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ONTOLOGY REPORT - ANNOTATIONS


Term:8-bromo-3',5'-cyclic GMP
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Accession:CHEBI:64108 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Synonyms:exact_synonym: 8-bromoguanosine 3',5'-(hydrogen phosphate)
 related_synonym: 8-Br-Cyclic GMP;   8-Br-cGMP;   8-Bromo-cgmp;   8-Bromocyclic GMP;   8-Bromocyclic guanosine monophosphate;   8-Bromoguanosine 3',5'-cyclic monophosphate;   8-Bromoguanosine 3',5'-monophosphate;   Formula=C10H11BrN5O7P;   InChI=1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1;   InChIKey=YUFCOOWNNHGGOD-UMMCILCDSA-N;   SMILES=Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1
 xref: CAS:31356-94-2 "ChemIDplus";   CAS:31356-94-2 "KEGG COMPOUND";   KEGG:C13817
 xref_mesh: MESH:C016276
 xref: PMID:10703694 "Europe PMC";   PMID:18509055 "Europe PMC";   PMID:18841072 "Europe PMC";   PMID:21918260 "Europe PMC";   Reaxys:1233440 "Reaxys";   Wikipedia:8-Bromoguanosine_3'\,5'-cyclic_monophosphate


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8-bromo-3',5'-cyclic GMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgef17 Rho guanine nucleotide exchange factor 17 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Edn3 endothelin 3 JBrowse link 3 172,856,730 172,879,276 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Pde5a phosphodiesterase 5A JBrowse link 2 226,899,604 227,044,916 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 8 117,679,328 117,691,073 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      application 19246
        pharmaceutical 19108
          drug 19108
            neuromuscular agent 1283
              muscle relaxant 1278
                8-bromo-3',5'-cyclic GMP 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      chalcogen 19242
                        oxygen atom 19196
                          oxygen molecular entity 19196
                            hydroxides 18973
                              oxoacid 18084
                                pnictogen oxoacid 8540
                                  phosphorus oxoacid 8434
                                    phosphoric acids 7318
                                      phosphoric acid 7318
                                        phosphoric acid derivative 6968
                                          phosphate 6968
                                            organic phosphate 6967
                                              carbohydrate phosphate 1498
                                                phospho sugar 1433
                                                  aldose phosphate 1431
                                                    aldopentose phosphate 1425
                                                      ribose phosphate 1419
                                                        ribonucleotide 1378
                                                          purine ribonucleotide 1351
                                                            guanyl ribonucleotide 123
                                                              3',5'-cyclic GMP 74
                                                                8-bromo-3',5'-cyclic GMP 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.