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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:celastrol
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Accession:CHEBI:63959 term browser browse the term
Definition:A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Synonyms:exact_synonym: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
 related_synonym: (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid;   3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid;   D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-;   Formula=C29H38O4;   InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1;   InChIKey=KQJSQWZMSAGSHN-JJWQIEBTSA-N;   SMILES=[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(O)=O;   Tripterine
 xref: CAS:34157-83-0;   HMDB:HMDB0002385
 xref_mesh: MESH:C050414
 xref: PMID:11809076;   PMID:15593077;   PMID:20934245;   PMID:20954803;   PMID:21134410;   PMID:21414301;   PMID:21425580;   PMID:21466843;   PMID:21569548;   PMID:21666907;   PMID:21850367;   PMID:21865725;   PMID:21866552;   PMID:22087583;   PMID:22206928;   PMID:22334592;   Patent:KR20100097843;   Patent:US2011263693;   Reaxys:2194425



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celastrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]
celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein] CTD PMID:28435131 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO celastrol results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO celastrol results in increased expression of AKR1C1 mRNA CTD PMID:17010675 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO celastrol results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
celastrol results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]
celastrol results in increased phosphorylation of AKT1 protein
celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]
CTD PMID:21466843 PMID:24111524 PMID:25903958 PMID:31715269 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein] CTD PMID:31715269 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases degradation
ISO calpain inhibitor 2 inhibits the reaction [celastrol results in increased degradation of AR protein]; CAST inhibits the reaction [celastrol results in increased degradation of AR protein]
celastrol results in decreased expression of AR protein
CTD PMID:17010675 PMID:18726991 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO celastrol results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein CTD PMID:31901889 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO celastrol results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Axin2 axin 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 protein] CTD PMID:31715269 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO celastrol results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO celastrol results in increased expression of BAX mRNA; celastrol results in increased expression of BAX protein
Uridine inhibits the reaction [celastrol results in increased expression of BAX protein]
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX protein]
CTD PMID:21466843 PMID:27374097 PMID:28435131 PMID:29643811 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression
ISO celastrol results in decreased expression of BCL2 protein
celastrol inhibits the reaction [Plant Preparations results in decreased expression of BCL2 protein]
celastrol results in increased expression of BCL2 mRNA
CTD PMID:21466843 PMID:29643811 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression EXP celastrol results in increased expression of BECN1 protein CTD PMID:32470352 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO celastrol results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO celastrol results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Cacybp calcyclin binding protein increases expression ISO celastrol results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
JBrowse link
G Casp1 caspase 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]] CTD PMID:32470352 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO
EXP
celastrol results in increased cleavage of CASP3 protein
celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 protein]
celastrol results in increased expression of CASP3 mRNA
celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]
[TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [celastrol results in increased cleavage of CASP3 protein]
CTD PMID:20605676 PMID:21466843 PMID:24111524 PMID:27374097 PMID:29643811 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
ISO celastrol results in increased cleavage of CASP8 protein
celastrol results in decreased expression of CASP8 mRNA
CTD PMID:21466843 PMID:27374097 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
multiple interactions
ISO celastrol results in increased cleavage of CASP9 protein
celastrol results in increased expression of CASP9 mRNA
Uridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein]
CTD PMID:21466843 PMID:27374097 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [celastrol results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cat catalase multiple interactions EXP
ISO
celastrol inhibits the reaction [Bleomycin results in decreased activity of CAT protein]
celastrol inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]
CTD PMID:26768587 PMID:28984147 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO celastrol results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO celastrol results in increased expression of CCL3 mRNA CTD PMID:25477506 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 protein]
celastrol results in decreased expression of CCND1 mRNA; celastrol results in decreased expression of CCND1 protein
CTD PMID:31715269 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cda cytidine deaminase increases expression ISO celastrol results in increased expression of CDA mRNA CTD PMID:27374097 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231
JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO celastrol results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO celastrol results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO celastrol affects the expression of CEBPA mRNA; celastrol affects the expression of CEBPA protein CTD PMID:27085773 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO celastrol results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased phosphorylation of CHUK protein] CTD PMID:30588110 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO celastrol results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Ckb creatine kinase B multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein; celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA] CTD PMID:30588110 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cryab crystallin, alpha B increases expression ISO celastrol results in increased expression of CRYAB mRNA CTD PMID:25477506 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
ISO celastrol results in decreased expression of CTNNB1 protein
celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CTNNB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; SB 216763 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]
CTD PMID:31715269 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO celastrol results in increased expression of CXCL10 mRNA
celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
CTD PMID:25477506 PMID:31901889 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO celastrol results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO celastrol results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO celastrol results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases expression ISO celastrol results in decreased expression of DHODH mRNA; celastrol results in decreased expression of DHODH protein CTD PMID:27374097 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] CTD PMID:31715269 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO celastrol results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO celastrol results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Efnb2 ephrin B2 decreases expression ISO celastrol results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein
celastrol results in decreased expression of EGFR protein
