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ONTOLOGY REPORT - ANNOTATIONS


Term:N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
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Accession:CHEBI:63988 term browser browse the term
Definition:A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
Synonyms:exact_synonym: 1-phenyl-3-prop-2-en-1-yl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
 related_synonym: 3-Allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine;   3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;   Formula=C19H21NO2;   InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2;   InChIKey=QBUVZVXIRYFENV-UHFFFAOYSA-N;   N-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;   SK&F 77434;   SKF 77434;   SMILES=Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O
 xref: CAS:104422-04-0 "ChemIDplus";   LINCS:LSM-1702
 xref_mesh: MESH:C067114
 xref: Reaxys:1546935 "Reaxys";   Wikipedia:SKF-77434
 cyclic_relationship: is_conjugate_acid_of CHEBI:63987


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N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:6480464

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  CHEBI ontology 19654
    role 19598
      application 19220
        refrigerant 16977
          ammonia 16548
            organic amino compound 16547
              tertiary amino compound 8517
                N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 1
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  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        tertiary amino compound 8517
                                          N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 1
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