTD PMID:26705709 NCBI chr 7:112,679,356...112,906,784
Ensembl chr 7:112,679,318...112,906,807
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 increases expression ISO geldanamycin results in increased expression of TET2 mRNA CTD PMID:26705709 NCBI chr 3:133,463,677...133,545,136
Ensembl chr 3:133,463,679...133,545,139
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO geldanamycin results in increased expression of TFPI mRNA CTD PMID:26705709 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO geldanamycin results in increased expression of TGFB2 mRNA CTD PMID:26705709 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO geldanamycin results in increased expression of THBS1 mRNA CTD PMID:26705709 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Tle4 transducin-like enhancer of split 4 increases expression ISO geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 NCBI chr19:14,448,072...14,598,183
Ensembl chr19:14,448,150...14,598,051
JBrowse link
G Tlk1 tousled-like kinase 1 increases expression ISO geldanamycin results in increased expression of TLK1 mRNA CTD PMID:26705709 NCBI chr 2:70,712,407...70,825,816
Ensembl chr 2:70,712,407...70,825,728
JBrowse link
G Tll1 tolloid-like increases expression ISO geldanamycin results in increased expression of TLL1 mRNA CTD PMID:26705709 NCBI chr 8:64,013,098...64,206,008
Ensembl chr 8:64,014,931...64,206,271
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tmem33 transmembrane protein 33 increases expression ISO geldanamycin results in increased expression of TMEM33 mRNA CTD PMID:26705709 NCBI chr 5:67,260,565...67,291,461
Ensembl chr 5:67,260,565...67,291,461
JBrowse link
G Tmod3 tropomodulin 3 increases expression ISO geldanamycin results in increased expression of TMOD3 mRNA CTD PMID:26705709 NCBI chr 9:75,497,784...75,559,657
Ensembl chr 9:75,497,707...75,559,657
JBrowse link
G Tmtc3 transmembrane and tetratricopeptide repeat containing 3 increases expression ISO geldanamycin results in increased expression of TMTC3 mRNA CTD PMID:26705709 NCBI chr10:100,443,902...100,487,365
Ensembl chr10:100,443,902...100,487,350
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:11472980, PMID:12571865 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 decreases expression ISO geldanamycin results in decreased expression of TNFSF15 mRNA CTD PMID:26705709 NCBI chr 4:63,724,600...63,745,059
Ensembl chr 4:63,727,084...63,745,113
Ensembl chr 4:63,727,084...63,745,113
JBrowse link
G Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 increases expression ISO geldanamycin results in increased expression of TNKS2 mRNA CTD PMID:26705709 NCBI chr19:36,834,129...36,893,477
Ensembl chr19:36,834,232...36,893,477
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression ISO geldanamycin results in increased expression of TOB2 mRNA CTD PMID:26705709 NCBI chr15:81,848,270...81,858,326
Ensembl chr15:81,848,272...81,858,796
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO geldanamycin results in increased expression of TPM4 mRNA CTD PMID:26705709 NCBI chr 8:72,135,288...72,153,142
Ensembl chr 8:72,130,174...72,153,142
JBrowse link
G Tpp2 tripeptidyl peptidase II increases expression ISO geldanamycin results in increased expression of TPP2 mRNA CTD PMID:26705709 NCBI chr 1:43,933,970...44,003,000
Ensembl chr 1:43,933,647...44,003,000
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO geldanamycin results in increased expression of TPR mRNA CTD PMID:26705709 NCBI chr 1:150,392,802...150,449,935
Ensembl chr 1:150,392,838...150,449,935
JBrowse link
G Trim59 tripartite motif-containing 59 increases expression ISO geldanamycin results in increased expression of TRIM59 mRNA CTD PMID:26705709 NCBI chr 3:69,035,292...69,044,742
Ensembl chr 3:69,035,288...69,044,755
JBrowse link
G Trp53 transformation related protein 53 affects localization
affects expression
multiple interactions
ISO geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]
CTD PMID:17293044, PMID:24211270 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 increases expression ISO geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 NCBI chr 2:121,194,835...121,296,354
Ensembl chr 2:121,193,281...121,271,407
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 NCBI chr 9:8,543,867...8,680,752
Ensembl chr 9:8,544,142...8,680,741
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1] CTD PMID:11930156 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression ISO geldanamycin results in increased expression of TTC3 mRNA CTD PMID:26705709 NCBI chr16:94,370,625...94,469,222
Ensembl chr16:94,370,618...94,469,343
