The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
CYP2C8 protein results in decreased degradation of vanoxerine [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine
CYP2E1 protein results in decreased degradation of vanoxerine [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine
[Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine CYP3A4 protein results in decreased degradation of vanoxerine
vanoxerine binds to SLC6A3 protein [vanoxerine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] SLC6A3 gene mutant form results in decreased susceptibility to vanoxerine vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]] SLC6A3 protein affects the susceptibility to vanoxerine vanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]