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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:celastrol
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Accession:CHEBI:63959 term browser browse the term
Definition:A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Synonyms:exact_synonym: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
 related_synonym: (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid;   3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid;   D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-;   Formula=C29H38O4;   InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1;   InChIKey=KQJSQWZMSAGSHN-JJWQIEBTSA-N;   SMILES=[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(O)=O;   Tripterine
 xref: CAS:34157-83-0;   HMDB:HMDB0002385
 xref_mesh: MESH:C050414
 xref: PMID:11809076;   PMID:15593077;   PMID:20934245;   PMID:20954803;   PMID:21134410;   PMID:21414301;   PMID:21425580;   PMID:21466843;   PMID:21569548;   PMID:21666907;   PMID:21850367;   PMID:21865725;   PMID:21866552;   PMID:22087583;   PMID:22206928;   PMID:22334592;   Patent:KR20100097843;   Patent:US2011263693;   Reaxys:2194425


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celastrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO SR 144528 inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]; tripterine inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; tripterine inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]
tripterine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; tripterine inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein] CTD PMID:28435131 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO tripterine results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO tripterine results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO
EXP
tripterine results in decreased phosphorylation of AKT1 protein
tripterine results in increased phosphorylation of AKT1 protein
PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
CTD PMID:21466843 PMID:24111524 PMID:25903958 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases degradation
ISO calpain inhibitor 2 inhibits the reaction [tripterine results in increased degradation of AR protein]; CAST inhibits the reaction [tripterine results in increased degradation of AR protein]
tripterine results in decreased expression of AR protein
CTD PMID:17010675 PMID:18726991 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO tripterine results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:21,713,900...21,881,193
Ensembl chr20:21,564,975...21,880,715
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO [tripterine co-treated with CNR2 protein] affects the localization of ARRB2 protein CTD PMID:31901889 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO tripterine results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO tripterine results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO tripterine results in increased expression of BAX mRNA; tripterine results in increased expression of BAX protein
Uridine inhibits the reaction [tripterine results in increased expression of BAX protein]
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; tripterine inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
CTD PMID:21466843 PMID:27374097 PMID:28435131 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tripterine results in decreased expression of BCL2 protein CTD PMID:21466843 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression EXP tripterine results in increased expression of BECN1 protein CTD PMID:32470352 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO tripterine results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO tripterine results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Cacybp calcyclin binding protein increases expression ISO tripterine results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Casp1 caspase 1 multiple interactions EXP MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein] CTD PMID:32470352 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
multiple interactions
ISO
EXP
tripterine results in increased cleavage of CASP3 protein
tripterine results in increased expression of CASP3 mRNA
JUN mutant form promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
[TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [tripterine results in increased cleavage of CASP3 protein]
CTD PMID:20605676 PMID:21466843 PMID:24111524 PMID:27374097 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
ISO tripterine results in increased cleavage of CASP8 protein
tripterine results in decreased expression of CASP8 mRNA
CTD PMID:21466843 PMID:27374097 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
multiple interactions
ISO tripterine results in increased cleavage of CASP9 protein
tripterine results in increased expression of CASP9 mRNA
Uridine inhibits the reaction [tripterine results in increased cleavage of CASP9 protein]
CTD PMID:21466843 PMID:27374097 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [tripterine results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
JBrowse link
G Cat catalase multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in decreased activity of CAT protein] CTD PMID:26768587 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO tripterine results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO tripterine results in increased expression of CCL3 mRNA CTD PMID:25477506 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cda cytidine deaminase increases expression ISO tripterine results in increased expression of CDA mRNA CTD PMID:27374097 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO tripterine results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO tripterine results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO tripterine affects the expression of CEBPA mRNA; tripterine affects the expression of CEBPA protein CTD PMID:27085773 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO tripterine results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO tripterine results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO [tripterine co-treated with CNR2 protein] affects the localization of ARRB2 protein; tripterine inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; tripterine inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cryab crystallin, alpha B increases expression ISO tripterine results in increased expression of CRYAB mRNA CTD PMID:25477506 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO tripterine results in increased expression of CXCL10 mRNA
tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
CTD PMID:25477506 PMID:31901889 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO tripterine results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO tripterine results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO tripterine results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases expression ISO tripterine results in decreased expression of DHODH mRNA; tripterine results in decreased expression of DHODH protein CTD PMID:27374097 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO tripterine results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO tripterine results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Efnb2 ephrin B2 decreases expression ISO tripterine results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with tripterine] affects the expression of EGFR protein; [Sulfasalazine co-treated with tripterine] results in decreased expression of EGFR protein
tripterine results in decreased expression of EGFR protein
