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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.5.1.58 (protein farnesyltransferase) inhibitor
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Accession:CHEBI:64133 term browser browse the term
Definition:An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group.
Synonyms:related_synonym: EC 2.5.1.58 inhibitor;   EC 2.5.1.58 inhibitors;   FTase inhibitor;   FTase inhibitors;   farnesyl transferase inhibitor;   farnesyl transferase inhibitors;   farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor;   farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors;   farnesyltransferase inhibitor;   farnesyltransferase inhibitors;   protein farnesyltransferase (EC 2.5.1.58) inhibitors;   protein farnesyltransferase inhibitor;   protein farnesyltransferase inhibitors
 xref: Wikipedia:Farnesyltransferase



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andrastin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of CSF2 protein CTD PMID:28535995 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TGFB1 protein CTD PMID:28535995 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
B 581 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO B 581 results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO B 581 results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO B 581 results in decreased activity of RELA protein CTD PMID:12085227 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
gliotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] CTD PMID:17466404 PMID:20958918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP Gliotoxin results in decreased expression of CYP2B2 mRNA CTD PMID:18346771 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 decreases expression EXP Gliotoxin results in decreased expression of DECR2 mRNA CTD PMID:18346771 NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Gliotoxin results in increased expression of DNAJB1 mRNA CTD PMID:18346771 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dpys dihydropyrimidinase decreases expression EXP Gliotoxin results in decreased expression of DPYS mRNA CTD PMID:18346771 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Gliotoxin results in decreased expression of ECH1 mRNA CTD PMID:18346771 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Gliotoxin results in increased expression of GADD45A mRNA CTD PMID:18346771 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Gliotoxin results in decreased expression of GJB1 mRNA CTD PMID:18346771 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Gliotoxin results in decreased expression of GNMT mRNA CTD PMID:18346771 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Gliotoxin results in decreased expression of GSTM2 mRNA CTD PMID:18346771 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Gliotoxin results in decreased expression of HAL mRNA CTD PMID:18346771 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Gliotoxin results in decreased expression of HIF1A mRNA CTD PMID:20432243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein] CTD PMID:19739265 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma decreases expression
decreases secretion
ISO Gliotoxin results in decreased expression of IFNG mRNA
Gliotoxin results in decreased secretion of IFNG protein
CTD PMID:12112629 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression EXP Gliotoxin results in increased expression of IFRD1 mRNA CTD PMID:18346771 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Gliotoxin results in increased expression of JUNB mRNA CTD PMID:18346771 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:17466404 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:17466404 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17466404 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Gliotoxin results in decreased expression of MBL1 mRNA CTD PMID:18346771 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Gliotoxin results in increased expression of PPP1R15A mRNA CTD PMID:18346771 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] CTD PMID:10653605 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Gliotoxin results in decreased expression of SULT1B1 mRNA CTD PMID:18346771 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:10653605 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ttpa alpha tocopherol transfer protein decreases expression EXP Gliotoxin results in decreased expression of TTPA mRNA CTD PMID:18346771 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP Gliotoxin results in decreased expression of UPB1 mRNA CTD PMID:18346771 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
JBrowse link
lonafarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein; [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein modified form CTD PMID:16118318 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2 protein modified form] CTD PMID:15090542 PMID:16118318 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15090542 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2L1 protein] CTD PMID:16118318 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15090542 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15090542 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15090542 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP3 protein CTD PMID:16118318 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein CTD PMID:16118318 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP9 protein
lonafarnib results in increased cleavage of CASP9 protein
CTD PMID:16118318 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15090542 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15090542 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3A protein modified form CTD PMID:16118318 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3B protein modified form CTD PMID:16118318 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein] CTD PMID:15090542 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lmna lamin A/C decreases farnesylation ISO lonafarnib results in decreased farnesylation of LMNA protein CTD PMID:16996129 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15090542 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15090542 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:15090542 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15090542 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO lonafarnib results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:12673674 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15090542 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases activity
multiple interactions
ISO lonafarnib results in decreased activity of RHEB protein
[lonafarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin
CTD PMID:20554106 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein]; lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]
CTD PMID:15090542 PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein] CTD PMID:15090542 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15090542 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
manumycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP manumycin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:19002579 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO manumycin results in increased activity of CASP3
[Quercetin co-treated with manumycin] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [manumycin results in increased activity of CASP3]
CTD PMID:14625852 PMID:19409983 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO manumycin inhibits the reaction [Plant Extracts results in decreased expression of CCNB1 mRNA] CTD PMID:25051199 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CCND1 protein] CTD PMID:19409983 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO manumycin inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA] CTD PMID:25051199 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CDKN1A protein]
manumycin results in increased expression of CDKN1A protein
CTD PMID:19409983 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit multiple interactions ISO manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein] CTD PMID:18450646 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA] CTD PMID:19739265 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Enosf1 enolase superfamily member 1 decreases expression
affects localization
ISO manumycin results in decreased expression of ENOSF1 protein
manumycin affects the localization of ENOSF1 protein
CTD PMID:18357371 NCBI chr 9:113,275,267...113,314,842 JBrowse link
G Faslg Fas ligand multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of FASL mRNA] CTD PMID:19739265 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:16572112 PMID:17635749 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein] CTD PMID:18450646 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein] CTD PMID:19409983 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
decreases expression
ISO
EXP
manumycin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]
manumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]; manumycin inhibits the reaction [INS1 protein results in increased farnesylation of HRAS protein]
manumycin results in decreased expression of HRAS protein
CTD PMID:16572112 PMID:19002579 PMID:19739265 PMID:19958823 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG protein] CTD PMID:19739265 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
manumycin results in decreased susceptibility to IL1B protein
CTD PMID:21211511 PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein] CTD PMID:19409983 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:21575692 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19739265 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:19739265 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mras muscle RAS oncogene homolog multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased activity of MRAS protein] CTD PMID:18569938 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein] CTD PMID:19739265 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO manumycin results in increased cleavage of PARP1; manumycin results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1]; Quercetin promotes the reaction [manumycin results in increased cleavage of PARP1 protein]
CTD PMID:14625852 PMID:19409983 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP manumycin inhibits the reaction [Streptozocin results in increased expression of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein] CTD PMID:18569938 PMID:21575692 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 multiple interactions EXP manumycin inhibits the reaction [INS1 protein results in increased expression of RASGRF1 protein] CTD PMID:19002579 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of SOD1] CTD PMID:19409983 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased phosphorylation of STAT3 protein] CTD PMID:19409983 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TERT protein] CTD PMID:19409983 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA] CTD PMID:16572112 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; manumycin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]
manumycin results in decreased susceptibility to TNF protein
CTD PMID:19739265 PMID:21211511 PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnpo1 transportin 1 multiple interactions ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TNPO1] CTD PMID:19409983 NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
JBrowse link
G Txn1 thioredoxin 1 decreases expression ISO manumycin results in decreased expression of TXN CTD PMID:19409983 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; manumycin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:18569938 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
tipifarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene SNP affects the susceptibility to tipifarnib CTD PMID:15122075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:22315502 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ap1b1 adaptor related protein complex 1 subunit beta 1 increases expression EXP tipifarnib results in increased expression of AP1B1 mRNA CTD PMID:16403772 NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778
JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression EXP tipifarnib results in increased expression of APC mRNA CTD PMID:16403772 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression EXP tipifarnib results in increased expression of BMP6 mRNA CTD PMID:16403772 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [tipifarnib co-treated with Paclitaxel] results in increased activity of CASP3 protein CTD PMID:15728126 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in decreased expression of CCND1 protein CTD PMID:17876043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein CTD PMID:17876043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases activity
ISO tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein]; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein]; tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein]
tipifarnib results in decreased activity of CSF2 protein
CTD PMID:22315502 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [tipifarnib co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:15728126 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fgf14 fibroblast growth factor 14 increases expression EXP tipifarnib results in increased expression of FGF14 mRNA CTD PMID:16403772 NCBI chr15:101,045,038...101,679,888
Ensembl chr15:101,045,036...101,679,900
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP tipifarnib results in increased expression of FGFR2 mRNA CTD PMID:16403772 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP tipifarnib results in increased expression of GABBR2 mRNA CTD PMID:16403772 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP tipifarnib results in decreased expression of GNAI2 mRNA CTD PMID:16403772 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance
decreases metabolic processing
EXP
ISO
HRAS gene mutant form results in increased susceptibility to tipifarnib
tipifarnib results in decreased metabolism of HRAS protein
