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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:estrogen receptor agonist
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Accession:CHEBI:63951 term browser browse the term
Definition:An agonist at the estrogen receptor.
Synonyms:related_synonym: estrogen receptor agonists


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17beta-estradiol 3-benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin increases methylation ISO estradiol 3-benzoate results in increased methylation of A2M promoter CTD PMID:27415467 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
multiple interactions
increases expression
ISO estradiol 3-benzoate results in decreased expression of ABCB1A mRNA
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCB1A mRNA]
CTD PMID:23707492 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases expression ISO estradiol 3-benzoate results in decreased expression of ABCC1 protein CTD PMID:23707492 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of ABCC2 promoter CTD PMID:27415467 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 decreases expression
increases expression
multiple interactions
ISO estradiol 3-benzoate results in decreased expression of ABCC4 protein
estradiol 3-benzoate results in increased expression of ABCC4 mRNA; estradiol 3-benzoate results in increased expression of ABCC4 protein
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCC4 mRNA]
CTD PMID:23707492 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 affects expression
increases expression
ISO estradiol 3-benzoate affects the expression of ABCC5 protein
estradiol 3-benzoate results in increased expression of ABCC5 mRNA; estradiol 3-benzoate results in increased expression of ABCC5 protein
CTD PMID:23707492 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases expression ISO estradiol 3-benzoate results in decreased expression of ABCG2 mRNA; estradiol 3-benzoate results in decreased expression of ABCG2 protein CTD PMID:23707492 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACRBP acrosin binding protein increases methylation ISO estradiol 3-benzoate results in increased methylation of ACRBP promoter CTD PMID:27415467 NCBI chr12:6,638,075...6,647,432
Ensembl chr12:6,638,075...6,647,433
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO estradiol 3-benzoate promotes the reaction [Thioacetamide results in increased expression of ACTA2 mRNA] CTD PMID:15716488 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ACVR2B activin A receptor type 2B decreases expression ISO estradiol 3-benzoate results in decreased expression of ACVR2B mRNA CTD PMID:14994273 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142
JBrowse link
G ADGRB2 adhesion G protein-coupled receptor B2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of ADGRB2 promoter CTD PMID:27415467 NCBI chr 1:31,727,105...31,764,340
Ensembl chr 1:31,727,117...31,764,893
JBrowse link
G ADO 2-aminoethanethiol dioxygenase increases methylation ISO estradiol 3-benzoate results in increased methylation of ADO promoter CTD PMID:27415467 NCBI chr10:62,804,720...62,808,479
Ensembl chr10:62,804,720...62,808,479
JBrowse link
G AP1M2 adaptor related protein complex 1 subunit mu 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of AP1M2 promoter CTD PMID:27415467 NCBI chr19:10,572,671...10,587,315
Ensembl chr19:10,572,671...10,587,315
JBrowse link
G AR androgen receptor multiple interactions
affects expression
ISO Flutamide inhibits the reaction [estradiol 3-benzoate results in increased expression of AR mRNA]
estradiol 3-benzoate affects the expression of AR mRNA
CTD PMID:15925091 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARF6 ADP ribosylation factor 6 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of ARF6 promoter CTD PMID:27415467 NCBI chr14:49,893,082...49,897,054
Ensembl chr14:49,893,082...49,897,054
JBrowse link
G ARNT2 aryl hydrocarbon receptor nuclear translocator 2 increases expression ISO estradiol 3-benzoate results in increased expression of ARNT2 mRNA; estradiol 3-benzoate results in increased expression of ARNT2 protein CTD PMID:12859947 NCBI chr15:80,404,382...80,597,933
Ensembl chr15:80,404,350...80,597,933
JBrowse link
G ASL argininosuccinate lyase increases methylation ISO estradiol 3-benzoate results in increased methylation of ASL promoter CTD PMID:27415467 NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO estradiol 3-benzoate results in increased expression of and results in increased activity of ATP1A1 protein CTD PMID:22759964 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G BAALC BAALC binder of MAP3K1 and KLF4 increases methylation ISO estradiol 3-benzoate results in increased methylation of BAALC promoter CTD PMID:27415467 NCBI chr 8:103,140,725...103,230,305
Ensembl chr 8:103,140,713...103,230,305
JBrowse link
G BATF basic leucine zipper ATF-like transcription factor decreases methylation ISO estradiol 3-benzoate results in decreased methylation of BATF promoter CTD PMID:27415467 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993
Ensembl chr14:75,522,455...75,546,993
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of BAX mRNA; estradiol 3-benzoate results in increased expression of BAX protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BAX protein]
CTD PMID:24316378 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
ISO Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BCL2 mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BCL2 protein]
estradiol 3-benzoate results in increased expression of BCL2 mRNA; estradiol 3-benzoate results in increased expression of BCL2 protein
CTD PMID:24316378 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 affects expression ISO estradiol 3-benzoate affects the expression of BCL2L1 mRNA CTD PMID:15664431 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor decreases expression ISO estradiol 3-benzoate results in decreased expression of BDNF mRNA CTD PMID:21277884 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BID BH3 interacting domain death agonist increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of BID protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BID protein]
CTD PMID:24316378 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BTBD3 BTB domain containing 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of BTBD3 promoter CTD PMID:27415467 NCBI chr20:11,890,723...11,926,595
Ensembl chr20:11,890,723...11,926,609
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of CACNB2 promoter CTD PMID:27415467 NCBI chr10:18,140,424...18,545,881
Ensembl chr10:18,140,677...18,543,557
Ensembl chr10:18,140,677...18,543,557
JBrowse link
G CACYBP calcyclin binding protein increases methylation ISO estradiol 3-benzoate results in increased methylation of CACYBP promoter CTD PMID:27415467 NCBI chr 1:174,999,435...175,012,027
Ensembl chr 1:174,999,163...175,012,027
JBrowse link
G CAPNS2 calpain small subunit 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of CAPNS2 promoter CTD PMID:27415467 NCBI chr16:55,566,684...55,567,687
Ensembl chr16:55,566,684...55,567,687
JBrowse link
G CASP3 caspase 3 multiple interactions ISO estradiol 3-benzoate results in increased expression of and results in increased activity of CASP3 protein; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of and results in increased activity of CASP3 protein] CTD PMID:24316378 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of CASP8 mRNA
estradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of CASP8 mRNA]
CTD PMID:24316378 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
