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ONTOLOGY REPORT - ANNOTATIONS


Term:RS 39604
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Accession:CHEBI:64083 term browser browse the term
Definition:An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Synonyms:related_synonym: Formula=C26H36ClN3O6S;   InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3;   InChIKey=BKVIWGRFRKLFIO-UHFFFAOYSA-N;   RS-67506;   RS67506;   SMILES=COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
 xref: LINCS:LSM-2461
 xref_mesh: MESH:C475107
 xref: PMID:11739263 "Europe PMC";   PMID:12095647 "Europe PMC";   PMID:15272208 "Europe PMC";   PMID:21689105 "Europe PMC";   PMID:7582507 "Europe PMC";   PMID:8903510 "Europe PMC";   PMID:9243330 "Europe PMC";   PMID:9689461 "Europe PMC";   Reaxys:8524141 "Reaxys"


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RS 39604 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr4 5-hydroxytryptamine receptor 4 JBrowse link 18 57,637,013 57,820,317 RGD:6480464

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  CHEBI ontology 19654
    role 19598
      biological role 19596
        pharmacological role 18671
          neurotransmitter agent 16221
            serotonergic drug 3847
              serotonergic antagonist 2221
                RS 39604 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      chalcogen 19217
                        oxygen atom 19171
                          oxygen molecular entity 19171
                            hydroxides 18951
                              oxoacid 18064
                                chalcogen oxoacid 11391
                                  sulfur oxoacid 10981
                                    sulfonic acid 7233
                                      sulfonic acid derivative 7233
                                        sulfonamide 3121
                                          RS 39604 1
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