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ONTOLOGY REPORT - ANNOTATIONS


Term:sodium 8-bromo-3',5'-cyclic GMP
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Accession:CHEBI:64104 term browser browse the term
Definition:An organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Synonyms:exact_synonym: sodium 8-bromoguanosine 3',5'-phosphate
 related_synonym: 8-bromo cGMP sodium salt;   8-bromoguanosine 3',5'-cyclic phosphate sodium;   8-bromoguanosine 3',5'-cyclic phosphate sodium salt;   Formula=C10H10BrN5NaO7P;   InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-;/m1./s1;   InChIKey=ZJRFCXHKYQVNFK-YEOHUATISA-M;   SMILES=[Na+].Nc1nc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1
 xref: Reaxys:8378760 "Reaxys"


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.