The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
SR 144528 inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]; tripterine inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; tripterine inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein] tripterine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; tripterine inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]
tripterine results in decreased phosphorylation of AKT1 protein tripterine results in increased phosphorylation of AKT1 protein PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
calpain inhibitor 2 inhibits the reaction [tripterine results in increased degradation of AR protein]; CAST inhibits the reaction [tripterine results in increased degradation of AR protein] tripterine results in decreased expression of AR protein
tripterine results in increased expression of BAX mRNA; tripterine results in increased expression of BAX protein Uridine inhibits the reaction [tripterine results in increased expression of BAX protein] [tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; tripterine inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]
tripterine results in increased cleavage of CASP3 protein tripterine results in increased expression of CASP3 mRNA JUN mutant form promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein] [TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [tripterine results in increased cleavage of CASP3 protein]
tripterine results in increased cleavage of CASP9 protein tripterine results in increased expression of CASP9 mRNA Uridine inhibits the reaction [tripterine results in increased cleavage of CASP9 protein]
[tripterine co-treated with CNR2 protein] affects the localization of ARRB2 protein; tripterine inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein] 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; tripterine inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]
tripterine results in increased expression of CXCL10 mRNA tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
[Sulfasalazine co-treated with tripterine] affects the expression of EGFR protein; [Sulfasalazine co-treated with tripterine] results in decreased expression of EGFR protein tripterine results in decreased expression of EGFR protein
tripterine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] SR 144528 inhibits the reaction [tripterine inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]; tripterine inhibits the reaction [Folic Acid results in increased expression of FN1 protein]
[coomassie Brilliant Blue co-treated with tripterine] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; tripterine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
tripterine results in increased expression of HMOX1 mRNA tripterine results in increased expression of HMOX1 protein tripterine inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]
tripterine results in decreased activity of HSP90AA1 protein tripterine inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA]
tripterine results in increased expression of HSPA1A mRNA HSPA1A protein affects the reaction [tripterine results in decreased expression of FBXO32 protein]
tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein] tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; tripterine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]
MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]
tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]] tripterine results in increased expression of IL1B mRNA tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein]
tripterine results in increased expression of IL6 mRNA tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
JUN mutant form promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]
tripterine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein] tripterine results in increased phosphorylation of MAPK1 protein
tripterine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein] tripterine results in increased phosphorylation of MAPK3 protein
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; tripterine inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] tripterine inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
[MCC-950 co-treated with tripterine] results in decreased expression of MTOR protein modified form; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form]
tripterine results in increased expression of NFE2L2 protein tripterine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]
MCC-950 promotes the reaction [tripterine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]
[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]
PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]
PTEN protein promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; tripterine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein]
tripterine results in decreased expression of SQSTM1 protein MCC-950 promotes the reaction [tripterine results in decreased expression of SQSTM1 protein]
tripterine inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; tripterine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
tripterine inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] tripterine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; tripterine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; tripterine promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]] tripterine results in increased expression of TNF mRNA tripterine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tripterine promotes the reaction [Dextran Sulfate results in increased expression of TNF protein]
tripterine results in increased expression of TNFRSF10A mRNA TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; tripterine results in increased expression of and results in increased localization of TNFRSF10A protein
[TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] tripterine results in increased expression of TNFSF10 mRNA tripterine results in increased susceptibility to TNFSF10 protein
tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]; tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
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