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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:letrozole
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Accession:CHEBI:6413 term browser browse the term
Definition:A triazole that has formula C17H11N5.
Synonyms:exact_synonym: 4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile
 related_synonym: Femara;   Formula=C17H11N5;   InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H;   InChIKey=HPJKCIUCZWXJDR-UHFFFAOYSA-N;   Letrozol;   SMILES=N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1
 xref: Beilstein:6813913;   CAS:112809-51-5;   DrugBank:DB01006;   Drug_Central:1556;   KEGG:C08163;   KEGG:D00964;   LINCS:LSM-3980
 xref_mesh: MESH:C067431
 xref: Patent:EP236940;   Patent:US4978672;   Wikipedia:Letrozole


show annotations for term's descendants           Sort by:
letrozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions		 EXP Letrozole results in decreased expression of ADIPOQ protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]		 CTD PMID:33359182 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adm adrenomedullin increases expression
multiple interactions		 EXP Letrozole results in increased expression of ADM protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA]; ADM protein promotes the reaction [Letrozole results in increased expression of ADM protein]		 CTD PMID:33491863 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions		 EXP Letrozole results in decreased expression of AKT1 mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]		 CTD PMID:33491863 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT2 mRNA CTD PMID:19620711 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT4 mRNA CTD PMID:19620711 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO diacerein inhibits the reaction [Letrozole results in decreased expression of AR mRNA] CTD PMID:37030623 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 EXP Letrozole results in increased expression of ATF6 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]		 CTD PMID:33491863 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Letrozole results in increased expression of BAX protein
ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]		 CTD PMID:33491863 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein] CTD PMID:33491863 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of BMP2 mRNA CTD PMID:19620711 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO Letrozole results in decreased activity of CAT protein
diacerein inhibits the reaction [Letrozole results in decreased activity of CAT protein]		 CTD PMID:37030623 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 EXP Letrozole results in increased expression of CCN2 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]		 CTD PMID:33491863 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO [Letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein; [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein; [Sorafenib co-treated with Letrozole] results in decreased expression of CCND1 protein
letrozole results in decreased expression of CCND1 protein		 CTD PMID:16033851 PMID:20054642 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression		 ISO [letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
letrozole results in decreased expression of CCND2 protein		 CTD PMID:16033851 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO letrozole results in increased expression of CDKN1A protein CTD PMID:20054642 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with letrozole] affects the localization of CYCS protein; [Olive Oil co-treated with letrozole] affects the localization of CYCS protein CTD PMID:24161488 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO diacerein inhibits the reaction [Letrozole results in decreased expression of CYP11A1 mRNA] CTD PMID:37030623 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 Letrozole results in increased expression of CYP17A1 mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
diacerein inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]		 CTD PMID:32298659 PMID:37030623 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
decreases expression		 ISO
EXP		 Letrozole inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; Letrozole inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [sodium arsenite results in increased expression of CYP19A1 mRNA]
Letrozole results in decreased activity of CYP19A1 protein
letrozole results in increased activity of CYP19A1 protein
letrozole results in decreased activity of CYP19A1 protein
letrozole binds to and results in decreased activity of CYP19A1 protein
Letrozole results in decreased expression of CYP19A1 mRNA
diacerein inhibits the reaction [Letrozole results in decreased expression of CYP19A1 mRNA]		 CTD PMID:15837728 PMID:15909811 PMID:15967659 PMID:16009161 PMID:16013988 More... NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of Letrozole CTD PMID:19845430 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO letrozole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 EXP Letrozole results in increased expression of DDIT3 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]		 CTD PMID:33491863 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO letrozole results in increased expression of DKK1 mRNA CTD PMID:21851939 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; letrozole results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein CTD PMID:16033851 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases expression ISO letrozole results in increased expression of ELK1 protein CTD PMID:15967659 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA CTD PMID:19620711 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions		 ISO Letrozole results in decreased expression of ESR1 mRNA
diacerein inhibits the reaction [Letrozole results in decreased expression of ESR1 mRNA]		 CTD PMID:37030623 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fgf22 fibroblast growth factor 22 increases expression ISO letrozole results in increased expression of FGF22 mRNA CTD PMID:21851939 NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 letrozole results in increased expression of FSHB protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]
diacerein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]		 CTD PMID:15123030 PMID:31295448 PMID:33491863 PMID:37030623 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions
decreases expression		 ISO diacerein inhibits the reaction [Letrozole results in decreased expression of FSHR mRNA] CTD PMID:37030623 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO letrozole results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression ISO letrozole results in increased expression of GRB2 protein CTD PMID:15967659 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions		 EXP Letrozole results in decreased expression of GSR protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein]		 CTD PMID:31295448 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions		 EXP letrozole results in decreased expression of HMOX1 protein
indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]		 CTD PMID:28619389 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP letrozole results in increased expression of IL10 protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]]		 CTD PMID:28619389 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP Letrozole results in increased expression of IL6 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]		 CTD PMID:33359182 PMID:33491863 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression		 EXP
ISO		 ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein]
diacerein inhibits the reaction [Letrozole results in increased expression of INS1 protein]		 CTD PMID:28619389 PMID:33359182 PMID:33491863 PMID:37030623 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kitlg KIT ligand multiple interactions
decreases expression		 ISO diacerein inhibits the reaction [Letrozole results in decreased expression of KITL mRNA] CTD PMID:37030623 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
multiple interactions
increases secretion		 ISO
EXP		 letrozole results in increased expression of LHB protein
Letrozole results in increased expression of LHB protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]]; LHB protein inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]]; Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Niacinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]
diacerein inhibits the reaction [Letrozole results in increased expression of LHB protein]		 CTD PMID:15123030 PMID:16046582 PMID:28619389 PMID:31295448 PMID:32298659 More... NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions
decreases expression		 ISO diacerein inhibits the reaction [Letrozole results in decreased expression of LHR mRNA] CTD PMID:37030623 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO letrozole results in increased expression of LIF mRNA; letrozole results in increased expression of LIF protein CTD PMID:21851939 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO letrozole results in increased expression of LIFR mRNA CTD PMID:21851939 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO letrozole results in increased expression of MAP2K1 protein CTD PMID:15967659 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression ISO letrozole results in increased expression of MAP2K2 protein CTD PMID:15967659 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:15967659 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:15967659 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO letrozole results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP2 protein] CTD PMID:24068038 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP9 protein] CTD PMID:24068038 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein] CTD PMID:16033851 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Sirolimus co-treated with letrozole] results in decreased expression of MYC protein; [sorafenib co-treated with letrozole] results in decreased expression of MYC protein CTD PMID:20054642 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
increases expression		 EXP Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA] CTD PMID:32298659 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]] CTD PMID:28619389 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of PECAM1 protein CTD PMID:19620711 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pgr progesterone receptor decreases expression ISO letrozole results in decreased expression of PGR protein CTD PMID:16002280 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases expression
multiple interactions		 EXP Letrozole results in decreased expression of PIK3CG mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]		 CTD PMID:33491863 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 EXP ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA] CTD PMID:33491863 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 EXP Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] CTD PMID:33359182 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO letrozole results in increased expression of RAF1 protein CTD PMID:15967659 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; [sorafenib co-treated with letrozole] results in decreased expression of RB1 protein; letrozole results in decreased phosphorylation of and affects the activity of RB1 protein CTD PMID:16033851 PMID:20054642 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 EXP indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]] CTD PMID:28619389 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Retn resistin increases expression
multiple interactions		 EXP Letrozole results in increased expression of RETN mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of RETN mRNA]		 CTD PMID:32298659 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein
letrozole results in decreased phosphorylation of RPS6 protein		 CTD PMID:16033851 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of RPS6KA1 protein CTD PMID:15967659 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO letrozole results in increased expression of SHC1 protein CTD PMID:15967659 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO letrozole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression		 EXP Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]; Niacinamide inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA] CTD PMID:32298659 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein] CTD PMID:19561322 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]] CTD PMID:28619389 PMID:33491863 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP Letrozole results in increased expression of TNF protein
ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]		 CTD PMID:28619389 PMID:33359182 PMID:33491863 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO diacerein inhibits the reaction [Letrozole results in increased expression of VEGFA protein] CTD PMID:37030623 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression		 EXP ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA] CTD PMID:33491863 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      group 19877
        pseudohalo group 4563
          cyano group 4563
            nitrile 4563
              letrozole 72
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic molecule 19764
                              organic cyclic compound 19572
                                organic heterocyclic compound 18905
                                  heteroarene 17155
                                    monocyclic heteroarene 14797
                                      azole 14287
                                        triazoles 8138
                                          letrozole 72
paths to the root