ISO estradiol 3-benzoate results in increased expression of and results in increased activity of CASP9 protein; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of and results in increased activity of CASP9 protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of CASP9 mRNA] CTD PMID:24316378 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of CAT protein] CTD PMID:24316378 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCR10 C-C motif chemokine receptor 10 increases methylation ISO estradiol 3-benzoate results in increased methylation of CCR10 promoter CTD PMID:27415467 NCBI chr17:42,678,889...42,681,843
Ensembl chr17:42,678,889...42,683,917
JBrowse link
G CD52 CD52 molecule increases methylation ISO estradiol 3-benzoate results in increased methylation of CD52 promoter CTD PMID:27415467 NCBI chr 1:26,317,958...26,320,523
Ensembl chr 1:26,317,958...26,320,523
JBrowse link
G CFI complement factor I increases methylation ISO estradiol 3-benzoate results in increased methylation of CFI promoter CTD PMID:27415467 NCBI chr 4:109,730,982...109,802,040
Ensembl chr 4:109,740,694...109,802,179
Ensembl chr 4:109,740,694...109,802,179
JBrowse link
G CGA glycoprotein hormones, alpha polypeptide decreases expression ISO estradiol 3-benzoate results in decreased expression of CGA mRNA CTD PMID:15223135 NCBI chr 6:87,085,498...87,095,106
Ensembl chr 6:87,085,498...87,095,106
Ensembl chr 6:87,085,498...87,095,106
JBrowse link
G CHAD chondroadherin increases methylation ISO estradiol 3-benzoate results in increased methylation of CHAD promoter CTD PMID:27415467 NCBI chr17:50,464,492...50,469,881
Ensembl chr17:50,464,496...50,468,906
JBrowse link
G CHST14 carbohydrate sulfotransferase 14 increases expression
decreases methylation
ISO estradiol 3-benzoate results in increased expression of CHST14 mRNA
estradiol 3-benzoate results in decreased methylation of CHST14 promoter
CTD PMID:27415467 NCBI chr15:40,470,984...40,473,158
Ensembl chr15:40,470,998...40,474,571
Ensembl chr15:40,470,998...40,474,571
JBrowse link
G CLTRN collectrin, amino acid transport regulator increases methylation ISO estradiol 3-benzoate results in increased methylation of CLTRN promoter CTD PMID:27415467 NCBI chr  X:15,627,318...15,675,624
Ensembl chr  X:15,627,318...15,675,012
JBrowse link
G CLU clusterin affects expression ISO estradiol 3-benzoate affects the expression of CLU mRNA CTD PMID:15925091 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 increases expression ISO estradiol 3-benzoate results in increased expression of CNGA1 protein CTD PMID:22759964 NCBI chr 4:47,935,015...48,016,718
Ensembl chr 4:47,935,977...48,016,672
Ensembl chr 4:47,935,977...48,016,672
JBrowse link
G CNTNAP1 contactin associated protein 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of CNTNAP1 promoter CTD PMID:27415467 NCBI chr17:42,679,767...42,699,993
Ensembl chr17:42,682,531...42,699,993
JBrowse link
G COASY Coenzyme A synthase decreases methylation ISO estradiol 3-benzoate results in decreased methylation of COASY promoter CTD PMID:27415467 NCBI chr17:42,562,148...42,566,277
Ensembl chr17:42,561,467...42,566,277
JBrowse link
G CREB3L4 cAMP responsive element binding protein 3 like 4 increases methylation ISO estradiol 3-benzoate results in increased methylation of CREB3L4 promoter CTD PMID:27415467 NCBI chr 1:153,967,487...153,974,364
Ensembl chr 1:153,967,534...153,974,361
JBrowse link
G CYGB cytoglobin multiple interactions ISO estradiol 3-benzoate promotes the reaction [Thioacetamide results in increased expression of CYGB mRNA] CTD PMID:15716488 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 decreases expression ISO estradiol 3-benzoate results in decreased expression of CYP17A1 protein CTD PMID:24752506 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 affects response to substance ISO CYP19A1 protein affects the susceptibility to estradiol 3-benzoate CTD PMID:16884724 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression ISO estradiol 3-benzoate results in decreased expression of CYP1B1 protein CTD PMID:24752506 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 decreases expression ISO estradiol 3-benzoate results in decreased expression of CYP2A1 protein CTD PMID:24752506 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
JBrowse link
G DDAH2 dimethylarginine dimethylaminohydrolase 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of DDAH2 promoter CTD PMID:27415467 NCBI chr 6:31,727,040...31,730,263
Ensembl chr 6:31,727,038...31,730,617
JBrowse link
G DEUP1 deuterosome assembly protein 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of DEUP1 promoter CTD PMID:27415467 NCBI chr11:93,329,079...93,438,470
Ensembl chr11:93,329,971...93,438,487
JBrowse link
G DLX4 distal-less homeobox 4 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of DLX4 promoter CTD PMID:27415467 NCBI chr17:49,968,970...49,974,959
Ensembl chr17:49,968,970...49,974,959
JBrowse link
G DNASE2B deoxyribonuclease 2 beta increases methylation ISO estradiol 3-benzoate results in increased methylation of DNASE2B promoter CTD PMID:27415467 NCBI chr 1:84,398,484...84,415,895
Ensembl chr 1:84,398,532...84,415,018
Ensembl chr 1:84,398,532...84,415,018
JBrowse link
G DNTTIP1 deoxynucleotidyltransferase terminal interacting protein 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of DNTTIP1 promoter CTD PMID:27415467 NCBI chr20:45,791,954...45,811,419
Ensembl chr20:45,791,954...45,811,427
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions ISO estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine] CTD PMID:10936494 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DSC2 desmocollin 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of DSC2 promoter CTD PMID:27415467 NCBI chr18:31,058,840...31,102,421
Ensembl chr18:31,058,840...31,102,522
JBrowse link
G DSC3 desmocollin 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of DSC3 promoter CTD PMID:27415467 NCBI chr18:30,989,365...31,042,742
Ensembl chr18:30,989,365...31,042,815
JBrowse link
G EGFR epidermal growth factor receptor increases expression ISO estradiol 3-benzoate results in increased expression of EGFR protein CTD PMID:15778002 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EPHX1 epoxide hydrolase 1 decreases expression ISO estradiol 3-benzoate results in decreased expression of EPHX1 protein CTD PMID:24752506 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G ESR1 estrogen receptor 1 affects binding
increases expression
decreases expression
increases methylation
affects expression
ISO
EXP
estradiol 3-benzoate binds to ESR1 protein
estradiol 3-benzoate results in increased expression of ESR1 mRNA; estradiol 3-benzoate results in increased expression of ESR1 protein
estradiol 3-benzoate results in decreased expression of ESR1; estradiol 3-benzoate results in decreased expression of ESR1 protein
estradiol 3-benzoate results in increased methylation of ESR1 exon; estradiol 3-benzoate results in increased methylation of ESR1 intron
estradiol 3-benzoate affects the expression of ESR1 mRNA
CTD PMID:11162928 PMID:15375486 PMID:15716488 PMID:15778002 PMID:15925091 PMID:19350480 PMID:22016562 PMID:27830003 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 affects expression
increases expression
decreases expression
ISO estradiol 3-benzoate affects the expression of ESR2 mRNA
estradiol 3-benzoate results in increased expression of ESR2 mRNA
estradiol 3-benzoate results in decreased expression of ESR2; estradiol 3-benzoate results in decreased expression of ESR2 mRNA
CTD PMID:15375486 PMID:19350480 PMID:24352099 PMID:27830003 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G F11R F11 receptor multiple interactions
increases expression