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 increases expression ISO geldanamycin results in increased expression of TTC37 mRNA CTD PMID:26705709 NCBI chr13:76,098,705...76,190,318
Ensembl chr13:76,098,734...76,190,316
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression EXP geldanamycin results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr15:98,949,847...98,953,501
Ensembl chr15:98,949,837...98,953,703
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H increases expression ISO geldanamycin results in increased expression of UBE2H mRNA CTD PMID:26705709 NCBI chr 6:30,211,289...30,304,539
Ensembl chr 6:30,211,289...30,304,539
JBrowse link
G Ubn2 ubinuclein 2 increases expression ISO geldanamycin results in increased expression of UBN2 mRNA CTD PMID:26705709 NCBI chr 6:38,433,925...38,512,763
Ensembl chr 6:38,433,950...38,524,825
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO geldanamycin results in increased expression of UGCG mRNA CTD PMID:26705709 NCBI chr 4:59,189,507...59,222,833
Ensembl chr 4:59,189,257...59,222,833
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 increases expression ISO geldanamycin results in increased expression of UGGT1 mRNA CTD PMID:26705709 NCBI chr 1:36,140,028...36,244,320
Ensembl chr 1:36,140,027...36,244,720
JBrowse link
G Uhmk1 U2AF homology motif (UHM) kinase 1 increases expression ISO geldanamycin results in increased expression of UHMK1 mRNA CTD PMID:26705709 NCBI chr 1:170,193,422...170,215,897
Ensembl chr 1:170,193,420...170,215,397
JBrowse link
G Usp10 ubiquitin specific peptidase 10 increases expression ISO geldanamycin results in increased expression of USP10 mRNA CTD PMID:26705709 NCBI chr 8:119,910,360...119,957,560
Ensembl chr 8:119,910,360...119,957,560
JBrowse link
G Usp12 ubiquitin specific peptidase 12 increases expression ISO geldanamycin results in increased expression of USP12 mRNA CTD PMID:26705709 NCBI chr 5:146,734,809...146,794,956
Ensembl chr 5:146,734,809...146,795,006
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression ISO geldanamycin results in increased expression of USP25 mRNA CTD PMID:26705709 NCBI chr16:77,013,684...77,116,783
Ensembl chr16:77,013,706...77,116,780
JBrowse link
G Usp36 ubiquitin specific peptidase 36 increases expression ISO geldanamycin results in increased expression of USP36 mRNA CTD PMID:26705709 NCBI chr11:118,259,651...118,290,260
Ensembl chr11:118,259,651...118,290,244
JBrowse link
G Vapb vesicle-associated membrane protein, associated protein B and C increases expression ISO geldanamycin results in increased expression of VAPB mRNA CTD PMID:26705709 NCBI chr 2:173,737,571...173,784,336
Ensembl chr 2:173,737,511...173,784,339
JBrowse link
G Vdac3 voltage-dependent anion channel 3 decreases expression ISO geldanamycin results in decreased expression of VDAC3 mRNA CTD PMID:30166341 NCBI chr 8:22,577,075...22,593,813
Ensembl chr 8:22,577,075...22,593,813
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions ISO geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr19:27,216,480...27,254,231
Ensembl chr19:27,216,484...27,254,231
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO geldanamycin results in increased expression of VMP1 mRNA CTD PMID:26705709 NCBI chr11:86,583,858...86,683,836
Ensembl chr11:86,583,865...86,683,836
JBrowse link
G Vps50 VPS50 EARP/GARPII complex subunit increases expression ISO geldanamycin results in increased expression of VPS50 mRNA CTD PMID:26705709 NCBI chr 6:3,498,393...3,603,531
Ensembl chr 6:3,498,382...3,603,531
JBrowse link
G Zbed6 zinc finger, BED type containing 6 increases expression ISO geldanamycin results in increased expression of ZBED6 mRNA CTD PMID:26705709 NCBI chr 1:133,655,879...133,660,885
Ensembl chr 1:133,655,879...133,660,885
Ensembl chr 1:133,655,879...133,660,885
JBrowse link
G Zc3h11a zinc finger CCCH type containing 11A increases expression ISO geldanamycin results in increased expression of ZC3H11A mRNA CTD PMID:26705709 NCBI chr 1:133,619,862...133,661,399
Ensembl chr 1:133,619,871...133,661,380
Ensembl chr 1:133,619,871...133,661,380
JBrowse link
G Zfhx4 zinc finger homeodomain 4 increases expression ISO geldanamycin results in increased expression of ZFHX4 mRNA CTD PMID:26705709 NCBI chr 3:5,218,218...5,415,861
Ensembl chr 3:5,218,526...5,415,857
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO geldanamycin results in decreased expression of ZNF207 mRNA CTD PMID:30166341 NCBI chr11:80,383,279...80,408,561
Ensembl chr11:80,383,279...80,405,733
JBrowse link