CTD PMID:17010675 PMID:20007406 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:24111524 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO tripterine affects the expression of FABP4 mRNA CTD PMID:27085773 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO tripterine results in increased expression of FAS protein CTD PMID:21466843 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO tripterine results in increased expression of FASLG protein CTD PMID:21466843 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
decreases expression
EXP HSPA1A protein affects the reaction [tripterine results in decreased expression of FBXO32 protein] CTD PMID:25903958 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO tripterine results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:48,658,283...48,663,175
Ensembl chr12:48,658,283...48,663,143
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO tripterine results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO tripterine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]
SR 144528 inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]; tripterine inhibits the reaction [Folic Acid results in increased expression of FN1 protein]
CTD PMID:29789558 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation EXP tripterine results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gatd3a glutamine amidotransferase like class 1 domain containing 3A decreases expression ISO tripterine results in decreased expression of GATD3A mRNA CTD PMID:17010675 NCBI chr20:11,244,353...11,252,450
Ensembl chr20:11,244,353...11,252,449
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO tripterine results in increased expression of GCLM mRNA CTD PMID:17010675 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO tripterine results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 affects activity ISO tripterine affects the activity of GPD1 protein CTD PMID:27085773 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [coomassie Brilliant Blue co-treated with tripterine] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; tripterine inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:28435131 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in decreased activity of GSR protein] CTD PMID:26768587 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO tripterine results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:17,198,957...17,208,456
Ensembl chr 9:17,198,957...17,209,220
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO tripterine results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO tripterine results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
tripterine results in increased expression of HMOX1 mRNA
tripterine results in increased expression of HMOX1 protein
tripterine inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]
CTD PMID:17010675 PMID:23942037 PMID:26768587 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP tripterine results in increased phosphorylation of and affects the localization of HSF1 protein CTD PMID:25903958 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity
multiple interactions
ISO
EXP
tripterine results in decreased activity of HSP90AA1 protein
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA]
CTD PMID:17010675 PMID:32470352 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP tripterine inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AB1 protein] CTD PMID:32470352 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO tripterine results in increased expression of STCH mRNA CTD PMID:17010675 NCBI chr11:14,146,515...14,160,697
Ensembl chr11:14,144,130...14,160,892
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
tripterine results in increased expression of HSPA1A mRNA
HSPA1A protein affects the reaction [tripterine results in decreased expression of FBXO32 protein]
CTD PMID:17010675 PMID:25477506 PMID:25903958 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO tripterine results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tripterine results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO tripterine results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16769766 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:16769766 PMID:24384223 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; tripterine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:24384223 PMID:28435131 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions EXP MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]] CTD PMID:32470352 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
tripterine results in increased expression of IL1B mRNA
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:31901889 PMID:32470352 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO tripterine results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
tripterine results in increased expression of IL6 mRNA
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD PMID:25477506 PMID:32470352 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO tripterine results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO tripterine results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP JUN mutant form promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein] CTD PMID:24111524 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO tripterine results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO tripterine results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO tripterine results in increased expression of HSPA6 mRNA CTD PMID:25477506 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Lpin1 lipin 1 increases expression ISO tripterine results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO tripterine results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:27,023,328...27,080,575
Ensembl chr11:27,022,986...27,080,701
JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO tripterine results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:156,338,993...156,340,913
Ensembl chr 3:156,339,004...156,340,913
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP tripterine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]
tripterine results in increased phosphorylation of MAPK1 protein
CTD PMID:24111524 PMID:25903958 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP tripterine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]
tripterine results in increased phosphorylation of MAPK3 protein
CTD PMID:24111524 PMID:25903958 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO tripterine results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Me1 malic enzyme 1 increases expression ISO tripterine results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in increased expression of MMP2 protein] CTD PMID:26768587 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in increased expression of MMP9 protein] CTD PMID:26768587 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO tripterine results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:61,683,776...61,700,504
Ensembl chr10:61,685,241...61,700,491
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; tripterine inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
tripterine inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:24384223 PMID:28435131 PMID:32470352 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO tripterine results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:48,033,531...48,038,726
Ensembl chr 1:48,033,768...48,038,726
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO tripterine results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO tripterine results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [MCC-950 co-treated with tripterine] results in decreased expression of MTOR protein modified form; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form] CTD PMID:32470352 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO tripterine results in decreased expression of MYC protein CTD PMID:26474287 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO tripterine results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:87,405,472...87,450,812