EXP Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of F11R mRNA]; Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of F11R protein]
estradiol 3-benzoate results in increased expression of F11R mRNA; estradiol 3-benzoate results in increased expression of F11R protein
CTD PMID:19433574 NCBI chr 1:160,995,211...161,021,152
Ensembl chr 1:160,995,211...161,021,343
JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of FAIM2 promoter CTD PMID:27415467 NCBI chr12:49,866,896...49,903,900
Ensembl chr12:49,866,896...49,904,217
JBrowse link
G FAM229B family with sequence similarity 229 member B increases methylation ISO estradiol 3-benzoate results in increased methylation of FAM229B promoter CTD PMID:27415467 NCBI chr 6:112,087,591...112,102,790
Ensembl chr 6:112,087,591...112,102,790
JBrowse link
G FAS Fas cell surface death receptor increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of FAS mRNA; estradiol 3-benzoate results in increased expression of FAS protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FAS mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FAS protein]
CTD PMID:24316378 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of FASLG mRNA; estradiol 3-benzoate results in increased expression of FASLG protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FASLG mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FASLG protein]
CTD PMID:24316378 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FBXO6 F-box protein 6 increases methylation ISO estradiol 3-benzoate results in increased methylation of FBXO6 promoter CTD PMID:27415467 NCBI chr 1:11,664,200...11,674,354
Ensembl chr 1:11,664,200...11,674,354
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO estradiol 3-benzoate results in decreased expression of FOS protein
[estradiol 3-benzoate co-treated with Progesterone] results in increased abundance of FOS protein
CTD PMID:21190954 PMID:22577852 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression
decreases secretion
multiple interactions
ISO estradiol 3-benzoate results in decreased expression of FSHB mRNA
estradiol 3-benzoate results in decreased secretion of FSHB protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased secretion of FSHB protein]
CTD PMID:15223135 PMID:24316378 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
Ensembl chr11:30,231,016...30,235,261
JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 increases expression ISO estradiol 3-benzoate results in increased expression of GABBR1 mRNA CTD PMID:21277884 NCBI chr 6:29,602,230...29,633,183
Ensembl chr 6:29,555,629...29,633,976
JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 multiple interactions ISO [Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of GABRA4 mRNA CTD PMID:19394921 NCBI chr 4:46,918,900...46,993,581
Ensembl chr 4:46,918,900...46,993,581
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO [estradiol 3-benzoate co-treated with GNRH1 protein] results in increased secretion of LH protein CTD PMID:19574278 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GNRHR gonadotropin releasing hormone receptor decreases expression ISO estradiol 3-benzoate results in decreased expression of GNRHR mRNA CTD PMID:15223135 NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,739,328...67,754,360
Ensembl chr 4:67,739,328...67,754,360
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of GPX1 mRNA] CTD PMID:24316378 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX7 glutathione peroxidase 7 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of GPX7 promoter CTD PMID:27415467 NCBI chr 1:52,602,371...52,609,051
Ensembl chr 1:52,602,371...52,609,051
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 increases phosphorylation
multiple interactions
ISO estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]; U 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]
CTD PMID:21763338 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B increases expression
increases phosphorylation
multiple interactions
decreases expression
ISO estradiol 3-benzoate results in increased expression of GRIN2B mRNA
estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]; U 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]
estradiol 3-benzoate results in decreased expression of GRIN2B mRNA
CTD PMID:21190954 PMID:21277884 PMID:21763338 NCBI chr12:13,537,337...13,982,012
Ensembl chr12:13,437,942...13,982,002
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C increases expression ISO estradiol 3-benzoate results in increased expression of GRIN2C mRNA CTD PMID:21277884 NCBI chr17:74,842,021...74,860,843
Ensembl chr17:74,842,023...74,861,504
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of GRK3 promoter CTD PMID:27415467 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294
JBrowse link
G GRN granulin precursor increases expression ISO estradiol 3-benzoate results in increased expression of GRN mRNA CTD PMID:11137762 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
JBrowse link
G GUCY2C guanylate cyclase 2C increases methylation ISO estradiol 3-benzoate results in increased methylation of GUCY2C promoter CTD PMID:27415467 NCBI chr12:14,612,632...14,696,625
Ensembl chr12:14,612,632...14,696,599
JBrowse link
G HABP2 hyaluronan binding protein 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of HABP2 promoter CTD PMID:27415467 NCBI chr10:113,550,831...113,589,602
Ensembl chr10:113,550,837...113,589,602
JBrowse link
G HOXC5 homeobox C5 increases methylation ISO estradiol 3-benzoate results in increased methylation of HOXC5 promoter CTD PMID:27415467 NCBI chr12:54,016,888...54,035,361
Ensembl chr12:54,017,110...54,035,361
Ensembl chr12:54,017,110...54,035,361
Ensembl chr12:54,017,110...54,035,361
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of HSPA2 promoter CTD PMID:27415467 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression
ISO [estradiol 3-benzoate co-treated with Progesterone] results in increased expression of HSPA8 mRNA; Progesterone promotes the reaction [estradiol 3-benzoate results in increased expression of HSPA8 mRNA] CTD PMID:9990085 NCBI chr11:123,057,489...123,062,366
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
ISO Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]; Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]
estradiol 3-benzoate results in increased expression of HTR2A mRNA; estradiol 3-benzoate results in increased expression of HTR2A protein
CTD PMID:17398000 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,550...46,897,076
Ensembl chr13:46,831,550...46,897,076
JBrowse link
G HYAL3 hyaluronidase 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of HYAL3 promoter CTD PMID:27415467 NCBI chr 3:50,292,832...50,299,405
Ensembl chr 3:50,292,831...50,299,405
JBrowse link
G IGF1 insulin like growth factor 1 affects expression
decreases expression
ISO estradiol 3-benzoate affects the expression of IGF1 mRNA
estradiol 3-benzoate results in decreased expression of IGF1 mRNA
CTD PMID:15925091 PMID:19350480 PMID:21190954 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGSF9 immunoglobulin superfamily member 9 increases methylation ISO estradiol 3-benzoate results in increased methylation of IGSF9 promoter CTD PMID:27415467 NCBI chr 1:159,927,041...159,945,661
Ensembl chr 1:159,927,039...159,945,613
JBrowse link
G IP6K1 inositol hexakisphosphate kinase 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of IP6K1 promoter CTD PMID:27415467 NCBI chr 3:49,724,294...49,786,542
Ensembl chr 3:49,724,294...49,786,542
JBrowse link
G KATNB1 katanin regulatory subunit B1 increases methylation ISO estradiol 3-benzoate results in increased methylation of KATNB1 promoter CTD PMID:27415467 NCBI chr16:57,735,770...57,757,244
