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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:22,23-dihydroavermectin B1a
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Accession:CHEBI:63941 term browser browse the term
Definition:A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.
Synonyms:exact_synonym: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
 related_synonym: 5-O-demethyl-22,23-dihydroavermectin A1a;   Formula=C48H74O14;   H2B1a;   InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1;   InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N;   SMILES=[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(CC[C@H](C)[C@]([H])(O1)[C@@H](C)CC)O2)[C@]34O;   avermectin H2B1a;   dihydroavermectin B1a;   ivermectin B1a
 xref: CAS:71827-03-7
 xref_mesh: MESH:C052102
 xref: PDBeChem:IVM;   PMID:2411323;   PMID:6125361;   PMID:6148214;   PMID:6547280;   Reaxys:4643153;   VSDB:1455

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22,23-dihydroavermectin B1a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
increases transport
increases expression
decreases activity
increases export
decreases response to substance
multiple interactions
increases response to substance
affects binding
affects response to substance		 ISO ABCB1 gene polymorphism affects the abundance of Ivermectin
ABCB1 protein results in increased transport of Ivermectin
Ivermectin results in increased expression of ABCB1A mRNA
Ivermectin results in decreased activity of ABCB1A protein
ABCB1A protein results in increased export of Ivermectin
ABCB1A protein results in decreased susceptibility to Ivermectin
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin
Ivermectin results in decreased activity of ABCB1 protein
ABCB1 protein affects the abundance of Ivermectin
Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Ivermectin]
Ivermectin binds to ABCB1 protein
ABCB1 gene polymorphism affects the susceptibility to Ivermectin		 CTD PMID:8917702 PMID:8949985 PMID:9144452 PMID:17134887 PMID:18633165 PMID:19161460 PMID:20513441 PMID:20595473 PMID:20630055 PMID:21321059 PMID:22024132 PMID:22834856 PMID:24998875 PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
increases expression		 ISO [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin results in increased expression of and results in increased stability of ABCB1B mRNA
Ivermectin results in increased expression of ABCB1B mRNA		 CTD PMID:19161460 PMID:22024132 PMID:24998875 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin results in decreased activity of ABCC1 protein		 CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Ivermectin results in increased expression of ABCC2 mRNA CTD PMID:24998875 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ivermectin results in increased expression of ABCG2 mRNA CTD PMID:24998875 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression
decreases expression
multiple interactions		 ISO Ivermectin affects the expression of ACACA mRNA
Ivermectin results in decreased expression of ACACA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]
Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]		 CTD PMID:30738135 PMID:31199990 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081 		JBrowse link
G Adm adrenomedullin decreases expression ISO Ivermectin results in decreased expression of ADM mRNA CTD PMID:28942281 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Ivermectin results in increased expression of ALDH1L2 mRNA CTD PMID:28942281 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108 		JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Ivermectin results in increased expression of ANGPTL6 mRNA CTD PMID:28942281 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829 		JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Ivermectin results in increased expression of ATF4 mRNA CTD PMID:28942281 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Ivermectin results in increased expression of ATF5 mRNA CTD PMID:28942281 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Ivermectin results in increased expression of ATF6 mRNA CTD PMID:28942281 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ivermectin results in increased expression of BAX protein CTD PMID:28811376 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA] CTD PMID:24658405 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Ivermectin results in decreased expression of BNIP3 mRNA CTD PMID:28942281 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein CTD PMID:28653460 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP Ivermectin results in decreased activity of CAT protein
Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]		 CTD PMID:28880400 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456 		JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610 		JBrowse link
G Cd36 CD36 molecule affects expression ISO Ivermectin affects the expression of CD36 mRNA CTD PMID:31199990 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Ivermectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ivermectin results in increased expression of CDKN1A protein CTD PMID:28811376 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ivermectin results in increased expression of CDKN1B protein CTD PMID:28811376 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
multiple interactions		 ISO Ivermectin affects the expression of CEBPA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA]		 CTD PMID:31199990 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression ISO Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein CTD PMID:28942281 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression
multiple interactions		 ISO Ivermectin affects the expression of CPT1A mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]		 CTD PMID:30738135 PMID:31199990 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crp C-reactive protein increases expression ISO Ivermectin results in increased expression of CRP protein CTD PMID:8555762 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression		 ISO Ivermectin results in decreased activity of CYP1A1 protein
Ivermectin results in increased expression of CYP1A1 mRNA		 CTD PMID:18420780 PMID:24998875 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Ivermectin results in increased expression of CYP1A2 mRNA CTD PMID:24998875 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity
increases expression		 ISO Ivermectin results in decreased activity of CYP2B10 protein
Ivermectin results in increased expression of CYP2B10 mRNA		 CTD PMID:18420780 PMID:24998875 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Ivermectin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Ivermectin results in decreased activity of CYP2D6 protein
Ivermectin results in decreased activity of CYP2D22 protein		 CTD PMID:11124226 PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Ivermectin results in decreased activity of CYP3A4 protein CTD PMID:11124226 PMID:18420780 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
affects expression
multiple interactions		 ISO Ivermectin results in increased expression of DDIT3 mRNA
Ivermectin affects the expression of DDIT3 mRNA
Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]		 CTD PMID:28942281 PMID:30738135 PMID:31199990 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Ivermectin results in increased expression of EDEM1 mRNA CTD PMID:28942281 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Ivermectin results in decreased expression of EGLN3 mRNA CTD PMID:28942281 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Ivermectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression
multiple interactions		 ISO Ivermectin affects the expression of FABP4 mRNA
Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA]		 CTD PMID:31199990 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fasn fatty acid synthase affects expression ISO Ivermectin affects the expression of FASN mRNA CTD PMID:31199990 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Ivermectin results in increased expression of GDF15 mRNA CTD PMID:28942281 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661 		JBrowse link
G Glra1 glycine receptor, alpha 1 increases activity
multiple interactions
affects activity		 ISO Ivermectin results in increased activity of GLRA1 protein mutant form
Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form]
Ivermectin affects the activity of GLRA1 protein mutant form		 CTD PMID:25231486 PMID:27958714 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651 		JBrowse link
G Glra3 glycine receptor, alpha 3 affects expression ISO Ivermectin affects the expression of GLRA3 mRNA CTD PMID:31199990 NCBI chr16:37,676,959...37,908,221
Ensembl chr16:37,676,962...38,063,821 		JBrowse link
G Glrb glycine receptor, beta affects expression ISO Ivermectin affects the expression of GLRB mRNA CTD PMID:31199990 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547 		JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions		 EXP Ivermectin results in increased expression of HSPA1A mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA]		 CTD PMID:28880400 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ivermectin results in increased expression of HSPA5 protein CTD PMID:30738135 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Ivermectin results in increased expression of HSPA9 mRNA CTD PMID:28942281 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression		 ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA
Ivermectin results in increased expression of HSPD1 mRNA		 CTD PMID:16861626 PMID:28942281 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression
multiple interactions		 EXP Ivermectin results in increased expression of IGFBP3 mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA]		 CTD PMID:28880400 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:19168156 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:19168156 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:19168156 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mxd1 max dimerization protein 1 multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179 		JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP Ivermectin inhibits the reaction [Potassium Chloride affects the localization of MYH4 protein] CTD PMID:29293066 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein CTD PMID:29257278 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO Ivermectin results in decreased expression of NDRG1 mRNA CTD PMID:28942281 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:19168156 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein CTD PMID:22021338 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
affects expression		 ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
Ivermectin results in increased expression of NR1H4 mRNA
Ivermectin affects the expression of NR1H4 mRNA		 CTD PMID:27773686 PMID:30738135 PMID:31199990 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ivermectin results in increased expression of NUPR1 mRNA CTD PMID:28942281 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions
increases activity		 ISO Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
Ivermectin results in increased activity of P2RX4 protein		 CTD PMID:19560503 PMID:21638035 PMID:30545933 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pfkl phosphofructokinase, liver type decreases expression ISO Ivermectin results in decreased expression of PFKL mRNA CTD PMID:28942281 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein CTD PMID:29257278 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO Ivermectin results in decreased expression of PPARA mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]		 CTD PMID:30738135 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions		 ISO Ivermectin affects the expression of PPARG mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA]		 CTD PMID:31199990 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:19168156 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 increases expression ISO Ivermectin results in increased expression of RPP14 mRNA CTD PMID:28942281 NCBI chr15:18,625,963...18,636,157
Ensembl chr15:18,625,964...18,632,536 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Ivermectin results in decreased expression of SERPINE1 mRNA CTD PMID:28942281 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Ivermectin results in decreased expression of SLC2A1 mRNA CTD PMID:28942281 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression ISO Ivermectin affects the expression of SLC2A4 mRNA CTD PMID:31199990 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein CTD PMID:29257278 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393 		JBrowse link
G St13 ST13, Hsp70 interacting protein multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731 		JBrowse link
G Tcp1 t-complex 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO Ivermectin results in decreased expression of TFRC mRNA CTD PMID:28942281 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Ivermectin results in decreased expression of TLR2 protein CTD PMID:28653460 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Ivermectin results in decreased expression of TNF mRNA CTD PMID:28653460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form] CTD PMID:24658405 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Ivermectin results in increased expression of TRIB3 mRNA CTD PMID:28942281 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    chemical entity 19817
      molecular entity 19814
        polyatomic entity 19727
          molecule 19563
            cyclic compound 19386
              macrocycle 2314
                macrocyclic lactone 1743
                  22,23-dihydroavermectin B1a 112
                    ivermectin 112
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18435
                                    carbonyl compound 18435
                                      carboxylic ester 14365
                                        lactone 5997
                                          macrocyclic lactone 1743
                                            macrolide 1613
                                              avermectin 118
                                                avermectin B1a 117
                                                  22,23-dihydroavermectin B1a 112
                                                    ivermectin 112
paths to the root