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Accession:CHEBI:6402 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Synonyms:exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
 related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide;   5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;   Arava;   Formula=C12H9F3N2O2;   InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18);   InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N;   SMILES=Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F;   alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide;   leflunomida;   leflunomidum
 xref: Beilstein:4323174 "Beilstein";   CAS:75706-12-6 "ChemIDplus";   CAS:75706-12-6 "KEGG COMPOUND";   DrugBank:DB01097;   Drug_Central:1552 "DrugCentral";   HMDB:HMDB0015229;   KEGG:C07905;   KEGG:D00749;   LINCS:LSM-3771
 xref_mesh: MESH:C045463
 xref: PMID:10515382 "Europe PMC";   PMID:10702725 "Europe PMC";   PMID:10890256 "Europe PMC";   PMID:11043056 "Europe PMC";   PMID:11053058 "Europe PMC";   PMID:11067959 "Europe PMC";   PMID:11271257 "Europe PMC";   PMID:11333342 "Europe PMC";   PMID:11340750 "Europe PMC";   PMID:11391470 "Europe PMC";   PMID:11475244 "Europe PMC";   PMID:11522581 "Europe PMC";   PMID:11707749 "Europe PMC";   PMID:11718154 "Europe PMC";   PMID:11876141 "Europe PMC";   PMID:11884931 "Europe PMC";   PMID:11994686 "Europe PMC";   PMID:12017890 "Europe PMC";   PMID:12074690 "Europe PMC";   PMID:12833393 "Europe PMC";   PMID:14622739 "Europe PMC";   PMID:15030575 "Europe PMC";   PMID:15127968 "Europe PMC";   PMID:15127974 "Europe PMC";   PMID:15188371 "Europe PMC";   PMID:15214907 "Europe PMC";   PMID:15385935 "Europe PMC";   PMID:15489872 "Europe PMC";   PMID:15537652 "Europe PMC";   PMID:15652966 "Europe PMC";   PMID:15665760 "Europe PMC";   PMID:15789891 "Europe PMC";   PMID:15899055 "Europe PMC";   PMID:15934905 "Europe PMC";   PMID:16106593 "Europe PMC";   PMID:16142756 "Europe PMC";   PMID:16202258 "Europe PMC";   PMID:16284916 "Europe PMC";   PMID:16638062 "Europe PMC";   PMID:16638420 "Europe PMC";   PMID:16645972 "Europe PMC";   PMID:16688677 "Europe PMC";   PMID:16769661 "Europe PMC";   PMID:16778342 "Europe PMC";   PMID:17366662 "Europe PMC";   PMID:17604599 "Europe PMC";   PMID:17646975 "Europe PMC";   PMID:17854740 "Europe PMC";   PMID:18034546 "Europe PMC";   PMID:18173611 "Europe PMC";   PMID:18413415 "Europe PMC";   PMID:18496682 "Europe PMC";   PMID:18663553 "Europe PMC";   PMID:18688040 "Europe PMC";   PMID:19169882 "Europe PMC";   PMID:19190124 "Europe PMC";   PMID:19344337 "Europe PMC";   PMID:19581389 "Europe PMC";   PMID:19715969 "Europe PMC";   PMID:19751817 "Europe PMC";   PMID:19770782 "Europe PMC";   PMID:7496341 "Europe PMC";   PMID:7676489 "Europe PMC";   PMID:8610393 "Europe PMC";   PMID:9075844 "Europe PMC";   PMID:9123314 "Europe PMC";   PMID:9625011 "Europe PMC";   PMID:9777697 "Europe PMC";   Patent:DE2854439;   Patent:US4284786;   Reaxys:4323174 "Reaxys";   Wikipedia:Leflunomide

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  CHEBI ontology 19669
    role 19613
      biological role 19611
        immunomodulator 12650
          immunosuppressive agent 11918
            leflunomide 2605
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  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  leflunomide 2605
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