CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 22,23-dihydroavermectin B1a
Accession: CHEBI:63941
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Definition: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.
Synonyms: exact_synonym: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
related_synonym: 5-O-demethyl-22,23-dihydroavermectin A1a; Formula=C48H74O14; H2B1a; InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1; InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N; SMILES=[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(CC[C@H](C)[C@]([H])(O1)[C@@H](C)CC)O2)[C@]34O; avermectin H2B1a; dihydroavermectin B1a; ivermectin B1a
xref: CAS:71827-03-7
xref_mesh: MESH:C052102
xref: PDBeChem:IVM; PMID:2411323; PMID:6125361; PMID:6148214; PMID:6547280; Reaxys:4643153; VSDB:1455
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]
CTD
PMID:25257666
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Abcb1a
ATP binding cassette subfamily B member 1A
affects abundance increases transport increases expression decreases activity increases export decreases response to substance multiple interactions increases response to substance affects binding affects response to substance
ISO
ABCB1 gene polymorphism affects the abundance of Ivermectin ABCB1 protein results in increased transport of Ivermectin Ivermectin results in increased expression of ABCB1A mRNA Ivermectin results in decreased activity of ABCB1A protein ABCB1A protein results in increased export of Ivermectin ABCB1A protein results in decreased susceptibility to Ivermectin [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes] ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin Ivermectin results in decreased activity of ABCB1 protein ABCB1 protein affects the abundance of Ivermectin Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Ivermectin] Ivermectin binds to ABCB1 protein ABCB1 gene polymorphism affects the susceptibility to Ivermectin
CTD
PMID:8917702 PMID:8949985 PMID:9144452 PMID:17134887 PMID:18633165 PMID:19161460 PMID:20513441 PMID:20595473 PMID:20630055 PMID:21321059 PMID:22024132 PMID:22834856 PMID:24998875 PMID:25865432
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcb1b
ATP-binding cassette, subfamily B (MDR/TAP), member 1B
multiple interactions increases expression
ISO
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin results in increased expression of and results in increased stability of ABCB1B mRNA Ivermectin results in increased expression of ABCB1B mRNA
CTD
PMID:19161460 PMID:22024132 PMID:24998875
NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions decreases activity
ISO
Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] Ivermectin results in decreased activity of ABCC1 protein
CTD
PMID:25865432
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
Ivermectin results in increased expression of ABCC2 mRNA
CTD
PMID:24998875
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcg2
ATP binding cassette subfamily G member 2
increases expression
ISO
Ivermectin results in increased expression of ABCG2 mRNA
CTD
PMID:24998875
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Acaca
acetyl-CoA carboxylase alpha
affects expression decreases expression multiple interactions
ISO
Ivermectin affects the expression of ACACA mRNA Ivermectin results in decreased expression of ACACA mRNA Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein] Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]
CTD
PMID:30738135 PMID:31199990
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
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Adcy7
adenylate cyclase 7
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA
CTD
PMID:16861626
NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
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Adm
adrenomedullin
decreases expression
ISO
Ivermectin results in decreased expression of ADM mRNA
CTD
PMID:28942281
NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
increases expression
ISO
Ivermectin results in increased expression of ALDH1L2 mRNA
CTD
PMID:28942281
NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
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Angptl6
angiopoietin-like 6
increases expression
ISO
Ivermectin results in increased expression of ANGPTL6 mRNA
CTD
PMID:28942281
NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
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Arl4c
ADP ribosylation factor like GTPase 4C
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA
CTD
PMID:16861626
NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
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Atf4
activating transcription factor 4
increases expression
ISO
Ivermectin results in increased expression of ATF4 mRNA
CTD
PMID:28942281
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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Atf5
activating transcription factor 5
increases expression
ISO
Ivermectin results in increased expression of ATF5 mRNA
CTD
PMID:28942281
NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
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Atf6
activating transcription factor 6
increases expression
ISO
Ivermectin results in increased expression of ATF6 mRNA
CTD
PMID:28942281
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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Bag3
BAG cochaperone 3
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA
CTD
PMID:16861626
NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Ivermectin results in increased expression of BAX protein
CTD
PMID:28811376
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bbc3
Bcl-2 binding component 3
multiple interactions
ISO
Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA]
CTD
PMID:24658405
NCBI chr 1:78,261,491...78,267,802
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Bnip3
BCL2 interacting protein 3
decreases expression
ISO
Ivermectin results in decreased expression of BNIP3 mRNA
CTD
PMID:28942281
NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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Camp
cathelicidin antimicrobial peptide
decreases expression
ISO
Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein
CTD
PMID:28653460
NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
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Cat
catalase
decreases activity multiple interactions
