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ONTOLOGY REPORT - ANNOTATIONS


Term:leflunomide
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Accession:CHEBI:6402 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Synonyms:exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
 related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide;   5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;   Arava;   Formula=C12H9F3N2O2;   InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18);   InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N;   SMILES=Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F;   alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide;   leflunomida;   leflunomidum
 xref: Beilstein:4323174 "Beilstein";   CAS:75706-12-6 "ChemIDplus";   CAS:75706-12-6 "KEGG COMPOUND";   DrugBank:DB01097;   Drug_Central:1552 "DrugCentral";   HMDB:HMDB0015229;   KEGG:C07905;   KEGG:D00749;   LINCS:LSM-3771
 xref_mesh: MESH:C045463
 xref: PMID:10515382 "Europe PMC";   PMID:10702725 "Europe PMC";   PMID:10890256 "Europe PMC";   PMID:11043056 "Europe PMC";   PMID:11053058 "Europe PMC";   PMID:11067959 "Europe PMC";   PMID:11271257 "Europe PMC";   PMID:11333342 "Europe PMC";   PMID:11340750 "Europe PMC";   PMID:11391470 "Europe PMC";   PMID:11475244 "Europe PMC";   PMID:11522581 "Europe PMC";   PMID:11707749 "Europe PMC";   PMID:11718154 "Europe PMC";   PMID:11876141 "Europe PMC";   PMID:11884931 "Europe PMC";   PMID:11994686 "Europe PMC";   PMID:12017890 "Europe PMC";   PMID:12074690 "Europe PMC";   PMID:12833393 "Europe PMC";   PMID:14622739 "Europe PMC";   PMID:15030575 "Europe PMC";   PMID:15127968 "Europe PMC";   PMID:15127974 "Europe PMC";   PMID:15188371 "Europe PMC";   PMID:15214907 "Europe PMC";   PMID:15385935 "Europe PMC";   PMID:15489872 "Europe PMC";   PMID:15537652 "Europe PMC";   PMID:15652966 "Europe PMC";   PMID:15665760 "Europe PMC";   PMID:15789891 "Europe PMC";   PMID:15899055 "Europe PMC";   PMID:15934905 "Europe PMC";   PMID:16106593 "Europe PMC";   PMID:16142756 "Europe PMC";   PMID:16202258 "Europe PMC";   PMID:16284916 "Europe PMC";   PMID:16638062 "Europe PMC";   PMID:16638420 "Europe PMC";   PMID:16645972 "Europe PMC";   PMID:16688677 "Europe PMC";   PMID:16769661 "Europe PMC";   PMID:16778342 "Europe PMC";   PMID:17366662 "Europe PMC";   PMID:17604599 "Europe PMC";   PMID:17646975 "Europe PMC";   PMID:17854740 "Europe PMC";   PMID:18034546 "Europe PMC";   PMID:18173611 "Europe PMC";   PMID:18413415 "Europe PMC";   PMID:18496682 "Europe PMC";   PMID:18663553 "Europe PMC";   PMID:18688040 "Europe PMC";   PMID:19169882 "Europe PMC";   PMID:19190124 "Europe PMC";   PMID:19344337 "Europe PMC";   PMID:19581389 "Europe PMC";   PMID:19715969 "Europe PMC";   PMID:19751817 "Europe PMC";   PMID:19770782 "Europe PMC";   PMID:7496341 "Europe PMC";   PMID:7676489 "Europe PMC";   PMID:8610393 "Europe PMC";   PMID:9075844 "Europe PMC";   PMID:9123314 "Europe PMC";   PMID:9625011 "Europe PMC";   PMID:9777697 "Europe PMC";   Patent:DE2854439;   Patent:US4284786;   Reaxys:4323174 "Reaxys";   Wikipedia:Leflunomide


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  CHEBI ontology 21025
    role 21006
      biological role 21004
        immunomodulator 13983
          immunosuppressive agent 12205
            leflunomide 2636
Path 2
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  CHEBI ontology 21025
    subatomic particle 21019
      composite particle 21019
        hadron 21019
          baryon 21019
            nucleon 21019
              atomic nucleus 21019
                atom 21019
                  main group element atom 20860
                    p-block element atom 20860
                      carbon group element atom 20601
                        carbon atom 20578
                          organic molecular entity 20578
                            organic group 19174
                              organic divalent group 19164
                                organodiyl group 19164
                                  carbonyl group 19134
                                    carbonyl compound 19134
                                      carboxylic acid 18814
                                        carboacyl group 17452
                                          univalent carboacyl group 17452
                                            carbamoyl group 17153
                                              carboxamide 17153
                                                monocarboxylic acid amide 14453
                                                  leflunomide 2636
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