G Zfp326 zinc finger protein 326 increases expression ISO geldanamycin results in increased expression of ZNF326 mRNA CTD PMID:26705709 NCBI chr 5:105,876,556...105,915,818
Ensembl chr 5:105,876,565...105,915,818
JBrowse link
G Zfp518a zinc finger protein 518A increases expression ISO geldanamycin results in increased expression of ZNF518A mRNA CTD PMID:26705709 NCBI chr19:40,894,031...40,917,947
Ensembl chr19:40,894,705...40,917,947
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO geldanamycin results in increased expression of ZNF638 mRNA CTD PMID:26705709 NCBI chr 6:83,867,068...83,986,871
Ensembl chr 6:83,867,109...83,989,550
JBrowse link
G Zfp655 zinc finger protein 655 increases expression ISO geldanamycin results in increased expression of ZNF655 mRNA CTD PMID:26705709 NCBI chr 5:145,231,595...145,247,306
Ensembl chr 5:145,231,715...145,247,302
JBrowse link
G Zfp660 zinc finger protein 660 increases expression ISO geldanamycin results in increased expression of ZNF660 mRNA CTD PMID:26705709 NCBI chr 9:122,903,248...122,914,158
Ensembl chr 9:122,903,246...122,914,154
JBrowse link
G Zfp704 zinc finger protein 704 increases expression ISO geldanamycin results in increased expression of ZNF704 mRNA CTD PMID:26705709 NCBI chr 3:9,427,010...9,610,085
Ensembl chr 3:9,427,020...9,610,085
JBrowse link
G Zfp711 zinc finger protein 711 increases expression ISO geldanamycin results in increased expression of ZNF711 mRNA CTD PMID:26705709 NCBI chr  X:112,600,526...112,635,070
Ensembl chr  X:112,600,526...112,635,070
JBrowse link
G Zfp770 zinc finger protein 770 increases expression ISO geldanamycin results in increased expression of ZNF770 mRNA CTD PMID:26705709 NCBI chr 2:114,193,456...114,201,432
Ensembl chr 2:114,193,461...114,201,469
JBrowse link
G Zfr zinc finger RNA binding protein increases expression ISO geldanamycin results in increased expression of ZFR mRNA CTD PMID:26705709 NCBI chr15:12,117,563...12,185,449
Ensembl chr15:12,117,831...12,185,683
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO geldanamycin results in increased expression of ZFX mRNA CTD PMID:26705709 NCBI chr  X:94,074,631...94,150,645
Ensembl chr  X:94,074,631...94,123,702
JBrowse link
G Zmynd11 zinc finger, MYND domain containing 11 increases expression ISO geldanamycin results in increased expression of ZMYND11 mRNA CTD PMID:26705709 NCBI chr13:9,684,836...9,766,014
Ensembl chr13:9,684,833...9,765,330
JBrowse link
G Zxdc ZXD family zinc finger C increases expression ISO geldanamycin results in increased expression of ZXDC mRNA CTD PMID:26705709 NCBI chr 6:90,369,478...90,403,490
Ensembl chr 6:90,369,492...90,403,490
JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO
EXP
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
CTD PMID:25968939 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD PMID:25968939 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ftl1 ferritin light polypeptide 1 decreases expression EXP
ISO
ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein
CTD PMID:25968939 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Tfrc transferrin receptor increases expression EXP
ISO
ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
leupeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:21818627 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aqp8 aquaporin 8 multiple interactions ISO leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein] CTD PMID:17110522 NCBI chr 7:123,462,294...123,468,003
Ensembl chr 7:123,462,291...123,468,004
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein] CTD PMID:16242776 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Casp6 caspase 6 multiple interactions ISO leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein] CTD PMID:15086513 NCBI chr 3:129,901,415...129,914,112
Ensembl chr 3:129,901,425...129,914,103
JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions
ISO leupeptin results in increased expression of CDC25C protein
leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]
CTD PMID:29074359 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein] CTD PMID:19464575 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A multiple interactions ISO leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr16:48,994,157...49,019,716
Ensembl chr16:48,994,185...49,019,709