EXP
Ivermectin results in decreased activity of CAT protein Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]
CTD
PMID:28880400
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein
CTD
PMID:16861626
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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Ccr7
C-C motif chemokine receptor 7
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA
CTD
PMID:16861626
NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
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Cct3
chaperonin containing TCP1 subunit 3
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA
CTD
PMID:16861626
NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
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Cd36
CD36 molecule
affects expression
ISO
Ivermectin affects the expression of CD36 mRNA
CTD
PMID:31199990
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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Cdh1
cadherin 1
increases expression
ISO
Ivermectin results in increased expression of CDH1
CTD
PMID:26078298
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Ivermectin results in increased expression of CDKN1A protein
CTD
PMID:28811376
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Ivermectin results in increased expression of CDKN1B protein
CTD
PMID:28811376
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Cebpa
CCAAT/enhancer binding protein alpha
affects expression multiple interactions
ISO
Ivermectin affects the expression of CEBPA mRNA Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA]
CTD
PMID:31199990
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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Cox6a2
cytochrome c oxidase subunit 6A2
increases expression
ISO
Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein
CTD
PMID:28942281
NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
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Cpt1a
carnitine palmitoyltransferase 1A
affects expression multiple interactions
ISO
Ivermectin affects the expression of CPT1A mRNA Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
CTD
PMID:30738135 PMID:31199990
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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Crp
C-reactive protein
increases expression
ISO
Ivermectin results in increased expression of CRP protein
CTD
PMID:8555762
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Ctsl
cathepsin L
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA
CTD
PMID:16861626
NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity increases expression
ISO
Ivermectin results in decreased activity of CYP1A1 protein Ivermectin results in increased expression of CYP1A1 mRNA
CTD
PMID:18420780 PMID:24998875
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
Ivermectin results in increased expression of CYP1A2 mRNA
CTD
PMID:24998875
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Ivermectin results in decreased activity of CYP1B1 protein
CTD
PMID:18420780
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity increases expression
ISO
Ivermectin results in decreased activity of CYP2B10 protein Ivermectin results in increased expression of CYP2B10 mRNA
CTD
PMID:18420780 PMID:24998875
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity
ISO
Ivermectin results in decreased activity of CYP2C29 protein
CTD
PMID:18420780
NCBI chr 1:147,236,480...147,307,988
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Ivermectin results in decreased activity of CYP2D6 protein Ivermectin results in decreased activity of CYP2D22 protein
CTD
PMID:11124226 PMID:18420780
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Ivermectin results in decreased activity of CYP2E1 protein
CTD
PMID:18420780
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity
ISO
Ivermectin results in decreased activity of CYP3A4 protein
CTD
PMID:11124226 PMID:18420780
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Ddit3
DNA-damage inducible transcript 3
increases expression affects expression multiple interactions
ISO
Ivermectin results in increased expression of DDIT3 mRNA Ivermectin affects the expression of DDIT3 mRNA Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]
CTD
PMID:28942281 PMID:30738135 PMID:31199990
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA
CTD
PMID:16861626
NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
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Dpysl2
dihydropyrimidinase-like 2
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA
CTD
PMID:16861626
NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
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Edem1
ER degradation enhancing alpha-mannosidase like protein 1
increases expression
ISO
Ivermectin results in increased expression of EDEM1 mRNA
CTD
PMID:28942281
NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
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Edn1
endothelin 1
multiple interactions
ISO
Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]
CTD
PMID:28942281
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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Egln3
egl-9 family hypoxia-inducible factor 3
decreases expression
ISO
Ivermectin results in decreased expression of EGLN3 mRNA
CTD
PMID:28942281
NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
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Esr1
estrogen receptor 1
increases expression
ISO
Ivermectin results in increased expression of ESR1
CTD
PMID:26078298
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Fabp4
fatty acid binding protein 4
affects expression multiple interactions
ISO
Ivermectin affects the expression of FABP4 mRNA Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA]
CTD
PMID:31199990
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
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Fasn
fatty acid synthase
affects expression
ISO
Ivermectin affects the expression of FASN mRNA
CTD
PMID:31199990
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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Gdf15
growth differentiation factor 15
increases expression
ISO
Ivermectin results in increased expression of GDF15 mRNA
CTD
PMID:28942281
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
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Gem
