Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:8-bromo-3',5'-cyclic GMP
go back to main search page
Accession:CHEBI:64108 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Synonyms:exact_synonym: 8-bromoguanosine 3',5'-(hydrogen phosphate)
 related_synonym: 8-Br-Cyclic GMP;   8-Br-cGMP;   8-Bromo-cgmp;   8-Bromocyclic GMP;   8-Bromocyclic guanosine monophosphate;   8-Bromoguanosine 3',5'-cyclic monophosphate;   8-Bromoguanosine 3',5'-monophosphate;   Formula=C10H11BrN5O7P;   InChI=1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1;   InChIKey=YUFCOOWNNHGGOD-UMMCILCDSA-N;   SMILES=Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1
 xref: CAS:31356-94-2;   KEGG:C13817
 xref_mesh: MESH:C016276
 xref: PMID:10703694;   PMID:18509055;   PMID:18841072;   PMID:21918260;   Reaxys:1233440;   Wikipedia:8-Bromoguanosine_3'\,5'-cyclic_monophosphate


show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      application 863
        pharmaceutical 723
          drug 713
            neuromuscular agent 4
              muscle relaxant 4
                8-bromo-3',5'-cyclic GMP 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      chalcogen 4915
                        oxygen atom 4910
                          oxygen molecular entity 4883
                            hydroxides 4835
                              oxoacid 403
                                pnictogen oxoacid 87
                                  phosphorus oxoacid 84
                                    phosphoric acids 54
                                      phosphoric acid 53
                                        phosphoric acid derivative 49
                                          phosphate 49
                                            organic phosphate 49
                                              carbohydrate phosphate 26
                                                phospho sugar 14
                                                  aldose phosphate 14
                                                    aldopentose phosphate 14
                                                      ribose phosphate 14
                                                        ribonucleotide 14
                                                          purine ribonucleotide 14
                                                            guanyl ribonucleotide 3
                                                              3',5'-cyclic GMP 3
                                                                8-bromo-3',5'-cyclic GMP 0
paths to the root