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G |
KCNJ3 |
potassium inwardly rectifying channel subfamily J member 3 |
multiple interactions |
EXP |
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
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G |
KCNJ6 |
potassium inwardly rectifying channel subfamily J member 6 |
multiple interactions |
EXP |
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
|
NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
multiple interactions |
EXP |
Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein |
CTD |
PMID:9688607 |
|
NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Aspirin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
ACHE |
acetylcholinesterase |
multiple interactions |
EXP |
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] |
CTD |
PMID:16915560 |
|
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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G |
SCT |
secretin |
multiple interactions |
EXP |
Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] |
CTD |
PMID:3562434 |
|
|
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 |
affects export |
EXP |
ABCC1 protein affects the export of calcein AM |
CTD |
PMID:12516967 |
|
NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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G |
MGMT |
O-6-methylguanine-DNA methyltransferase |
decreases response to substance multiple interactions |
EXP |
MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine] |
CTD |
PMID:14617759 PMID:15053863 |
|
NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380
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G |
HSP70 |
heat shock protein 70 |
multiple interactions |
EXP |
carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein] |
CTD |
PMID:31940135 |
|
NCBI chr12:1,285,282...1,287,670
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:12639917 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:12639917 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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G |
CLDN4 |
claudin 4 |
increases expression |
EXP |
Mannitol results in increased expression of CLDN4 protein |
CTD |
PMID:23816505 |
|
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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G |
CYP2C18 |
cytochrome P450 2C21 |
increases hydroxylation |
EXP |
CYP2C19 protein results in increased hydroxylation of Diclofenac |
CTD |
PMID:15677349 |
|
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
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G |
CYP2C41 |
cytochrome P450 2C41 |
affects metabolic processing |
EXP |
CYP2C9 protein affects the metabolism of Diclofenac |
CTD |
PMID:15801540 |
|
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Diclofenac results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] |
CTD |
PMID:18339021 |
|
NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
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G |
MMP2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] |
CTD |
PMID:18339021 |
|
NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
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G |
MMP9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] |
CTD |
PMID:18339021 |
|
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
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G |
CLDN4 |
claudin 4 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:23816505 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23816505 |
|
NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23816505 |
|
NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
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G |
CFTR |
CF transmembrane conductance regulator |
decreases activity |
EXP |
Glyburide results in decreased activity of CFTR protein |
CTD |
PMID:15496164 |
|
NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
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G |
HEXB |
hexosaminidase subunit beta |
multiple interactions |
EXP |
Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] |
CTD |
PMID:21671308 |
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NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Indomethacin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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G |
CLDN4 |
claudin 4 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:23816505 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23816505 |
|
NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23816505 |
|
NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
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G |
CPNE6 |
copine 6 |
increases reduction |
EXP |
DHRS4 protein results in increased reduction of 2,3-pentanedione |
CTD |
PMID:17827741 |
|
NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
affects metabolic processing |
EXP |
CYP1A2 protein affects the metabolism of Phenacetin |
CTD |
PMID:15801540 |
|
NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Phenacetin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
INS |
insulin |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:12639917 |
|
NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:12639917 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:12639917 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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G |
SLC6A9 |
solute carrier family 6 member 9 |
multiple interactions affects localization |
EXP |
Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein] Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein |
CTD |
PMID:19473961 |
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NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933
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G |
SOD1 |
superoxide dismutase 1 |
affects response to substance |
EXP |
SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate |
CTD |
PMID:6333936 |
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NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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G |
SCT |
secretin |
decreases abundance |
EXP |
SCT protein results in decreased abundance of Lactic Acid |
CTD |
PMID:2418308 |
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
EXP |
allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] |
CTD |
PMID:15266218 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Ritonavir results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
EXP |
Sulindac results in decreased expression of PTGS2 protein |
CTD |
PMID:12857884 |
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NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
decreases localization |
EXP |
Sulindac results in decreased localization of RELA protein |
CTD |
PMID:12857884 |
|
NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Troleandomycin results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
ACHE |
acetylcholinesterase |
multiple interactions |
EXP |
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] |
CTD |
PMID:16915560 |
|
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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G |
SCT |
secretin |
multiple interactions |
EXP |
Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] |
CTD |
PMID:3562434 |
|
|
|
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G |
CLDN4 |
claudin 4 |
increases expression |
EXP |
Urea results in increased expression of CLDN4 protein |
CTD |
PMID:23816505 |
|
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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G |
SOD2 |
superoxide dismutase 2 |
increases expression |
EXP |
Urea results in increased expression of SOD2 protein |
CTD |
PMID:22718889 |
|
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
increases export multiple interactions affects response to substance |
EXP |
ABCB1 protein results in increased export of Vincristine valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine] |
CTD |
PMID:24975508 PMID:28093773 |
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NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 |
decreases response to substance |
EXP |
ABCC1 protein results in decreased susceptibility to Vincristine |
CTD |
PMID:12516967 |
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NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
decreases activity |
EXP |
zileuton results in decreased activity of ALOX5 protein |
CTD |
PMID:1618819 |
|
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
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