Ensembl chr16:57,735,739...57,757,244
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of KCNK2 promoter CTD PMID:27415467 NCBI chr 1:215,002,920...215,237,093
Ensembl chr 1:215,005,775...215,237,090
Ensembl chr 1:215,005,775...215,237,090
JBrowse link
G KISS1 KiSS-1 metastasis suppressor decreases expression ISO estradiol 3-benzoate results in decreased expression of KISS1 mRNA; estradiol 3-benzoate results in decreased expression of KISS1 protein CTD PMID:19106226 PMID:19442818 PMID:20951797 PMID:21190954 PMID:22016562 NCBI chr 1:204,190,341...204,196,491
Ensembl chr 1:204,190,341...204,196,491
JBrowse link
G KISS1R KISS1 receptor decreases expression ISO estradiol 3-benzoate results in decreased expression of KISS1R mRNA CTD PMID:21277884 NCBI chr19:916,693...921,005
Ensembl chr19:917,287...921,005
JBrowse link
G KRT25 keratin 25 increases methylation ISO estradiol 3-benzoate results in increased methylation of KRT25 promoter CTD PMID:27415467 NCBI chr17:40,748,021...40,755,542
Ensembl chr17:40,748,021...40,755,331
JBrowse link
G KRT8 keratin 8 increases methylation ISO estradiol 3-benzoate results in increased methylation of KRT8 promoter CTD PMID:27415467 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G KRT83 keratin 83 increases methylation ISO estradiol 3-benzoate results in increased methylation of KRT83 promoter CTD PMID:27415467 NCBI chr12:52,314,301...52,321,398
Ensembl chr12:52,314,301...52,321,398
JBrowse link
G KRT87P keratin 87 pseudogene increases methylation ISO estradiol 3-benzoate results in increased methylation of KB23 promoter CTD PMID:27415467 NCBI chr12:52,250,544...52,258,508
Ensembl chr12:52,250,466...52,258,867
JBrowse link
G LHB luteinizing hormone subunit beta decreases expression
decreases secretion
multiple interactions
increases secretion
ISO estradiol 3-benzoate results in decreased expression of LHB mRNA
estradiol 3-benzoate results in decreased secretion of LHB protein
Atrazine inhibits the reaction [[estradiol 3-benzoate co-treated with Progesterone] results in increased secretion of LHB protein]; Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased secretion of LHB protein]; Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]
[estradiol 3-benzoate co-treated with Progesterone] results in increased abundance of LHB protein
CTD PMID:10696778 PMID:15056801 PMID:15223135 PMID:16614383 PMID:17398000 PMID:22577852 PMID:24316378 NCBI chr19:49,015,980...49,017,091
Ensembl chr19:49,015,980...49,017,090
Ensembl chr19:49,015,980...49,017,090
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor increases expression ISO estradiol 3-benzoate results in increased expression of LHCGR mRNA CTD PMID:15223135 NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730
JBrowse link
G LRRC15 leucine rich repeat containing 15 increases methylation ISO estradiol 3-benzoate results in increased methylation of LRRC15 promoter CTD PMID:27415467 NCBI chr 3:194,355,249...194,369,743
Ensembl chr 3:194,355,247...194,369,743
Ensembl chr 3:194,355,247...194,369,743
JBrowse link
G LRRC18 leucine rich repeat containing 18 increases methylation ISO estradiol 3-benzoate results in increased methylation of LRRC18 promoter CTD PMID:27415467 NCBI chr10:48,909,480...48,940,126
Ensembl chr10:48,909,483...48,914,232
JBrowse link
G LTBP2 latent transforming growth factor beta binding protein 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of LTBP2 promoter CTD PMID:27415467 NCBI chr14:74,498,183...74,612,593
Ensembl chr14:74,498,183...74,612,378
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 decreases phosphorylation ISO estradiol 3-benzoate results in decreased phosphorylation of MAP2K1 protein CTD PMID:15778002 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases phosphorylation ISO estradiol 3-benzoate results in decreased phosphorylation of MAP2K2 protein CTD PMID:15778002 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation ISO estradiol 3-benzoate results in decreased phosphorylation of MAPK1 protein CTD PMID:15778002 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation ISO estradiol 3-benzoate results in decreased phosphorylation of MAPK3 protein CTD PMID:15778002 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MARCHF10 membrane associated ring-CH-type finger 10 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of MARCHF10 promoter CTD PMID:27415467 NCBI chr17:62,701,314...62,808,346
Ensembl chr17:62,701,314...62,808,344
JBrowse link
G MIR615 microRNA 615 increases methylation ISO estradiol 3-benzoate results in increased methylation of MIR615 promoter CTD PMID:27415467 NCBI chr12:54,033,950...54,034,045
Ensembl chr12:54,033,950...54,034,045
JBrowse link
G MPO myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [estradiol 3-benzoate inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]]; estradiol 3-benzoate inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein] CTD PMID:27363640 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MSTN myostatin multiple interactions
decreases expression
ISO estradiol 3-benzoate promotes the reaction [Progesterone results in decreased expression of MSTN mRNA]
estradiol 3-benzoate results in decreased expression of MSTN mRNA
CTD PMID:18845635 NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729
JBrowse link
G MYH9 myosin heavy chain 9 increases methylation ISO estradiol 3-benzoate results in increased methylation of MYH9 promoter CTD PMID:27415467 NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,277...36,388,067
Ensembl chr22:36,281,277...36,388,067
JBrowse link
G NECAB2 N-terminal EF-hand calcium binding protein 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of NECAB2 promoter CTD PMID:27415467 NCBI chr16:83,968,244...84,002,776
Ensembl chr16:83,968,632...84,002,776
Ensembl chr16:83,968,632...84,002,776
JBrowse link
G NFIA nuclear factor I A increases methylation ISO estradiol 3-benzoate results in increased methylation of NFIA promoter CTD PMID:27415467 NCBI chr 1:61,077,227...61,462,788
Ensembl chr 1:60,865,259...61,462,788
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO [Progesterone co-treated with estradiol 3-benzoate] results in increased expression of NOS1 protein CTD PMID:15347845 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NRTN neurturin decreases methylation ISO estradiol 3-benzoate results in decreased methylation of NRTN promoter CTD PMID:27415467 NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,823,802...5,828,324
JBrowse link
G OCLN occludin increases expression
multiple interactions
EXP
ISO
estradiol 3-benzoate results in increased expression of OCLN mRNA; estradiol 3-benzoate results in increased expression of OCLN protein
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN mRNA]
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN mRNA]; fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN protein]
CTD PMID:19433574 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
JBrowse link
G ODC1 ornithine decarboxylase 1 affects expression ISO estradiol 3-benzoate affects the expression of ODC1 mRNA CTD PMID:15925091 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OR56B4 olfactory receptor family 56 subfamily B member 4 increases methylation ISO estradiol 3-benzoate results in increased methylation of OLR198 promoter CTD PMID:27415467 NCBI chr11:6,107,684...6,108,835
Ensembl chr11:6,107,684...6,108,835
JBrowse link
G OSBPL6 oxysterol binding protein like 6 increases methylation ISO estradiol 3-benzoate results in increased methylation of OSBPL6 promoter CTD PMID:27415467 NCBI chr 2:178,194,465...178,402,893
Ensembl chr 2:178,194,481...178,402,893
JBrowse link
