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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazinoindole
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Accession:CHEBI:64130 term browser browse the term
Definition:An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system.
Synonyms:related_synonym: pyrazinoindoles


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gliotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] CTD PMID:17466404 PMID:20958918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP Gliotoxin results in decreased expression of CYP2B2 mRNA CTD PMID:18346771 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 decreases expression EXP Gliotoxin results in decreased expression of DECR2 mRNA CTD PMID:18346771 NCBI chr10:15,104,907...15,113,281 JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Gliotoxin results in increased expression of DNAJB1 mRNA CTD PMID:18346771 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dpys dihydropyrimidinase decreases expression EXP Gliotoxin results in decreased expression of DPYS mRNA CTD PMID:18346771 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Gliotoxin results in decreased expression of ECH1 mRNA CTD PMID:18346771 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Gliotoxin results in increased expression of GADD45A mRNA CTD PMID:18346771 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Gliotoxin results in decreased expression of GJB1 mRNA CTD PMID:18346771 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Gliotoxin results in decreased expression of GNMT mRNA CTD PMID:18346771 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Gliotoxin results in decreased expression of GSTM2 mRNA CTD PMID:18346771 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Gliotoxin results in decreased expression of HAL mRNA CTD PMID:18346771 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Gliotoxin results in decreased expression of HIF1A mRNA CTD PMID:20432243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein] CTD PMID:19739265 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ifng interferon gamma decreases expression
decreases secretion		 ISO Gliotoxin results in decreased expression of IFNG mRNA
Gliotoxin results in decreased secretion of IFNG protein		 CTD PMID:12112629 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression EXP Gliotoxin results in increased expression of IFRD1 mRNA CTD PMID:18346771 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Gliotoxin results in increased expression of JUNB mRNA CTD PMID:18346771 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:17466404 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:17466404 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17466404 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Gliotoxin results in decreased expression of MBL1 mRNA CTD PMID:18346771 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Gliotoxin results in increased expression of PPP1R15A mRNA CTD PMID:18346771 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] CTD PMID:10653605 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Gliotoxin results in decreased expression of SULT1B1 mRNA CTD PMID:18346771 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:10653605 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ttpa alpha tocopherol transfer protein decreases expression EXP Gliotoxin results in decreased expression of TTPA mRNA CTD PMID:18346771 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP Gliotoxin results in decreased expression of UPB1 mRNA CTD PMID:18346771 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  pyrazinoindole 29
                    glionitrin A 0
                    gliotoxin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organonitrogen heterocyclic compound 17661
                                    pyrazinoindole 29
                                      glionitrin A 0
                                      gliotoxin 29
paths to the root