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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzodiazepine
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Accession:CHEBI:64051 term browser browse the term
Definition:Any organic heterotricyclic compound with a skeleton consisting of two benzene rings fused to a diazepine ring.
Synonyms:related_synonym: dibenzodiazepines


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N-desmethylclozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases chemical synthesis ISO CYP1A1 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
increases metabolic processing
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]
CYP1A2 protein results in increased metabolism of norclozapine
CTD PMID:11151749, PMID:12969762, PMID:18809730 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases chemical synthesis ISO CYP1B1 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases chemical synthesis ISO CYP2D6 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases chemical synthesis ISO CYP2J2 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression ISO
EXP
norclozapine results in decreased expression of HTR2A mRNA
norclozapine results in decreased expression of HTR2A protein
CTD PMID:14751426 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          molecule 19518
            cyclic compound 19321
              polycyclic compound 18523
                heteropolycyclic compound 17820
                  heterotricyclic compound 14571
                    organic heterotricyclic compound 14571
                      dibenzodiazepine 9
                        3-chloro-6-(1-piperazinyl)-5H-benzo[b][1,4]benzodiazepine 0
                        3-chloro-6-(4-methyl-1-piperazinyl)-5H-benzo[b][1,4]benzodiazepine 0
                        4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid 0
                        5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone 0
                        Dibenzepin hydrochloride 0
                        N-desmethylclozapine 9
                        clobenzepam 0
                        diazepinomicin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      dibenzodiazepine 9
                                        3-chloro-6-(1-piperazinyl)-5H-benzo[b][1,4]benzodiazepine 0
                                        3-chloro-6-(4-methyl-1-piperazinyl)-5H-benzo[b][1,4]benzodiazepine 0
                                        4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid 0
                                        5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone 0
                                        Dibenzepin hydrochloride 0
                                        N-desmethylclozapine 9
                                        clobenzepam 0
                                        diazepinomicin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.