CTD PMID:15728126 PMID:16403772 PMID:16648579 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP tipifarnib results in increased expression of IGF2 mRNA CTD PMID:16403772 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]
geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
CTD PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jak3 Janus kinase 3 increases expression EXP tipifarnib results in increased expression of JAK3 mRNA CTD PMID:16403772 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP tipifarnib results in increased expression of KRAS mRNA CTD PMID:16403772 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases expression EXP tipifarnib results in increased expression of LPAR1 mRNA CTD PMID:16403772 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Maf MAF bZIP transcription factor increases expression EXP tipifarnib results in increased expression of MAF mRNA CTD PMID:16403772 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP tipifarnib results in increased expression of MAP3K1 mRNA CTD PMID:16403772 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK1 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein] CTD PMID:19383813 PMID:22315502 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases expression EXP tipifarnib results in increased expression of MAPK12 mRNA CTD PMID:16403772 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein] CTD PMID:19383813 PMID:22315502 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of MOS mRNA CTD PMID:16403772 NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
JBrowse link
G Mras muscle RAS oncogene homolog increases expression EXP tipifarnib results in increased expression of MRAS mRNA CTD PMID:16403772 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Mrgprf MAS related GPR family member F increases expression EXP tipifarnib results in increased expression of MRGPRF mRNA CTD PMID:16403772 NCBI chr 1:200,464,100...200,473,588
Ensembl chr 1:200,463,973...200,473,660
JBrowse link
G Mvk mevalonate kinase multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] CTD PMID:21430599 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Mybbp1a MYB binding protein 1a increases expression EXP tipifarnib results in increased expression of MYBBP1A mRNA CTD PMID:16403772 NCBI chr10:57,056,913...57,067,263
Ensembl chr10:57,056,874...57,067,255
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP tipifarnib results in decreased expression of NDRG2 mRNA CTD PMID:16403772 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor increases expression EXP tipifarnib results in increased expression of NF2 mRNA CTD PMID:16403772 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 increases expression EXP tipifarnib results in increased expression of PGAP2 mRNA CTD PMID:16403772 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma increases expression EXP tipifarnib results in increased expression of PIK3C2G mRNA CTD PMID:16403772 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 increases expression EXP tipifarnib results in increased expression of PLAAT3 mRNA CTD PMID:16403772 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO tipifarnib promotes the reaction [PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] CTD PMID:22315502 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB14 mRNA CTD PMID:16403772 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172
JBrowse link
G Rab29 RAB29, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB29 mRNA CTD PMID:16403772 NCBI chr13:43,307,757...43,313,420
Ensembl chr13:43,307,775...43,313,417
JBrowse link
G Rab2a RAB2A, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB2 mRNA CTD PMID:16403772 NCBI chr 5:21,676,219...21,738,833
Ensembl chr 5:21,676,129...21,739,899
JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB38 mRNA CTD PMID:16403772 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rab3c RAB3C, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB3C mRNA CTD PMID:16403772 NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB8B mRNA CTD PMID:16403772 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of RAF1 mRNA CTD PMID:16403772 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator decreases expression EXP tipifarnib results in decreased expression of RALGDS mRNA CTD PMID:16403772 NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP tipifarnib results in increased expression of RGS8 mRNA CTD PMID:16403772 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Rheb Ras homolog, mTORC1 binding multiple interactions
decreases activity
ISO [tipifarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin CTD PMID:20554106 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rin1 Ras and Rab interactor 1 increases expression EXP tipifarnib results in increased expression of RIN1 mRNA CTD PMID:16403772 NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression EXP tipifarnib results in increased expression of ROCK1 mRNA CTD PMID:16403772 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression EXP tipifarnib results in increased expression of ROCK2 mRNA CTD PMID:16403772 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression EXP tipifarnib results in increased expression of RRAD mRNA CTD PMID:16403772 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP tipifarnib results in decreased expression of TGFB1 mRNA CTD PMID:16403772 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP tipifarnib results in increased expression of TGFBR2 mRNA CTD PMID:16403772 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]] CTD PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP tipifarnib results in decreased expression of TP53 mRNA CTD PMID:16403772 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 increases expression EXP tipifarnib results in increased expression of VAV1 mRNA CTD PMID:16403772 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP tipifarnib results in increased expression of ZMAT3 mRNA CTD PMID:16403772 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
JBrowse link

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  CHEBI ontology 19727
    role 19700
      biological role 19698
        biochemical role 19412
          enzyme inhibitor 18528
            EC 2.* (transferase) inhibitor 14626
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 2482
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 2482
                  EC 2.5.1.58 (protein farnesyltransferase) inhibitor 119
                    B 581 3
                    BMS-214662 0
                    L-744,832 0
                    L-778,123 (free base) + 0
                    L-778,123 hydrochloride 0
                    LB42908 0
                    andrastin A 3
                    andrastin A(1-) 0
                    andrastin B + 3
                    andrastin B(1-) 0
                    andrastin C + 3
                    andrastin C(1-) 0
                    andrastin D + 0
                    andrastin D(1-) 0
                    gliotoxin 29
                    lonafarnib 28
                    manumycin A 35
                    tipifarnib 57
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