Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-chlorokynurenic acid
go back to main search page
Accession:CHEBI:63965 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Synonyms:exact_synonym: 7-chloro-4-hydroxyquinoline-2-carboxylic acid
 related_synonym: 7-CKA;   7-Cl-KYNA;   7-chloro-4-hydroxy-2-carboxyquinoline;   Formula=C10H6ClNO3;   InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15);   InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)c2ccc(Cl)cc2n1
 xref: CAS:18000-24-3;   LINCS:LSM-24944
 xref_mesh: MESH:C057013
 xref: PMID:11224142;   Reaxys:185645



show annotations for term's descendants           Sort by:
 
7-chlorokynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP 7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      biological role 20025
        pharmacological role 19122
          antagonist 16754
            excitatory amino acid antagonist 10221
              NMDA receptor antagonist 8773
                7-chlorokynurenic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic group 18994
                              organic divalent group 18980
                                organodiyl group 18980
                                  carbonyl group 18933
                                    carbonyl compound 18933
                                      carboxylic acid 18629
                                        aromatic carboxylic acid 11814
                                          quinolinemonocarboxylic acid 103
                                            7-chlorokynurenic acid 1
paths to the root