CTD PMID:17010675 PMID:20007406 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:24111524 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO celastrol affects the expression of FABP4 mRNA CTD PMID:27085773 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO celastrol results in increased expression of FAS protein CTD PMID:21466843 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO celastrol results in increased expression of FASLG protein CTD PMID:21466843 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
decreases expression
EXP HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein] CTD PMID:25903958 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO celastrol results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO celastrol results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]
celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]
CTD PMID:29789558 PMID:30588110 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation EXP celastrol results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO celastrol results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of GCLM mRNA
celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLM mRNA]
CTD PMID:17010675 PMID:30588110 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO celastrol results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 affects activity ISO celastrol affects the activity of GPD1 protein CTD PMID:27085773 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [coomassie Brilliant Blue co-treated with celastrol] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:28435131 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
ISO celastrol results in decreased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased phosphorylation of GSK3B protein]
celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein]
CTD PMID:31715269 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
celastrol inhibits the reaction [Bleomycin results in decreased activity of GSR protein]
celastrol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]
CTD PMID:26768587 PMID:28984147 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO celastrol results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO celastrol results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:57,871,076...57,875,206
Ensembl chr 4:57,871,110...57,874,557
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO celastrol results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HMOX1 mRNA
celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 protein]
celastrol results in increased expression of HMOX1 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
CTD PMID:17010675 PMID:23942037 PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
increases activity
EXP
ISO
celastrol results in increased phosphorylation of and affects the localization of HSF1 protein
celastrol results in increased activity of HSF1 protein
CTD PMID:25903958 PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity
multiple interactions
ISO
EXP
celastrol results in decreased activity of HSP90AA1 protein
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA]
CTD PMID:17010675 PMID:32470352 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AB1 protein] CTD PMID:32470352 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO celastrol results in increased expression of STCH mRNA CTD PMID:17010675 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HSPA1A mRNA
HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein]
CTD PMID:17010675 PMID:25477506 PMID:25903958
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO celastrol results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO celastrol results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO celastrol results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16769766 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:16769766 PMID:24384223 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; celastrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:24384223 PMID:28435131 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]] CTD PMID:32470352 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
celastrol results in increased expression of IL1B mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL1B protein]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:29643811 PMID:31715269 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO celastrol results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of IL6 mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL6 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD PMID:25477506 PMID:29643811 PMID:30588110 PMID:31715269 PMID:32470352 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO celastrol results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO celastrol results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]] CTD PMID:24111524 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO celastrol results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO celastrol results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 protein] CTD PMID:31715269 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO celastrol results in increased expression of HSPA6 mRNA CTD PMID:25477506 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Lpin1 lipin 1 increases expression ISO celastrol results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LRP5 mRNA] CTD PMID:31715269 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO celastrol results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO celastrol results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]
celastrol results in increased phosphorylation of MAPK1 protein
CTD PMID:24111524 PMID:25903958 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]
celastrol results in increased phosphorylation of MAPK3 protein
CTD PMID:24111524 PMID:25903958 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO celastrol results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Me1 malic enzyme 1 increases expression ISO celastrol results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP2 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:26768587 PMID:30588110 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MMP7 mRNA] CTD PMID:31715269 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:26768587 PMID:30588110 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO celastrol results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:59,699,208...59,714,848
Ensembl chr10:59,699,585...59,714,835
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:24384223 PMID:28435131 PMID:32470352 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO celastrol results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO celastrol results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO celastrol results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with celastrol] results in decreased expression of MTOR protein modified form; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form] CTD PMID:32470352 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO celastrol results in decreased expression of MYC mRNA; celastrol results in decreased expression of MYC protein
celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC protein]
CTD PMID:26474287 PMID:31715269 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO celastrol results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
JBrowse link
G Mynn myoneurin decreases expression ISO celastrol results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:112,779,654...112,797,188
Ensembl chr 2:112,779,657...112,796,397
JBrowse link
G Nbn nibrin decreases expression ISO celastrol results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
increases activity
multiple interactions
EXP
ISO
celastrol results in increased expression of NFE2L2 protein
celastrol results in increased expression of NFE2L2 mRNA
celastrol results in increased activity of NFE2L2 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]
CTD PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of NFKBIA protein modified form] CTD PMID:30588110 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NKD1 mRNA] CTD PMID:31715269 NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO celastrol results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]] CTD PMID:32470352 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31901889 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notum NOTUM, palmitoleoyl-protein carboxylesterase multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NOTUM mRNA] CTD PMID:31715269 NCBI chr10:105,933,245...105,940,315