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein] CTD PMID:19464575 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctsb cathepsin B multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of CXCL8 protein] CTD PMID:21818627 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Egf epidermal growth factor decreases degradation ISO leupeptin results in decreased degradation of EGF protein CTD PMID:23125191 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein] CTD PMID:21818627 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il6 interleukin 6 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] CTD PMID:21818627 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Klk8 kallikrein related-peptidase 8 decreases activity ISO leupeptin results in decreased activity of KLK8 protein CTD PMID:16800733 NCBI chr 7:43,797,532...43,803,826
Ensembl chr 7:43,797,577...43,803,826
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr14:68,083,863...68,089,095
Ensembl chr14:68,083,863...68,089,095
JBrowse link
G Plin1 perilipin 1 multiple interactions
decreases degradation
EXP leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein]
leupeptin results in decreased degradation of PLIN1 protein
CTD PMID:17488708 NCBI chr 7:79,721,164...79,732,904
Ensembl chr 7:79,720,218...79,732,903
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I increases expression ISO leupeptin results in increased expression of TGFBR1 protein CTD PMID:27826032 NCBI chr 4:47,353,222...47,414,926
Ensembl chr 4:47,353,222...47,414,931
JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity
multiple interactions
ISO sciadopitysin results in decreased activity of ABCB1 protein
sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
CTD PMID:30790579 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions
EXP sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr 5:135,009,152...135,012,175
Ensembl chr 5:135,009,152...135,012,175
JBrowse link
G Actr1a ARP1 actin-related protein 1A, centractin alpha multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr19:46,376,813...46,395,741
Ensembl chr19:46,376,811...46,395,748
JBrowse link
G Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 increases expression ISO tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr16:85,793,827...85,803,113
Ensembl chr16:85,793,827...85,803,113
JBrowse link
G Agr2 anterior gradient 2 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein
CTD PMID:31370342 NCBI chr12:35,992,925...36,004,081
Ensembl chr12:35,992,907...36,004,087
JBrowse link
G Ak9 adenylate kinase 9 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr10:41,303,432...41,433,569
Ensembl chr10:41,303,980...41,434,534
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression
ISO Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:16923571, PMID:17157164, PMID:18566239, PMID:22810956 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]
CTD PMID:18393300 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Alk anaplastic lymphoma kinase decreases activity
decreases expression
ISO tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form
CTD PMID:21030459, PMID:21502504 NCBI chr17:71,868,988...72,604,702
Ensembl chr17:71,868,972...72,604,627
JBrowse link
G Anxa1 annexin A1 increases expression ISO tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr19:20,373,434...20,390,671
Ensembl chr19:20,373,428...20,390,944
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
ISO Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Ar androgen receptor decreases expression ISO tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:77,773,768...77,782,869
Ensembl chr18:77,773,729...77,782,869
JBrowse link
G Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit decreases expression ISO tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr10:128,083,307...128,090,388
Ensembl chr10:128,083,273...128,090,391
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571, PMID:28673683 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression ISO tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Braf Braf transforming gene decreases expression
increases expression
ISO tanespimycin results in decreased expression of BRAF protein
tanespimycin analog results in increased expression of BRAF protein
CTD PMID:22810956, PMID:31370342 NCBI chr 6:39,603,231...39,725,658
Ensembl chr 6:39,603,237...39,725,463
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15993848, PMID:17157164, PMID:18194434, PMID:19913524, PMID:22810956, PMID:24189122 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein
CTD PMID:17121904 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein
CTD PMID:17121904 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein
CTD PMID:17121904, PMID:17157164 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cct8 chaperonin containing Tcp1, subunit 8 (theta) multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr16:87,483,325...87,495,869
