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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:64045 term browser browse the term
Definition:A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects.
Synonyms:exact_synonym: 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
 related_synonym: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;   4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide;   Aminosultopride;   Formula=C17H27N3O4S;   InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21);   InChIKey=NTJOBXMMWNYJFB-UHFFFAOYSA-N;   SMILES=CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC;   amisulprida;   amisulpridum
 xref: CAS:71675-85-9;   DrugBank:DB06288;   Drug_Central:179;   HMDB:HMDB0015633;   KEGG:D07310;   LINCS:LSM-1669
 xref_mesh: MESH:D000077582
 xref: PMID:21176108;   PMID:21647545;   PMID:21663752;   PMID:21746752;   PMID:21822161;   PMID:21845006;   PMID:21852060;   PMID:21886905;   PMID:21888613;   PMID:21969105;   PMID:22035899;   PMID:22059694;   PMID:22121864;   PMID:22241281;   PMID:22250612;   Patent:BE872585;   Patent:US4401822;   Reaxys:6876191;   Wikipedia:Amisulpride

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amisulpride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Amisulpride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Amisulpride binds to DRD2 protein CTD PMID:12191584 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Prl prolactin increases secretion
multiple interactions
increases expression
Amisulpride results in increased secretion of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein]
Amisulpride results in increased expression of PRL protein
CTD PMID:12106810 PMID:14966260 PMID:14997280 PMID:15665803 PMID:16938372 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 decreases expression ISO Amisulpride results in decreased expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597
JBrowse link

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  CHEBI ontology 20089
    role 20042
      biological role 20011
        xenobiotic 18699
          amisulpride 4
Path 2
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  arenecarboxamide 7310
                                                    benzamides 7314
                                                      amisulpride 4
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