Ensembl chr10:105,933,249...105,940,315
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of NQO1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein] CTD PMID:26768587 PMID:30588110 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO celastrol results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO celastrol results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO celastrol results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:152,066,975...152,085,180
Ensembl chr 3:152,066,975...152,085,149
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
celastrol results in increased cleavage of PARP1 protein
CTD PMID:20605676 PMID:31715269 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO celastrol promotes the reaction [[coomassie Brilliant Blue co-treated with Acetaminophen] results in increased expression of PCNA protein] CTD PMID:28435131 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO celastrol results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO celastrol results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO celastrol results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plin1 perilipin 1 affects expression ISO celastrol affects the expression of PLIN1 mRNA CTD PMID:27085773 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO celastrol affects the expression of PPARG mRNA; celastrol affects the expression of PPARG protein CTD PMID:27085773 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO celastrol results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO celastrol results in increased expression of PTGS1 mRNA CTD PMID:25477506 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO celastrol results in decreased expression of PTGS2 mRNA; celastrol results in decreased expression of PTGS2 protein CTD PMID:31715269 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pura purine rich element binding protein A decreases expression ISO celastrol results in decreased expression of PURA mRNA CTD PMID:17010675
G Rac3 Rac family small GTPase 3 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of RAC3 mRNA] CTD PMID:31715269 NCBI chr10:106,002,808...106,005,244
Ensembl chr10:105,993,087...106,005,260
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
celastrol inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]
celastrol inhibits the reaction [Plant Preparations results in increased expression of RELA protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of RELA protein]
CTD PMID:16769766 PMID:29643811 PMID:30588110 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO celastrol results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Sele selectin E multiple interactions ISO celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO celastrol results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO celastrol results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO celastrol results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases response to substance
increases expression
ISO SLC7A11 protein results in decreased susceptibility to celastrol
celastrol results in increased expression of SLC7A11 mRNA
CTD PMID:17010675 PMID:20007406 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO celastrol results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein] CTD PMID:26768587 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO celastrol results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
EXP celastrol results in decreased expression of SQSTM1 protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol results in decreased expression of SQSTM1 protein]
CTD PMID:32470352 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO celastrol results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO celastrol results in decreased expression of TAOK3 mRNA CTD PMID:17010675 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of TCF7 mRNA] CTD PMID:31715269 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]
CTD PMID:29789558 PMID:30588110 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:30588110 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO celastrol results in decreased expression of TMPRSS2 mRNA CTD PMID:17010675 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
celastrol inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE protein]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]]
celastrol results in increased expression of TNF mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of TNF protein]; celastrol promotes the reaction [Dextran Sulfate results in increased expression of TNF protein]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:26768587 PMID:29643811 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
multiple interactions
ISO celastrol results in increased expression of TNFRSF10A mRNA
celastrol results in increased expression of and results in increased localization of TNFRSF10A protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
CTD PMID:20605676 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
increases response to substance
ISO [TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
celastrol results in increased expression of TNFSF10 mRNA
celastrol results in increased susceptibility to TNFSF10 protein
CTD PMID:20605676 PMID:25477506 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of TNNI3 protein] CTD PMID:30588110 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein] CTD PMID:30588110 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO celastrol results in increased expression of TP53 protein
Uridine inhibits the reaction [celastrol results in increased expression of TP53 protein]
CTD PMID:27374097 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO celastrol results in decreased expression of TXNIP mRNA CTD PMID:17010675 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO celastrol results in increased expression of TXNRD1 mRNA CTD PMID:17010675 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression ISO celastrol results in increased expression of UBE2B mRNA CTD PMID:17010675 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
JBrowse link
G Uck1 uridine-cytidine kinase 1 increases expression ISO celastrol results in increased expression of UCK1 mRNA CTD PMID:27374097 NCBI chr 3:15,538,580...15,544,465
Ensembl chr 3:15,538,591...15,544,465
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO celastrol results in increased expression of UGDH mRNA CTD PMID:17010675 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16769766 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Wdr77 WD repeat domain 77 decreases expression ISO celastrol results in decreased expression of WDR77 mRNA CTD PMID:17010675 NCBI chr 2:193,435,465...193,445,534
Ensembl chr 2:193,435,468...193,445,520
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WIF1 mRNA] CTD PMID:31715269 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link
G Wnt10a Wnt family member 10A multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT10A mRNA] CTD PMID:31715269 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
JBrowse link
G Wnt3 Wnt family member 3 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT3 mRNA] CTD PMID:31715269 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
G Wnt6 Wnt family member 6 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT6 mRNA] CTD PMID:31715269 NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523
JBrowse link
G Wnt7b Wnt family member 7B multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT7B mRNA] CTD PMID:31715269 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Zbtb43 zinc finger and BTB domain containing 43 decreases expression ISO celastrol results in decreased expression of ZBTB43 mRNA CTD PMID:17010675 NCBI chr 3:16,744,535...16,763,854
Ensembl chr 3:16,744,535...16,763,909
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO celastrol results in decreased expression of ZC3H12A mRNA CTD PMID:17010675 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      chemical role 19539
        antioxidant 14502
          celastrol 181
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        monocarboxylic acid 17748
                                          celastrol 181
paths to the root