Ensembl chr16:87,483,326...87,495,873
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein
CTD PMID:21156818, PMID:22810956 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein
CTD PMID:21156818, PMID:24784839 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164, PMID:28673683 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr 5:146,230,795...146,302,874
Ensembl chr 5:146,231,230...146,302,874
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr 7:122,208,621...122,222,539
Ensembl chr 7:122,219,496...122,222,824
JBrowse link
G Commd1 COMM domain containing 1 multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr11:22,899,728...22,984,539
Ensembl chr11:22,896,136...22,982,382
JBrowse link
G Csde1 cold shock domain containing E1, RNA binding multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 3:103,020,431...103,058,186
Ensembl chr 3:103,020,426...103,058,186
JBrowse link
G Cttn cortactin multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein
CTD PMID:31370342 NCBI chr 7:144,435,724...144,471,560
Ensembl chr 7:144,435,733...144,471,009
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects metabolic processing ISO CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Dars aspartyl-tRNA synthetase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr 1:128,363,707...128,417,416
Ensembl chr 1:128,363,707...128,417,368
JBrowse link
G Dhrs2 dehydrogenase/reductase member 2 increases expression ISO tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr14:55,222,007...55,241,440
Ensembl chr14:55,222,007...55,241,435
JBrowse link
G Ebf2 early B cell factor 2 increases expression ISO tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr14:67,233,292...67,430,952
Ensembl chr14:67,233,292...67,430,918
JBrowse link
G Echdc3 enoyl Coenzyme A hydratase domain containing 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr 2:6,188,465...6,212,994
Ensembl chr 2:6,188,465...6,213,033
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein
CTD PMID:31370342 NCBI chr19:8,967,041...8,978,180
Ensembl chr19:8,967,041...8,978,479
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein
CTD PMID:31370342 NCBI chr10:81,176,631...81,182,509
Ensembl chr10:81,176,631...81,182,498
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein
CTD PMID:16061882, PMID:17010675, PMID:22810956, PMID:31370342 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein
CTD PMID:31370342 NCBI chr 4:129,591,974...129,600,648
Ensembl chr 4:129,591,960...129,600,648
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr15:102,073,773...102,097,173
Ensembl chr15:102,073,773...102,097,173
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr 5:134,619,872...134,639,409
Ensembl chr 5:134,619,721...134,639,490
JBrowse link
G Eml5 echinoderm microtubule associated protein like 5 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein
CTD PMID:31370342 NCBI chr12:98,786,604...98,901,511
Ensembl chr12:98,786,805...98,901,484
JBrowse link
G Eno1 enolase 1, alpha non-neuron increases expression ISO tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein
CTD PMID:16061882, PMID:24784839 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Eri1 exoribonuclease 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr 8:35,465,265...35,495,533
Ensembl chr 8:35,465,253...35,496,196
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr 5:121,444,753...121,452,474
Ensembl chr 5:121,428,590...121,452,506
JBrowse link
G Farsb phenylalanyl-tRNA synthetase, beta subunit increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
[tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
CTD PMID:31370342 NCBI chr 1:78,417,958...78,488,897
Ensembl chr 1:78,417,975...78,488,897
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr18:38,838,672...38,929,470
Ensembl chr18:38,838,673...38,929,472
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr 5:33,721,724...33,737,068
Ensembl chr 5:33,721,674...33,737,068
JBrowse link
G Flt3 FMS-like tyrosine kinase 3 decreases expression ISO tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr 5:147,330,741...147,400,489
Ensembl chr 5:147,330,741...147,400,489
JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 3:152,210,422...152,236,830
Ensembl chr 3:152,210,422...152,236,826
JBrowse link
G Gcfc2 GC-rich sequence DNA binding factor 2 increases expression ISO tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 6:81,910,562...81,959,098
Ensembl chr 6:81,923,669...81,959,915
JBrowse link
G Gls glutaminase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 1:52,163,449...52,235,009
Ensembl chr 1:52,163,448...52,233,232
