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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tert-butyl hydroperoxide
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Accession:CHEBI:64090 term browser browse the term
Definition:An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Synonyms:related_synonym: 1,1-Dimethylethyl hydroperoxide;   2-Hydroperoxy-2-methylpropane;   Dimethylethyl hydroperoxide;   Formula=C4H10O2;   Hydroperoxyde de butyle tertiaire;   InChI=1S/C4H10O2/c1-4(2,3)6-5/h5H,1-3H3;   InChIKey=CIHOLLKRGTVIJN-UHFFFAOYSA-N;   SMILES=CC(C)(C)OO;   TBHP;   Tertiary-butyl hydroperoxide;   t-Butylhydroperoxide;   t-butyl hydroperoxide;   tert-Butylhydroperoxide
 xref: Beilstein:1098280;   CAS:75-91-2
 xref_mesh: MESH:D020122
 xref: PMID:21418283;   PMID:22037478;   PMID:22039964;   PMID:22326806;   PMID:22337620;   PMID:22369679;   Reaxys:1098280;   Wikipedia:Tert-Butyl_hydroperoxide


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tert-butyl hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP tert-Butylhydroperoxide results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132 		JBrowse link
G CAPN2 calpain 2 increases expression
increases cleavage		 EXP tert-Butylhydroperoxide results in increased expression of CAPN2 protein
tert-Butylhydroperoxide results in increased cleavage of CAPN2 protein		 CTD PMID:16920763 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246 		JBrowse link
G CASP3 caspase 3 increases cleavage EXP tert-Butylhydroperoxide results in increased cleavage of CASP3 protein CTD PMID:16005169 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression
multiple interactions
increases expression		 EXP tert-Butylhydroperoxide results in decreased expression of HSP90B1 protein
PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSP90B1 protein]		 CTD PMID:16005169 PMID:16920763 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP tert-Butylhydroperoxide results in increased expression of HSPA5 protein
PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSPA5 protein]		 CTD PMID:16005169 PMID:16920763 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      chemical role 824
        oxidising agent 30
          tert-butyl hydroperoxide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            heteroorganic entity 4768
                              organochalcogen compound 4730
                                organooxygen compound 4692
                                  peroxol 5
                                    alkyl hydroperoxide 5
                                      tert-butyl hydroperoxide 5
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