NCBI chr15:93,678,062...93,901,556
Ensembl chr15:87,506,959...93,868,301
JBrowse link
G Mynn myoneurin decreases expression ISO tripterine results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:116,397,154...116,414,702
Ensembl chr 2:116,398,242...116,413,873
JBrowse link
G Nbn nibrin decreases expression ISO tripterine results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
EXP tripterine results in increased expression of NFE2L2 protein
tripterine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]
CTD PMID:26768587 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tripterine results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA] CTD PMID:32470352 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31901889 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in decreased activity of NQO1 protein] CTD PMID:26768587 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO tripterine results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO tripterine results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO tripterine results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:159,784,131...159,802,923
Ensembl chr 3:159,784,128...159,802,952
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] CTD PMID:20605676 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO tripterine promotes the reaction [[coomassie Brilliant Blue co-treated with Acetaminophen] results in increased expression of PCNA protein] CTD PMID:28435131 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO tripterine results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO tripterine results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO tripterine results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plin1 perilipin 1 affects expression ISO tripterine affects the expression of PLIN1 mRNA CTD PMID:27085773 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO tripterine affects the expression of PPARG mRNA; tripterine affects the expression of PPARG protein CTD PMID:27085773 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO tripterine results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:24111524 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO tripterine results in increased expression of PTGS1 mRNA CTD PMID:25477506 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Pura purine rich element binding protein A decreases expression ISO tripterine results in decreased expression of PURA mRNA CTD PMID:17010675 NCBI chr18:29,104,712...29,114,918
Ensembl chr18:29,110,242...29,111,156
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO tripterine inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein] CTD PMID:16769766 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:24111524 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO tripterine results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Sele selectin E multiple interactions ISO tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO tripterine results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO tripterine results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO tripterine results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases response to substance
increases expression
ISO SLC7A11 protein results in decreased susceptibility to tripterine
tripterine results in increased expression of SLC7A11 mRNA
CTD PMID:17010675 PMID:20007406 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO tripterine results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:76,977,698...77,022,847
Ensembl chr 8:76,977,822...77,022,837
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO tripterine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP tripterine inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein] CTD PMID:26768587 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO tripterine results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
EXP tripterine results in decreased expression of SQSTM1 protein
MCC-950 promotes the reaction [tripterine results in decreased expression of SQSTM1 protein]
CTD PMID:32470352 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO tripterine results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO tripterine results in decreased expression of TAOK3 mRNA CTD PMID:17010675 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tripterine inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO tripterine results in decreased expression of TMPRSS2 mRNA CTD PMID:17010675 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
tripterine inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
tripterine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]]
tripterine results in increased expression of TNF mRNA
tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tripterine promotes the reaction [Dextran Sulfate results in increased expression of TNF protein]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:26768587 PMID:31901889 PMID:32470352 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
multiple interactions
ISO tripterine results in increased expression of TNFRSF10A mRNA
TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; tripterine results in increased expression of and results in increased localization of TNFRSF10A protein
CTD PMID:20605676 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
increases response to substance
ISO [TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]
tripterine results in increased expression of TNFSF10 mRNA
tripterine results in increased susceptibility to TNFSF10 protein
CTD PMID:20605676 PMID:25477506 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO tripterine results in increased expression of TP53 protein
Uridine inhibits the reaction [tripterine results in increased expression of TP53 protein]
CTD PMID:27374097 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO tripterine results in decreased expression of TXNIP mRNA CTD PMID:17010675 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO tripterine results in increased expression of TXNRD1 mRNA CTD PMID:17010675 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression ISO tripterine results in increased expression of UBE2B mRNA CTD PMID:17010675 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
G Uck1 uridine-cytidine kinase 1 increases expression ISO tripterine results in increased expression of UCK1 mRNA CTD PMID:27374097 NCBI chr 3:11,271,874...11,277,757
Ensembl chr 3:11,271,885...11,277,757
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO tripterine results in increased expression of UGDH mRNA CTD PMID:17010675 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16769766 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wdr77 WD repeat domain 77 decreases expression ISO tripterine results in decreased expression of WDR77 mRNA CTD PMID:17010675 NCBI chr 2:208,577,292...208,587,263
Ensembl chr 2:208,420,309...208,587,260
Ensembl chr 2:208,420,309...208,587,260
JBrowse link
G Zbtb43 zinc finger and BTB domain containing 43 decreases expression ISO tripterine results in decreased expression of ZBTB43 mRNA CTD PMID:17010675 NCBI chr 3:12,489,774...12,509,372
Ensembl chr 3:12,493,179...12,502,859
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO tripterine results in decreased expression of ZC3H12A mRNA CTD PMID:17010675 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          celastrol 152
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        monocarboxylic acid 17526
                                          celastrol 152
paths to the root