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gtf2a2 general transcription factor II A, 2 increases expression ISO tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr 9:70,012,548...70,022,866
Ensembl chr 9:70,012,550...70,022,866
JBrowse link
G Gtf2ird1 general transcription factor II I repeat domain-containing 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr 5:134,357,661...134,456,867
Ensembl chr 5:134,357,656...134,456,716
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr11:54,866,383...54,870,506
Ensembl chr11:54,866,383...54,870,501
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein
CTD PMID:31370342 NCBI chr  X:152,001,896...152,004,442
Ensembl chr  X:152,001,845...152,004,442
JBrowse link
G Hsf1 heat shock factor 1 affects localization
multiple interactions
ISO tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
CTD PMID:20090934 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions
affects binding
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein
CTD PMID:18830594, PMID:22895790, PMID:31370342 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 affects binding ISO tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions
increases expression
ISO [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein
CTD PMID:20090934, PMID:31370342 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa1b heat shock protein 1B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hspa4 heat shock protein 4 increases expression
multiple interactions
ISO tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) decreases expression
multiple interactions
EXP
ISO
tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein
CTD PMID:23144451, PMID:31370342 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression
affects expression
ISO tanespimycin results in decreased expression of IGF1R protein
tanespimycin affects the expression of IGF1R protein
CTD PMID:22810956 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr 9:21,367,731...21,405,363
Ensembl chr 9:21,367,871...21,405,361
JBrowse link
G Kcnv2 potassium channel, subfamily V, member 2 multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
tanespimycin analog results in decreased expression of KCNV2 protein
CTD PMID:31370342 NCBI chr19:27,322,061...27,337,179
Ensembl chr19:27,322,588...27,337,179
JBrowse link
G Kdm3a lysine (K)-specific demethylase 3A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 6:71,588,970...71,632,990
Ensembl chr 6:71,588,972...71,632,990
JBrowse link
G Kdr kinase insert domain protein receptor decreases expression
affects expression
ISO tanespimycin results in decreased expression of KDR protein
tanespimycin affects the expression of KDR protein
CTD PMID:22810956 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein
CTD PMID:16061882, PMID:16213582, PMID:22810956 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Larp7 La ribonucleoprotein domain family, member 7 increases expression ISO tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 3:127,536,714...127,553,349
Ensembl chr 3:127,536,714...127,553,349
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
tanespimycin analog results in increased expression of LCP1 protein
CTD PMID:31370342 NCBI chr14:75,131,105...75,230,842
Ensembl chr14:75,131,101...75,230,842
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr 7:46,842,274...46,855,627
Ensembl chr 7:46,841,475...46,855,627
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr 6:142,490,249...142,507,957
Ensembl chr 6:142,490,249...142,507,957
JBrowse link
G Lmna lamin A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 3:88,481,148...88,509,932
Ensembl chr 3:88,480,147...88,509,956
JBrowse link
G Lrpprc leucine-rich PPR-motif containing multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr17:84,705,247...84,790,786
Ensembl chr17:84,705,247...84,790,789
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr11:110,399,102...110,525,522
Ensembl chr11:110,399,122...110,525,522
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases degradation ISO tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Met met proto-oncogene decreases expression ISO tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein
CTD PMID:31370342 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mllt10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr 2:18,055,160...18,212,390
Ensembl chr 2:18,055,237...18,212,388
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Msn moesin increases expression ISO tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G Mtap methylthioadenosine phosphorylase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 4:89,137,370...89,181,090