G OSR2 odd-skipped related transciption factor 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of OSR2 promoter CTD PMID:27415467 NCBI chr 8:98,944,442...98,952,100
Ensembl chr 8:98,944,403...98,952,104
JBrowse link
G OXGR1 oxoglutarate receptor 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of OXGR1 promoter CTD PMID:27415467 NCBI chr13:96,985,713...96,994,730
Ensembl chr13:96,985,719...96,994,730
JBrowse link
G PAQR4 progestin and adipoQ receptor family member 4 decreases methylation
increases expression
ISO estradiol 3-benzoate results in decreased methylation of PAQR4 promoter
estradiol 3-benzoate results in increased expression of PAQR4 mRNA
CTD PMID:27415467 PMID:28728135 NCBI chr16:2,969,348...2,973,484
Ensembl chr16:2,969,270...2,973,484
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO estradiol 3-benzoate results in increased cleavage of PARP1 protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased cleavage of PARP1 protein]
CTD PMID:24316378 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PAX9 paired box 9 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of PAX9 promoter CTD PMID:27415467 NCBI chr14:36,657,568...36,679,362
Ensembl chr14:36,657,568...36,679,362
Ensembl chr14:36,657,568...36,679,362
JBrowse link
G PCDHA13 protocadherin alpha 13 increases methylation ISO estradiol 3-benzoate results in increased methylation of PCDHA13 promoter CTD PMID:27415467 NCBI chr 5:140,882,124...141,012,347
Ensembl chr 5:140,882,124...141,012,347
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression ISO estradiol 3-benzoate results in increased expression of PCNA mRNA; estradiol 3-benzoate results in increased expression of PCNA protein CTD PMID:27830003 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PGR progesterone receptor increases expression ISO estradiol 3-benzoate results in increased expression of PGR mRNA; estradiol 3-benzoate results in increased expression of PGR protein; estradiol 3-benzoate results in increased expression of PGR protein alternative form CTD PMID:15456929 PMID:15778002 PMID:19574278 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHACTR1 phosphatase and actin regulator 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of PHACTR1 promoter CTD PMID:27415467 NCBI chr 6:12,716,635...13,290,462
Ensembl chr 6:12,716,554...13,287,843
Ensembl chr 6:12,716,554...13,287,843
JBrowse link
G PHPT1 phosphohistidine phosphatase 1 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of PHPT1 promoter CTD PMID:27415467 NCBI chr 9:136,849,409...136,851,024
Ensembl chr 9:136,848,724...136,851,027
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma increases methylation ISO estradiol 3-benzoate results in increased methylation of PIK3C2G promoter CTD PMID:27415467 NCBI chr12:18,242,946...18,716,861
Ensembl chr12:18,242,961...18,648,416
Ensembl chr12:18,242,961...18,648,416
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of PIK3R1 promoter CTD PMID:27415467 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PITX3 paired like homeodomain 3 increases expression
decreases methylation
ISO estradiol 3-benzoate results in increased expression of PITX3 mRNA
estradiol 3-benzoate results in decreased methylation of PITX3 promoter
CTD PMID:27415467 NCBI chr10:102,230,189...102,241,512
Ensembl chr10:102,230,186...102,241,512
JBrowse link
G POR cytochrome p450 oxidoreductase decreases expression ISO estradiol 3-benzoate results in decreased expression of POR protein CTD PMID:24752506 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha increases methylation ISO estradiol 3-benzoate results in increased methylation of PRKAR1A promoter CTD PMID:27415467 NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319
JBrowse link
G PRKG2 protein kinase cGMP-dependent 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of PRKG2 promoter CTD PMID:27415467 NCBI chr 4:81,087,370...81,217,837
Ensembl chr 4:81,087,370...81,215,117
JBrowse link
G PRL prolactin multiple interactions
increases secretion
ISO Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of PRL protein]; estradiol 3-benzoate results in increased expression of and results in increased secretion of PRL protein; Mifepristone promotes the reaction [estradiol 3-benzoate results in increased secretion of PRL protein] CTD PMID:2159045 PMID:10696778 PMID:27830003 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PRRC1 proline rich coiled-coil 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of PRRC1 promoter CTD PMID:27415467 NCBI chr 5:127,517,624...127,555,085
Ensembl chr 5:127,517,609...127,555,089
Ensembl chr 5:127,517,609...127,555,089
JBrowse link
G PRRC2A proline rich coiled-coil 2A increases methylation ISO estradiol 3-benzoate results in increased methylation of PRRC2A promoter CTD PMID:27415467 NCBI chr 6:31,620,715...31,637,780
Ensembl chr 6:31,620,715...31,637,771
JBrowse link
G PTTG1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO estradiol 3-benzoate results in increased expression of PTTG1 mRNA; estradiol 3-benzoate results in increased expression of PTTG1 protein CTD PMID:27830003 NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
JBrowse link
G PTX3 pentraxin 3 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of PTX3 promoter CTD PMID:27415467 NCBI chr 3:157,436,850...157,443,633
Ensembl chr 3:157,436,850...157,443,633
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO estradiol 3-benzoate results in decreased phosphorylation of RAF1 protein CTD PMID:15778002 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
Ensembl chr 3:12,583,601...12,664,226
JBrowse link
G RBPJL recombination signal binding protein for immunoglobulin kappa J region like decreases methylation ISO estradiol 3-benzoate results in decreased methylation of RBPJL promoter CTD PMID:27415467 NCBI chr20:45,306,836...45,319,677
Ensembl chr20:45,306,840...45,317,824
JBrowse link
G RCAN3 RCAN family member 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of RCAN3 promoter CTD PMID:27415467 NCBI chr 1:24,502,344...24,541,040
Ensembl chr 1:24,502,351...24,541,040
JBrowse link
G RGS20 regulator of G protein signaling 20 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of RGS20 promoter CTD PMID:27415467 NCBI chr 8:53,851,795...53,959,304
Ensembl chr 8:53,851,795...53,959,303
JBrowse link
G RNF186 ring finger protein 186 increases methylation ISO estradiol 3-benzoate results in increased methylation of RNF186 promoter CTD PMID:27415467 NCBI chr 1:19,814,029...19,815,283
Ensembl chr 1:19,814,029...19,815,283
JBrowse link
G RSPH1 radial spoke head component 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of RSPH1 promoter CTD PMID:27415467 NCBI chr21:42,472,486...42,496,246
Ensembl chr21:42,472,486...42,496,246
JBrowse link
G RUNX3 RUNX family transcription factor 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of RUNX3 promoter CTD PMID:27415467 NCBI chr 1:24,899,511...24,965,158
Ensembl chr 1:24,899,511...24,965,121
JBrowse link
G SCEL sciellin increases methylation ISO estradiol 3-benzoate results in increased methylation of SCEL promoter CTD PMID:27415467 NCBI chr13:77,535,694...77,645,263
Ensembl chr13:77,535,674...77,645,263
JBrowse link
G SCGB2A2 secretoglobin family 2A member 2 affects expression ISO estradiol 3-benzoate affects the expression of SCGB2A2 mRNA CTD PMID:15925091 NCBI chr11:62,270,130...62,273,160
Ensembl chr11:62,270,158...62,273,160
JBrowse link
G SEC14L2 SEC14 like lipid binding 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of SEC14L2 promoter CTD PMID:27415467 NCBI chr22:30,397,018...30,425,303
Ensembl chr22:30,396,941...30,425,303
JBrowse link
G SIRT4 sirtuin 4 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of SIRT4 promoter CTD PMID:27415467 NCBI chr12:120,291,780...120,313,249
