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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclazosin
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Accession:CHEBI:63937 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of furoic acid with the secondary amino group of 6,7-dimethoxy-2-[(4aR,8aS)-octahydroquinoxalin-1-yl]quinazolin-4-amine.
Synonyms:exact_synonym: [(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](2-furyl)methanone
 related_synonym: Formula=C23H27N5O4;   InChI=1S/C23H27N5O4/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26)/t16-,17+/m0/s1;   InChIKey=XBRXTUGRUXGBPX-DLBZAZTESA-N;   SMILES=[H][C@]12CCCC[C@@]1([H])N(CCN2C(=O)c1ccco1)c1nc(N)c2cc(OC)c(OC)cc2n1;   cis-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydroquinoxaline
 xref: CAS:139953-73-4
 xref_mesh: MESH:C080462
 xref: PMID:11036156;   PMID:11294762;   PMID:14634588;   PMID:15598431;   PMID:16213480;   PMID:17276073;   PMID:18037913;   PMID:18702011;   PMID:8666020;   PMID:8917649;   PMID:9851544;   PMID:9871765;   Reaxys:8020551



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cyclazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B multiple interactions EXP cyclazosin binds to and results in decreased activity of ADRA1B protein CTD PMID:15951348 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          antagonist 16715
            adenosine receptor antagonist 1154
              adenosine A2A receptor antagonist 698
                cyclazosin 1
                  cyclazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                monocarboxylic acid amide 15515
                                                  cyclazosin 1
                                                    cyclazosin hydrochloride 0
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