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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazinoindole
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Accession:CHEBI:64130 term browser browse the term
Definition:An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system.
Synonyms:related_synonym: pyrazinoindoles

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gliotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] CTD PMID:17466404 PMID:20958918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP Gliotoxin results in decreased expression of CYP2B2 mRNA CTD PMID:18346771 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 decreases expression EXP Gliotoxin results in decreased expression of DECR2 mRNA CTD PMID:18346771 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Gliotoxin results in increased expression of DNAJB1 mRNA CTD PMID:18346771 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dpys dihydropyrimidinase decreases expression EXP Gliotoxin results in decreased expression of DPYS mRNA CTD PMID:18346771 NCBI chr 7:78,769,918...78,847,941
Ensembl chr 7:78,769,807...78,847,974 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Gliotoxin results in decreased expression of ECH1 mRNA CTD PMID:18346771 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Gliotoxin results in increased expression of GADD45A mRNA CTD PMID:18346771 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Gliotoxin results in decreased expression of GJB1 mRNA CTD PMID:18346771 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Gliotoxin results in decreased expression of GNMT mRNA CTD PMID:18346771 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Gliotoxin results in decreased expression of GSTM2 mRNA CTD PMID:18346771 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Gliotoxin results in decreased expression of HAL mRNA CTD PMID:18346771 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Gliotoxin results in decreased expression of HIF1A mRNA CTD PMID:20432243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein] CTD PMID:19739265 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Ifng interferon gamma decreases expression
decreases secretion		 ISO Gliotoxin results in decreased expression of IFNG mRNA
Gliotoxin results in decreased secretion of IFNG protein		 CTD PMID:12112629 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression EXP Gliotoxin results in increased expression of IFRD1 mRNA CTD PMID:18346771 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Gliotoxin results in increased expression of JUNB mRNA CTD PMID:18346771 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:17466404 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:17466404 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17466404 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Gliotoxin results in decreased expression of MBL1 mRNA CTD PMID:18346771 NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Gliotoxin results in increased expression of PPP1R15A mRNA CTD PMID:18346771 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] CTD PMID:10653605 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Gliotoxin results in decreased expression of SULT1B1 mRNA CTD PMID:18346771 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:10653605 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ttpa alpha tocopherol transfer protein decreases expression EXP Gliotoxin results in decreased expression of TTPA mRNA CTD PMID:18346771 NCBI chr 5:34,007,926...34,029,315
Ensembl chr 5:34,007,920...34,028,452 		JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP Gliotoxin results in decreased expression of UPB1 mRNA CTD PMID:18346771 NCBI chr20:14,167,383...14,193,724
Ensembl chr20:14,167,586...14,193,690 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              organonitrogen compound 18386
                organonitrogen heterocyclic compound 17559
                  pyrazinoindole 29
                    glionitrin A 0
                    gliotoxin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organonitrogen heterocyclic compound 17559
                                    pyrazinoindole 29
                                      glionitrin A 0
                                      gliotoxin 29
paths to the root