Ensembl chr 4:89,137,122...89,181,081
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr15:58,941,234...59,083,956
Ensembl chr15:58,941,234...59,082,005
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr12:32,820,335...32,853,369
Ensembl chr12:32,819,545...32,853,349
JBrowse link
G Nans N-acetylneuraminic acid synthase (sialic acid synthase) multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 4:46,489,329...46,503,438
Ensembl chr 4:46,489,248...46,503,632
JBrowse link
G Ncl nucleolin multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 1:86,344,719...86,359,455
Ensembl chr 1:86,344,719...86,359,400
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases expression
decreases phosphorylation
ISO tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein
CTD PMID:11835313, PMID:22810956 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases response to substance
increases reduction
increases abundance
ISO [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
CTD PMID:10564678, PMID:21156818, PMID:24552538 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
[tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
CTD PMID:31370342 NCBI chr10:128,557,766...128,565,934
Ensembl chr10:128,557,766...128,565,987
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Parp2 poly (ADP-ribose) polymerase family, member 2 increases expression ISO tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr14:50,807,897...50,821,301
Ensembl chr14:50,807,841...50,821,301
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide decreases expression ISO tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 6:47,796,141...47,813,512
Ensembl chr 6:47,796,141...47,813,430
JBrowse link
G Pfn1 profilin 1 increases expression ISO tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr11:70,651,844...70,656,799
Ensembl chr11:70,651,850...70,654,644
JBrowse link
G Pgr progesterone receptor decreases expression EXP tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr10:127,197,067...127,211,628
Ensembl chr10:127,197,067...127,211,585
JBrowse link
G Pkm pyruvate kinase, muscle decreases expression ISO tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375
JBrowse link
G Pnn pinin increases expression ISO tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr12:59,066,919...59,074,017
Ensembl chr12:59,066,884...59,073,998
JBrowse link
G Prkrip1 Prkr interacting protein 1 (IL11 inducible) increases expression ISO tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr 5:136,180,357...136,198,954
Ensembl chr 5:136,178,127...136,198,963
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:167,346,320...167,382,872
Ensembl chr  X:167,346,322...167,382,749
JBrowse link
G Psma6 proteasome subunit alpha 6 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr12:55,384,222...55,418,459
Ensembl chr12:55,384,222...55,418,454
JBrowse link
G Psma7 proteasome subunit alpha 7 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr 2:180,036,367...180,042,464
Ensembl chr 2:180,036,374...180,042,433
JBrowse link
G Rab17 RAB17, member RAS oncogene family multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 1:90,958,133...90,969,673
Ensembl chr 1:90,958,133...90,969,661
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases expression ISO tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein
CTD PMID:17121904 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rdx radixin increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein
CTD PMID:31370342 NCBI chr 9:52,047,150...52,088,738
Ensembl chr 9:52,047,173...52,100,463
JBrowse link
G Rplp0 ribosomal protein, large, P0 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr 5:115,559,467...115,563,729
Ensembl chr 5:115,559,467...115,563,727
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
ISO tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein
CTD PMID:17121904, PMID:27255535 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
G Selenbp1 selenium binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342 NCBI chr 3:94,933,083...94,944,758
Ensembl chr 3:94,933,056...94,944,758
JBrowse link
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 increases expression ISO tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr 1:106,861,175...106,883,348
Ensembl chr 1:106,861,173...106,883,348
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) decreases expression ISO tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr10:127,517,123...127,522,444
Ensembl chr10:127,517,123...127,522,444
