CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyrazinoindole
Accession: CHEBI:64130
browse the term
Definition: An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system.
Synonyms: related_synonym: pyrazinoindoles
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Birc3
baculoviral IAP repeat-containing 3
multiple interactions
ISO
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA]
CTD
PMID:14527959
NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
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Casp3
caspase 3
multiple interactions increases activity
EXP
Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein]
CTD
PMID:17466404 PMID:20958918
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
decreases expression
EXP
Gliotoxin results in decreased expression of CYP2B2 mRNA
CTD
PMID:18346771
NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
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Decr2
2,4-dienoyl-CoA reductase 2
decreases expression
EXP
Gliotoxin results in decreased expression of DECR2 mRNA
CTD
PMID:18346771
NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
EXP
Gliotoxin results in increased expression of DNAJB1 mRNA
CTD
PMID:18346771
NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
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Dpys
dihydropyrimidinase
decreases expression
EXP
Gliotoxin results in decreased expression of DPYS mRNA
CTD
PMID:18346771
NCBI chr 7:78,769,918...78,847,941
Ensembl chr 7:78,769,807...78,847,974
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Ech1
enoyl-CoA hydratase 1
decreases expression
EXP
Gliotoxin results in decreased expression of ECH1 mRNA
CTD
PMID:18346771
NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Gliotoxin results in increased expression of GADD45A mRNA
CTD
PMID:18346771
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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Gjb1
gap junction protein, beta 1
decreases expression
EXP
Gliotoxin results in decreased expression of GJB1 mRNA
CTD
PMID:18346771
NCBI chr X:71,272,030...71,279,973
Ensembl chr X:71,272,042...71,279,977
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Gnmt
glycine N-methyltransferase
decreases expression
EXP
Gliotoxin results in decreased expression of GNMT mRNA
CTD
PMID:18346771
NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
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Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
Gliotoxin results in decreased expression of GSTM2 mRNA
CTD
PMID:18346771
NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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Hal
histidine ammonia lyase
decreases expression
EXP
Gliotoxin results in decreased expression of HAL mRNA
CTD
PMID:18346771
NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
Gliotoxin results in decreased expression of HIF1A mRNA
CTD
PMID:20432243
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]
CTD
PMID:19739265
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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Ifng
interferon gamma
decreases expression decreases secretion
ISO
Gliotoxin results in decreased expression of IFNG mRNA Gliotoxin results in decreased secretion of IFNG protein
CTD
PMID:12112629
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Ifrd1
interferon-related developmental regulator 1
increases expression
EXP
Gliotoxin results in increased expression of IFRD1 mRNA
CTD
PMID:18346771
NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Gliotoxin results in increased expression of JUNB mRNA
CTD
PMID:18346771
NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
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Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:17466404
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:17466404
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD
PMID:17466404
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mbl1
mannose binding lectin 1
decreases expression
EXP
Gliotoxin results in decreased expression of MBL1 mRNA
CTD
PMID:18346771
NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:14527959
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP
Gliotoxin results in increased expression of PPP1R15A mRNA
CTD
PMID:18346771
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:14527959
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Sod2
superoxide dismutase 2
multiple interactions
ISO
Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA]
CTD
PMID:10653605
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Sult1b1
sulfotransferase family 1B member 1
decreases expression
EXP
Gliotoxin results in decreased expression of SULT1B1 mRNA
CTD
PMID:18346771
NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
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Tnf
tumor necrosis factor
multiple interactions
ISO
Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:10653605
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Ttpa
alpha tocopherol transfer protein
decreases expression
EXP
Gliotoxin results in decreased expression of TTPA mRNA
CTD
PMID:18346771
NCBI chr 5:34,007,926...34,029,315
Ensembl chr 5:34,007,920...34,028,452
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Upb1
beta-ureidopropionase 1
decreases expression
EXP
Gliotoxin results in decreased expression of UPB1 mRNA
CTD
PMID:18346771
NCBI chr20:14,167,383...14,193,724
Ensembl chr20:14,167,586...14,193,690
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