Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
go back to main search page
Accession:CHEBI:64093 term browser browse the term
Definition:An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Synonyms:exact_synonym: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
 related_synonym: Formula=C28H34N2O;   GBR 12935;   GBR12935;   InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2;   InChIKey=RAQPOZGWANIDQT-UHFFFAOYSA-N;   SMILES=C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1
 xref: CAS:76778-22-8;   LINCS:LSM-3101
 xref_mesh: MESH:C044630
 xref: PMID:1346964;   PMID:18596684;   PMID:18784647;   PMID:19924693;   PMID:20576034;   PMID:21693154;   PMID:21741457;   PMID:21990355;   PMID:2952763;   PMID:3436357;   PMID:8007761;   PMID:9286626;   Reaxys:578614;   Wikipedia:GBR-12935
 cyclic_relationship: is_conjugate_base_of CHEBI:64092


show annotations for term's descendants           Sort by:
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein] CTD PMID:11226678 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects binding
multiple interactions		 ISO
EXP		 1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein
1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine inhibits the reaction [Dextroamphetamine results in increased activity of SLC6A3 protein]; NR3C1 protein inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein]
Paraquat inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein]		 CTD PMID:11226678 PMID:12716422 PMID:15985715 PMID:16190885 PMID:17493592 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        NMR chemical shift reference compound 18090
          ammonia 17865
            organic amino compound 17888
              tertiary amino compound 10155
                1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          N-alkylpiperazine 3404
                                            1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine 2
paths to the root