Ensembl chr12:120,302,316...120,313,249
JBrowse link
G SLC16A7 solute carrier family 16 member 7 increases methylation ISO estradiol 3-benzoate results in increased methylation of SLC16A7 promoter CTD PMID:27415467 NCBI chr12:59,595,934...59,789,841
Ensembl chr12:59,596,029...59,789,855
JBrowse link
G SLC26A1 solute carrier family 26 member 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of SLC26A1 promoter CTD PMID:27415467 NCBI chr 4:979,035...993,404
Ensembl chr 4:979,073...993,440
JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of SLC2A3 promoter CTD PMID:27415467 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SLC6A1 solute carrier family 6 member 1 decreases expression ISO estradiol 3-benzoate results in decreased expression of SLC6A1 mRNA CTD PMID:15664431 NCBI chr 3:10,992,748...11,039,247
Ensembl chr 3:10,992,186...11,039,247
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions ISO estradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 mRNA]; estradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:15249736 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLC6A4 solute carrier family 6 member 4 increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of SLC6A4 protein
Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of SLC6A4 protein]
CTD PMID:17398000 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G SLC8A1 solute carrier family 8 member A1 increases methylation ISO estradiol 3-benzoate results in increased methylation of SLC8A1 promoter CTD PMID:27415467 NCBI chr 2:40,094,523...40,512,452
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression
multiple interactions
ISO estradiol 3-benzoate results in decreased expression of SOD1 mRNA; estradiol 3-benzoate results in decreased expression of SOD1 protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of SOD1 mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of SOD1 protein]
CTD PMID:24316378 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases methylation
increases expression
ISO estradiol 3-benzoate results in decreased methylation of SOX2 promoter
estradiol 3-benzoate results in increased expression of SOX2 mRNA
CTD PMID:27415467 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G STAT5B signal transducer and activator of transcription 5B increases methylation ISO estradiol 3-benzoate results in increased methylation of STAT5B promoter CTD PMID:27415467 NCBI chr17:42,199,177...42,288,437
Ensembl chr17:42,199,177...42,276,707
Ensembl chr17:42,199,177...42,276,707
JBrowse link
G STK16 serine/threonine kinase 16 increases methylation ISO estradiol 3-benzoate results in increased methylation of STK16 promoter CTD PMID:27415467 NCBI chr 2:219,245,469...219,250,337
Ensembl chr 2:219,245,455...219,250,337
JBrowse link
G TACSTD2 tumor associated calcium signal transducer 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of TACSTD2 promoter CTD PMID:27415467 NCBI chr 1:58,575,433...58,577,252
Ensembl chr 1:58,575,433...58,577,252
JBrowse link
G TARBP2 TARBP2 subunit of RISC loading complex increases methylation ISO estradiol 3-benzoate results in increased methylation of TARBP2 promoter CTD PMID:27415467 NCBI chr12:53,500,923...53,506,431
Ensembl chr12:53,500,921...53,506,431
JBrowse link
G TAT tyrosine aminotransferase increases methylation ISO estradiol 3-benzoate results in increased methylation of TAT promoter CTD PMID:27415467 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TBX4 T-box transcription factor 4 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of TBX4 promoter CTD PMID:27415467 NCBI chr17:61,452,422...61,485,110
Ensembl chr17:61,452,404...61,485,110
JBrowse link
G THEGL theg spermatid protein like increases methylation ISO estradiol 3-benzoate results in increased methylation of THEGL promoter CTD PMID:27415467 NCBI chr 4:56,530,575...56,626,214
Ensembl chr 4:56,530,606...56,603,507
JBrowse link
G TNPO3 transportin 3 increases methylation ISO estradiol 3-benzoate results in increased methylation of TNPO3 promoter CTD PMID:27415467 NCBI chr 7:128,954,185...129,055,111
Ensembl chr 7:128,954,180...129,055,173
JBrowse link
G TOB1 transducer of ERBB2, 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of TOB1 promoter CTD PMID:27415467 NCBI chr17:50,862,223...50,867,978
Ensembl chr17:50,862,223...50,867,978
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
ISO estradiol 3-benzoate results in increased expression of TP53 mRNA; estradiol 3-benzoate results in increased expression of TP53 protein
Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of TP53 mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of TP53 protein]
CTD PMID:24316378 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPD52 tumor protein D52 increases methylation
decreases expression
ISO estradiol 3-benzoate results in increased methylation of TPD52 promoter
estradiol 3-benzoate results in decreased expression of TPD52 mRNA
CTD PMID:27415467 NCBI chr 8:79,918,717...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
G TRIM2 tripartite motif containing 2 decreases methylation ISO estradiol 3-benzoate results in decreased methylation of TRIM2 promoter CTD PMID:27415467 NCBI chr 4:153,152,163...153,339,317
Ensembl chr 4:153,152,163...153,339,319
Ensembl chr 4:153,152,163...153,339,319
JBrowse link
G TSHB thyroid stimulating hormone subunit beta increases expression ISO estradiol 3-benzoate results in increased expression of TSHB protein CTD PMID:16570238 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G TUBB2B tubulin beta 2B class IIb decreases methylation ISO estradiol 3-benzoate results in decreased methylation of TUBB2B promoter CTD PMID:27415467 NCBI chr 6:3,224,277...3,227,653
Ensembl chr 6:3,224,277...3,231,730
Ensembl chr 6:3,224,277...3,231,730
JBrowse link
G TUBE1 tubulin epsilon 1 increases methylation ISO estradiol 3-benzoate results in increased methylation of TUBE1 promoter CTD PMID:27415467 NCBI chr 6:112,070,663...112,087,529
Ensembl chr 6:112,070,663...112,087,529
JBrowse link
G TYMP thymidine phosphorylase increases methylation ISO estradiol 3-benzoate results in increased methylation of TYMP promoter CTD PMID:27415467 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases methylation ISO estradiol 3-benzoate results in increased methylation of UGT1A1 promoter CTD PMID:27415467 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UTS2 urotensin 2 increases methylation ISO estradiol 3-benzoate results in increased methylation of UTS2 promoter CTD PMID:27415467 NCBI chr 1:7,846,345...7,913,615
Ensembl chr 1:7,843,083...7,853,512
JBrowse link
G WIZ WIZ zinc finger increases methylation ISO estradiol 3-benzoate results in increased methylation of WIZ promoter CTD PMID:27415467 NCBI chr19:15,419,978...15,449,956
Ensembl chr19:15,419,978...15,449,956
Ensembl chr19:15,419,978...15,449,956
JBrowse link
G WNT10B Wnt family member 10B decreases methylation
increases expression
ISO estradiol 3-benzoate results in decreased methylation of WNT10B promoter
estradiol 3-benzoate results in increased expression of WNT10B mRNA
CTD PMID:27415467 NCBI chr12:48,965,340...48,979,587
Ensembl chr12:48,965,340...48,971,735
JBrowse link
2,3-bis(4-hydroxyphenyl)propionitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
EXP
ISO
2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 mRNA; 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 protein
2,3-bis(4-hydroxyphenyl)-propionitrile promotes the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BCL2 protein]
ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 protein]; ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 mRNA]