GTP binding protein overexpressed in skeletal muscle
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA
CTD
PMID:16861626
NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
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Glra1
glycine receptor, alpha 1
increases activity multiple interactions affects activity
ISO
Ivermectin results in increased activity of GLRA1 protein mutant form Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form] Ivermectin affects the activity of GLRA1 protein mutant form
CTD
PMID:25231486 PMID:27958714
NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
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Glra3
glycine receptor, alpha 3
affects expression
ISO
Ivermectin affects the expression of GLRA3 mRNA
CTD
PMID:31199990
NCBI chr16:37,676,959...37,908,221
Ensembl chr16:37,676,962...38,063,821
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Glrb
glycine receptor, beta
affects expression
ISO
Ivermectin affects the expression of GLRB mRNA
CTD
PMID:31199990
NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
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Gpr183
G protein-coupled receptor 183
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA
CTD
PMID:16861626
NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA
CTD
PMID:16861626
NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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Hsp90ab1
heat shock protein 90 alpha family class B member 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA
CTD
PMID:16861626
NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
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Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression multiple interactions
EXP
Ivermectin results in increased expression of HSPA1A mRNA Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA]
CTD
PMID:28880400
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
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Hspa4
heat shock protein family A (Hsp70) member 4
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA
CTD
PMID:16861626
NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Ivermectin results in increased expression of HSPA5 protein
CTD
PMID:30738135
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA
CTD
PMID:16861626
NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
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Hspa9
heat shock protein family A (Hsp70) member 9
increases expression
ISO
Ivermectin results in increased expression of HSPA9 mRNA
CTD
PMID:28942281
NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
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Hspd1
heat shock protein family D (Hsp60) member 1
multiple interactions increases expression
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA Ivermectin results in increased expression of HSPD1 mRNA
CTD
PMID:16861626 PMID:28942281
NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
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Hspe1
heat shock protein family E (Hsp10) member 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA
CTD
PMID:16861626
NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
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Hsph1
heat shock protein family H (Hsp110) member 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA
CTD
PMID:16861626
NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
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Igfbp3
insulin-like growth factor binding protein 3
increases expression multiple interactions
EXP
Ivermectin results in increased expression of IGFBP3 mRNA Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA]
CTD
PMID:28880400
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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Il10
interleukin 10
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein
CTD
PMID:16861626
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein
CTD
PMID:16861626
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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Il1r1
interleukin 1 receptor type 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA
CTD
PMID:16861626
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
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Lonp1
lon peptidase 1, mitochondrial
increases expression
ISO
Ivermectin results in increased expression of LONP1 mRNA
CTD
PMID:28942281
NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177
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Map3k8
mitogen-activated protein kinase kinase kinase 8
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA
CTD
PMID:16861626
NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19168156
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19168156
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]
CTD
PMID:19168156
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mxd1
max dimerization protein 1
multiple interactions
ISO
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein]
CTD
PMID:26078298
NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179
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Myh4
myosin heavy chain 4
multiple interactions
EXP
Ivermectin inhibits the reaction [Potassium Chloride affects the localization of MYH4 protein]
CTD
PMID:29293066
NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
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Nanog
Nanog homeobox
decreases expression
ISO
Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein
CTD
PMID:29257278
NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
CTD
PMID:27773686
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
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Ndrg1
N-myc downstream regulated 1
decreases expression
ISO
Ivermectin results in decreased expression of NDRG1 mRNA
CTD
PMID:28942281
NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]
CTD
PMID:19168156
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nppb
natriuretic peptide B
multiple interactions
ISO
Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]
CTD
PMID:28942281
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein
CTD
PMID:22021338
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions increases expression affects expression
ISO
Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] Ivermectin results in increased expression of NR1H4 mRNA Ivermectin affects the expression of NR1H4 mRNA
