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ONTOLOGY REPORT - ANNOTATIONS


Term:ionomycin
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Accession:CHEBI:63954 term browser browse the term
Definition:A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
Synonyms:exact_synonym: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
 related_synonym: Formula=C41H72O9;   InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1;   InChIKey=PGHMRUGBZOYCAA-ADZNBVRBSA-N;   SMILES=[H][C@]1(CC[C@](C)(O1)[C@@]1([H])CC[C@](C)(O1)[C@@H](C)O)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\\C=C\\C[C@@H](C)C[C@@H](C)C(\\O)=C\\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O
 xref: CAS:56092-81-0 "ChemIDplus"
 xref_mesh: MESH:D015759
 xref: PMID:19079959 "Europe PMC";   PMID:19496091 "Europe PMC";   Patent:US3873693;   Reaxys:3642126 "Reaxys"


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ionomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:6480464
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:6480464
G Bach2 BTB domain and CNC homolog 2 JBrowse link 5 47,458,891 47,807,176 RGD:6480464
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:6480464
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:6480464
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 JBrowse link 12 39,253,409 39,302,601 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:6480464
G Cct5 chaperonin containing TCP1 subunit 5 JBrowse link 2 84,667,578 84,678,730 RGD:6480464
G Cd200 Cd200 molecule JBrowse link 11 60,371,617 60,398,450 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:6480464
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:6480464
G Cd69 Cd69 molecule JBrowse link 4 163,041,147 163,049,065 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cdh17 cadherin 17 JBrowse link 5 25,354,187 25,443,675 RGD:6480464
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:6480464
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:6480464
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:6480464
G Col6a1 collagen type VI alpha 1 chain JBrowse link 20 12,657,913 12,676,370 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 17 57,021,704 57,090,888 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6480464
G Ctbp1 C-terminal binding protein 1 JBrowse link 14 82,762,109 82,789,350 RGD:6480464
G Cul5 cullin 5 JBrowse link 8 58,199,992 58,255,149 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 15 104,186,918 104,226,236 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:6480464
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:6480464
G Evi2a ecotropic viral integration site 2A JBrowse link 10 66,870,048 66,873,948 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fosl2 FOS like 2, AP-1 transcription factor subunit JBrowse link 6 25,598,936 25,616,995 RGD:6480464
G Foxp1 forkhead box P1 JBrowse link 4 131,362,178 131,963,466 RGD:6480464
G Fyb1 FYN binding protein 1 JBrowse link 2 55,834,904 55,983,805 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Gfra2 GDNF family receptor alpha 2 JBrowse link 15 52,557,004 52,648,984 RGD:6480464
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:6480464
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha JBrowse link 6 27,589,840 27,628,921 RGD:6480464
G Hars1 histidyl-tRNA synthetase 1 JBrowse link 18 29,611,545 29,629,087 RGD:6480464
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6480464
G Hexb hexosaminidase subunit beta JBrowse link 2 27,983,925 28,003,260 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ifngr2 interferon gamma receptor 2 JBrowse link 11 31,694,339 31,712,611 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6480464
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6480464
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kcnn3 potassium calcium-activated channel subfamily N member 3 JBrowse link 2 188,837,280 188,991,794 RGD:6480464
G Kcnn4 potassium calcium-activated channel subfamily N member 4 JBrowse link 1 81,227,855 81,245,986 RGD:6480464
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Kpnb1 karyopherin subunit beta 1 JBrowse link 10 85,096,517 85,124,641 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:6480464
G Lcp1 lymphocyte cytosolic protein 1 JBrowse link 15 57,170,566 57,277,811 RGD:6480464
G Ltbp4 latent transforming growth factor beta binding protein 4 JBrowse link 1 84,118,046 84,152,095 RGD:6480464
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6480464
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Myl9 myosin light chain 9 JBrowse link 3 152,857,573 152,863,961 RGD:6480464
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit JBrowse link 8 116,336,441 116,339,691 RGD:6480464
G Ncs1 neuronal calcium sensor 1 JBrowse link 3 10,556,250 10,602,672 RGD:6480464
G Nell1 neural EGFL like 1 JBrowse link 1 105,348,577 106,218,970 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6480464
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:6480464
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nkg7 natural killer cell granule protein 7 JBrowse link 1 98,492,873 98,493,940 RGD:6480464
G Nmi N-myc (and STAT) interactor JBrowse link 3 37,458,891 37,480,984 RGD:6480464
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:6480464
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:6480464
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:6480464
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6480464
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Pnpla4 patatin like phospholipase domain containing 4 JBrowse link X 45,519,406 45,522,988 RGD:6480464
G Pou2f1 POU class 2 homeobox 1 JBrowse link 13 84,075,316 84,217,368 RGD:6480464
G Pou2f2 POU class 2 homeobox 2 JBrowse link 1 81,966,791 82,049,116 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6480464
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:6480464
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:6480464
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:6480464
G Psmb10 proteasome 20S subunit beta 10 JBrowse link 19 37,909,543 37,912,027 RGD:6480464
G Psmb8 proteasome 20S subunit beta 8 JBrowse link 20 3,990,809 3,993,772 RGD:6480464
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6480464
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:6480464
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:6480464
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:6480464
G Rhog ras homolog family member G JBrowse link 1 167,336,147 167,347,720 RGD:6480464
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:6480464
G RT1-Da RT1 class II, locus Da JBrowse link 20 4,127,644 4,132,616 RGD:6480464
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP JBrowse link 1 220,762,496 220,771,158 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sf3b4 splicing factor 3b, subunit 4 JBrowse link 2 198,312,428 198,317,180 RGD:6480464
G Sftpb surfactant protein B JBrowse link 4 100,166,855 100,175,941 RGD:6480464
G Sftpc surfactant protein C JBrowse link 15 52,211,538 52,214,480 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Sla src-like adaptor JBrowse link 7 107,585,055 107,604,950 RGD:6480464
G Slc39a7 solute carrier family 39 member 7 JBrowse link 20 3,819,416 3,822,788 RGD:6480464
G Slc3a2 solute carrier family 3 member 2 JBrowse link 1 224,906,566 224,921,029 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Srpra SRP receptor subunit alpha JBrowse link 8 36,410,683 36,416,766 RGD:6480464
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:6480464
G Syn1 synapsin I JBrowse link X 1,321,315 1,379,202 RGD:6480464
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link 5 173,447,784 173,450,474 RGD:6480464
G Tnfsf9 TNF superfamily member 9 JBrowse link 9 9,909,942 9,912,276 RGD:6480464
G Tnpo1 transportin 1 JBrowse link 2 29,056,219 29,126,882 RGD:6480464
G Traf1 TNF receptor-associated factor 1 JBrowse link 3 14,003,340 14,022,955 RGD:6480464
G Trib2 tribbles pseudokinase 2 JBrowse link 6 41,016,722 41,040,972 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 10 59,799,123 59,824,208 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 17 54,656,627 54,714,920 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            ionomycin 166
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        monocarboxylic acid 17256
                                          fatty acid 15817
                                            unsaturated fatty acid 889
                                              polyunsaturated fatty acid 646
                                                ionomycin 166
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.