CTD PMID:19264808 PMID:24216299 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO 2,3-bis(4-hydroxyphenyl)-propionitrile promotes the reaction [Chlorodiphenyl (54% Chlorine) results in increased activity of CASP3 protein] CTD PMID:24216299 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO 2,3-bis(4-hydroxyphenyl)-propionitrile promotes the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CCND1 protein] CTD PMID:24216299 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR1 protein; ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 protein]; ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein]; ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein] CTD PMID:19264808 PMID:24425189 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases expression
increases activity
EXP
ISO
2,3-bis(4-hydroxyphenyl)-propionitrile results in increased phosphorylation of and results in increased localization of and results in increased activity of ESR2 protein; ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 mRNA]; ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 mRNA]
2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of ESR2 protein; 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of ESR2 protein alternative form
2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein; [2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] inhibits the reaction [resveratrol results in decreased expression of PRL protein]
2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein; [2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] which results in increased secretion of Bicarbonates; ESR2 protein alternative form inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of ESR2 protein]
2,3-bis(4-hydroxyphenyl)-propionitrile results in increased activity of ESR2 protein
CTD PMID:18499763 PMID:19264808 PMID:20623183 PMID:22104698 PMID:22257560 PMID:25106122 PMID:27634370 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects phosphorylation ISO 2,3-bis(4-hydroxyphenyl)-propionitrile affects the phosphorylation of MAPK1 protein CTD PMID:20870566 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects phosphorylation ISO 2,3-bis(4-hydroxyphenyl)-propionitrile affects the phosphorylation of MAPK3 protein CTD PMID:20870566 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MIR21 microRNA 21 decreases expression EXP 2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of MIR21 mRNA CTD PMID:19264808 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G PDCD4 programmed cell death 4 increases expression
multiple interactions
decreases expression
EXP 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein
ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein]; ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 mRNA]
2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PDCD4 mRNA
CTD PMID:19264808 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PRL prolactin multiple interactions ISO [2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] inhibits the reaction [resveratrol results in decreased expression of PRL protein] CTD PMID:22104698 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PTEN phosphatase and tensin homolog increases expression
multiple interactions
EXP 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein
ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein]
CTD PMID:19264808 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGER2 prostaglandin E receptor 2 decreases expression ISO 2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PTGER2 mRNA CTD PMID:22257560 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598
JBrowse link
G PTGER4 prostaglandin E receptor 4 decreases expression ISO 2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PTGER4 mRNA CTD PMID:22257560 NCBI chr 5:40,679,915...40,740,936
Ensembl chr 5:40,679,915...40,693,735
JBrowse link
G RYR2 ryanodine receptor 2 increases phosphorylation ISO 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased phosphorylation of RYR2 protein CTD PMID:25723814 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO
EXP
2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of SOD2 protein]
2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of SOD2 protein]]
CTD PMID:20962025 PMID:24465521 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STAR steroidogenic acute regulatory protein increases expression EXP 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of STAR protein CTD PMID:30206973 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
fludioxonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP fludioxonil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ANXA10 annexin A10 increases expression EXP fludioxonil results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr 4:168,092,525...168,187,736
Ensembl chr 4:168,092,537...168,187,736
JBrowse link
G AR androgen receptor multiple interactions
affects binding
EXP fludioxonil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
fludioxonil binds to AR protein
CTD PMID:21310686 PMID:23436777 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARG1 arginase 1 decreases expression EXP fludioxonil results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
decreases expression
EXP fludioxonil results in increased expression of BCL2 mRNA
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]
CTD PMID:23052036 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
fludioxonil results in increased expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase affects binding EXP fludioxonil binds to CAT protein CTD PMID:32278787 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
decreases expression
EXP ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein]
fludioxonil results in increased expression of CCND1 mRNA; fludioxonil results in increased expression of CCND1 protein
CTD PMID:23052036 PMID:23436777 PMID:27539251 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 increases expression
multiple interactions
EXP fludioxonil results in increased expression of CCNE1 protein
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]
CTD PMID:27539251 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDH1 cadherin 1 decreases expression
multiple interactions
EXP fludioxonil results in decreased expression of CDH1 protein
fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]
CTD PMID:27539251 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 increases expression
multiple interactions
EXP fludioxonil results in increased expression of CDH2 protein
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein]
CTD PMID:27539251 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
multiple interactions
EXP fludioxonil results in decreased expression of CDKN1A protein
fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDKN1A protein]
CTD PMID:27539251 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CTSD cathepsin D multiple interactions
increases expression
EXP fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein] CTD PMID:27539251 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP fludioxonil results in increased expression of CYP1A1 mRNA; fludioxonil results in increased expression of CYP1A1 protein CTD PMID:32194361 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression EXP fludioxonil results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP fludioxonil results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 affects binding EXP fludioxonil binds to ERBB2 protein CTD PMID:32278787 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
increases activity
decreases expression
EXP [fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; fludioxonil binds to and results in increased activity of ESR1 protein; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