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases abundance
increases response to substance
ISO SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin
CTD PMID:21156818 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein
CTD PMID:31370342 NCBI chr11:97,509,340...97,575,246
Ensembl chr11:97,509,340...97,576,186
JBrowse link
G Tagln2 transgelin 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr 1:172,500,246...172,507,375
Ensembl chr 1:172,500,047...172,507,380
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 increases expression ISO tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr10:86,300,412...86,349,505
Ensembl chr10:86,300,372...86,349,506
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Tpte transmembrane phosphatase with tensin homology increases expression ISO tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr 8:22,283,315...22,371,418
Ensembl chr 8:22,283,441...22,371,418
JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
CTD PMID:30796972 NCBI chr15:89,371,631...89,377,036
Ensembl chr15:89,371,931...89,377,039
JBrowse link
G Tyms thymidylate synthase decreases expression ISO tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr 5:30,038,546...30,073,645
Ensembl chr 5:30,058,202...30,073,617
JBrowse link
G Ugdh UDP-glucose dehydrogenase increases expression ISO tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr11:21,321,126...21,371,267
Ensembl chr11:21,321,138...21,371,201
JBrowse link
G Vil1 villin 1 increases expression ISO tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 1:74,409,384...74,435,560
Ensembl chr 1:74,409,376...74,435,559
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656
JBrowse link
G Yars tyrosyl-tRNA synthetase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 4:129,189,734...129,219,240
Ensembl chr 4:129,189,760...129,219,607
JBrowse link
G Zyg11b zyg-ll family member B, cell cycle regulator increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of ZYG11B protein
[tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
CTD PMID:31370342 NCBI chr 4:108,227,755...108,301,125
Ensembl chr 4:108,229,724...108,301,096
JBrowse link
Z-Val-Phe-H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:16891617 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Capn1 calpain 1 multiple interactions
decreases activity
ISO calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin]
calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
calpain inhibitor III results in decreased activity of CAPN1 protein
CTD PMID:13678654, PMID:20878076, PMID:21985864, PMID:29289695 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn2 calpain 2 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:16891617 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein] CTD PMID:19336499 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Il1a interleukin 1 alpha affects localization ISO calpain inhibitor III affects the localization of IL1A protein CTD PMID:24024155 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein] CTD PMID:15275793 NCBI chr14:68,083,863...68,089,095
Ensembl chr14:68,083,863...68,089,095
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA] CTD PMID:15316131 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 multiple interactions EXP
ISO
calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]
CTD PMID:21683092, PMID:21985864 NCBI chr 2:29,965,560...30,031,451
Ensembl chr 2:29,965,560...30,031,451
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] CTD PMID:15316131 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21450
    role 21426
      biological role 21424
        inhibitor 19251
          enzyme inhibitor 19166
            EC 3.* (hydrolase) inhibitor 18649
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3239
                protease inhibitor 2066
                  cysteine protease inhibitor 554
                    EC 3.4.22.2 (papain) inhibitor + 0
                    EC 3.4.22.38 (cathepsin K) inhibitor + 0
                    acetylleucyl-leucyl-norleucinal 32
                    berkeleydione 0
                    berkeleyone A 0
                    berkeleyone B 0
                    berkeleyone C 0
                    berkeleytrione 0
                    calpain inhibitor + 28
                    cathepsin B inhibitor + 52
                    cathepsin L (EC 3.4.22.15) inhibitor + 0
                    cathestatin A 0
                    cathestatin B 0
                    cryptolepine 24
                    geldanamycin + 478
                    preaustinoid A1 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.