CTD
PMID:27773686 PMID:30738135 PMID:31199990
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Ivermectin results in increased expression of NUPR1 mRNA
CTD
PMID:28942281
NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
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P2rx4
purinergic receptor P2X 4
multiple interactions increases activity
ISO
Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] Ivermectin results in increased activity of P2RX4 protein
CTD
PMID:19560503 PMID:21638035 PMID:30545933
NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
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Parp1
poly (ADP-ribose) polymerase 1
increases expression
ISO
Ivermectin results in increased expression of PARP1 protein modified form
CTD
PMID:28811376
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pfkl
phosphofructokinase, liver type
decreases expression
ISO
Ivermectin results in decreased expression of PFKL mRNA
CTD
PMID:28942281
NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
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Pou5f1
POU class 5 homeobox 1
decreases expression
ISO
Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein
CTD
PMID:29257278
NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
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Ppara
peroxisome proliferator activated receptor alpha
decreases expression multiple interactions
ISO
Ivermectin results in decreased expression of PPARA mRNA Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]
CTD
PMID:30738135
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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Pparg
peroxisome proliferator-activated receptor gamma
affects expression multiple interactions
ISO
Ivermectin affects the expression of PPARG mRNA Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA]
CTD
PMID:31199990
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Ppid
peptidylprolyl isomerase D
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA
CTD
PMID:16861626
NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
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Ppif
peptidylprolyl isomerase F
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA
CTD
PMID:16861626
NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
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Ptges3
prostaglandin E synthase 3
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA
CTD
PMID:16861626
NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]
CTD
PMID:19168156
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rpp14
ribonuclease P/MRP subunit p14
increases expression
ISO
Ivermectin results in increased expression of RPP14 mRNA
CTD
PMID:28942281
NCBI chr15:18,625,963...18,636,157
Ensembl chr15:18,625,964...18,632,536
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Serpine1
serpin family E member 1
decreases expression
ISO
Ivermectin results in decreased expression of SERPINE1 mRNA
CTD
PMID:28942281
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Sin3a
SIN3 transcription regulator family member A
multiple interactions
ISO
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein]
CTD
PMID:26078298
NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
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Skap2
src kinase associated phosphoprotein 2
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA
CTD
PMID:16861626
NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
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Slc2a1
solute carrier family 2 member 1
decreases expression
ISO
Ivermectin results in decreased expression of SLC2A1 mRNA
CTD
PMID:28942281
NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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Slc2a4
solute carrier family 2 member 4
affects expression
ISO
Ivermectin affects the expression of SLC2A4 mRNA
CTD
PMID:31199990
NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein
CTD
PMID:29257278
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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Sphk1
sphingosine kinase 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA
CTD
PMID:16861626
NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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St13
ST13, Hsp70 interacting protein
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA
CTD
PMID:16861626
NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
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Tcp1
t-complex 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA
CTD
PMID:16861626
NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
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Tfrc
transferrin receptor
decreases expression
ISO
Ivermectin results in decreased expression of TFRC mRNA
CTD
PMID:28942281
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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Tgif1
TGFB-induced factor homeobox 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA
CTD
PMID:16861626
NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
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Tlr2
toll-like receptor 2
decreases expression
ISO
Ivermectin results in decreased expression of TLR2 protein
CTD
PMID:28653460
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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Tlr4
toll-like receptor 4
decreases expression
ISO
Ivermectin results in decreased expression of TLR4 mRNA
CTD
PMID:28653460
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnf
tumor necrosis factor
decreases expression
ISO
Ivermectin results in decreased expression of TNF mRNA
CTD
PMID:28653460
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
multiple interactions
ISO
Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form]
CTD
PMID:24658405
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Trib3
tribbles pseudokinase 3
increases expression
ISO
Ivermectin results in increased expression of TRIB3 mRNA
CTD
PMID:28942281
NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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Tsc22d1
TSC22 domain family, member 1
multiple interactions
ISO
[Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA
CTD
PMID:16861626
NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
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