fludioxonil results in increased activity of ESR1 protein
fludioxonil results in decreased expression of ESR1 mRNA
CTD PMID:20143881 PMID:23052036 PMID:23436777 PMID:26812056 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases activity
decreases expression
increases expression
EXP [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
fludioxonil results in increased activity of ESR2 protein
fludioxonil results in decreased expression of ESR2 mRNA
fludioxonil results in increased expression of ESR2 mRNA
CTD PMID:23052036 PMID:23436777 PMID:26812056 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP fludioxonil results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GPX1 glutathione peroxidase 1 increases expression
multiple interactions
EXP fludioxonil results in increased expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G H2AX H2A.X variant histone multiple interactions
increases phosphorylation
EXP [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein
fludioxonil results in increased phosphorylation of H2AX protein
CTD PMID:22389207 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 increases activity EXP fludioxonil results in increased activity of HSD11B2 protein CTD PMID:31927052 NCBI chr16:67,431,121...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G MIR200A microRNA 200a increases expression EXP fludioxonil results in increased expression of MIR200A mRNA CTD PMID:23052036 NCBI chr 1:1,167,863...1,167,952
Ensembl chr 1:1,167,863...1,167,952
JBrowse link
G MIR21 microRNA 21 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] CTD PMID:23052036 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR22 microRNA 22 decreases expression EXP fludioxonil results in decreased expression of MIR22 mRNA CTD PMID:23052036 NCBI chr17:1,713,903...1,713,987
Ensembl chr17:1,713,903...1,713,987
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression EXP fludioxonil results in increased expression of NRF1 mRNA CTD PMID:23436777 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases expression EXP fludioxonil results in increased expression of PARP1 protein CTD PMID:23052036 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP fludioxonil results in increased expression of PCNA protein CTD PMID:27539251 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDCD4 programmed cell death 4 decreases expression
multiple interactions
EXP fludioxonil results in decreased expression of PDCD4 mRNA; fludioxonil results in decreased expression of PDCD4 protein
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]
CTD PMID:23052036 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PGR progesterone receptor increases expression
multiple interactions
decreases expression
EXP fludioxonil results in increased expression of PGR mRNA
Estradiol inhibits the reaction [fludioxonil results in increased expression of PGR mRNA]
fludioxonil results in decreased expression of PGR mRNA
CTD PMID:23052036 PMID:23436777 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PTEN phosphatase and tensin homolog decreases expression EXP fludioxonil results in decreased expression of PTEN mRNA CTD PMID:23052036 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [fludioxonil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RARB retinoic acid receptor beta decreases expression EXP fludioxonil results in decreased expression of RARB mRNA CTD PMID:23436777 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:25,174,332...25,597,932
JBrowse link
G RXRB retinoid X receptor beta increases activity EXP fludioxonil results in increased activity of RXRB protein CTD PMID:20143881 NCBI chr 6:33,193,588...33,200,991
Ensembl chr 6:33,193,588...33,200,665
Ensembl chr 6:33,193,588...33,200,665
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP fludioxonil results in increased expression of S100P mRNA; fludioxonil results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SNAI1 snail family transcriptional repressor 1 increases expression
multiple interactions
EXP fludioxonil results in increased expression of SNAI1 protein
fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]
CTD PMID:27539251 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G VMP1 vacuole membrane protein 1 multiple interactions EXP [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA CTD PMID:23052036 NCBI chr17:59,707,654...59,842,255
Ensembl chr17:59,707,192...59,842,255
JBrowse link
lasofoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor increases expression ISO Lasofoxifene results in increased expression of AR protein CTD PMID:16837883 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G AREG amphiregulin multiple interactions
increases expression
ISO Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Lasofoxifene results in increased expression of AREG mRNA
CTD PMID:19022889 NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005
JBrowse link
G DEFB1 defensin beta 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA CTD PMID:18367319 NCBI chr 8:6,870,592...6,877,936
Ensembl chr 8:6,870,592...6,877,936
JBrowse link
G ESR2 estrogen receptor 2 increases expression ISO Lasofoxifene results in increased expression of ESR2 protein CTD PMID:16837883 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Lasofoxifene results in increased expression of IDO1 mRNA
Lasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
CTD PMID:18367319 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G MMP2 matrix metallopeptidase 2 increases activity ISO Lasofoxifene results in increased activity of MMP2 protein CTD PMID:15576828 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G P2RY14 purinergic receptor P2Y14 multiple interactions ISO Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] CTD PMID:18367319 NCBI chr 3:151,212,115...151,279,167
Ensembl chr 3:151,212,117...151,278,542
JBrowse link
G PGR progesterone receptor increases expression ISO Lasofoxifene results in increased expression of PGR protein CTD PMID:16837883 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA CTD PMID:18367319 NCBI chr 5:147,824,582...147,839,196
Ensembl chr 5:147,824,568...147,831,786
Ensembl chr 5:147,824,568...147,831,786
JBrowse link
psoralidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
multiple interactions
ISO psoralidin results in decreased activity of CYP2E1 protein
psoralidin inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]
CTD PMID:31870919 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression ISO psoralidin results in increased expression of CYP3A4 mRNA CTD PMID:31870919 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
resolvin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAL integrin subunit alpha L multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr16:30,472,683...30,523,185
Ensembl chr16:30,472,719...30,523,185
Ensembl chr16:30,472,719...30,523,185
JBrowse link
G MPO myeloperoxidase multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; resolvin D2 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21724996 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 24386
    role 24296
      biological role 24263
        pharmacological role 21140
          agonist 19121
            estrogen receptor agonist 236
              17-epiestriol + 0
              17beta-estradiol 3-benzoate 182
              2,3-bis(4-hydroxyphenyl)propionitrile 16
              4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol 0
              estetrol 0
              fludioxonil 40
              lasofoxifene 9
              psoralidin 2
              resolvin D2 14
paths to the root