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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-chlorokynurenic acid
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Accession:CHEBI:63965 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Synonyms:exact_synonym: 7-chloro-4-hydroxyquinoline-2-carboxylic acid
 related_synonym: 7-CKA;   7-Cl-KYNA;   7-chloro-4-hydroxy-2-carboxyquinoline;   Formula=C10H6ClNO3;   InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15);   InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)c2ccc(Cl)cc2n1
 xref: CAS:18000-24-3;   LINCS:LSM-24944
 xref_mesh: MESH:C057013
 xref: PMID:11224142;   Reaxys:185645


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7-chlorokynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP 7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        pharmacological role 18830
          antagonist 16277
            excitatory amino acid antagonist 10139
              NMDA receptor antagonist 8667
                7-chlorokynurenic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        aromatic carboxylic acid 11263
                                          quinolinemonocarboxylic acid 98
                                            7-chlorokynurenic acid 1
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