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ONTOLOGY REPORT - ANNOTATIONS


Term:2,3-bis(4-hydroxyphenyl)propionitrile
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Accession:CHEBI:63949 term browser browse the term
Definition:A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).
Synonyms:exact_synonym: 2,3-BHPPN ;   2,3-bis(4-hydroxyphenyl)propanenitrile;   DPN compound
 related_synonym: 2,3-bis(p-hydroxyphenyl)propionitrile;   Formula=C15H13NO2;   InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2;   InChIKey=GHZHWDWADLAOIQ-UHFFFAOYSA-N;   SMILES=Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
 alt_id: MESH:C486182
 xref: CAS:1428-67-7;   LINCS:LSM-1423
 xref_mesh: MESH:C486182
 xref: PMID:21268084;   PMID:21397017;   PMID:21636213;   PMID:21712365;   Reaxys:3337109


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2,3-bis(4-hydroxyphenyl)propionitrile term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mir21 microRNA 21 JBrowse link 10 73,902,210 73,902,301 RGD:6480464
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Ptger2 prostaglandin E receptor 2 JBrowse link 15 19,336,029 19,349,759 RGD:6480464
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:6480464
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      group 19680
        pseudohalo group 2877
          cyano group 2877
            nitrile 2877
              2,3-bis(4-hydroxyphenyl)propionitrile 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            one-carbon compound 17393
                              hydrogen cyanide 2882
                                cyanides 2882
                                  nitrile 2877
                                    2,3-bis(4-hydroxyphenyl)propionitrile 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.