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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroperoxy fatty acid
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Accession:CHEBI:64009 term browser browse the term
Definition:Any fatty acid carrying one or more hydroperoxy substituents.
Synonyms:related_synonym: hydroperoxy fatty acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:64012



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12(S)-HPETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 protein results in increased susceptibility to 12-HPETE CTD PMID:11115402 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 increases chemical synthesis ISO GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
13-HPODE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA CTD PMID:27257344 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein CTD PMID:22135674 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein CTD PMID:22135674 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
linoleic acid hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases lipidation
ISO Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form] CTD PMID:26111765 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cygb cytoglobin increases metabolic processing EXP CYGB protein results in increased metabolism of linoleic acid hydroperoxide CTD PMID:11320098 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Gpx1 glutathione peroxidase 1 increases reduction ISO GPX1 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          carbon atom 19633
            organic molecular entity 19633
              lipid 17492
                fatty acid 16011
                  hydroperoxy fatty acid 12
                    (15S)-hydroperoxy-(11Z,13E)-icosadienoic acid 0
                    (4Z,7Z,10Z,12E,16Z)-14-hydroperoxydocosapentaenoic acid 0
                    (4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid 0
                    (4Z,7Z,10Z,13Z,15E,17S)-17-hydroperoxydocosapentaenoic acid 0
                    (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid 0
                    (4Z,7Z,11E,13Z,16Z,19Z)-10-hydroperoxydocosahexaenoic acid 0
                    (4Z,7Z,11Z,13Z,15E,17S)-10,17-bis(hydroperoxy)docosapentaenoic acid 0
                    (4Z,7Z,11Z,13Z,15E,17S,19Z)-10,17-bis(hydroperoxy)docosahexaenoic acid 0
                    (4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid 0
                    (5Z,9E,11Z,14Z,17Z)-8-hydroperoxyicosapentaenoic acid + 0
                    (7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid 0
                    (7S,17S)-bis(hydroperoxy)-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid 0
                    (7Z,10Z,12E,16Z,19Z)-14-hydroperoxydocosapentaenoic acid + 0
                    (7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoic acid 0
                    (7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoic acid 0
                    (7Z,11Z,13Z,15E,19Z)-10,17-bis(hydroperoxy)docosapentaenoic acid 0
                    (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoic acid 0
                    (8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoic acid 0
                    (8E,12Z)-10-hydroperoxy-8,12-octadecadienoic acid + 0
                    (9S,10E,12Z,14E,16S)-9,16-bis(hydroperoxy)octadecatrienoic acid 0
                    (9Z,11E)-9-hydroperoxyoctadeca-9,11-dienoic acid 0
                    11-HpETE 0
                    12(S)-HPE(5,8,10)TrE 0
                    12-HPE(8,10,14)TrE + 0
                    12-HPEPE + 0
                    13-hydroperoxylinoleic acid 0
                    14-HPDHE + 0
                    2-hydroperoxy fatty acid + 0
                    4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid 0
                    4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid 0
                    5,12-DiHPETE 0
                    5,15-DiHPETE 0
                    5-hydroperoxy-15-HETE + 0
                    7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid 0
                    8,15-DiHPETE 0
                    HPETE + 3
                    HPODE + 10
                    bis(hydroperoxy)icosatetraenoic acid + 0
                    hydroperoxy fatty amide + 0
                    hydroperoxy fatty ester + 0
                    hydroperoxy(epoxy)icosatrienoic acid + 0
                    hydroperoxy(hydroxy)icosapentaenoic acid + 0
                    hydroperoxy(hydroxy)icosatetraenoic acid + 0
                    hydroperoxyicosapentaenoic acid + 0
                    hydroperoxyicosatrienoic acid + 0
                    hydroperoxyoctadecatrienoic acid + 0
                    hydroperoxyoctadecenoic acid + 0
                    prostaglandin G1 0
                    prostaglandin G3 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          fatty acid 16011
                                            hydroperoxy fatty acid 12
                                              (15S)-hydroperoxy-(11Z,13E)-icosadienoic acid 0
                                              (4Z,7Z,10Z,12E,16Z)-14-hydroperoxydocosapentaenoic acid 0
                                              (4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid 0
                                              (4Z,7Z,10Z,13Z,15E,17S)-17-hydroperoxydocosapentaenoic acid 0
                                              (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid 0
                                              (4Z,7Z,11E,13Z,16Z,19Z)-10-hydroperoxydocosahexaenoic acid 0
                                              (4Z,7Z,11Z,13Z,15E,17S)-10,17-bis(hydroperoxy)docosapentaenoic acid 0
                                              (4Z,7Z,11Z,13Z,15E,17S,19Z)-10,17-bis(hydroperoxy)docosahexaenoic acid 0
                                              (4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid 0
                                              (5Z,9E,11Z,14Z,17Z)-8-hydroperoxyicosapentaenoic acid + 0
                                              (7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid 0
                                              (7S,17S)-bis(hydroperoxy)-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid 0
                                              (7Z,10Z,12E,16Z,19Z)-14-hydroperoxydocosapentaenoic acid + 0
                                              (7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoic acid 0
                                              (7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoic acid 0
                                              (7Z,11Z,13Z,15E,19Z)-10,17-bis(hydroperoxy)docosapentaenoic acid 0
                                              (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoic acid 0
                                              (8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoic acid 0
                                              (8E,12Z)-10-hydroperoxy-8,12-octadecadienoic acid + 0
                                              (9S,10E,12Z,14E,16S)-9,16-bis(hydroperoxy)octadecatrienoic acid 0
                                              (9Z,11E)-9-hydroperoxyoctadeca-9,11-dienoic acid 0
                                              11-HpETE 0
                                              12(S)-HPE(5,8,10)TrE 0
                                              12-HPE(8,10,14)TrE + 0
                                              12-HPEPE + 0
                                              13-hydroperoxylinoleic acid 0
                                              14-HPDHE + 0
                                              2-hydroperoxy fatty acid + 0
                                              4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid 0
                                              4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid 0
                                              5,12-DiHPETE 0
                                              5,15-DiHPETE 0
                                              5-hydroperoxy-15-HETE + 0
                                              7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid 0
                                              8,15-DiHPETE 0
                                              HPETE + 3
                                              HPODE + 10
                                              bis(hydroperoxy)icosatetraenoic acid + 0
                                              hydroperoxy fatty amide + 0
                                              hydroperoxy fatty ester + 0
                                              hydroperoxy(epoxy)icosatrienoic acid + 0
                                              hydroperoxy(hydroxy)icosapentaenoic acid + 0
                                              hydroperoxy(hydroxy)icosatetraenoic acid + 0
                                              hydroperoxyicosapentaenoic acid + 0
                                              hydroperoxyicosatrienoic acid + 0
                                              hydroperoxyoctadecatrienoic acid + 0
                                              hydroperoxyoctadecenoic acid + 0
                                              prostaglandin G1 0
                                              prostaglandin G3 0
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