CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: EET
Accession: CHEBI:64007
browse the term
Definition: An icosanoid obtained by formal epoxidation of one of the double bonds of arachidonic acid.
Synonyms: related_synonym: epoxyeicosatrienoic acid; epoxyeicosatrienoic acids; epoxyicosatrienoic acid; epoxyicosatrienoic acids
xref: PMID:14636671; PMID:16473964; PMID:21704394; PMID:22100745; PMID:22116511; PMID:22182836; PMID:22182838; PMID:22223859; PMID:22245571; PMID:22280237; PMID:22298653; PMID:22303912; Wikipedia:Epoxyeicosatrienoic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:131865
G
Ace
angiotensin I converting enzyme
decreases activity
EXP
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein
CTD
PMID:27428043
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Ace2
angiotensin converting enzyme 2
multiple interactions
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein]
CTD
PMID:27428043
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Agt
angiotensinogen
decreases expression increases cleavage multiple interactions
EXP ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form] [14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD
PMID:27428043
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein
CTD
PMID:16286479
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions increases chemical synthesis
ISO
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD
PMID:12675279
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases chemical synthesis
ISO
CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD
PMID:12675279
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis
ISO
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD
PMID:12675279
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Ephx2
epoxide hydrolase 2
multiple interactions increases abundance
ISO
[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD
PMID:19896470 PMID:22680237 PMID:24472606
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Fgf2
fibroblast growth factor 2
increases expression
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein
CTD
PMID:16286479
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein
CTD
PMID:19464254
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein
CTD
PMID:19464254
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Rps6kb1
ribosomal protein S6 kinase B1
increases phosphorylation
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein
CTD
PMID:16286479
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
G
Tgfb1
transforming growth factor, beta 1
decreases secretion multiple interactions
ISO
TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD
PMID:28694203
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis
ISO
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]
CTD
PMID:12675279
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Ephx2
epoxide hydrolase 2
increases abundance
ISO
EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid
CTD
PMID:19896470
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions increases chemical synthesis
ISO
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD
PMID:12675279
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis
ISO
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD
PMID:12675279
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Ephx1
epoxide hydrolase 1
affects hydrolysis
ISO
EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid
CTD
PMID:28975360
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Ephx2
epoxide hydrolase 2
increases abundance
ISO
EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid
CTD
PMID:19896470
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19918
role
19894
biological role
19892
biochemical role
19588
metabolite
19574
EET
14
11,12-EET +
0
14,15-EET +
13
5,6-EET +
2
8,9-EET +
4
Path 2
CHEBI ontology
19918
subatomic particle
19916
composite particle
19916
hadron
19916
baryon
19916
nucleon
19916
atomic nucleus
19916
atom
19916
main group element atom
19866
p-block element atom
19866
carbon group element atom
19811
carbon atom
19806
organic molecular entity
19806
organic group
18995
organic divalent group
18969
organodiyl group
18969
carbonyl group
18922
carbonyl compound
18922
carboxylic acid
18646
monocarboxylic acid
17984
fatty acid
16709
unsaturated fatty acid
1095
polyunsaturated fatty acid
839
fatty acid 20:4
360
icosatetraenoic acid
360
icosa-5,8,11,14-tetraenoic acid
316
arachidonic acid
316
EET
14
11,12-EET +
0
14,15-EET +
13
5,6-EET +
2
8,9-EET +
4