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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amisulpride
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Accession:CHEBI:64045 term browser browse the term
Definition:A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects.
Synonyms:exact_synonym: 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
 related_synonym: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;   4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide;   Aminosultopride;   Formula=C17H27N3O4S;   InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21);   InChIKey=NTJOBXMMWNYJFB-UHFFFAOYSA-N;   SMILES=CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC;   amisulprida;   amisulpridum
 xref: CAS:71675-85-9;   DrugBank:DB06288;   Drug_Central:179;   HMDB:HMDB0015633;   KEGG:D07310;   LINCS:LSM-1669
 xref_mesh: MESH:D000077582
 xref: PMID:21176108;   PMID:21647545;   PMID:21663752;   PMID:21746752;   PMID:21822161;   PMID:21845006;   PMID:21852060;   PMID:21886905;   PMID:21888613;   PMID:21969105;   PMID:22035899;   PMID:22059694;   PMID:22121864;   PMID:22241281;   PMID:22250612;   Patent:BE872585;   Patent:US4401822;   Reaxys:6876191;   Wikipedia:Amisulpride



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amisulpride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Amisulpride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Amisulpride binds to DRD2 protein CTD PMID:12191584 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Prl prolactin increases secretion
multiple interactions
increases expression
ISO
EXP
Amisulpride results in increased secretion of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein]
Amisulpride results in increased expression of PRL protein
CTD PMID:12106810 PMID:14966260 PMID:14997280 PMID:15665803 PMID:16938372 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 decreases expression ISO Amisulpride results in decreased expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          amisulpride 4
Path 2
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  arenecarboxamide 8255
                                                    benzamides 8255
                                                      amisulpride 4
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